AU729290B2 - Transgenic non-human animals capable of producing heterologous antibodies - Google Patents

Transgenic non-human animals capable of producing heterologous antibodies Download PDF

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Publication number
AU729290B2
AU729290B2 AU11149/97A AU1114997A AU729290B2 AU 729290 B2 AU729290 B2 AU 729290B2 AU 11149/97 A AU11149/97 A AU 11149/97A AU 1114997 A AU1114997 A AU 1114997A AU 729290 B2 AU729290 B2 AU 729290B2
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human
immunoglobulin
sequence
segment
transgene
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AU11149/97A
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AU1114997A (en
Inventor
Robert M. Kay
Nils Lonberg
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Genpharm International Inc
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Genpharm International Inc
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • A01K67/0276—Knock-out vertebrates
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
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AU11149/97A 1995-10-10 1996-10-10 Transgenic non-human animals capable of producing heterologous antibodies Expired AU729290B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/544,404 US5770429A (en) 1990-08-29 1995-10-10 Transgenic non-human animals capable of producing heterologous antibodies
US08/544404 1995-10-10
PCT/US1996/016433 WO1997013852A1 (en) 1995-10-10 1996-10-10 Transgenic non-human animals capable of producing heterologous antibodies

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AU1114997A AU1114997A (en) 1997-04-30
AU729290B2 true AU729290B2 (en) 2001-02-01

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US (1) US5770429A (enExample)
EP (3) EP2186888A1 (enExample)
JP (6) JP2000502324A (enExample)
CN (3) CN102827283B (enExample)
AT (1) ATE466936T1 (enExample)
AU (1) AU729290B2 (enExample)
CA (1) CA2232813C (enExample)
DE (1) DE69638184D1 (enExample)
DK (1) DK0854917T3 (enExample)
ES (1) ES2345580T3 (enExample)
IL (2) IL124043A (enExample)
NZ (1) NZ324076A (enExample)
WO (1) WO1997013852A1 (enExample)

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