BR112012033119A2 - anticorpos para o fragamento c3d do componente do complemento 3. - Google Patents

anticorpos para o fragamento c3d do componente do complemento 3.

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Publication number
BR112012033119A2
BR112012033119A2 BR112012033119A BR112012033119A BR112012033119A2 BR 112012033119 A2 BR112012033119 A2 BR 112012033119A2 BR 112012033119 A BR112012033119 A BR 112012033119A BR 112012033119 A BR112012033119 A BR 112012033119A BR 112012033119 A2 BR112012033119 A2 BR 112012033119A2
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Brazil
Prior art keywords
materials
methods
present
complement
modulating
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BR112012033119A
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English (en)
Inventor
Michael V Holers
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Univ Colorado Regents
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Publication of BR112012033119A2 publication Critical patent/BR112012033119A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

anticorpos para o fragmento c3d do componente do complemento 3. a presente invenção refere-se a métodos e materiais para a modulação da via alternativa do complemento (cap), da via clássica do complemento (ccp), da via de lectina / manose do complemento (cmp) ou suas combinações, bem como a métodos e materiais para tornar alvo os agentes de diagnósticos, profiláticos e terapêuticos para áreas localizadas de tecido dentro do corpo, onde eles possam exercem os seus efeitos mais diretamente sobre as células ou tecidos alvo pretendidos com efeitos sistêmicos associados reduzidos, em comparação com a administração dos mesmos agentes ou similares de uma maneira sistêmica não alvo. os métodos e materiais da presente invenção podem, portanto, permitir o aumento da eficácia, dosagens eficazes de limite inferior e/ ou doses de manutenção eficazes inferiores, e / ou efeitos adversos ou indesejados associados reduzidos, em termos da frequência ou gravidade da ocorrência, ou ambas. a presente invenção também se refere a métodos e materiais para modular uma resposta imune humoral no hospedeiro, especialmente reduzindo, inibindo ou prevenindo uma resposta imune humoral no hospedeiro.
BR112012033119A 2010-06-22 2011-06-22 anticorpos para o fragamento c3d do componente do complemento 3. BR112012033119A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35749910P 2010-06-22 2010-06-22
PCT/US2011/041517 WO2011163412A1 (en) 2010-06-22 2011-06-22 Antibodies to the c3d fragment of complement component 3

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BR112012033119A2 true BR112012033119A2 (pt) 2016-10-25

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BR112012033119A BR112012033119A2 (pt) 2010-06-22 2011-06-22 anticorpos para o fragamento c3d do componente do complemento 3.

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US (3) US9815890B2 (pt)
EP (1) EP2585110A4 (pt)
JP (1) JP2013533243A (pt)
KR (1) KR20130036276A (pt)
CN (1) CN103249432A (pt)
AU (1) AU2011270959A1 (pt)
BR (1) BR112012033119A2 (pt)
CA (1) CA2803588A1 (pt)
CO (1) CO6680613A2 (pt)
EA (1) EA201291328A1 (pt)
MX (1) MX2012014975A (pt)
SG (1) SG186397A1 (pt)
WO (1) WO2011163412A1 (pt)
ZA (1) ZA201209430B (pt)

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