RU93046497A - Фенильные гетероциклические производные, способ их получения, фармацевтическая композиция и промежуточный продукт - Google Patents
Фенильные гетероциклические производные, способ их получения, фармацевтическая композиция и промежуточный продуктInfo
- Publication number
- RU93046497A RU93046497A RU93046497/04A RU93046497A RU93046497A RU 93046497 A RU93046497 A RU 93046497A RU 93046497/04 A RU93046497/04 A RU 93046497/04A RU 93046497 A RU93046497 A RU 93046497A RU 93046497 A RU93046497 A RU 93046497A
- Authority
- RU
- Russia
- Prior art keywords
- phenylic
- production
- pharmaceutical composition
- intermediate product
- heterocyclic derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000012450 pharmaceutical intermediate Substances 0.000 title 1
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Claims (1)
- Изобретение представляет новые фенильные и гетероциклические производные, их фармацевтические препаративные формы и способы их употребления для противодействия рецепторам ангиотензина II у млекопитающих.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89286792A | 1992-06-03 | 1992-06-03 | |
US07/892.867 | 1992-06-03 | ||
US07/892,867 | 1992-06-03 | ||
US08/049.917 | 1993-04-20 | ||
US08/049,917 US5401851A (en) | 1992-06-03 | 1993-04-20 | Angiotensin II antagonists |
US08/049,917 | 1993-04-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93046497A true RU93046497A (ru) | 1996-06-20 |
RU2110515C1 RU2110515C1 (ru) | 1998-05-10 |
Family
ID=26727701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93046497A RU2110515C1 (ru) | 1992-06-03 | 1993-06-02 | Производные имидазола и фармацевтическая композиция |
Country Status (16)
Country | Link |
---|---|
US (2) | US5401851A (ru) |
EP (1) | EP0573271A1 (ru) |
JP (1) | JPH07304752A (ru) |
CN (1) | CN1045768C (ru) |
AU (1) | AU667903B2 (ru) |
CA (1) | CA2097462A1 (ru) |
CZ (1) | CZ104493A3 (ru) |
FI (1) | FI932517A (ru) |
HU (1) | HUT64328A (ru) |
IL (1) | IL105877A (ru) |
MY (1) | MY131434A (ru) |
NO (1) | NO932005L (ru) |
NZ (1) | NZ247769A (ru) |
PL (1) | PL173340B1 (ru) |
RU (1) | RU2110515C1 (ru) |
TW (1) | TW235295B (ru) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2142883A1 (en) * | 1992-08-21 | 1994-03-03 | Saizo Shibata | Dioxacycloalkane compound having renin-inhibitory activity |
DE4302957A1 (de) * | 1993-02-03 | 1994-08-04 | Bayer Ag | Imidazolyl-substituierte Phenylessigsäureprolinamide |
US5344937A (en) * | 1993-04-20 | 1994-09-06 | Eli Lilly And Company | Alkyl substituted nitroimidazole acetic acids |
ES2076085B1 (es) * | 1993-06-15 | 1997-03-01 | Lilly Co Eli | Antagonistas de angiotensina ii. |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
TW375612B (en) * | 1995-04-06 | 1999-12-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CN1159009C (zh) * | 1995-12-27 | 2004-07-28 | 三菱制药株式会社 | 苯甲酸衍生物的制药应用 |
EP0891339A1 (en) * | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP0891335A4 (en) * | 1996-04-03 | 2001-08-16 | Merck & Co Inc | FARNESYL-PROTEIN TRANSFERASE INHIBITORS |
US5874452A (en) * | 1996-04-03 | 1999-02-23 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
US6309975B1 (en) | 1997-03-14 | 2001-10-30 | Micron Technology, Inc. | Methods of making implanted structures |
US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
US7378108B1 (en) | 1999-02-19 | 2008-05-27 | Takeda Pharmaceutical Company Limited | Percutaneous absorption preparation of compound having angiotensin II antagonistic activity |
US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
AU2001269885A1 (en) * | 2000-06-14 | 2001-12-24 | The Scripps Research Institute | Distamycin a analogs |
US6756385B2 (en) * | 2000-07-31 | 2004-06-29 | Pfizer Inc. | Imidazole derivatives |
GT200100147A (es) * | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
WO2002079188A1 (en) * | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Pyrrolidine sulfonamides |
WO2002079155A1 (en) * | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Pyrrolidine sulfonamides |
US7125840B2 (en) * | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
WO2003087069A2 (en) * | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
US20060167268A1 (en) * | 2002-04-09 | 2006-07-27 | Eli Lilly And Company, Patent Division, | Growth hormone secretagogues |
US20050113450A1 (en) * | 2002-08-23 | 2005-05-26 | Atli Thorarensen | Antibacterial agents |
TW200408393A (en) | 2002-10-03 | 2004-06-01 | Ono Pharmaceutical Co | Antagonist of lysophosphatidine acid receptor |
EA011689B1 (ru) | 2004-03-23 | 2009-04-28 | Пфайзер Продактс Инк. | Имидазольные соединения для лечения нейродегенеративных расстройств |
US20070010454A1 (en) * | 2005-07-06 | 2007-01-11 | Moridani Majid Y | Method for treating tumor cells resulting in minimal liver toxicity |
RS20080139A (en) | 2005-09-22 | 2009-05-06 | Pfizer Products Inc., | Imidazole coumpounds for the treatment of neurological disorders |
EP2493861A1 (en) * | 2009-10-26 | 2012-09-05 | Lexicon Pharmaceuticals, Inc. | Methods of preparing 1-(4-((1r,2s,3r)-1,2,3,4-tetrahydroxybutyl)-1h-imidazol-2-yl)ethanone |
RU2013128562A (ru) * | 2010-11-22 | 2015-01-10 | Инвиста Текнолоджиз С.А. Р.Л. | Получение ароматических карбоновых кислот |
NL1038473C2 (en) * | 2010-12-24 | 2012-06-27 | Centre Nat Rech Scient | Cancer targeting using carbonic anhydrase isoform ix inhibitors. |
CN102219636A (zh) * | 2011-04-26 | 2011-10-19 | 巨化集团公司 | 一种含氟碘代烷的合成方法 |
NZ626973A (en) | 2012-01-06 | 2016-09-30 | Novartis Ag | Heterocyclic compounds and methods for their use |
RU2475243C1 (ru) * | 2012-02-16 | 2013-02-20 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Средство, обладающее антигипертензивной активностью |
US10065943B2 (en) * | 2015-01-13 | 2018-09-04 | Novartis Ag | Pyrrolidine derivatives as angiotensin II type 2 antagonists |
CN107857691A (zh) * | 2017-10-30 | 2018-03-30 | 大丰跃龙化学有限公司 | 一种一氟一碘甲烷制备的新方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH528514A (de) * | 1969-05-22 | 1972-09-30 | Bayer Ag | Verfahren zur Herstellung von Acylimidazolen |
US3737422A (en) * | 1970-02-04 | 1973-06-05 | Abbott Lab | L-histidyl-l-proline amide |
DE2220906A1 (de) * | 1972-04-28 | 1973-11-15 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung |
GB1547564A (en) * | 1975-06-05 | 1979-06-20 | Lilly Industries Ltd | Acylated amino-heteroaryl compounds |
EP0003732B1 (en) * | 1978-02-01 | 1983-10-19 | The Wellcome Foundation Limited | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
JPS54148788A (en) * | 1978-05-15 | 1979-11-21 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation |
JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
DK531479A (da) * | 1979-01-19 | 1980-07-20 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
US4299769A (en) * | 1980-04-28 | 1981-11-10 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
DE3106150A1 (de) * | 1981-02-13 | 1982-09-16 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "verfahren zur herstellung von imidazolessigsaeurederivaten" |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
JPS58157768A (ja) * | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体 |
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
FI833794A0 (fi) * | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
FR2592042B1 (fr) * | 1985-12-19 | 1988-03-25 | Ile De France | Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
DK59888A (da) * | 1987-03-20 | 1988-09-21 | Hoffmann La Roche | Imidazolderivater |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
US5151497A (en) * | 1989-02-21 | 1992-09-29 | Japan Tobacco Inc. | Histidyl peptide derivatives |
US4962120A (en) * | 1989-03-22 | 1990-10-09 | Sterling Drug Inc. | 1H-imidazole-1-acetamides |
US5102880A (en) * | 1989-05-30 | 1992-04-07 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
US5055467A (en) * | 1989-11-13 | 1991-10-08 | Allergan, Inc. | Pharmaceutical epinephrine-pilocarpine compounds |
PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
US5234917A (en) * | 1989-12-29 | 1993-08-10 | Finkelstein Joseph A | Substituted 5-(alkyl)carboxamide imidazoles |
US5183810A (en) * | 1990-02-13 | 1993-02-02 | Merck & Co., Inc. | Imidazole angiotensin II antagonists incorporating a substituted benzyl element |
US5173494A (en) * | 1990-03-20 | 1992-12-22 | E. I. Du Pont De Nemours And Company | Specific inhibition of angiotensin-II binding to angiotensin-II receptor subtype-2 |
US5102903A (en) * | 1990-05-10 | 1992-04-07 | E. I. Du Pont De Nemours And Company | Treatment of glaucoma and ocular hypertension with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists |
US5053329A (en) * | 1990-07-05 | 1991-10-01 | Merck & Co., Inc. | Process for preparation of novel angiotensin II antagonists |
US5177074A (en) * | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
GB9107398D0 (en) * | 1991-04-09 | 1991-05-22 | British Bio Technology | Compounds |
US5175164A (en) * | 1991-06-05 | 1992-12-29 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted indole or dihydroindole |
US5210211A (en) * | 1991-06-21 | 1993-05-11 | Warner-Lambert Company | 4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity |
-
1993
- 1993-04-20 US US08/049,917 patent/US5401851A/en not_active Expired - Fee Related
- 1993-06-01 TW TW082104354A patent/TW235295B/zh active
- 1993-06-01 IL IL10587793A patent/IL105877A/en not_active IP Right Cessation
- 1993-06-01 HU HU9301603A patent/HUT64328A/hu unknown
- 1993-06-01 CZ CZ931044A patent/CZ104493A3/cs unknown
- 1993-06-01 CA CA002097462A patent/CA2097462A1/en not_active Abandoned
- 1993-06-02 EP EP93304264A patent/EP0573271A1/en not_active Ceased
- 1993-06-02 AU AU39985/93A patent/AU667903B2/en not_active Ceased
- 1993-06-02 NZ NZ247769A patent/NZ247769A/en unknown
- 1993-06-02 NO NO932005A patent/NO932005L/no unknown
- 1993-06-02 MY MYPI93001065A patent/MY131434A/en unknown
- 1993-06-02 FI FI932517A patent/FI932517A/fi unknown
- 1993-06-02 RU RU93046497A patent/RU2110515C1/ru active
- 1993-06-03 JP JP5133212A patent/JPH07304752A/ja active Pending
- 1993-06-03 CN CN93107578A patent/CN1045768C/zh not_active Expired - Fee Related
- 1993-06-03 PL PL93299176A patent/PL173340B1/pl unknown
-
1994
- 1994-12-14 US US08/355,778 patent/US5484780A/en not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU93046497A (ru) | Фенильные гетероциклические производные, способ их получения, фармацевтическая композиция и промежуточный продукт | |
FR2677984B1 (fr) | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. | |
MA26439A1 (fr) | Derives d'indazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA20292A1 (fr) | Nouveaux derives de 2,2' -iminobisethanol, intermediaires pour leur preparation et procedes pour la preparation de ces derives et intermediaires. | |
CA2134964A1 (en) | Bridged Aza-Bicyclic Derivatives as Substance P Antagonists | |
FR2729951B1 (fr) | Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant | |
NO973479L (no) | Substituerte heterosykliske forbindelser, fremgangsmåte for fremstilling og farmasöytiske blandinger inneholdende samme | |
FR2555987B1 (fr) | Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation | |
MA26526A1 (fr) | Derives d'indole inhibiteurs de cyclo-oxygenase, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
FR2740136B1 (fr) | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant | |
FR2665898B1 (fr) | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
RU93058531A (ru) | Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ лечения | |
CA2316921A1 (en) | Aryl fused azapolycyclic compounds | |
ES2160949T3 (es) | Derivados de fenilen-sulfonamida sustituidos en meta. | |
MA24158A1 (fr) | Derives d'imidazole substitues, procede pour leur preparation et compositions les contenant | |
MX9803954A (es) | Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos. | |
ATE227293T1 (de) | 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one | |
DE69510928D1 (de) | Heterocyclische verbindungen, ihre herstellung und verwendung | |
MA26490A1 (fr) | Derives de tetrahydroisoquinoleine nouveaux, procedes pour leur preparation et compositions pharmaceutiques les contenant. | |
FR2498188B1 (fr) | Nouveaux derives de l'indole, leur preparation et leur application comme medicaments | |
RU93004793A (ru) | Производные хиназолина, способ их получения, фармацевтическая композиция на их основе | |
HUT77360A (hu) | Apoliprotein-B szintézis inhibitor hatású azolszármazékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyszerkészítmények és intermedierjeik | |
FR2754258B1 (fr) | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant | |
MA26519A1 (fr) | Derives d'azetidinylpropylpiperidine, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
RU93004860A (ru) | Гетероциклические соединения, способ их получения, использование и фармацевтическая композиция |