CN101851277B - 一种道古霉素关键中间体a40926 bo组分的纯化制备方法 - Google Patents
一种道古霉素关键中间体a40926 bo组分的纯化制备方法 Download PDFInfo
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- CN101851277B CN101851277B CN200910058576A CN200910058576A CN101851277B CN 101851277 B CN101851277 B CN 101851277B CN 200910058576 A CN200910058576 A CN 200910058576A CN 200910058576 A CN200910058576 A CN 200910058576A CN 101851277 B CN101851277 B CN 101851277B
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- 229960002488 dalbavancin Drugs 0.000 title abstract description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
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- 239000003463 adsorbent Substances 0.000 claims description 2
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- 230000000274 adsorptive effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 13
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 239000012530 fluid Substances 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
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- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
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- 206010041925 Staphylococcal infections Diseases 0.000 description 1
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- 239000002253 acid Substances 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
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- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
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- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN200910058576A CN101851277B (zh) | 2009-03-12 | 2009-03-12 | 一种道古霉素关键中间体a40926 bo组分的纯化制备方法 |
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CN200910058576A CN101851277B (zh) | 2009-03-12 | 2009-03-12 | 一种道古霉素关键中间体a40926 bo组分的纯化制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN105671110B (zh) * | 2015-05-05 | 2019-02-01 | 重庆乾泰生物医药有限公司 | 一种生产达巴万星前体a40926的方法 |
CN107365357B (zh) * | 2016-05-12 | 2021-07-30 | 鲁南新时代生物技术有限公司 | 一种糖肽类抗生素达巴万星中间体a40926的纯化制备方法 |
CN110156876A (zh) * | 2019-05-25 | 2019-08-23 | 聊城大学 | 一种适合工业化生产的高纯度a40926b0制备方法 |
CN110940763B (zh) * | 2019-12-19 | 2022-07-26 | 宜昌东阳光生化制药有限公司 | 分离纯化达巴万星前体a40926的方法 |
CN113444091B (zh) * | 2020-03-26 | 2024-07-05 | 重庆乾泰生物医药有限公司 | 一种去除达巴万星中间体a-40926b0中组胺的方法 |
CN112480214B (zh) * | 2020-12-14 | 2023-03-28 | 成都雅途生物技术有限公司 | 一种达巴万星关键中间体a40926的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85107903A (zh) * | 1984-10-11 | 1987-05-06 | 格鲁波莱佩蒂特公司 | 生产抗生素a40926复合物及其纯因子pa.pb.a.b.及b0的方法 |
EP0259781A2 (en) * | 1986-09-11 | 1988-03-16 | GRUPPO LEPETIT S.p.A. | Method for selectively increasing the ratio of single major components of antibiotic A 40926 complex |
CN86108977A (zh) * | 1986-04-11 | 1988-04-27 | 格鲁波莱佩蒂特公司 | N-酰氨基葡糖苷酸糖苷配基抗菌素a40926族和糖苷配基抗菌素a40926 |
EP0836619A1 (en) * | 1995-07-05 | 1998-04-22 | GRUPPO LEPETIT S.p.A. | Purification of dalbaheptide antibiotics by isoelectric focusing |
-
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- 2009-03-12 CN CN200910058576A patent/CN101851277B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85107903A (zh) * | 1984-10-11 | 1987-05-06 | 格鲁波莱佩蒂特公司 | 生产抗生素a40926复合物及其纯因子pa.pb.a.b.及b0的方法 |
CN86108977A (zh) * | 1986-04-11 | 1988-04-27 | 格鲁波莱佩蒂特公司 | N-酰氨基葡糖苷酸糖苷配基抗菌素a40926族和糖苷配基抗菌素a40926 |
EP0259781A2 (en) * | 1986-09-11 | 1988-03-16 | GRUPPO LEPETIT S.p.A. | Method for selectively increasing the ratio of single major components of antibiotic A 40926 complex |
EP0836619A1 (en) * | 1995-07-05 | 1998-04-22 | GRUPPO LEPETIT S.p.A. | Purification of dalbaheptide antibiotics by isoelectric focusing |
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Denomination of invention: A kind of dalbavancin key intermediate A40926 BO group the purification preparation method Effective date of registration: 20131213 Granted publication date: 20121003 Pledgee: Chengdu technology transfer (Group) Co., Ltd. Pledgor: Chengdu Yatu Biotechnology Co., Ltd. Registration number: 2013990000975 |
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Denomination of invention: Purification method for preparation of A40926 BO component of a key intermediate of dhoomycin Effective date of registration: 20180413 Granted publication date: 20121003 Pledgee: Chengdu technical transformation incubator management Co., Ltd. Pledgor: Chengdu Yatu Biotechnology Co., Ltd. Registration number: 2018510000042 |
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