DE69631586D1 - Für menschliches papillomavirus stamm 18 kodierende dns - Google Patents

Für menschliches papillomavirus stamm 18 kodierende dns

Info

Publication number
DE69631586D1
DE69631586D1 DE69631586T DE69631586T DE69631586D1 DE 69631586 D1 DE69631586 D1 DE 69631586D1 DE 69631586 T DE69631586 T DE 69631586T DE 69631586 T DE69631586 T DE 69631586T DE 69631586 D1 DE69631586 D1 DE 69631586D1
Authority
DE
Germany
Prior art keywords
dna encoding
human papillomavirus
papillomavirus
human
hpv18
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631586T
Other languages
English (en)
Other versions
DE122007000025I1 (de
DE69631586T2 (de
DE69631586T9 (de
Inventor
J Hofmann
U Jansen
P Neeper
G Joyce
A George
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27020342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69631586(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/409,122 external-priority patent/US5820870A/en
Priority claimed from US08/408,669 external-priority patent/US5840306A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69631586D1 publication Critical patent/DE69631586D1/de
Publication of DE69631586T2 publication Critical patent/DE69631586T2/de
Application granted granted Critical
Publication of DE69631586T9 publication Critical patent/DE69631586T9/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/905—Stable introduction of foreign DNA into chromosome using homologous recombination in yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69631586T 1995-03-22 1996-03-18 Für menschliches papillomavirus stamm 18 kodierende dns Active DE69631586T9 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/409,122 US5820870A (en) 1995-03-22 1995-03-22 Recombinant human papillomavirus type 18 vaccine
US08/408,669 US5840306A (en) 1995-03-22 1995-03-22 DNA encoding human papillomavirus type 18
US408669 1995-03-22
US409122 1995-03-22
PCT/US1996/003649 WO1996029413A2 (en) 1995-03-22 1996-03-18 Dna encoding human papilloma virus type 18

Publications (3)

Publication Number Publication Date
DE69631586D1 true DE69631586D1 (de) 2004-03-25
DE69631586T2 DE69631586T2 (de) 2005-01-27
DE69631586T9 DE69631586T9 (de) 2005-06-16

Family

ID=27020342

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69631586T Active DE69631586T9 (de) 1995-03-22 1996-03-18 Für menschliches papillomavirus stamm 18 kodierende dns
DE1996631586 Pending DE122007000025I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS
DE200712000031 Pending DE122007000031I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS
DE200712000030 Pending DE122007000030I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE1996631586 Pending DE122007000025I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS
DE200712000031 Pending DE122007000031I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS
DE200712000030 Pending DE122007000030I1 (de) 1995-03-22 1996-03-18 Für menschliches Papillomavirus stamm 18 kodierende DNS

Country Status (22)

Country Link
EP (2) EP0817851B9 (de)
JP (1) JPH11502704A (de)
KR (1) KR100430698B1 (de)
CN (1) CN1100876C (de)
AT (1) ATE259879T1 (de)
AU (1) AU714533B2 (de)
CA (1) CA2215834C (de)
CZ (1) CZ291242B6 (de)
DE (4) DE69631586T9 (de)
DK (1) DK0817851T5 (de)
EA (1) EA001092B1 (de)
ES (1) ES2213772T3 (de)
FR (1) FR07C0023I2 (de)
HU (1) HU223761B1 (de)
IL (1) IL117459A (de)
NL (3) NL300271I1 (de)
NO (1) NO322254B1 (de)
NZ (1) NZ305188A (de)
PL (1) PL184022B1 (de)
PT (1) PT817851E (de)
SK (1) SK284281B6 (de)
WO (1) WO1996029413A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
EE9900612A (et) * 1997-04-08 2000-08-15 Merck & Co., Inc. Inimese papilloomiviiruse stabiliseeritud preparaadid
ZA982950B (en) 1997-04-08 1998-10-19 Merck & Co Inc Stabilized human papillomavirus formulations
CN1354787A (zh) * 1998-08-14 2002-06-19 麦克公司 纯化人乳头瘤病毒样颗粒的方法
AUPP765398A0 (en) 1998-12-11 1999-01-14 University Of Queensland, The Treatment of papillomavirus infections
SI1150712T1 (sl) 1999-02-05 2009-02-28 Merck & Co Inc Pripravek cepiva proti humanem papiloma virusu
FR2795074A1 (fr) * 1999-05-21 2000-12-22 Inst Nat Sante Rech Med Polypeptides transporteurs d'acides amines, et en particulier du glutamate, et procedes de criblage de composes inhibiteurs ou activateurs de l'activite de transport
MY140664A (en) * 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2008134935A1 (fr) * 2007-04-29 2008-11-13 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Protéines 18 l1 de type papillomavirus humain tronqué
CN101293918B (zh) 2007-04-29 2013-03-27 北京万泰生物药业股份有限公司 截短的人乳头瘤病毒16型l1蛋白
CN101440373B (zh) * 2007-11-23 2012-09-05 上海泽润生物科技有限公司 一种截短型的18型人乳头状瘤病毒主要衣壳蛋白l1基因
EA022213B1 (ru) * 2009-06-25 2015-11-30 Глаксосмитклайн Байолоджикалс С.А. Новые конструкции белка вируса папилломы человека (hpv) и их применение в предупреждении заболевания, вызываемого hpv
EP2722389B1 (de) * 2011-06-15 2018-03-07 Hong Jin Kim Verfahren zur steigerung der produktionsausbeute des menschlichen papillomavirus-proteins l1
WO2013139744A1 (en) 2012-03-18 2013-09-26 Glaxosmithkline Biologicals S.A. Method of vaccination against human papillomavirus
CN108276491B (zh) * 2018-02-05 2021-01-12 南京薇熙生物医药科技有限公司 一种可特异性识别hpv18 l1蛋白的单克隆抗体及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625257A1 (de) * 1986-07-23 1988-02-04 Behringwerke Ag Expressionsprodukte der menschlichen papillomviren typ 16 und 18, fuer diese proteine spezifische antikoerper und diese antikoerper bzw. entsprechende dna enthaltende diagnostika
DE4015044A1 (de) * 1990-05-10 1991-11-14 Behringwerke Ag Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18
DE122007000017I1 (de) * 1991-07-19 2007-07-26 Univ Queensland Impfstoffe gegen Papillomavirus
DE122007000099I1 (de) * 1992-06-25 2008-03-27 Papillomavirus vakzine
US5437951A (en) * 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
EP1588713B1 (de) * 1993-03-09 2010-12-22 The University Of Rochester Herstellung von menschlichen papillomavirus HBV-11 Kapsidprotein L1 und Virus-ähnliche Partikeln

Also Published As

Publication number Publication date
DE122007000031I1 (de) 2007-07-19
KR100430698B1 (ko) 2004-07-15
AU5314196A (en) 1996-10-08
HUP9801334A2 (hu) 1998-08-28
EP1422294A1 (de) 2004-05-26
HUP9801334A3 (en) 1999-04-28
IL117459A (en) 2005-11-20
DE122007000025I1 (de) 2007-07-12
FR07C0023I1 (de) 2007-04-27
CZ291242B6 (cs) 2003-01-15
WO1996029413A2 (en) 1996-09-26
CZ293697A3 (cs) 1998-02-18
NO322254B1 (no) 2006-09-04
WO1996029413A3 (en) 1996-11-28
NL300273I1 (nl) 2007-05-01
PL322333A1 (en) 1998-01-19
EA001092B1 (ru) 2000-10-30
CA2215834A1 (en) 1996-09-26
NL300271I1 (nl) 2007-05-01
EP0817851B1 (de) 2004-02-18
DE69631586T2 (de) 2005-01-27
MX9707208A (es) 1997-11-29
SK127897A3 (en) 1998-07-08
FR07C0023I2 (fr) 2012-08-03
IL117459A0 (en) 1996-07-23
JPH11502704A (ja) 1999-03-09
EP0817851A2 (de) 1998-01-14
ES2213772T3 (es) 2004-09-01
DK0817851T3 (da) 2004-08-16
HU223761B1 (hu) 2005-01-28
NZ305188A (en) 1999-11-29
PL184022B1 (pl) 2002-08-30
EP0817851B9 (de) 2004-08-18
CA2215834C (en) 2007-06-12
EA199700256A1 (ru) 1999-06-24
AU714533B2 (en) 2000-01-06
NO974322L (no) 1997-11-24
CN1100876C (zh) 2003-02-05
NL300272I1 (nl) 2007-05-01
NO974322D0 (no) 1997-09-19
ATE259879T1 (de) 2004-03-15
SK284281B6 (sk) 2004-12-01
DE122007000030I1 (de) 2007-07-19
CN1185176A (zh) 1998-06-17
DK0817851T5 (da) 2004-10-25
DE69631586T9 (de) 2005-06-16
PT817851E (pt) 2004-06-30

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