JP2011515069A5 - - Google Patents
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- Publication number
- JP2011515069A5 JP2011515069A5 JP2010545049A JP2010545049A JP2011515069A5 JP 2011515069 A5 JP2011515069 A5 JP 2011515069A5 JP 2010545049 A JP2010545049 A JP 2010545049A JP 2010545049 A JP2010545049 A JP 2010545049A JP 2011515069 A5 JP2011515069 A5 JP 2011515069A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug conjugate
- cd79b
- cysteine
- cysteine engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/023,811 | 2008-01-31 | ||
| US12/023,811 US20090068178A1 (en) | 2002-05-08 | 2008-01-31 | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| PCT/US2009/030851 WO2009099719A2 (en) | 2008-01-31 | 2009-01-13 | Compositions and methods for the treatment of tumor of hematopoietic origin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011515069A JP2011515069A (ja) | 2011-05-19 |
| JP2011515069A5 true JP2011515069A5 (enExample) | 2012-03-01 |
Family
ID=40578249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545049A Withdrawn JP2011515069A (ja) | 2008-01-31 | 2009-01-13 | 造血系起源の腫瘍の治療のための組成物と方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20090068178A1 (enExample) |
| EP (1) | EP2247312A2 (enExample) |
| JP (1) | JP2011515069A (enExample) |
| KR (1) | KR20100128286A (enExample) |
| CN (1) | CN102014964A (enExample) |
| AR (1) | AR071829A1 (enExample) |
| AU (1) | AU2009210627A1 (enExample) |
| BR (1) | BRPI0908854A2 (enExample) |
| CA (1) | CA2712518A1 (enExample) |
| CL (1) | CL2009000082A1 (enExample) |
| IL (1) | IL206970A0 (enExample) |
| MX (1) | MX2010008199A (enExample) |
| NZ (1) | NZ587652A (enExample) |
| PE (1) | PE20091404A1 (enExample) |
| RU (1) | RU2010136303A (enExample) |
| WO (1) | WO2009099719A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8709412B2 (en) | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
| US20110045005A1 (en) | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| ES2605443T3 (es) * | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| US7811572B2 (en) | 2005-08-24 | 2010-10-12 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| PE20140625A1 (es) | 2007-07-16 | 2014-05-29 | Genentech Inc | ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS |
| PT2474557E (pt) | 2007-07-16 | 2014-12-03 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| DK2657253T3 (en) | 2008-01-31 | 2017-10-09 | Genentech Inc | Anti-CD79b antibodies and immune conjugates and methods of use |
| JP5784592B2 (ja) | 2009-06-03 | 2015-09-24 | イミュノジェン・インコーポレーテッド | 抱合方法 |
| CA2825424A1 (en) * | 2010-02-08 | 2011-08-11 | Board Of Regents Of The University Of Nebraska | Biomineral and metal binding liposomes, their synthesis, and methods of use thereof |
| WO2011100398A1 (en) * | 2010-02-10 | 2011-08-18 | Immunogen, Inc. | Cd20 antibodies and uses thereof |
| WO2011109308A1 (en) * | 2010-03-02 | 2011-09-09 | Seattle Genetics, Inc. | Methods for screening antibodies |
| JP6121906B2 (ja) | 2010-10-22 | 2017-04-26 | シアトル ジェネティクス,インコーポレーテッド | アウリスタチン系抗体薬物複合体とPI3K−AKTmTOR経路インヒビターの間の相乗効果 |
| EA033468B1 (ru) | 2011-03-29 | 2019-10-31 | Immunogen Inc | Способы получения конъюгата "антитело-майтансиноид" |
| HUE031017T2 (en) * | 2011-04-01 | 2017-06-28 | Wyeth Llc | Antibody Drug Conjugates |
| CN104640572B (zh) * | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物,偶联方法,及其用途 |
| CA2879814A1 (en) * | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| CA2886996A1 (en) * | 2012-10-04 | 2014-04-10 | Immunogen, Inc. | Use of an ion exchange membrane to remove impurities from cell-binding agent cytotoxic agent conjugates |
| EP2904089A4 (en) | 2012-10-04 | 2016-05-25 | Immunogen Inc | USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| CN104936618A (zh) * | 2012-11-29 | 2015-09-23 | 拜尔健康护理有限责任公司 | 针对活化蛋白c的人源化单克隆抗体及其用途 |
| KR20210132742A (ko) | 2012-12-21 | 2021-11-04 | 알트루바이오 인코퍼레이티드 | 친수성 자기-희생 링커 및 그것의 포합체 |
| EA201591465A1 (ru) | 2013-02-08 | 2015-12-30 | АйАрЭм ЭлЭлСи | Специфичные участки для модификации антител для получения иммуноконъюгатов |
| HK1219044A1 (zh) * | 2013-03-15 | 2017-03-24 | 艾伯维德国有限责任两合公司 | 抗egfr抗体药物偶联物制剂 |
| EP3964237B1 (en) | 2013-03-15 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| MY173295A (en) | 2013-04-16 | 2020-01-14 | Genentech Inc | Pertuzumab variants and evaluation thereof |
| AR097161A1 (es) * | 2013-08-01 | 2016-02-24 | Agensys Inc | Conjugados de fármacos anticuerpo (adc) que se unen a las proteínas cd37 |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| AU2014311361B2 (en) | 2013-08-26 | 2018-11-29 | Regeneron Pharmaceuticals, Inc. | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses |
| AU2014337317A1 (en) | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| PT3057585T (pt) | 2013-10-15 | 2020-10-21 | Seagen Inc | Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando |
| JP6980384B2 (ja) | 2013-12-16 | 2021-12-15 | ジェネンテック, インコーポレイテッド | 1−(クロロメチル)−2,3−ジヒドロ−1h−ベンゾ[e]インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| WO2015095301A2 (en) | 2013-12-17 | 2015-06-25 | Irm Llc | Cytotoxic peptides and conjugates thereof |
| US9884817B2 (en) | 2014-06-13 | 2018-02-06 | Novartis Ag | Auristatin derivatives and conjugates thereof |
| KR20170020868A (ko) | 2014-06-20 | 2017-02-24 | 바이오얼라이언스 씨.브이. | 항-폴레이트 수용체 알파 (fra) 항체-약물 컨쥬게이트 및 그것의 사용 방법 |
| PL3178929T3 (pl) | 2014-08-06 | 2021-12-20 | Astellas Pharma Inc. | Nowe przeciwciało przeciwko ludzkiej ig(beta) |
| MA40539A (fr) * | 2014-09-02 | 2016-03-10 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicaments |
| CA2979671C (en) | 2014-09-23 | 2020-03-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates |
| MX386587B (es) | 2014-12-05 | 2025-03-19 | Genentech Inc | ANTICUERPOS ANTI-CD79b Y MÉTODOS DE USO. |
| JP6871858B2 (ja) | 2015-01-28 | 2021-05-19 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | 抗体薬物コンジュゲート |
| CN106153935B (zh) * | 2015-03-26 | 2018-05-08 | 广州瑞博奥生物科技有限公司 | 一种定量检测CD79α的酶联免疫试剂盒 |
| CA2978340C (en) | 2015-03-27 | 2024-05-28 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
| CR20180229A (es) | 2015-10-29 | 2018-08-24 | Novartis Ag | Conjugados de anticuerpos que comprenden un agonista del receptor tipo toll |
| US11077187B2 (en) | 2015-11-17 | 2021-08-03 | Oklahoma Medical Research Foundation | Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| US11229708B2 (en) | 2015-12-04 | 2022-01-25 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| WO2017120534A1 (en) | 2016-01-08 | 2017-07-13 | Bioalliance C.V. | Tetravalent anti-psgl-1 antibodies and uses thereof |
| MX390630B (es) | 2016-01-25 | 2025-03-21 | Regeneron Pharma | Derivados de maitansinoide, conjugados de los mismos y metodos de uso. |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
| SG11201907288RA (en) | 2017-02-28 | 2019-09-27 | Seattle Genetics Inc | Cysteine mutated antibodies for conjugation |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物-リンカーの調製のためのプロセスおよびその中間体 |
| CN109893538B (zh) * | 2017-12-07 | 2021-05-07 | 苏州凯祥生物科技有限公司 | 聚炔类在降尿酸中的新用途 |
| CA3127556A1 (en) | 2019-01-28 | 2020-08-06 | Tuojie Biotech (Shanghai) Co., Ltd. | Anti-cd79b antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| CN111675762B (zh) * | 2019-03-11 | 2023-12-01 | 凯惠科技发展(上海)有限公司 | 一种含半胱氨酸的抗体、药物偶联物及其应用 |
| EP4190812A4 (en) | 2020-07-27 | 2024-09-04 | Tuojie Biotech (Shanghai) Co., Ltd. | ANTI-CD79B ANTIBODY-DRUG CONJUGATE, ITS PREPARATION METHOD AND ITS PHARMACEUTICAL USE |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
| US20240339220A1 (en) * | 2021-07-15 | 2024-10-10 | Nx Prenatal Inc. | Longitudinal predictive model for predicting adverse gestational outcomes |
| US20240367065A1 (en) * | 2021-09-10 | 2024-11-07 | Sony Group Corporation | Autonomous mobile body, information processing method, and program |
| WO2024129756A1 (en) * | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| CN117983056A (zh) * | 2023-12-27 | 2024-05-07 | 安徽建筑大学 | 二次集成胺功能化碳点的抗酸、抗氯、抗菌及高效Mg2+/Li+分离的聚酰胺纳滤膜 |
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| US4137230A (en) * | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4307016A (en) * | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
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| JPS55164685A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
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| US20110045005A1 (en) * | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
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| NZ576411A (en) * | 2003-11-17 | 2010-04-30 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
| CA2556752C (en) * | 2004-02-23 | 2016-02-02 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| NZ551180A (en) * | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
| TR201808537T4 (tr) * | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| PE20140625A1 (es) * | 2007-07-16 | 2014-05-29 | Genentech Inc | ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS |
| PT2474557E (pt) * | 2007-07-16 | 2014-12-03 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| DK2657253T3 (en) * | 2008-01-31 | 2017-10-09 | Genentech Inc | Anti-CD79b antibodies and immune conjugates and methods of use |
-
2008
- 2008-01-31 US US12/023,811 patent/US20090068178A1/en not_active Abandoned
-
2009
- 2009-01-13 CN CN2009801110932A patent/CN102014964A/zh active Pending
- 2009-01-13 RU RU2010136303/10A patent/RU2010136303A/ru not_active Application Discontinuation
- 2009-01-13 KR KR1020107019272A patent/KR20100128286A/ko not_active Withdrawn
- 2009-01-13 BR BRPI0908854-7A patent/BRPI0908854A2/pt not_active IP Right Cessation
- 2009-01-13 JP JP2010545049A patent/JP2011515069A/ja not_active Withdrawn
- 2009-01-13 EP EP09707533A patent/EP2247312A2/en not_active Withdrawn
- 2009-01-13 MX MX2010008199A patent/MX2010008199A/es active IP Right Grant
- 2009-01-13 CA CA2712518A patent/CA2712518A1/en not_active Abandoned
- 2009-01-13 NZ NZ587652A patent/NZ587652A/xx not_active IP Right Cessation
- 2009-01-13 WO PCT/US2009/030851 patent/WO2009099719A2/en not_active Ceased
- 2009-01-13 AU AU2009210627A patent/AU2009210627A1/en not_active Abandoned
- 2009-01-16 PE PE2009000055A patent/PE20091404A1/es not_active Application Discontinuation
- 2009-01-16 AR ARP090100153A patent/AR071829A1/es not_active Application Discontinuation
- 2009-01-16 CL CL2009000082A patent/CL2009000082A1/es unknown
-
2010
- 2010-07-13 IL IL206970A patent/IL206970A0/en unknown
- 2010-09-09 US US12/878,920 patent/US20110070243A1/en not_active Abandoned
- 2010-10-12 US US12/902,434 patent/US20110206658A1/en not_active Abandoned
-
2017
- 2017-01-13 US US15/406,583 patent/US20170362318A1/en not_active Abandoned
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