JP2008521920A5 - - Google Patents
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- JP2008521920A5 JP2008521920A5 JP2007544495A JP2007544495A JP2008521920A5 JP 2008521920 A5 JP2008521920 A5 JP 2008521920A5 JP 2007544495 A JP2007544495 A JP 2007544495A JP 2007544495 A JP2007544495 A JP 2007544495A JP 2008521920 A5 JP2008521920 A5 JP 2008521920A5
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- JP
- Japan
- Prior art keywords
- compound
- accession number
- genbank accession
- antibody
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)C(C(N[C@@](CCCNC(N)=O)C(*(C)(C)*)=O)=O)N*(C(C)*)=C Chemical compound CC(C)C(C(N[C@@](CCCNC(N)=O)C(*(C)(C)*)=O)=O)N*(C(C)*)=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63261304P | 2004-12-01 | 2004-12-01 | |
| US60/632,613 | 2004-12-01 | ||
| PCT/US2005/043409 WO2006060533A2 (en) | 2004-12-01 | 2005-11-29 | Conjugates of 1, 8-bis-naphthalimides with an antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521920A JP2008521920A (ja) | 2008-06-26 |
| JP2008521920A5 true JP2008521920A5 (enExample) | 2008-12-25 |
| JP4993645B2 JP4993645B2 (ja) | 2012-08-08 |
Family
ID=36263731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544495A Expired - Fee Related JP4993645B2 (ja) | 2004-12-01 | 2005-11-29 | 抗体薬剤結合体および方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1817059A2 (enExample) |
| JP (1) | JP4993645B2 (enExample) |
| WO (1) | WO2006060533A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| US20070134243A1 (en) * | 2004-12-01 | 2007-06-14 | Gazzard Lewis J | Antibody drug conjugates and methods |
| US8070830B2 (en) | 2006-03-24 | 2011-12-06 | L'oreal S.A. | Fluorescent entity, dyeing composition containing at least one fluorescent entity comprising at least one heterocycle, with at least one internal cationic charge, and method for lightening keratin materials using said at least one fluorescent entity |
| FR2898903B1 (fr) | 2006-03-24 | 2012-08-31 | Oreal | Composition de teinture comprenant un colorant disulfure fluorescent, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2898902B1 (fr) * | 2006-03-24 | 2010-09-10 | Oreal | Colorants particuliers de type naphtalimide, composition tinctoriale comprenant au moins un tel colorant, procede de mise en oeuvre et utilisations |
| EP2024444B1 (fr) * | 2006-03-24 | 2011-07-06 | L'Oréal | Composition de teinture comprenant un colorant fluorescent naphtylimide thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| EP2069308B1 (en) * | 2006-09-12 | 2017-03-29 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Azonafide derived tumor and cancer targeting compounds |
| PE20090943A1 (es) | 2007-07-16 | 2009-08-05 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados |
| EP2176295B1 (en) | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| FR2921376B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Compose styryl tetrahydroquinolinium thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921373B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Colorant derive d'indole styryle a linker alkylene, composition tinctoriale comprenant ce colorant, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921381B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Colorant hemicyanine styryle thiol/disulfure, composition tinctoriale comprenant ce colorant, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921377B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Compose styryl a motif hydroxy(cyclo)alkylamino thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| US8119656B2 (en) | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
| WO2009089537A2 (en) * | 2008-01-11 | 2009-07-16 | Northwestern University | Anti-cancer compounds |
| KR101607346B1 (ko) | 2008-01-31 | 2016-03-29 | 제넨테크, 인크. | 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법 |
| WO2009144205A1 (en) | 2008-05-30 | 2009-12-03 | Basf Se | Rylene-based semiconductor materials and methods of preparation and use thereof |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| MA34057B1 (fr) | 2010-02-23 | 2013-03-05 | Genentech Inc | Compositions et methodes pour le diagnostic et le traitement d'une tumeur |
| BR112013014527A2 (pt) | 2010-12-20 | 2017-03-07 | Genentech Inc | anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| US9056910B2 (en) | 2012-05-01 | 2015-06-16 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| CN104411739B (zh) * | 2012-05-02 | 2017-03-08 | 路博润高级材料公司 | 芳族分散剂组合物 |
| CN104640572B (zh) * | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| CN104540519B (zh) | 2012-05-21 | 2018-06-01 | 基因泰克公司 | 抗Ly6E抗体和免疫缀合物及使用方法 |
| JP2015528818A (ja) | 2012-08-02 | 2015-10-01 | ジェネンテック， インコーポレイテッド | 抗ｅｔｂｒ抗体およびイムノコンジュゲート |
| CA2879670A1 (en) | 2012-08-02 | 2014-02-06 | Genentech, Inc. | Anti-etbr antibodies and immunoconjugates |
| CN103013497A (zh) * | 2012-12-21 | 2013-04-03 | 武汉大学 | 一种巯基荧光探针及其制备方法 |
| GB201309807D0 (en) | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| JP2016537399A (ja) | 2013-09-17 | 2016-12-01 | ジェネンテック， インコーポレイテッド | 抗ｌｇｒ５抗体を使用する方法 |
| WO2015061209A1 (en) | 2013-10-21 | 2015-04-30 | Genentech, Inc. | ANTI-Ly6E ANTIBODIES AND METHODS OF USE |
| HUE049175T2 (hu) | 2014-09-23 | 2020-09-28 | Hoffmann La Roche | Eljárás anti-CD79b immunkonjugátumok alkalmazására |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| TR201618160A2 (tr) * | 2016-12-09 | 2018-06-21 | T C Istanbul Medipol Ueniversitesi | Parazi̇ti̇k ve neoplasti̇k hastaliklarin tedavi̇si̇nde kullanima uygun özgün i̇laç molekülleri̇ ve bunlarin hazirlanmasinda kullanilacak usuller |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
| CN107625771B (zh) * | 2017-09-27 | 2018-12-14 | 徐州玖胜医疗器械有限公司 | 一种miR-17基因抑制剂及用于治疗胃癌的用途 |
| CN119405832A (zh) | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| TWI824043B (zh) | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
| WO2021043951A1 (en) | 2019-09-05 | 2021-03-11 | Pharma Mar, S.A. | Drug antibody conjugates |
| CN115427081B (zh) | 2020-04-21 | 2025-12-09 | 法马马有限公司 | 药物抗体共轭物 |
| CN116063284A (zh) * | 2023-02-10 | 2023-05-05 | 河南大学 | 一类含有与黏蛋白共价结合片段的肠限制性tgr5激动剂及其在治疗糖尿病药物中的应用 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| DE3707651A1 (de) | 1987-03-10 | 1988-09-22 | Knoll Ag | Bis-naphthalimide, ihre herstellung und verwendung |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5416089A (en) | 1993-06-24 | 1995-05-16 | The Du Pont Merck Pharmaceutical Company | Polycyclic and heterocyclic chromophores for bis-imide tumoricidals |
| IL110460A (en) | 1993-08-18 | 2001-01-11 | Basf Ag | Bis-naphthalimides, their preparation and pharmaceutical compositions containing them |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
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| AU2048901A (en) | 1999-11-29 | 2001-06-04 | Trustees Of Columbia University In The City Of New York, The | Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma |
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-
2005
- 2005-11-29 JP JP2007544495A patent/JP4993645B2/ja not_active Expired - Fee Related
- 2005-11-29 EP EP05852595A patent/EP1817059A2/en not_active Withdrawn
- 2005-11-29 WO PCT/US2005/043409 patent/WO2006060533A2/en not_active Ceased
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