JPWO2020005819A5 - - Google Patents

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Publication number
JPWO2020005819A5
JPWO2020005819A5 JP2020567827A JP2020567827A JPWO2020005819A5 JP WO2020005819 A5 JPWO2020005819 A5 JP WO2020005819A5 JP 2020567827 A JP2020567827 A JP 2020567827A JP 2020567827 A JP2020567827 A JP 2020567827A JP WO2020005819 A5 JPWO2020005819 A5 JP WO2020005819A5
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JP
Japan
Prior art keywords
seq
amino acid
residue
polypeptide
acid sequence
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2020567827A
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English (en)
Japanese (ja)
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JP2021528052A (ja
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Priority claimed from PCT/US2019/038703 external-priority patent/WO2020005819A1/en
Publication of JP2021528052A publication Critical patent/JP2021528052A/ja
Priority to JP2024007979A priority Critical patent/JP7741903B2/ja
Publication of JPWO2020005819A5 publication Critical patent/JPWO2020005819A5/ja
Pending legal-status Critical Current

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JP2020567827A 2018-06-25 2019-06-24 強力で選択的なインターロイキン模倣体のデノボ設計 Pending JP2021528052A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024007979A JP7741903B2 (ja) 2018-06-25 2024-01-23 強力で選択的なインターロイキン模倣体のデノボ設計

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862689769P 2018-06-25 2018-06-25
US62/689,769 2018-06-25
US201862768733P 2018-11-16 2018-11-16
US62/768,733 2018-11-16
PCT/US2019/038703 WO2020005819A1 (en) 2018-06-25 2019-06-24 De novo design of potent and selective interleukin mimetics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024007979A Division JP7741903B2 (ja) 2018-06-25 2024-01-23 強力で選択的なインターロイキン模倣体のデノボ設計

Publications (2)

Publication Number Publication Date
JP2021528052A JP2021528052A (ja) 2021-10-21
JPWO2020005819A5 true JPWO2020005819A5 (enExample) 2024-01-31

Family

ID=67352582

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020567827A Pending JP2021528052A (ja) 2018-06-25 2019-06-24 強力で選択的なインターロイキン模倣体のデノボ設計
JP2024007979A Active JP7741903B2 (ja) 2018-06-25 2024-01-23 強力で選択的なインターロイキン模倣体のデノボ設計

Family Applications After (1)

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JP2024007979A Active JP7741903B2 (ja) 2018-06-25 2024-01-23 強力で選択的なインターロイキン模倣体のデノボ設計

Country Status (13)

Country Link
US (8) US10703791B2 (enExample)
EP (1) EP3810640A1 (enExample)
JP (2) JP2021528052A (enExample)
KR (1) KR20210025522A (enExample)
CN (1) CN112739713A (enExample)
AU (1) AU2019295637B2 (enExample)
BR (1) BR112020025287A2 (enExample)
CA (1) CA3102653A1 (enExample)
IL (1) IL279415A (enExample)
MX (1) MX2020014027A (enExample)
PH (1) PH12020552140A1 (enExample)
SG (1) SG11202011460YA (enExample)
WO (1) WO2020005819A1 (enExample)

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SG11202011460YA (en) 2018-06-25 2020-12-30 Univ Washington De novo design of potent and selective interleukin mimetics
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
US12234572B2 (en) * 2018-11-20 2025-02-25 University Of Washington Split interleukin mimetics and their use
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
GB2599228B (en) 2019-02-21 2024-02-07 Marengo Therapeutics Inc Multifunctional molecules that bind to T cell related cancer cells and uses thereof
US20220370563A1 (en) * 2019-10-25 2022-11-24 Neoleukin Therapeutics, Inc. Methods of administration of il-2 receptor agonists
US20210188934A1 (en) 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Novel il2 agonists and methods of use thereof
JP2023509708A (ja) 2020-01-03 2023-03-09 マレンゴ・セラピューティクス,インコーポレーテッド 抗tcr抗体分子およびその使用
WO2021188374A2 (en) * 2020-03-16 2021-09-23 Neoleukin Therapeutics, Inc. Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
CN114380919B (zh) * 2020-10-18 2024-06-25 北京志道生物科技有限公司 经修饰的il-2分子及其用途
CN112266413A (zh) * 2020-10-22 2021-01-26 中国人民解放军海军军医大学 扩增nk细胞并增强其杀伤活性的因子、饲养细胞系及方法
WO2022200525A1 (en) 2021-03-26 2022-09-29 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
CN117616050A (zh) 2021-06-09 2024-02-27 先天制药公司 与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
CN113603791A (zh) * 2021-08-11 2021-11-05 厦门目青股权投资合伙企业(有限合伙) 一种融合蛋白及其应用
WO2023044318A2 (en) * 2021-09-15 2023-03-23 Neoleukin Therapeutics, Inc. Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
WO2023052541A1 (en) * 2021-09-30 2023-04-06 Imcheck Therapeutics Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy
MX2024008642A (es) * 2022-01-11 2024-09-23 Outpace Bio Inc Composiciones de citocinas dise?adas y metodos de uso.
WO2023150733A2 (en) * 2022-02-04 2023-08-10 The Board Of Trustees Of The Leland Stanford Junior University Surrogate cytokine polypeptides
CN114333985B (zh) * 2022-03-03 2022-07-12 北京晶泰科技有限公司 环肽设计方法、复合物结构的生成方法、装置及电子设备
CN115124627A (zh) * 2022-06-20 2022-09-30 中国人民解放军海军军医大学 一种自分泌IL2Rβγ激动剂的MSLN-CAR-NK细胞及其应用
CN114773433B (zh) * 2022-06-23 2022-09-06 北京肿瘤医院(北京大学肿瘤医院) 一种cd25靶向多肽、分子探针及应用
AU2023298151A1 (en) * 2022-07-01 2025-01-02 Neurogene Inc. Neo-2/15 variants and uses thereof for preferentially stimulating t-regulatory cells
WO2024177972A2 (en) * 2023-02-20 2024-08-29 The Wistar Institute Of Anatomy And Biology Antibody-cytokine chimeras
WO2024240233A1 (zh) * 2023-05-24 2024-11-28 南通壹宸生物医药科技有限公司 多肽及其偶联物和应用

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WO2015164815A1 (en) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
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CN113234138A (zh) 2014-08-11 2021-08-10 德里尼亚公司 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3585806A1 (en) 2017-02-24 2020-01-01 Philogen S.p.A. Immunoconjugates with optimized linkers and orientation
JP2020514419A (ja) 2017-03-15 2020-05-21 シルバーバック セラピューティックス インコーポレイテッド ベンズアゼピン化合物、そのコンジュゲート及び使用
SG11202011460YA (en) * 2018-06-25 2020-12-30 Univ Washington De novo design of potent and selective interleukin mimetics
US12234572B2 (en) * 2018-11-20 2025-02-25 University Of Washington Split interleukin mimetics and their use
AU2019384145A1 (en) * 2018-11-20 2021-06-10 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
US20220370563A1 (en) 2019-10-25 2022-11-24 Neoleukin Therapeutics, Inc. Methods of administration of il-2 receptor agonists
CA3161364A1 (en) 2019-12-24 2021-07-01 Carl WALKEY Combination therapy using an il-2 receptor agonist and an immune checkpoint inhibitor
CN111040981A (zh) * 2019-12-26 2020-04-21 南昌大学 表达重组IL-2的重组大肠杆菌Nissle 1917及其功能验证方法
WO2021188374A2 (en) 2020-03-16 2021-09-23 Neoleukin Therapeutics, Inc. Interleukin-2 receptor βeta (il-2rβ) binding polypeptides

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