JP2008516896A5 - - Google Patents

Info

Publication number

JP2008516896A5

JP2008516896A5 JP2007533692A JP2007533692A JP2008516896A5 JP 2008516896 A5 JP2008516896 A5 JP 2008516896A5 JP 2007533692 A JP2007533692 A JP 2007533692A JP 2007533692 A JP2007533692 A JP 2007533692A JP 2008516896 A5 JP2008516896 A5 JP 2008516896A5

Authority

JP

Japan

Prior art keywords

antibody

seq

cysteine engineered

drug conjugate

conjugate compound

Prior art date

2005-09-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 61
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 59
• 150000001875 compounds Chemical class 0.000 claims 37
• 239000000611 antibody drug conjugate Substances 0.000 claims 26
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 26
• -1 free cysteine amino acids Chemical class 0.000 claims 20
• 229940079593 drug Drugs 0.000 claims 14
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• 108090000623 proteins and genes Proteins 0.000 claims 12
• 102100032780 Semaphorin-5B Human genes 0.000 claims 10
• 210000003719 b-lymphocyte Anatomy 0.000 claims 10
• 239000000562 conjugate Substances 0.000 claims 10
• 235000018102 proteins Nutrition 0.000 claims 10
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• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
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• 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims 2
• 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims 2
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• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
• 101000883798 Homo sapiens Probable ATP-dependent RNA helicase DDX53 Proteins 0.000 claims 2
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
• 206010020853 Hypertonic bladder Diseases 0.000 claims 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
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