CN104870022B - 蛋白质的体内产生 - Google Patents

蛋白质的体内产生 Download PDF

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Publication number
CN104870022B
CN104870022B CN201380028186.5A CN201380028186A CN104870022B CN 104870022 B CN104870022 B CN 104870022B CN 201380028186 A CN201380028186 A CN 201380028186A CN 104870022 B CN104870022 B CN 104870022B
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China
Prior art keywords
optionally substituted
protein
production
mmrna
polypeptide
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Expired - Fee Related
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CN201380028186.5A
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Chinese (zh)
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CN104870022A (zh
Inventor
斯蒂芬·邦塞尔
提尔塔·柴可拉博提
安东宁·德富热罗勒
S·M·伊巴希尔
马蒂亚斯·约翰
阿坦恩·洛依
苏珊·沃利斯基
K·M·伍德
保罗·哈塔拉
杰森·P·斯洛姆
凯内齐·伊杰贝
杰夫·L·埃尔斯沃思
贾斯汀·基尔德
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Moderna Inc
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Moderna Therapeutics Inc
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Priority claimed from PCT/US2013/030062 external-priority patent/WO2013151666A2/en
Application filed by Moderna Therapeutics Inc filed Critical Moderna Therapeutics Inc
Priority to CN202010645626.3A priority Critical patent/CN112390871A/zh
Publication of CN104870022A publication Critical patent/CN104870022A/zh
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PCT/US2013/030067 WO2013151670A2 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of nuclear proteins
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USPCT/US2013/030066 2013-03-09
PCT/US2013/030063 WO2013151667A1 (en) 2012-04-02 2013-03-09 Modified polynucleotides
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USPCT/US2013/030060 2013-03-09
PCT/US2013/030062 WO2013151666A2 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of biologics and proteins associated with human disease
PCT/US2013/030070 WO2013151672A2 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of oncology-related proteins and peptides
PCT/US2013/030061 WO2013151665A2 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of proteins associated with human disease
PCT/US2013/030060 WO2013151664A1 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of proteins
PCT/US2013/030059 WO2013151663A1 (en) 2012-04-02 2013-03-09 Modified polynucleotides for the production of membrane proteins
USPCT/US2013/030067 2013-03-09
USPCT/US2013/030064 2013-03-09
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WO2013151669A1 (en) 2013-10-10
US20130259924A1 (en) 2013-10-03
CA2868440A1 (en) 2013-10-10
AU2018200381A1 (en) 2018-02-01
US20130259923A1 (en) 2013-10-03
JP2015516143A (ja) 2015-06-08
WO2013151663A1 (en) 2013-10-10
US20140221465A1 (en) 2014-08-07
WO2013151670A2 (en) 2013-10-10
AU2018247318A1 (en) 2018-11-08
US20140155475A1 (en) 2014-06-05
US9301993B2 (en) 2016-04-05
EP3978030A1 (en) 2022-04-06
US20140141067A1 (en) 2014-05-22
US20190240351A1 (en) 2019-08-08
JP2019107022A (ja) 2019-07-04
JP2015513914A (ja) 2015-05-18
JP2020072670A (ja) 2020-05-14
JP2015513916A (ja) 2015-05-18
US20140171485A1 (en) 2014-06-19
WO2013151667A1 (en) 2013-10-10
HK1206638A1 (zh) 2016-01-15
JP2025024198A (ja) 2025-02-19
WO2013151736A2 (en) 2013-10-10
US20140193482A1 (en) 2014-07-10
US20140105964A1 (en) 2014-04-17
AU2018200380A1 (en) 2018-03-22
AU2018200379A1 (en) 2018-03-22
CA2868429A1 (en) 2013-10-10
US20140155474A1 (en) 2014-06-05

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