JP2024056715A5 - - Google Patents
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- JP2024056715A5 JP2024056715A5 JP2024007979A JP2024007979A JP2024056715A5 JP 2024056715 A5 JP2024056715 A5 JP 2024056715A5 JP 2024007979 A JP2024007979 A JP 2024007979A JP 2024007979 A JP2024007979 A JP 2024007979A JP 2024056715 A5 JP2024056715 A5 JP 2024056715A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- residue
- receptor
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862689769P | 2018-06-25 | 2018-06-25 | |
| US62/689,769 | 2018-06-25 | ||
| US201862768733P | 2018-11-16 | 2018-11-16 | |
| US62/768,733 | 2018-11-16 | ||
| JP2020567827A JP2021528052A (ja) | 2018-06-25 | 2019-06-24 | 強力で選択的なインターロイキン模倣体のデノボ設計 |
| PCT/US2019/038703 WO2020005819A1 (en) | 2018-06-25 | 2019-06-24 | De novo design of potent and selective interleukin mimetics |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567827A Division JP2021528052A (ja) | 2018-06-25 | 2019-06-24 | 強力で選択的なインターロイキン模倣体のデノボ設計 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024056715A JP2024056715A (ja) | 2024-04-23 |
| JP2024056715A5 true JP2024056715A5 (enExample) | 2024-06-26 |
| JP7741903B2 JP7741903B2 (ja) | 2025-09-18 |
Family
ID=67352582
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567827A Pending JP2021528052A (ja) | 2018-06-25 | 2019-06-24 | 強力で選択的なインターロイキン模倣体のデノボ設計 |
| JP2024007979A Active JP7741903B2 (ja) | 2018-06-25 | 2024-01-23 | 強力で選択的なインターロイキン模倣体のデノボ設計 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567827A Pending JP2021528052A (ja) | 2018-06-25 | 2019-06-24 | 強力で選択的なインターロイキン模倣体のデノボ設計 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US10703791B2 (enExample) |
| EP (1) | EP3810640A1 (enExample) |
| JP (2) | JP2021528052A (enExample) |
| KR (1) | KR20210025522A (enExample) |
| CN (1) | CN112739713A (enExample) |
| AU (1) | AU2019295637B2 (enExample) |
| BR (1) | BR112020025287A2 (enExample) |
| CA (1) | CA3102653A1 (enExample) |
| IL (1) | IL279415A (enExample) |
| MX (1) | MX2020014027A (enExample) |
| PH (1) | PH12020552140A1 (enExample) |
| SG (1) | SG11202011460YA (enExample) |
| WO (1) | WO2020005819A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| SG11202011460YA (en) | 2018-06-25 | 2020-12-30 | Univ Washington | De novo design of potent and selective interleukin mimetics |
| AU2019297451A1 (en) | 2018-07-03 | 2021-01-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| US12234572B2 (en) * | 2018-11-20 | 2025-02-25 | University Of Washington | Split interleukin mimetics and their use |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| US20220370563A1 (en) * | 2019-10-25 | 2022-11-24 | Neoleukin Therapeutics, Inc. | Methods of administration of il-2 receptor agonists |
| US20210188934A1 (en) | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Novel il2 agonists and methods of use thereof |
| JP2023509708A (ja) | 2020-01-03 | 2023-03-09 | マレンゴ・セラピューティクス，インコーポレーテッド | 抗ｔｃｒ抗体分子およびその使用 |
| WO2021188374A2 (en) * | 2020-03-16 | 2021-09-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| CN114380919B (zh) * | 2020-10-18 | 2024-06-25 | 北京志道生物科技有限公司 | 经修饰的il-2分子及其用途 |
| CN112266413A (zh) * | 2020-10-22 | 2021-01-26 | 中国人民解放军海军军医大学 | 扩增nk细胞并增强其杀伤活性的因子、饲养细胞系及方法 |
| WO2022200525A1 (en) | 2021-03-26 | 2022-09-29 | Innate Pharma | Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging |
| CN117616050A (zh) | 2021-06-09 | 2024-02-27 | 先天制药公司 | 与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质 |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| CN113603791A (zh) * | 2021-08-11 | 2021-11-05 | 厦门目青股权投资合伙企业(有限合伙) | 一种融合蛋白及其应用 |
| WO2023044318A2 (en) * | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| WO2023052541A1 (en) * | 2021-09-30 | 2023-04-06 | Imcheck Therapeutics | Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy |
| MX2024008642A (es) * | 2022-01-11 | 2024-09-23 | Outpace Bio Inc | Composiciones de citocinas dise?adas y metodos de uso. |
| WO2023150733A2 (en) * | 2022-02-04 | 2023-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Surrogate cytokine polypeptides |
| CN114333985B (zh) * | 2022-03-03 | 2022-07-12 | 北京晶泰科技有限公司 | 环肽设计方法、复合物结构的生成方法、装置及电子设备 |
| CN115124627A (zh) * | 2022-06-20 | 2022-09-30 | 中国人民解放军海军军医大学 | 一种自分泌IL2Rβγ激动剂的MSLN-CAR-NK细胞及其应用 |
| CN114773433B (zh) * | 2022-06-23 | 2022-09-06 | 北京肿瘤医院(北京大学肿瘤医院) | 一种cd25靶向多肽、分子探针及应用 |
| AU2023298151A1 (en) * | 2022-07-01 | 2025-01-02 | Neurogene Inc. | Neo-2/15 variants and uses thereof for preferentially stimulating t-regulatory cells |
| WO2024177972A2 (en) * | 2023-02-20 | 2024-08-29 | The Wistar Institute Of Anatomy And Biology | Antibody-cytokine chimeras |
| WO2024240233A1 (zh) * | 2023-05-24 | 2024-11-28 | 南通壹宸生物医药科技有限公司 | 多肽及其偶联物和应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| JP2003520579A (ja) | 1999-12-08 | 2003-07-08 | アムジェン インコーポレイテッド | インターフェロン様分子およびその使用 |
| GB0019638D0 (en) * | 2000-08-09 | 2000-09-27 | European Molecular Biology Lab Embl | Peptide mimetics |
| CA2450147A1 (en) * | 2001-06-07 | 2002-12-19 | Wyeth | Solution structure of il-13 and uses thereof |
| BRPI0412668A (pt) * | 2003-08-07 | 2006-09-26 | Hoffmann La Roche | peptìdeos antigênicos de ar |
| CN1930300A (zh) | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| BRPI0617688A2 (pt) * | 2005-10-21 | 2011-06-07 | Hoffmann La Roche | método para expressão recombinante de um polipeptìdeo |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| WO2013177187A2 (en) | 2012-05-22 | 2013-11-28 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and therapeutic agents |
| US20170350886A1 (en) * | 2014-02-28 | 2017-12-07 | Glenmark Pharmaceuticals S.A. | Expression constructs and methods for selecting host cells expressing polypeptides |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| SG11201608953WA (en) | 2014-04-30 | 2016-11-29 | Pfizer | Anti-ptk7 antibody-drug conjugates |
| CN113234138A (zh) | 2014-08-11 | 2021-08-10 | 德里尼亚公司 | 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| EP3585806A1 (en) | 2017-02-24 | 2020-01-01 | Philogen S.p.A. | Immunoconjugates with optimized linkers and orientation |
| JP2020514419A (ja) | 2017-03-15 | 2020-05-21 | シルバーバック セラピューティックス インコーポレイテッド | ベンズアゼピン化合物、そのコンジュゲート及び使用 |
| SG11202011460YA (en) * | 2018-06-25 | 2020-12-30 | Univ Washington | De novo design of potent and selective interleukin mimetics |
| US12234572B2 (en) * | 2018-11-20 | 2025-02-25 | University Of Washington | Split interleukin mimetics and their use |
| AU2019384145A1 (en) * | 2018-11-20 | 2021-06-10 | Innovative Cellular Therapeutics Holdings, Ltd. | Modified cell expressing therapeutic agent and uses thereof |
| US20220370563A1 (en) | 2019-10-25 | 2022-11-24 | Neoleukin Therapeutics, Inc. | Methods of administration of il-2 receptor agonists |
| CA3161364A1 (en) | 2019-12-24 | 2021-07-01 | Carl WALKEY | Combination therapy using an il-2 receptor agonist and an immune checkpoint inhibitor |
| CN111040981A (zh) * | 2019-12-26 | 2020-04-21 | 南昌大学 | 表达重组IL-2的重组大肠杆菌Nissle 1917及其功能验证方法 |
| WO2021188374A2 (en) | 2020-03-16 | 2021-09-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
-
2019
- 2019-06-24 SG SG11202011460YA patent/SG11202011460YA/en unknown
- 2019-06-24 CN CN201980042036.7A patent/CN112739713A/zh active Pending
- 2019-06-24 BR BR112020025287-5A patent/BR112020025287A2/pt unknown
- 2019-06-24 KR KR1020207035974A patent/KR20210025522A/ko active Pending
- 2019-06-24 WO PCT/US2019/038703 patent/WO2020005819A1/en not_active Ceased
- 2019-06-24 CA CA3102653A patent/CA3102653A1/en active Pending
- 2019-06-24 JP JP2020567827A patent/JP2021528052A/ja active Pending
- 2019-06-24 EP EP19742110.0A patent/EP3810640A1/en active Pending
- 2019-06-24 AU AU2019295637A patent/AU2019295637B2/en active Active
- 2019-06-24 MX MX2020014027A patent/MX2020014027A/es unknown
- 2019-09-16 US US16/572,038 patent/US10703791B2/en active Active
-
2020
- 2020-06-18 US US16/905,669 patent/US11117944B2/en active Active
- 2020-06-23 US US16/909,185 patent/US10844105B2/en active Active
- 2020-06-23 US US16/909,210 patent/US11401313B2/en active Active
- 2020-12-11 PH PH12020552140A patent/PH12020552140A1/en unknown
- 2020-12-13 IL IL279415A patent/IL279415A/en unknown
-
2021
- 2021-09-13 US US17/473,731 patent/US11655278B2/en active Active
-
2022
- 2022-03-18 US US17/698,553 patent/US12240880B2/en active Active
-
2023
- 2023-03-21 US US18/187,639 patent/US12227553B2/en active Active
-
2024
- 2024-01-23 JP JP2024007979A patent/JP7741903B2/ja active Active
-
2025
- 2025-01-16 US US19/025,380 patent/US20250171514A1/en active Pending
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