BR112022015077A2 - Métodos para induzir células t cd8+ específicas de neoepítopos em um indivíduo com um tumor e para induzir o tráfico de células t cd8+, vacinas de rna, vacina de rna para uso e antagonistas de ligação - Google Patents

Métodos para induzir células t cd8+ específicas de neoepítopos em um indivíduo com um tumor e para induzir o tráfico de células t cd8+, vacinas de rna, vacina de rna para uso e antagonistas de ligação

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Publication number
BR112022015077A2
BR112022015077A2 BR112022015077A BR112022015077A BR112022015077A2 BR 112022015077 A2 BR112022015077 A2 BR 112022015077A2 BR 112022015077 A BR112022015077 A BR 112022015077A BR 112022015077 A BR112022015077 A BR 112022015077A BR 112022015077 A2 BR112022015077 A2 BR 112022015077A2
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Brazil
Prior art keywords
induce
specific
neoepitope
cells
individual
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BR112022015077A
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English (en)
Inventor
Mueller Lars
Lubong Sabado Rachel
Yadav Mahesh
Zhang Jingbin
Sahin Ugur
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Genentech Inc
BioNTech SE
Hoffmann La Roche
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Application filed by Genentech Inc, BioNTech SE, Hoffmann La Roche filed Critical Genentech Inc
Publication of BR112022015077A2 publication Critical patent/BR112022015077A2/pt

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Abstract

MÉTODOS PARA INDUZIR CÉLULAS T CD8+ ESPECÍFICAS DE NEOEPÍTOPOS EM UM INDIVÍDUO COM UM TUMOR E PARA INDUZIR O TRÁFICO DE CÉLULAS T CD8+, VACINAS DE RNA, VACINA DE RNA PARA USO E ANTAGONISTAS DE LIGAÇÃO. A presente divulgação fornece métodos para induzir células T CD8+ específicas de neoepítopo em um indivíduo ou para induzir o tráfico de células T CD8+ específicas de neoepítopo para um tumor em um indivíduo usando uma vacina de RNA ou usando uma vacina de RNA em combinação com um antagonista de ligação ao eixo PD-1. Também são fornecidos neste documento antagonistas de ligação ao eixo PD-1 e vacinas de RNA que incluem um ou mais polinucleotídeos que codificam um ou mais neoepítopos resultantes de mutações somáticas específicas de câncer presentes em um espécime de tumor obtido do indivíduo para uso em métodos para induzir células T CD8+ específicas de neoepítopo em um indivíduo ou para induzir o tráfego de células T CD8+ específicas de neoepítopos para um tumor em um indivíduo.
BR112022015077A 2020-01-31 2021-01-29 Métodos para induzir células t cd8+ específicas de neoepítopos em um indivíduo com um tumor e para induzir o tráfico de células t cd8+, vacinas de rna, vacina de rna para uso e antagonistas de ligação BR112022015077A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062968818P 2020-01-31 2020-01-31
US202063041707P 2020-06-19 2020-06-19
PCT/US2021/015710 WO2021155149A1 (en) 2020-01-31 2021-01-29 Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine

Publications (1)

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BR112022015077A2 true BR112022015077A2 (pt) 2022-10-04

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US (1) US20220378910A1 (pt)
EP (1) EP4096708A1 (pt)
JP (1) JP2023512654A (pt)
KR (1) KR20220136378A (pt)
CN (2) CN116650628A (pt)
AU (1) AU2021212197A1 (pt)
BR (1) BR112022015077A2 (pt)
CA (1) CA3164559A1 (pt)
IL (1) IL294859A (pt)
MX (1) MX2022009391A (pt)
TW (1) TW202142257A (pt)
WO (1) WO2021155149A1 (pt)

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WO2023237726A1 (en) 2022-06-10 2023-12-14 Pantarhei Oncology B.V. An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer

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