JP5148028B2 - 二本鎖rnaによる遺伝子阻害 - Google Patents
二本鎖rnaによる遺伝子阻害 Download PDFInfo
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- JP5148028B2 JP5148028B2 JP2000525538A JP2000525538A JP5148028B2 JP 5148028 B2 JP5148028 B2 JP 5148028B2 JP 2000525538 A JP2000525538 A JP 2000525538A JP 2000525538 A JP2000525538 A JP 2000525538A JP 5148028 B2 JP5148028 B2 JP 5148028B2
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- rna
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/703—Worms, e.g. Caenorhabdities elegans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6856297P | 1997-12-23 | 1997-12-23 | |
| US60/068,562 | 1997-12-23 | ||
| US09/215,257 | 1998-12-18 | ||
| US09/215,257 US6506559B1 (en) | 1997-12-23 | 1998-12-18 | Genetic inhibition by double-stranded RNA |
| PCT/US1998/027233 WO1999032619A1 (en) | 1997-12-23 | 1998-12-21 | Genetic inhibition by double-stranded rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009205958A Division JP2009291209A (ja) | 1997-12-23 | 2009-09-07 | 二本鎖rnaによる遺伝子阻害 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516062A JP2002516062A (ja) | 2002-06-04 |
| JP5148028B2 true JP5148028B2 (ja) | 2013-02-20 |
Family
ID=26749094
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525538A Expired - Lifetime JP5148028B2 (ja) | 1997-12-23 | 1998-12-21 | 二本鎖rnaによる遺伝子阻害 |
| JP2009205958A Pending JP2009291209A (ja) | 1997-12-23 | 2009-09-07 | 二本鎖rnaによる遺伝子阻害 |
| JP2012229547A Expired - Lifetime JP5969889B2 (ja) | 1997-12-23 | 2012-10-17 | 二本鎖rnaによる遺伝子阻害 |
| JP2015095160A Pending JP2015133993A (ja) | 1997-12-23 | 2015-05-07 | 二本鎖rnaによる遺伝子阻害 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009205958A Pending JP2009291209A (ja) | 1997-12-23 | 2009-09-07 | 二本鎖rnaによる遺伝子阻害 |
| JP2012229547A Expired - Lifetime JP5969889B2 (ja) | 1997-12-23 | 2012-10-17 | 二本鎖rnaによる遺伝子阻害 |
| JP2015095160A Pending JP2015133993A (ja) | 1997-12-23 | 2015-05-07 | 二本鎖rnaによる遺伝子阻害 |
Country Status (6)
| Country | Link |
|---|---|
| US (11) | US6506559B1 (enExample) |
| EP (2) | EP2267131B1 (enExample) |
| JP (4) | JP5148028B2 (enExample) |
| AU (1) | AU743798C (enExample) |
| CA (1) | CA2311999C (enExample) |
| WO (1) | WO1999032619A1 (enExample) |
Families Citing this family (2128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465188B1 (en) * | 1990-06-11 | 2002-10-15 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
| US20040033977A1 (en) * | 1990-08-14 | 2004-02-19 | Bennett C. Frank | Oligonucleotide modulation of cell adhesion |
| US6605712B1 (en) | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
| AU687736B2 (en) * | 1992-05-11 | 1998-03-05 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US5639647A (en) * | 1994-03-29 | 1997-06-17 | Ribozyme Pharmaceuticals, Inc. | 2'-deoxy-2'alkylnucleotide containing nucleic acid |
| US6156535A (en) * | 1995-08-04 | 2000-12-05 | University Of Ottawa | Mammalian IAP gene family, primers, probes, and detection methods |
| US20040142895A1 (en) * | 1995-10-26 | 2004-07-22 | Sirna Therapeutics, Inc. | Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway |
| US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
| US6133437A (en) * | 1997-02-13 | 2000-10-17 | Apoptogen, Inc. | Modulation of IAPs for the treatment of proliferative diseases |
| US7812149B2 (en) * | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
| US20040171031A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US20040203024A1 (en) * | 1996-06-06 | 2004-10-14 | Baker Brenda F. | Modified oligonucleotides for use in RNA interference |
| US20040147022A1 (en) * | 1996-06-06 | 2004-07-29 | Baker Brenda F. | 2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations |
| US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
| US20050053976A1 (en) * | 1996-06-06 | 2005-03-10 | Baker Brenda F. | Chimeric oligomeric compounds and their use in gene modulation |
| US20030044941A1 (en) * | 1996-06-06 | 2003-03-06 | Crooke Stanley T. | Human RNase III and compositions and uses thereof |
| US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US20050119470A1 (en) * | 1996-06-06 | 2005-06-02 | Muthiah Manoharan | Conjugated oligomeric compounds and their use in gene modulation |
| US20060008448A1 (en) * | 1996-06-11 | 2006-01-12 | Minzhen Xu | Inhibition of li expression in mammalian cells |
| US6586661B1 (en) | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| US6238876B1 (en) * | 1997-06-20 | 2001-05-29 | New York University | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma |
| US20040072345A1 (en) * | 1997-06-20 | 2004-04-15 | Altaba Ariel Ruiz I. | Method and compositions for inhibiting tumorigenesis |
| US7709454B2 (en) * | 1997-06-20 | 2010-05-04 | New York University | Methods and compositions for inhibiting tumorigenesis |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| IL135776A0 (en) * | 1997-10-24 | 2001-05-20 | Life Technologies Inc | Recombinational cloning using nucleic acids having recombination sites |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| FR2782325B1 (fr) | 1998-08-12 | 2002-05-24 | Proteus | Procede d'identification de sequences polynucleotidiques et/ou des proteines correspondantes a partir d'un echantillon d'acides nucleiques |
| US20060260005A1 (en) * | 1998-02-26 | 2006-11-16 | Zhizhen Chen | Transformation of Brassica |
| US20040045056A1 (en) * | 1998-02-26 | 2004-03-04 | Zhizheng Chen | Transformation of Brassica |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| ES2374290T3 (es) * | 1998-03-20 | 2012-02-15 | Commonwealth Scientific And Industrial Research Organisation | Genes sintéticos y constructos genéticos que comprenden los mismos. |
| US8598332B1 (en) * | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
| EP1068311B2 (en) * | 1998-04-08 | 2020-12-09 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| US20040214330A1 (en) * | 1999-04-07 | 2004-10-28 | Waterhouse Peter Michael | Methods and means for obtaining modified phenotypes |
| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| EP1071753A2 (en) * | 1998-04-20 | 2001-01-31 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
| US7078224B1 (en) * | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| US7019195B1 (en) * | 1998-05-26 | 2006-03-28 | Syngenta Participations Ag | Method for conferring resistance or tolerance aganist furovirus, potyvirus, tospovirus, and cucomovirus to plant cells |
| AR020078A1 (es) * | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) * | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| US7005423B1 (en) * | 1999-07-02 | 2006-02-28 | Devgen Nv | Characterization of gene function using double stranded RNA inhibition |
| US20060172925A1 (en) * | 1998-10-26 | 2006-08-03 | Board Of Regents, The University Of Texas System | Thio-siRNA aptamers |
| US20040242521A1 (en) * | 1999-10-25 | 2004-12-02 | Board Of Regents, The University Of Texas System | Thio-siRNA aptamers |
| US6759574B1 (en) * | 1998-11-05 | 2004-07-06 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Plants having enhanced gall resistance and methods and compositions for producing same |
| US6939712B1 (en) * | 1998-12-29 | 2005-09-06 | Impedagen, Llc | Muting gene activity using a transgenic nucleic acid |
| WO2000044914A1 (en) * | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| AU2008202208C1 (en) * | 1999-01-30 | 2014-04-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a defined gene |
| US6987025B1 (en) | 1999-02-11 | 2006-01-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Dwf4 polynucleotides, polypeptides and uses thereof |
| US7601494B2 (en) | 1999-03-17 | 2009-10-13 | The University Of North Carolina At Chapel Hill | Method of screening candidate compounds for susceptibility to biliary excretion |
| CA2365901A1 (en) * | 1999-04-14 | 2000-10-19 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
| WO2000063364A2 (en) * | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| US20040138168A1 (en) * | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| SK16222001A3 (sk) * | 1999-05-10 | 2002-04-04 | Syngenta Participations Ag | Spôsob zmeny expresie vírusového genómu |
| AU5299200A (en) * | 1999-05-27 | 2000-12-18 | Pharmacia & Upjohn Company | A nematode drug screen for modulators of mammalian disorders |
| US7485715B2 (en) | 1999-06-18 | 2009-02-03 | Ceres, Inc. | Sequence-determined DNA encoding AP2 domain polypeptides |
| US7479555B2 (en) | 1999-07-21 | 2009-01-20 | Ceres, Inc. | Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity |
| US20040002153A1 (en) * | 1999-07-21 | 2004-01-01 | Monia Brett P. | Modulation of PTEN expression via oligomeric compounds |
| CA2379819A1 (en) | 1999-07-29 | 2001-02-08 | Dana-Farber Cancer Institute, Inc. | Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo |
| US6924109B2 (en) * | 1999-07-30 | 2005-08-02 | Agy Therapeutics, Inc. | High-throughput transcriptome and functional validation analysis |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US6822086B1 (en) * | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| US6423885B1 (en) * | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| US7531718B2 (en) * | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| CN1378602A (zh) * | 1999-08-26 | 2002-11-06 | 卡尔根尼有限公司 | 含修饰的多不饱和脂肪酸的植物 |
| US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| US20040106567A1 (en) * | 1999-09-07 | 2004-06-03 | Hagstrom James E. | Intravascular delivery of non-viral nucleic acid |
| US20020006664A1 (en) * | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US20040157327A1 (en) * | 1999-10-22 | 2004-08-12 | Wyeth | Pablo, a polypeptide that interacts with BCL-XL, and uses related thereto |
| GB9925459D0 (en) * | 1999-10-27 | 1999-12-29 | Plant Bioscience Ltd | Gene silencing |
| US6326193B1 (en) * | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| US7829693B2 (en) * | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| DE10100586C1 (de) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) * | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| CN101041079A (zh) * | 1999-12-30 | 2007-09-26 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| WO2001049844A1 (en) * | 1999-12-30 | 2001-07-12 | Rutgers, The State University Of New Jersey | Compositions and methods for gene silencing |
| US6531644B1 (en) * | 2000-01-14 | 2003-03-11 | Exelixis, Inc. | Methods for identifying anti-cancer drug targets |
| US7179796B2 (en) * | 2000-01-18 | 2007-02-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| US20020055479A1 (en) * | 2000-01-18 | 2002-05-09 | Cowsert Lex M. | Antisense modulation of PTP1B expression |
| US7491805B2 (en) * | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| US20050032733A1 (en) * | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| US7833992B2 (en) * | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| US20050233329A1 (en) * | 2002-02-20 | 2005-10-20 | Sirna Therapeutics, Inc. | Inhibition of gene expression using duplex forming oligonucleotides |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| US8273866B2 (en) * | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
| US20080039414A1 (en) * | 2002-02-20 | 2008-02-14 | Sima Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| AU3811101A (en) * | 2000-02-11 | 2001-08-20 | Lawrence Blatt | Method and reagent for the modulation and diagnosis of cd20 and nogo gene expression |
| US8202979B2 (en) * | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US20030084471A1 (en) * | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
| AU2001245793A1 (en) * | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| EP1728862A1 (en) * | 2000-03-16 | 2006-12-06 | Genetica, Inc. | Methods and compositions for RNA interference |
| US8202846B2 (en) * | 2000-03-16 | 2012-06-19 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| JP2003527856A (ja) * | 2000-03-17 | 2003-09-24 | ベニテック オーストラリア リミテッド | 遺伝子のサイレンシング |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| ES2410907T5 (es) † | 2000-03-30 | 2019-08-20 | The Whitehead Institute For Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| US7691991B2 (en) | 2000-04-17 | 2010-04-06 | Ceres, Inc. | Sequence-determined DNA fragments encoding cytochrome P450 proteins |
| GB0012233D0 (en) | 2000-05-19 | 2000-07-12 | Devgen Nv | Vector constructs |
| ATE513910T1 (de) * | 2000-05-30 | 2011-07-15 | Johnson & Johnson Res Pty Ltd | Methoden zur gensuppression mithilfe von rnai verstärkenden faktoren |
| JP2002306183A (ja) * | 2000-06-02 | 2002-10-22 | Mitsubishi Chemicals Corp | 遺伝子機能同定法 |
| AU2001275474A1 (en) * | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| ATE507300T1 (de) | 2000-06-23 | 2011-05-15 | Du Pont | Rekombinante konstrukte und ihre verwendung bei der reduzierung der genexpression |
| US7662791B2 (en) * | 2000-08-02 | 2010-02-16 | University Of Southern California | Gene silencing using mRNA-cDNA hybrids |
| US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US20040053869A1 (en) * | 2000-08-19 | 2004-03-18 | Peter Andrews | Stem cell differentiation |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US20050209179A1 (en) * | 2000-08-30 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| US20080032942A1 (en) | 2000-08-30 | 2008-02-07 | Mcswiggen James | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| US20060247194A1 (en) * | 2000-08-30 | 2006-11-02 | Sirna Therapeutics , Inc. | Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina) |
| KR20030029885A (ko) | 2000-08-30 | 2003-04-16 | 노쓰 캐롤라이나 스테이트 유니버시티 | 단백질 함량을 변화시키는 분자 미끼를 포함하는유전자이식 식물 |
| US7429457B2 (en) * | 2000-09-14 | 2008-09-30 | The Regents Of The University Of California | Id-1 and Id-2 genes and products as markers of epithelial cancer |
| CA2422868A1 (en) * | 2000-09-19 | 2002-03-28 | University Of South Florida | Control of nk cell function and survival by modulation of ship activity |
| US20020165192A1 (en) * | 2000-09-19 | 2002-11-07 | Kerr William G. | Control of NK cell function and survival by modulation of ship activity |
| US7691821B2 (en) * | 2001-09-19 | 2010-04-06 | University Of South Florida | Inhibition of SHIP to enhance stem cell harvest and transplantation |
| CA2425193C (en) * | 2000-10-12 | 2011-09-20 | The Public Health Research Institute Of The City Of New York, Inc. | Oligonucleotide - facilitated coalescence |
| WO2002059257A2 (en) | 2000-10-31 | 2002-08-01 | Commonwealth Scientific And Industrial Research Organisation | Method and means for producing barley yellow dwarf virus resistant cereal plants |
| DE60128149D1 (en) | 2000-11-07 | 2007-06-06 | Univ North Carolina State | Putrescin-n-methyltransferasepromotor |
| US20020173478A1 (en) * | 2000-11-14 | 2002-11-21 | The Trustees Of The University Of Pennsylvania | Post-transcriptional gene silencing by RNAi in mammalian cells |
| CH695778A5 (de) * | 2000-11-29 | 2006-08-31 | Hoffmann La Roche | Hemmung der Transkription eines Zielgens in einer Zelle oder in Geweben. |
| RU2322500C2 (ru) | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| CA2433680A1 (en) * | 2000-12-28 | 2002-08-01 | Gregory M Arndt | Double-stranded rna-mediated gene suppression |
| US7385046B2 (en) | 2001-01-03 | 2008-06-10 | Ceres, Inc. | Sequence-determined DNA fragments encoding ethylene responsive element binding proteins |
| US7767802B2 (en) * | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7423142B2 (en) * | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| EP1860199B1 (en) | 2001-01-12 | 2014-03-05 | Exelixis, Inc. | Modulating insulin receptor signaling |
| JP2002208294A (ja) * | 2001-01-12 | 2002-07-26 | Toshiba Corp | リダンダンシーシステムを有する半導体記憶装置 |
| NZ526507A (en) | 2001-01-26 | 2005-07-29 | Commw Scient Ind Res Org | Methods and means for producing efficient silencing construct using recombinational cloning |
| EP1229134A3 (en) * | 2001-01-31 | 2004-01-28 | Nucleonics, Inc | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| WO2002062989A2 (en) * | 2001-02-08 | 2002-08-15 | Sequitur, Inc. | Methods of light activated release 0f ligands from endosomes |
| GB0104948D0 (en) * | 2001-02-28 | 2001-04-18 | Novartis Res Foundation | Novel methods |
| US7563618B2 (en) | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
| US8034791B2 (en) | 2001-04-06 | 2011-10-11 | The University Of Chicago | Activation of Egr-1 promoter by DNA damaging chemotherapeutics |
| US20050159380A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA) |
| US20040219671A1 (en) * | 2002-02-20 | 2004-11-04 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of parkinson disease using short interfering nucleic acid (siNA) |
| US20050209180A1 (en) * | 2001-05-18 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US20050191618A1 (en) * | 2001-05-18 | 2005-09-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
| US20050187174A1 (en) * | 2001-05-18 | 2005-08-25 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
| US20050233996A1 (en) * | 2002-02-20 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA) |
| US20050191638A1 (en) * | 2002-02-20 | 2005-09-01 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
| US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US20060142226A1 (en) * | 2001-05-18 | 2006-06-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of cholesteryl ester transfer protein (CETP) gene expression using short interfering nucleic acid (siNA) |
| US20050288242A1 (en) * | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA) |
| US20050159379A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc | RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA) |
| US20050119212A1 (en) * | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA) |
| US20050222066A1 (en) * | 2001-05-18 | 2005-10-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050136436A1 (en) * | 2001-05-18 | 2005-06-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA) |
| US7109165B2 (en) * | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US20050176666A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA) |
| US20090299045A1 (en) * | 2001-05-18 | 2009-12-03 | Sirna Therapeutics, Inc. | RNA Interference Mediated Inhibition Of Interleukin and Interleukin Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| US20050159376A1 (en) * | 2002-02-20 | 2005-07-21 | Slrna Therapeutics, Inc. | RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| US20050164967A1 (en) * | 2001-05-18 | 2005-07-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
| US20050256068A1 (en) * | 2001-05-18 | 2005-11-17 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA) |
| US20050124568A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA) |
| US20060241075A1 (en) * | 2001-05-18 | 2006-10-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA) |
| US20050014172A1 (en) | 2002-02-20 | 2005-01-20 | Ivan Richards | RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA) |
| US20050054598A1 (en) * | 2002-02-20 | 2005-03-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA) |
| US20050233344A1 (en) * | 2001-05-18 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA) |
| US20070042983A1 (en) * | 2001-05-18 | 2007-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US20050227935A1 (en) * | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA) |
| US20050196767A1 (en) * | 2001-05-18 | 2005-09-08 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA) |
| US20040019001A1 (en) * | 2002-02-20 | 2004-01-29 | Mcswiggen James A. | RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA |
| US20050164966A1 (en) * | 2001-05-18 | 2005-07-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050182006A1 (en) * | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc | RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA) |
| US20050196765A1 (en) * | 2001-05-18 | 2005-09-08 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
| US20060019913A1 (en) * | 2001-05-18 | 2006-01-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| US20070049543A1 (en) * | 2001-05-18 | 2007-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA |
| US20050182007A1 (en) * | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
| US20050182009A1 (en) * | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA) |
| US20060211642A1 (en) * | 2001-05-18 | 2006-09-21 | Sirna Therapeutics, Inc. | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
| US20070270579A1 (en) * | 2001-05-18 | 2007-11-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US20050079610A1 (en) * | 2001-05-18 | 2005-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) |
| US20050287128A1 (en) * | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
| US20050137155A1 (en) * | 2001-05-18 | 2005-06-23 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA) |
| US20030175950A1 (en) * | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| US20050080031A1 (en) * | 2001-05-18 | 2005-04-14 | Sirna Therapeutics, Inc. | Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV |
| US20050176664A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA) |
| US20050170371A1 (en) * | 2001-05-18 | 2005-08-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| US20050267058A1 (en) * | 2001-05-18 | 2005-12-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA) |
| US20050282188A1 (en) * | 2001-05-18 | 2005-12-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US20050153914A1 (en) * | 2001-05-18 | 2005-07-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA) |
| US20040006035A1 (en) * | 2001-05-29 | 2004-01-08 | Dennis Macejak | Nucleic acid mediated disruption of HIV fusogenic peptide interactions |
| US20070093437A1 (en) * | 2001-05-18 | 2007-04-26 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina) |
| US20050176665A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA) |
| US20080161256A1 (en) * | 2001-05-18 | 2008-07-03 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US7517864B2 (en) * | 2001-05-18 | 2009-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050164968A1 (en) * | 2001-05-18 | 2005-07-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA) |
| US20050124567A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA) |
| US20050054596A1 (en) * | 2001-11-30 | 2005-03-10 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050148530A1 (en) * | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050159378A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| US20050153915A1 (en) * | 2001-05-18 | 2005-07-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of early growth response gene expression using short interfering nucleic acid (siNA) |
| WO2003072590A1 (en) * | 2002-02-20 | 2003-09-04 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
| US20050124566A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
| US20050159382A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
| US20050143333A1 (en) * | 2001-05-18 | 2005-06-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
| US20060142225A1 (en) * | 2001-05-18 | 2006-06-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA) |
| US20050164224A1 (en) * | 2001-05-18 | 2005-07-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA) |
| US20080188430A1 (en) * | 2001-05-18 | 2008-08-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| US20040198682A1 (en) * | 2001-11-30 | 2004-10-07 | Mcswiggen James | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
| US20050130181A1 (en) * | 2001-05-18 | 2005-06-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA) |
| EP1572067A4 (en) | 2001-05-18 | 2009-05-13 | Sirna Therapeutics Inc | CONJUGATES AND COMPOSITIONS FOR CELLULAR RELEASE |
| US20050203040A1 (en) * | 2001-05-18 | 2005-09-15 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
| US20050233997A1 (en) * | 2001-05-18 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
| US8008472B2 (en) | 2001-05-29 | 2011-08-30 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
| EP1390472A4 (en) * | 2001-05-29 | 2004-11-17 | Sirna Therapeutics Inc | NUCLEIC ACID TREATMENT OF DISEASES OR SIDES RELATED TO RAS, HER2 AND HIV LEVELS |
| ATE483976T1 (de) | 2001-06-05 | 2010-10-15 | Exelixis Inc | Gfats als modifikatoren des p53-wegs und verwendungsverfahren |
| WO2002100199A2 (en) | 2001-06-08 | 2002-12-19 | Vector Tobacco Ltd. | Modifying nicotine and nitrosamine levels in tobacco |
| EP1406489A4 (en) * | 2001-06-22 | 2005-08-24 | Univ California | EUKARYONTIC GENES WHICH ARE PARTICIPATED IN THE REGULATION OF THE LIFE AGES AS ADULTS |
| US20040126867A1 (en) * | 2001-07-06 | 2004-07-01 | Crooke Stanley T. | Human RNase III and compositions and uses thereof |
| AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
| ES2192945B1 (es) * | 2001-07-06 | 2005-03-01 | Consejo Superior De Investigaciones Cientificas | Un metodo para interferir con la infeccion de virus en plantas. |
| WO2003006691A1 (en) * | 2001-07-10 | 2003-01-23 | Johnson & Johnson Research Pty Limited | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells |
| ES2566561T3 (es) | 2001-07-12 | 2016-04-13 | University Of Massachusetts | Producción in vivo de ARN pequeños de interferencia que median el silenciamiento génico |
| AU2002316631A1 (en) | 2001-07-12 | 2003-01-29 | Exelixis, Inc. | Ube2s as modifiers of the p21 pathway and methods of use |
| US8022272B2 (en) | 2001-07-13 | 2011-09-20 | Sungene Gmbh & Co. Kgaa | Expression cassettes for transgenic expression of nucleic acids |
| CA2454183C (en) | 2001-07-23 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| US7612194B2 (en) * | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| GB0118223D0 (en) * | 2001-07-26 | 2001-09-19 | Univ Sheffield | Stem loop RNA |
| US20050037989A1 (en) * | 2001-08-27 | 2005-02-17 | Lewis David L. | Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo |
| US20030198627A1 (en) * | 2001-09-01 | 2003-10-23 | Gert-Jan Arts | siRNA knockout assay method and constructs |
| US7456335B2 (en) | 2001-09-03 | 2008-11-25 | Basf Plant Science Gmbh | Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants |
| AU2002326906C1 (en) * | 2001-09-13 | 2009-01-29 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
| US7195916B2 (en) * | 2001-09-13 | 2007-03-27 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
| US7737124B2 (en) * | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
| AU2002341905A2 (en) | 2001-09-27 | 2003-04-07 | University Of Delaware | Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration |
| GB0123401D0 (en) * | 2001-09-28 | 2001-11-21 | Novartis Forschungsstiftung | Methods of inducing gene expression |
| EP2390328A1 (en) * | 2001-09-28 | 2011-11-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| CA2478681A1 (en) * | 2001-10-22 | 2003-05-01 | University Of Rochester | Telomerase interference |
| DE10230996A1 (de) * | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Behandlung eines Pankreaskarzinoms |
| JP2005506087A (ja) * | 2001-10-26 | 2005-03-03 | リボファーマ アーゲー | プラス鎖rnaウイルスによる感染症を処置するための2本鎖リボ核酸の使用 |
| DE10230997A1 (de) * | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels |
| WO2003035083A1 (de) * | 2001-10-26 | 2003-05-01 | Ribopharma Ag | Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz |
| AU2002368202B2 (en) * | 2001-11-02 | 2008-06-05 | Insert Therapeutics, Inc | Methods and compositions for therapeutic use of RNA interference |
| US20040063654A1 (en) * | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
| AU2002338926B2 (en) * | 2001-11-05 | 2007-05-24 | Janssen Pharmaceutica N.V. | Method for the in vitro synthesis of short double stranded RNAs |
| US20030150017A1 (en) * | 2001-11-07 | 2003-08-07 | Mesa Jose Ramon Botella | Method for facilitating pathogen resistance |
| US20030148519A1 (en) * | 2001-11-14 | 2003-08-07 | Engelke David R. | Intracellular expression and delivery of siRNAs in mammalian cells |
| AU2002352797A1 (en) * | 2001-11-19 | 2003-06-10 | Proteologics, Inc. | Methods for identifying and validating potential drug targets |
| CA2467936C (en) * | 2001-11-21 | 2013-11-05 | Mitsubishi Chemical Corporation | Method of inhibiting gene expression |
| WO2003046173A1 (en) * | 2001-11-28 | 2003-06-05 | Center For Advanced Science And Technology Incubation, Ltd. | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE-KNOCKDOWN CELLS AND THE LIKE USING THE SAME |
| US20050075304A1 (en) * | 2001-11-30 | 2005-04-07 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20070203333A1 (en) * | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20040138163A1 (en) * | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| GB0130199D0 (en) * | 2001-12-17 | 2002-02-06 | Syngenta Mogen Bv | New nematode feeding assay |
| US7294504B1 (en) * | 2001-12-27 | 2007-11-13 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods and compositions for DNA mediated gene silencing |
| AU2008246266B2 (en) * | 2002-01-22 | 2012-09-06 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| AU2012261651B2 (en) * | 2002-01-22 | 2015-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| DE10202419A1 (de) * | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
| WO2003064621A2 (en) * | 2002-02-01 | 2003-08-07 | Ambion, Inc. | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US20060009409A1 (en) * | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| EP2221377B2 (en) | 2002-02-01 | 2017-05-17 | Life Technologies Corporation | Oligonucleotide compositions with enhanced efficiency |
| US20030203868A1 (en) * | 2002-02-06 | 2003-10-30 | Bushman Frederic D. | Inhibition of pathogen replication by RNA interference |
| US20050096289A1 (en) * | 2002-02-07 | 2005-05-05 | Hans Prydz | Methods and compositions for modulating tissue factor |
| US20050202428A1 (en) * | 2002-02-13 | 2005-09-15 | Axordia Limited | Pluripotential stem cells |
| US7820632B2 (en) | 2002-02-14 | 2010-10-26 | City Of Hope | Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules |
| US7928220B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
| US20090253773A1 (en) | 2002-02-20 | 2009-10-08 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1432725A4 (en) * | 2002-02-20 | 2005-03-30 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF TELOMERASEGENEXPRESSION WITH SHORT INTERFERING NUCLEIC ACID (SINA) |
| US20090099117A1 (en) | 2002-02-20 | 2009-04-16 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF MYOSTATIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| AU2003207708A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
| EP1474433A4 (en) * | 2002-02-20 | 2005-02-23 | Sirna Therapeutics Inc | VALIDATION AND IDENTIFICATION OF RNA INTERFERENCE FACILITATED TARGETS USING SHORT INTERFERENT NUCLEIC ACID (siNA) |
| US7897752B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA) |
| US20050137153A1 (en) * | 2002-02-20 | 2005-06-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA) |
| US8013143B2 (en) | 2002-02-20 | 2011-09-06 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA) |
| US7928219B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA) |
| WO2003106476A1 (en) * | 2002-02-20 | 2003-12-24 | Sirna Therapeutics, Inc | Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity |
| US7700760B2 (en) | 2002-02-20 | 2010-04-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
| EP1476459A4 (en) * | 2002-02-20 | 2005-05-25 | Sirna Therapeutics Inc | INHIBITION OF RNA INTERFERENCE-INDUCED CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| US7893248B2 (en) * | 2002-02-20 | 2011-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| US7662952B2 (en) * | 2002-02-20 | 2010-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) |
| US7678897B2 (en) | 2002-02-20 | 2010-03-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
| US7683166B2 (en) | 2002-02-20 | 2010-03-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US7691999B2 (en) | 2002-02-20 | 2010-04-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) |
| JP2005517433A (ja) * | 2002-02-20 | 2005-06-16 | サーナ・セラピューティクス・インコーポレイテッド | 短干渉核酸(siNA)を用いるTNFおよびTNFレセプタースーパーファミリー遺伝子発現のRNA干渉媒介性阻害 |
| US7795422B2 (en) | 2002-02-20 | 2010-09-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| US7910724B2 (en) | 2002-02-20 | 2011-03-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) |
| AU2003220136A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20090253774A1 (en) | 2002-02-20 | 2009-10-08 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US8258288B2 (en) | 2002-02-20 | 2012-09-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
| EP1448590A4 (en) * | 2002-02-20 | 2004-12-15 | Sirna Therapeutics Inc | Inhibition of the myc and myb genes mediated by RNA interference mediated or genes of the corresponding synthetic pathways |
| US20090192105A1 (en) | 2002-02-20 | 2009-07-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA) |
| US7667030B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
| US20050096284A1 (en) * | 2002-02-20 | 2005-05-05 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
| US20050222064A1 (en) * | 2002-02-20 | 2005-10-06 | Sirna Therapeutics, Inc. | Polycationic compositions for cellular delivery of polynucleotides |
| US20090137510A1 (en) * | 2002-02-20 | 2009-05-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF NF-KAPPA B/ REL-A GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US7667029B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
| EP1430157B1 (en) | 2002-02-20 | 2011-08-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US8067575B2 (en) | 2002-02-20 | 2011-11-29 | Merck, Sharp & Dohme Corp. | RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA) |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20090137513A1 (en) * | 2002-02-20 | 2009-05-28 | Sirna Therapeutics, Inc. | RNA Interference Mediated Inhibition of Acetyl-CoA-Carboxylase Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| US7935812B2 (en) | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US7928218B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
| US7897753B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA) |
| US7683165B2 (en) | 2002-02-20 | 2010-03-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
| US7897757B2 (en) | 2002-02-20 | 2011-03-01 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
| WO2003070932A1 (en) * | 2002-02-22 | 2003-08-28 | Otsuka Pharmaceutical Co., Ltd. | Polynucleotide for target gene |
| US20050176008A1 (en) * | 2002-02-22 | 2005-08-11 | Mikio Suzuki | Polynucleotide for target gene |
| AUPS078002A0 (en) * | 2002-02-27 | 2002-03-21 | Unisearch Limited | Dnazyme therapeutics |
| AU2003223214B2 (en) | 2002-03-01 | 2008-09-18 | Celltech R & D, Inc. | Methods to increase or decrease bone density |
| US7274703B2 (en) * | 2002-03-11 | 2007-09-25 | 3Com Corporation | Stackable network units with resiliency facility |
| JP2005526778A (ja) * | 2002-03-15 | 2005-09-08 | アストラル,インコーポレイテッド | 免疫調節性非コードrnaモチーフを用いて抗体及び主要組織適合性クラスi拘束性又はクラスii拘束性t細胞の応答を開始或いは増強させるための組成物及び方法 |
| US20070037769A1 (en) * | 2003-03-14 | 2007-02-15 | Multicell Immunotherapeutics, Inc. | Compositions and methods to treat and control tumors by loading antigen presenting cells |
| EP2258712A3 (en) * | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs |
| EP1488231A2 (en) | 2002-03-19 | 2004-12-22 | Novartis AG | Methods for the identification of compounds useful for the suppression of chronic neuropathic pain and compositions thereof |
| DE10212892A1 (de) | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
| DE10212893A1 (de) * | 2002-03-20 | 2003-10-16 | Basf Plant Science Gmbh | Verfahren zum Erhöhen des Ölgehaltes in Pflanzen |
| US7872048B2 (en) | 2004-09-18 | 2011-01-18 | University Of Maryland, Baltimore | Methods for treating spinal cord injury with a compound that inhibits a NCCa-ATP channel |
| US7566813B2 (en) * | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
| US7166771B2 (en) | 2002-06-21 | 2007-01-23 | Monsanto Technology Llc | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs |
| EP1484959A4 (en) * | 2002-03-21 | 2005-08-31 | Monsanto Technology Llc | NUCLEIC ACID CONSTRUCTS AND METHOD FOR PRODUCING MODIFIED SEED OIL COMPOSITIONS |
| BR0308923A (pt) * | 2002-03-27 | 2005-01-04 | Aegera Therapeutics Inc | OligÈmeros de nucleobase de iap anti-sentido e empregos destes |
| US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| US7541150B2 (en) * | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
| EP1352960A1 (en) * | 2002-04-12 | 2003-10-15 | Viruvation B.V. | Antiviral therapy on the basis of RNA interference |
| CA2482904A1 (en) * | 2002-04-18 | 2003-10-23 | Lynkeus Biotech Gmbh | Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification |
| EA010903B1 (ru) | 2002-04-19 | 2008-12-30 | Дайверса Корпорейшн | Фосфолипазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения |
| US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| US20040180438A1 (en) | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| US6790641B2 (en) | 2002-05-01 | 2004-09-14 | Cell Genesys, Inc. | Lentiviral vector particles resistant to complement inactivation |
| ES2465574T3 (es) * | 2002-05-03 | 2014-06-06 | Duke University | Un método para regular la expresión génica |
| AU2003266014B2 (en) | 2002-05-06 | 2009-05-14 | Alnylam Pharmaceuticals, Inc. | Methods for delivery of nucleic acids |
| US20030228691A1 (en) * | 2002-05-17 | 2003-12-11 | Lewis David L. | Processes for inhibiting gene expression using polynucleotides |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| EP1546379A4 (en) * | 2002-05-23 | 2007-09-26 | Ceptyr Inc | MODULATION OF PTP1B SIGNAL TRANSMISSION BY RNA INTERFERENCE |
| GB0212303D0 (en) * | 2002-05-28 | 2002-07-10 | Isis Innovation | Molecular targetting of IGF-1 receptor |
| US20040019008A1 (en) * | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| GB0212302D0 (en) * | 2002-05-28 | 2002-07-10 | Isis Innovation | Method of selecting targets for gene silencing by RNA interference |
| FR2840217B1 (fr) * | 2002-06-03 | 2005-06-24 | Oreal | Compositions cosmetiques comprenant au moins un oligonucleotide d'arn double brin (dsrna)et leurs utilisations |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| CA2388441A1 (en) * | 2002-06-10 | 2003-12-10 | Wei-Ping Min | Immunomodulation using rna interference |
| GB2406169B (en) * | 2002-06-12 | 2006-11-01 | Ambion Inc | Methods and compositions relating to labeled rna molecules that reduce gene expression |
| US20100075423A1 (en) * | 2002-06-12 | 2010-03-25 | Life Technologies Corporation | Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference |
| US20040248094A1 (en) * | 2002-06-12 | 2004-12-09 | Ford Lance P. | Methods and compositions relating to labeled RNA molecules that reduce gene expression |
| WO2003106654A2 (en) | 2002-06-14 | 2003-12-24 | Diversa Corporation | Xylanases, nucleic adics encoding them and methods for making and using them |
| EP1516051A4 (en) * | 2002-06-21 | 2007-05-02 | Monsanto Technology Llc | DOUBLE-STRUCTURED INTRON RNA CONSTRUCTS AND USES THEREOF |
| WO2004002416A2 (en) * | 2002-06-26 | 2004-01-08 | The Penn State Research Foundation | Methods and materials for treating human papillomavirus infections |
| DE60331310D1 (de) * | 2002-06-26 | 2010-04-01 | Univ Louisville Res Found | Verfahren zum apoptosenachweis |
| AU2003247951A1 (en) * | 2002-07-10 | 2004-01-23 | Kansas State University Research Foundation | Compositions and methods for controlling parasitic nematodes |
| US7655790B2 (en) | 2002-07-12 | 2010-02-02 | Sirna Therapeutics, Inc. | Deprotection and purification of oligonucleotides and their derivatives |
| WO2004009768A2 (en) * | 2002-07-18 | 2004-01-29 | Invitrogen Corporation | Viral vectors containing recombination sites |
| DE10233327A1 (de) * | 2002-07-22 | 2004-02-05 | Basf Ag | Verfahren zum Erreichen einer Pathogenresistenz in Pflanzen |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| US7399851B2 (en) | 2002-07-25 | 2008-07-15 | Dana Farber Cancer Institute, Inc. | Composition and method for imaging cells |
| CA2884658A1 (en) | 2002-07-26 | 2004-02-05 | Novartis Vaccines And Diagnostics, Inc. | Modified small interfering rna molecules and methods of use |
| EP1527183B1 (de) | 2002-07-26 | 2008-08-20 | BASF Plant Science GmbH | Neue selektionsverfahren |
| EP1540004A4 (en) * | 2002-07-31 | 2007-10-03 | Nucleonics Inc | DOUBLE-STRING RNA STRUCTURES AND CONSTRUCTS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| WO2004013288A2 (en) | 2002-08-01 | 2004-02-12 | City Of Hope | Methods and kits for synthesis of sirna expression cassettes |
| US20050255086A1 (en) * | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
| ES2280826T5 (es) * | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Nuevas formas adicionales de moléculas de ARN de interferencia |
| US20040023390A1 (en) * | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
| US20050106731A1 (en) * | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US20080176812A1 (en) * | 2002-08-05 | 2008-07-24 | Davidson Beverly L | Allele-specific silencing of disease genes |
| US20080274989A1 (en) * | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| US20050042646A1 (en) * | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| EP1546173A4 (en) * | 2002-08-06 | 2006-05-31 | Intradigm Corp | METHOD FOR DOWNSTREGULATING THE EXPRESSION OF TARGET GENES IN VIVO BY INCLUDING INTERFERING RNA |
| CA2494626A1 (en) | 2002-08-07 | 2004-03-04 | Basf Plant Science Gmbh | Nucleic acid sequences encoding proteins associated with abiotic stress response |
| WO2004014933A1 (en) | 2002-08-07 | 2004-02-19 | University Of Massachusetts | Compositions for rna interference and methods of use thereof |
| US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
| EP1552018B1 (en) * | 2002-08-12 | 2009-07-01 | New England Biolabs, Inc. | Methods and compositions relating to gene silencing |
| WO2004022782A2 (en) * | 2002-09-04 | 2004-03-18 | Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Compositions and methods for tissue specific or inducible inhibition of gene expression |
| US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| WO2004022003A2 (en) | 2002-09-06 | 2004-03-18 | University Of South Florida | Materials and methods for treatment of allergic diseases |
| US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| US20080260744A1 (en) | 2002-09-09 | 2008-10-23 | Omeros Corporation | G protein coupled receptors and uses thereof |
| AU2003267785C1 (en) * | 2002-09-13 | 2009-12-24 | Replicor, Inc. | Non-sequence complementary antiviral oligonucleotides |
| US20050196382A1 (en) * | 2002-09-13 | 2005-09-08 | Replicor, Inc. | Antiviral oligonucleotides targeting viral families |
| WO2004024940A2 (en) * | 2002-09-16 | 2004-03-25 | University Of Southern California | Rna-mediated gene modulation |
| US7476777B2 (en) | 2002-09-17 | 2009-01-13 | Ceres, Inc. | Biological containment system |
| WO2004027030A2 (en) * | 2002-09-18 | 2004-04-01 | Isis Pharmaceuticals, Inc. | Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds |
| ATE513843T1 (de) | 2002-09-25 | 2011-07-15 | Univ Massachusetts | Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna |
| WO2004029215A2 (en) * | 2002-09-26 | 2004-04-08 | The Regents Of The University Of California | Conditional gene expression using rnai |
| US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| US20070224124A1 (en) * | 2002-09-30 | 2007-09-27 | University Of South Florida | Novel SH2containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein |
| WO2004033638A2 (en) * | 2002-10-07 | 2004-04-22 | Wyeth | Compositions, organisms and methodologies employing a novel human kinase |
| WO2005000194A2 (en) * | 2002-10-08 | 2005-01-06 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| JP4584713B2 (ja) * | 2002-10-08 | 2010-11-24 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって術後疼痛を処置するための方法および神経成長因子アンタゴニストを含有する組成物 |
| US20040096890A1 (en) * | 2002-10-10 | 2004-05-20 | Wyeth | Compositions, organisms and methodologies employing a novel human kinase |
| AU2003300027A1 (en) * | 2002-10-10 | 2004-05-04 | Wyeth | Compositions, organisms and methodologies employing a novel human kinase |
| US20050214292A1 (en) * | 2002-10-18 | 2005-09-29 | Wyeth | Compositions and methods for diagnosing and treating autoimmune disease |
| US7208306B2 (en) * | 2002-10-24 | 2007-04-24 | Wyeth | Compositions employing a novel human protein phosphatase |
| KR20120038546A (ko) * | 2002-11-01 | 2012-04-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | HIF-1 알파의 siRNA 억제를 위한 조성물 및 방법 |
| US7892793B2 (en) * | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
| EP1560840B1 (en) * | 2002-11-05 | 2015-05-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
| CA2504720C (en) | 2002-11-05 | 2013-12-24 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
| GB0225799D0 (en) * | 2002-11-05 | 2002-12-11 | Novartis Forschungsstiftung | Tel/etv6-mediated inhibition of cell proliferation |
| US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US9150606B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
| US7977471B2 (en) * | 2002-11-14 | 2011-07-12 | Dharmacon, Inc. | siRNA targeting TNFα |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US7781575B2 (en) | 2002-11-14 | 2010-08-24 | Dharmacon, Inc. | siRNA targeting tumor protein 53 (p53) |
| US8198427B1 (en) | 2002-11-14 | 2012-06-12 | Dharmacon, Inc. | SiRNA targeting catenin, beta-1 (CTNNB1) |
| US20090227780A1 (en) * | 2002-11-14 | 2009-09-10 | Dharmacon, Inc. | siRNA targeting connexin 43 |
| US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
| US20080268457A1 (en) * | 2002-11-14 | 2008-10-30 | Dharmacon, Inc. | siRNA targeting forkhead box P3 (FOXP3) |
| US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7592442B2 (en) * | 2002-11-14 | 2009-09-22 | Dharmacon, Inc. | siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2) |
| US7691998B2 (en) * | 2002-11-14 | 2010-04-06 | Dharmacon, Inc. | siRNA targeting nucleoporin 62kDa (Nup62) |
| US20100113307A1 (en) * | 2002-11-14 | 2010-05-06 | Dharmacon, Inc. | siRNA targeting vascular endothelial growth factor (VEGF) |
| US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
| US7612196B2 (en) * | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| US10011836B2 (en) | 2002-11-14 | 2018-07-03 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7635770B2 (en) * | 2002-11-14 | 2009-12-22 | Dharmacon, Inc. | siRNA targeting protein kinase N-3 (PKN-3) |
| US7951935B2 (en) | 2002-11-14 | 2011-05-31 | Dharmacon, Inc. | siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC) |
| US9839649B2 (en) | 2002-11-14 | 2017-12-12 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7619081B2 (en) * | 2002-11-14 | 2009-11-17 | Dharmacon, Inc. | siRNA targeting coatomer protein complex, subunit beta 2 (COPB2) |
| US9771586B2 (en) | 2002-11-14 | 2017-09-26 | Thermo Fisher Scientific Inc. | RNAi targeting ZNF205 |
| US20040214198A1 (en) * | 2002-11-15 | 2004-10-28 | University Of Massachusetts | Allele-targeted RNA interference |
| JP2006514554A (ja) * | 2002-11-21 | 2006-05-11 | ワイス | 腎細胞癌および他の固形腫瘍の診断法 |
| US20040191905A1 (en) * | 2002-11-22 | 2004-09-30 | University Of Massachusetts | Modulation of HIV replication by RNA interference |
| US7365186B2 (en) * | 2002-11-22 | 2008-04-29 | Arborgen, Llc | Vascular-preferred promoter sequences and uses thereof |
| CA2506617C (en) * | 2002-11-24 | 2012-03-06 | Daiichi Pharmaceutical Co., Ltd. | Colon cancer metastasis inhibitor |
| EP2112229A3 (en) | 2002-11-25 | 2009-12-02 | Sequenom, Inc. | Methods for identifying risk of breast cancer and treatments thereof |
| US7217807B2 (en) * | 2002-11-26 | 2007-05-15 | Rosetta Genomics Ltd | Bioinformatically detectable group of novel HIV regulatory genes and uses thereof |
| US20050048641A1 (en) * | 2002-11-26 | 2005-03-03 | Medtronic, Inc. | System and method for delivering polynucleotides to the central nervous system |
| US7605249B2 (en) * | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| AU2003290664A1 (en) * | 2002-11-27 | 2004-06-23 | Wei Liu | Compositions, organisms and methodologies employing a novel human kinase |
| DE60334247D1 (de) | 2002-11-27 | 2010-10-28 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
| US20040110698A1 (en) * | 2002-12-10 | 2004-06-10 | Kimron Veterinary Institute | Oligonucleotides and methods using same for treating cox-ll associated diseases |
| US20050014264A1 (en) * | 2002-12-11 | 2005-01-20 | University Of Massachusetts | Method of introducing siRNA into adipocytes |
| CA2508948A1 (en) | 2002-12-16 | 2004-07-15 | Halozyme, Inc. | Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof |
| AU2003301059A1 (en) * | 2002-12-18 | 2004-07-22 | Wyeth | Methods for screening, treating and diagnosing inflammatory bowel disease and compositions thereof |
| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| CN1301263C (zh) * | 2002-12-18 | 2007-02-21 | 北京昭衍新药研究中心 | 一组抗hiv感染及防治艾滋病的核苷酸序列及其应用 |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| CN101014364B (zh) * | 2002-12-24 | 2012-01-18 | 里纳特神经系统学公司 | 抗ngf抗体及其使用方法 |
| CA2511824A1 (en) | 2002-12-26 | 2004-07-22 | Syngenta Participations Ag | Cell proliferation-related polypeptides and uses therefor |
| US20040248299A1 (en) * | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
| DE602004015064D1 (de) * | 2003-01-06 | 2008-08-28 | Wyeth Corp | Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs |
| MXPA05007651A (es) * | 2003-01-16 | 2005-10-26 | Univ Pennsylvania | Composiciones y metodos para la inhibicion por arnsi de la molecula de adhesion intercelular-1. |
| DE602004030315D1 (de) | 2003-01-17 | 2011-01-13 | Max Planck Gesellschaft | Induzierbare sirna expressionskonstrukte zur gezielten genabschaltung |
| JP3792655B2 (ja) * | 2003-01-20 | 2006-07-05 | 日本電気株式会社 | 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途 |
| AU2004206250B8 (en) | 2003-01-21 | 2009-09-17 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof |
| US20040147027A1 (en) * | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| EP1589931A2 (en) * | 2003-02-05 | 2005-11-02 | University of Massachusetts | RNAi TARGETING OF VIRUSES |
| US7326768B2 (en) * | 2003-02-05 | 2008-02-05 | Juan Saus | Goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders |
| US20070104688A1 (en) | 2003-02-13 | 2007-05-10 | City Of Hope | Small interfering RNA mediated transcriptional gene silencing in mammalian cells |
| US20040171118A1 (en) * | 2003-02-13 | 2004-09-02 | City Of Hope | Methods for directing DNA methylation in mammalian cells using homologous short double stranded RNAs |
| US20070149449A1 (en) | 2003-02-14 | 2007-06-28 | Morris David W | Therapeutic targets in cancer |
| PL379983A1 (pl) * | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
| WO2005017127A2 (en) * | 2003-02-21 | 2005-02-24 | The Penn State Research Foundation | Rna interference compositions and methods |
| US20040261149A1 (en) * | 2003-02-24 | 2004-12-23 | Fauquet Claude M. | siRNA-mediated inhibition of gene expression in plant cells |
| WO2004076639A2 (en) * | 2003-02-26 | 2004-09-10 | Wyeth | Use of gene expression profiling in the diagnosis and treatment of lupus nephritis and systemic lupus erythematosus |
| DE602004032114D1 (de) | 2003-02-28 | 2011-05-19 | Oncotherapy Science Inc | Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen |
| WO2004078995A2 (en) | 2003-03-04 | 2004-09-16 | Neurogenetics, Inc. | Methods of modulating and of identifying agents that modulate intracellular calcium |
| NZ542665A (en) * | 2003-03-05 | 2008-05-30 | Senesco Technologies Inc | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| CA2517145C (en) | 2003-03-05 | 2017-08-01 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| ES2713024T3 (es) | 2003-03-06 | 2019-05-17 | Basf Enzymes Llc | Amilasas, ácidos nucleicos que las codifican y métodos para su fabricación y uso |
| EP1604022A2 (en) * | 2003-03-06 | 2005-12-14 | Oligo Engine, Inc. | Modulation of gene expression using dna-rna hybrids |
| BRPI0408158A8 (pt) * | 2003-03-06 | 2017-12-05 | Diversa Corp | Amilases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las |
| CA2515583C (en) | 2003-03-07 | 2015-07-14 | Diversa Corporation | Hydrolases, nucleic acids encoding them and methods for making and using them |
| WO2004081200A2 (en) * | 2003-03-13 | 2004-09-23 | University Of Utah Research Foundation | Phospholipid scramblase 3 |
| ES2576677T3 (es) | 2003-03-21 | 2016-07-08 | Roche Innovation Center Copenhagen A/S | Análogos de ARN interfirientes cortos |
| WO2004087901A2 (en) * | 2003-03-25 | 2004-10-14 | Wyeth | Brain-localized protein kinases homologous to homeodomain-interacting protein kinases |
| AU2004225480A1 (en) * | 2003-03-26 | 2004-10-14 | Multicell Immunotherapeutics, Inc. | Selected RNA motifs to include cell death and/or apoptosis |
| US20040265961A1 (en) * | 2003-03-28 | 2004-12-30 | Wei Liu | Novel proteins homologous to kinase suppressor of Ras |
| CN1836045B (zh) | 2003-03-28 | 2012-05-09 | 孟山都技术有限公司 | 用于早期种子发育的新型植物启动子 |
| US20070197457A1 (en) * | 2003-04-01 | 2007-08-23 | Dan Gazit | Tak1-mediated inhibition of osteogenesis |
| SG179290A1 (en) * | 2003-04-01 | 2012-04-27 | Intradigm Corp | Targets for tumor growth inhibition |
| JP4605799B2 (ja) * | 2003-04-02 | 2011-01-05 | ダーマコン, インコーポレイテッド | Rna干渉において使用するための修飾ポリヌクレオチド |
| WO2004090099A2 (en) | 2003-04-04 | 2004-10-21 | Diversa Corporation | Pectate lyases, nucleic acids encoding them and methods for making and using them |
| US8158420B2 (en) | 2003-04-04 | 2012-04-17 | The Trustees Of Columbia University In The City Of New York | Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5 |
| CA2521464C (en) * | 2003-04-09 | 2013-02-05 | Alnylam Pharmaceuticals, Inc. | Irna conjugates |
| EP1615611B1 (en) * | 2003-04-09 | 2013-02-13 | Alnylam Pharmaceuticals Inc. | iRNA CONJUGATES |
| JP4912873B2 (ja) * | 2003-04-09 | 2012-04-11 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | iRNA複合体 |
| EP1469070A1 (en) * | 2003-04-15 | 2004-10-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Livin-specific siRNAs for the treatment of therapy-resistant tumors |
| WO2004092383A2 (en) * | 2003-04-15 | 2004-10-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2006032707A2 (en) | 2004-09-24 | 2006-03-30 | Basf Plant Science Gmbh | Plant cells and plants with increased tolerance to environmental stress |
| WO2005014828A2 (en) | 2003-08-01 | 2005-02-17 | Basf Plant Science Gmbh | Process for the production of fine chemicals in plants |
| WO2004094606A2 (en) * | 2003-04-18 | 2004-11-04 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOPOIETIN 1 AND 2 AND THEIR RECEPTOR TIE2 |
| IL155561A0 (en) * | 2003-04-24 | 2006-12-31 | Yeda Res & Dev | Oligonucleotides that block toll-like receptors |
| US9062306B2 (en) | 2003-04-29 | 2015-06-23 | Biocrine Ab | Methods for identifying compounds for treating type 1 diabetes |
| EP1622572B1 (en) | 2003-04-30 | 2017-12-20 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| WO2004098634A2 (en) * | 2003-04-30 | 2004-11-18 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | Protein arginine n-methyltransferase 2 (prmt-2) |
| MXPA05011777A (es) * | 2003-05-08 | 2006-01-26 | Wyeth Corp | Proteina cinasa c zeta como un farmaco blanco para la artritis y otras enfermadades inflamatorias. |
| CA2525899C (en) | 2003-05-09 | 2016-03-08 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| JP2007502129A (ja) * | 2003-05-09 | 2007-02-08 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 短鎖干渉rnaライブラリーならびに合成および使用の方法 |
| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| AU2003241409A1 (en) * | 2003-05-12 | 2005-01-21 | Potomac Pharmaceuticals, Inc. | Gene expression suppression agents |
| CA2525619A1 (en) * | 2003-05-16 | 2005-03-03 | Rosetta Inpharmatics, Llc | Methods and compositions for rna interference |
| US20070027099A1 (en) * | 2003-05-19 | 2007-02-01 | Lin Marie C | Gene therapy of HBV infection via adeno-associated viral vector mediated long term expression of small hairpin RNA (shRNA) |
| US8217157B2 (en) | 2003-05-19 | 2012-07-10 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof |
| WO2005001092A2 (en) * | 2003-05-20 | 2005-01-06 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| NZ543654A (en) * | 2003-05-23 | 2009-05-31 | Wyeth Corp | GITR ligand and GITR ligand-related molecules and antibodies and uses thereof |
| US20050042641A1 (en) * | 2003-05-27 | 2005-02-24 | Cold Spring Harbor Laboratory | In vivo high throughput selection of RNAi probes |
| DE602004024300D1 (de) | 2003-05-28 | 2010-01-07 | Takeda Pharmaceutical | Anti-BAMBI Antikörper oder RNA zur Diagnose und Therapie bei Dickdarm- oder Leberkrebs |
| AU2004248138B2 (en) * | 2003-05-29 | 2009-09-03 | The Scripps Research Institute | Targeted delivery to legumain-expressing cells |
| WO2005001110A2 (en) * | 2003-05-29 | 2005-01-06 | The Salk Institute For Biological Studies | Transcriptional regulation of gene expression by small double-stranded modulatory rna |
| EP1640452A4 (en) | 2003-05-30 | 2009-12-23 | Nippon Shinyaku Co Ltd | OLIGOBICATENARY RNA INHIBITING BCL-2 EXPRESSION AND MEDICINAL COMPOSITION CONTAINING THE SAME |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| AU2004248136B2 (en) | 2003-06-02 | 2011-09-15 | University Of Massachusetts | Methods and compositions for controlling efficacy of RNA silencing |
| ATE485394T1 (de) * | 2003-06-02 | 2010-11-15 | Univ Massachusetts | Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai |
| US7541344B2 (en) | 2003-06-03 | 2009-06-02 | Eli Lilly And Company | Modulation of survivin expression |
| WO2004106517A1 (en) * | 2003-06-03 | 2004-12-09 | Benitec Australia Limited | Double-stranded nucleic acid |
| MXPA05013190A (es) | 2003-06-06 | 2007-05-23 | Arborgen Llc | Factores de transcripcion. |
| KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| BRPI0411219A (pt) | 2003-06-12 | 2006-07-18 | Nucleonics Inc | seqüências de hbv e hcv conservadas úteis para silenciamento de gene |
| WO2004113573A2 (en) * | 2003-06-19 | 2004-12-29 | The Samuel Roberts Noble Foundation, Inc. | Methods and compositions for analysis of plant gene function |
| WO2005044976A2 (en) * | 2003-06-20 | 2005-05-19 | Isis Pharmaceuticals, Inc. | Oligomeric compounds for use in gene modulation |
| EP1636385A4 (en) * | 2003-06-24 | 2010-06-02 | Mirus Bio Corp | INHIBITION OF GENE FUNCTION BY IN VIVO DISTRIBUTION OF GENE EXPRESSION INHIBITORS BASED ON POLYNUCLEOTIDES IN MAMMALIAN CELLS |
| US20080131874A1 (en) * | 2003-06-24 | 2008-06-05 | Amitava Mitra | Method for efficient post-transcriptional gene silencing using intrinsic direct repeat sequences and utilization thereof in functional genomics |
| AU2004252559B2 (en) * | 2003-06-25 | 2010-07-29 | Gencia Corporation | Modified vectors for organelle transfection |
| WO2005005613A2 (en) * | 2003-07-02 | 2005-01-20 | Medical University Of South Carolina | Dsrna induced specific and non-specific immunity in crustaceans and other invertebrates and biodelivery vehicles for use therein |
| BRPI0412279A (pt) | 2003-07-02 | 2006-09-19 | Diversa Corp | glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos |
| US20050019927A1 (en) * | 2003-07-13 | 2005-01-27 | Markus Hildinger | DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER |
| WO2005011590A2 (en) * | 2003-08-01 | 2005-02-10 | A & G Pharmaceutical, Inc. | Compositions and methods for restoring sensitivity to treatment with her2 antagonists |
| US20050026290A1 (en) * | 2003-08-01 | 2005-02-03 | Ciardi Joseph Anthony | Inhibiting gene expression with dsRNA |
| EP3222715A1 (en) | 2003-08-08 | 2017-09-27 | Sangamo BioSciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| EP1668113B1 (en) | 2003-08-11 | 2013-06-19 | Verenium Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
| JP2007502119A (ja) | 2003-08-14 | 2007-02-08 | エクセリクシス, インク. | βカテニン経路のモディファイヤーとしてのUPs及び使用方法 |
| IL157538A0 (en) | 2003-08-21 | 2004-03-28 | Bar Ilan Res & Dev Company Ltd | Plant resistant to cytoplasm-feeding parasites |
| US20050112763A1 (en) * | 2003-08-21 | 2005-05-26 | Cold Spring Harbor Laboratory | RNAI-based modification of heterochromatin |
| WO2005040388A2 (en) * | 2003-08-22 | 2005-05-06 | Nucleonics Inc. | Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments |
| EP1670924A1 (en) * | 2003-08-28 | 2006-06-21 | Aveo Pharmaceuticals, Inc. | Tumor-specific expression of reporter genes |
| CN1845993B (zh) * | 2003-08-28 | 2010-06-23 | 诺瓦提斯公司 | 具有平端和3'修饰的干扰rna双链体 |
| US20070123480A1 (en) * | 2003-09-11 | 2007-05-31 | Replicor Inc. | Oligonucleotides targeting prion diseases |
| WO2005026322A2 (en) * | 2003-09-11 | 2005-03-24 | Clontech Laboratories, Inc. | siRNA ENCODING CONSTRUCTS AND METHODS FOR USING THE SAME |
| US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| WO2005026356A1 (en) * | 2003-09-12 | 2005-03-24 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing nucleic acid molecules and uses thereof |
| EP2821085B1 (en) * | 2003-09-12 | 2020-04-29 | University of Massachusetts | Rna interference for the treatment of gain-of-function disorders |
| CA2538442A1 (en) | 2003-09-15 | 2005-03-24 | Cenix Bioscience Gmbh | Eukaryotic genes for modulating cell cycle progression |
| EP1663300A1 (en) * | 2003-09-16 | 2006-06-07 | Pharmacia Corporation | Inhibitors of pace4 for the treatment of arthritis |
| WO2005031002A2 (en) * | 2003-09-22 | 2005-04-07 | Rosetta Inpharmatics Llc | Synthetic lethal screen using rna interference |
| US20050282168A1 (en) * | 2003-09-29 | 2005-12-22 | Wyeth | Cell surface molecules as markers and therapeutic agents against kidney cancers |
| WO2005030948A1 (ja) * | 2003-09-30 | 2005-04-07 | Takara Bio Inc. | RNaseIII活性を有するポリペプチド |
| US20070218551A1 (en) * | 2003-10-02 | 2007-09-20 | Chuan-Yuan Li | Novel Sirna-Based Approach to Target the Hif-Alpha Factor for Gene Therapy |
| EP1687410A4 (en) * | 2003-10-07 | 2008-04-09 | Isis Pharmaceuticals Inc | ANTISENSE OLIGONUCLEOTIDE OPTIMIZED FOR KIDNEY TARGETING |
| EP1711613B1 (en) * | 2003-10-09 | 2013-04-10 | E.I. Du Pont De Nemours And Company | Gene silencing by using micro-rna molecules |
| JP2007529199A (ja) | 2003-10-23 | 2007-10-25 | イルミジェン バイオサイエンシーズ, インコーポレイテッド | ウイルス感染に対する抵抗性に関連する遺伝子である、oas1における変異の検出 |
| US8062891B2 (en) * | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US20090208478A1 (en) * | 2003-10-24 | 2009-08-20 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| JP4838722B2 (ja) | 2003-10-24 | 2011-12-14 | ゲンシア コーポレーション | ポリヌクレオチドを送達する方法、及び送達用組成物 |
| US20090123468A1 (en) * | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8507277B2 (en) * | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| ES2687645T3 (es) | 2003-10-27 | 2018-10-26 | Merck Sharp & Dohme Corp. | Método de diseño de ARNip para el silenciamiento de genes |
| US7553822B2 (en) * | 2003-10-30 | 2009-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene |
| US8012944B2 (en) * | 2003-10-30 | 2011-09-06 | Pharmascience Inc. | Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent |
| WO2005042782A1 (en) * | 2003-10-31 | 2005-05-12 | The Trustees Of Columbia University In The City Of New York | Methods for reducing seizure-induced neuronal damage |
| US20070083943A1 (en) * | 2003-10-31 | 2007-04-12 | Hannah L C | Materials and methods for improved sweet corn |
| US20050191653A1 (en) * | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
| US8227434B1 (en) | 2003-11-04 | 2012-07-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Materials and methods for treating oncological disorders |
| GB2422607A (en) * | 2003-11-10 | 2006-08-02 | Univ Utah Res Found | Improved methods and compositions for RNA interference |
| CA2546074A1 (en) * | 2003-11-14 | 2005-06-02 | Yale University | Syk-targeted nucleic acid interference |
| US7763592B1 (en) | 2003-11-20 | 2010-07-27 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| US7807646B1 (en) | 2003-11-20 | 2010-10-05 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| AU2004316293A1 (en) * | 2003-11-21 | 2005-09-09 | Revivicor, Inc. | Use of interfering RNA in the production of transgenic animals |
| JP2007512838A (ja) | 2003-12-01 | 2007-05-24 | インヴィトロジェン コーポレーション | 組換え部位を含む核酸分子およびその使用方法 |
| WO2005054439A2 (en) * | 2003-12-01 | 2005-06-16 | North Carolina State University | Small interfering rna (sirna)-mediated heritable gene manipulation in plants |
| AU2004294824A1 (en) | 2003-12-03 | 2005-06-16 | Coda Therapeutics (Nz) Ltd | Antisense compounds targeted to connexins and methods of use thereof |
| CA2549031A1 (en) * | 2003-12-10 | 2005-06-30 | University Of Utah Research Foundation | Method for obtaining an enriched population of sirna-expressing cells |
| US20080021205A1 (en) * | 2003-12-11 | 2008-01-24 | Helen Blau | Methods and Compositions for Use in Preparing Hairpin Rnas |
| JP4753130B2 (ja) * | 2003-12-12 | 2011-08-24 | 独立行政法人産業技術総合研究所 | インターフェロン応答が軽減された長い干渉用二重鎖rna |
| WO2005062937A2 (en) * | 2003-12-22 | 2005-07-14 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna |
| US20050164970A1 (en) * | 2003-12-22 | 2005-07-28 | University Of Kansas Medical Center | Method for treating prostate cancer using siRNA duplex for androgen receptor |
| US20060134787A1 (en) | 2004-12-22 | 2006-06-22 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA |
| BRPI0416713B8 (pt) * | 2003-12-23 | 2020-02-04 | Bayer Sas | métodos de produção de uma planta ou de uma célula vegetal resistente a um fungo fitopatogênico, métodos para inibir ou reduzir a expressão de um gene de fungo e uso de uma construção |
| FR2872383B1 (fr) * | 2004-07-02 | 2015-10-16 | Bayer Cropscience Sa | Methode pour modifier l'expression genetique d'un champignon phytopathogene |
| AU2004304665B2 (en) | 2003-12-24 | 2009-03-12 | Novo Nordisk A/S | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized C5aR |
| EP1704250B1 (en) | 2003-12-31 | 2012-09-19 | The Penn State Research Foundation | Methods for predicting and overcoming resistance to chemotherapy in ovarian cancer |
| EP1778858A4 (en) * | 2004-01-15 | 2009-08-19 | Univ Washington | USING DROSOPHILA TO PHARMACEUTICS, HIGH-PERFORMANCE SCREENING |
| US20080153764A1 (en) * | 2004-01-22 | 2008-06-26 | The Cbr Institute For Biomedical Research, Inc. | System and Methods For Short Rna Expression |
| WO2005072272A2 (en) | 2004-01-23 | 2005-08-11 | New England Biolabs, Inc. | Compositions and methods for generating short double-stranded rna using mutated rnase iii |
| US20050203043A1 (en) * | 2004-01-23 | 2005-09-15 | Dharmacon, Inc. | Identification of toxic nucleotide sequences |
| DK1713912T3 (da) * | 2004-01-30 | 2013-12-16 | Santaris Pharma As | Modificerede Korte Interfererende RNA (Modificerede siRNA) |
| EP1758998B1 (en) * | 2004-01-30 | 2010-12-15 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases |
| US20090280567A1 (en) * | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
| WO2005076979A2 (en) | 2004-02-06 | 2005-08-25 | Wyeth | Diagnosis and therapeutics for cancer |
| US20070269889A1 (en) * | 2004-02-06 | 2007-11-22 | Dharmacon, Inc. | Stabilized siRNAs as transfection controls and silencing reagents |
| US7683237B2 (en) * | 2004-02-10 | 2010-03-23 | Monsanto Technology Llc | Maize seed with synergistically enhanced lysine content |
| US7858769B2 (en) | 2004-02-10 | 2010-12-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional siNA) |
| US7855323B2 (en) | 2004-02-10 | 2010-12-21 | Monsanto Technology Llc | Recombinant DNA for gene suppression |
| US20060075515A1 (en) | 2004-08-11 | 2006-04-06 | Luethy Michael H | Enhanced zein reduction in transgenic corn seed |
| AR047598A1 (es) | 2004-02-10 | 2006-01-25 | Monsanto Technology Llc | Semilla de maiz transgenica con mayor contenido de aminoacidos |
| WO2005078848A2 (en) | 2004-02-11 | 2005-08-25 | University Of Tennessee Research Foundation | Inhibition of tumor growth and invasion by anti-matrix metalloproteinase dnazymes |
| WO2005079389A2 (en) | 2004-02-13 | 2005-09-01 | Monsanto Technology, Llc | In vivo assembly of transcription units |
| WO2005094420A2 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
| US7622301B2 (en) * | 2004-02-24 | 2009-11-24 | Basf Plant Science Gmbh | Compositions and methods using RNA interference for control of nematodes |
| ATE514434T1 (de) | 2004-02-25 | 2011-07-15 | Dana Farber Cancer Inst Inc | Hemmer des insulinartigen wachstumsfaktor- rezeptors-1 zur hemmung von tumorzellwachstum |
| US20060003956A1 (en) * | 2004-03-03 | 2006-01-05 | Casadome David O | Materials and methods for the derepression of the E-cadherin promoter |
| US8569474B2 (en) * | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
| AU2005222902B2 (en) | 2004-03-12 | 2010-06-10 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeting VEGF |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| JP5243789B2 (ja) | 2004-03-15 | 2013-07-24 | シティ・オブ・ホープ | 二本鎖rnaによる遺伝子発現の特異的阻害のための方法及び組成物 |
| US20050267060A1 (en) * | 2004-03-19 | 2005-12-01 | The Penn State Research Foundation | Combinatorial methods and compositions for treatment of melanoma |
| WO2005092030A2 (en) * | 2004-03-22 | 2005-10-06 | The Trustees Of The University Of Pennsylvania | Methods of use of bcl-6-derived nucleotides to induce apoptosis |
| JP4938451B2 (ja) * | 2004-03-23 | 2012-05-23 | オンコセラピー・サイエンス株式会社 | 非小細胞肺癌の診断のための方法 |
| TW200533376A (en) | 2004-03-24 | 2005-10-16 | Oncotherapy Science Inc | Compositions and methods for treating lung cancer |
| US20060041961A1 (en) | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
| WO2005098049A2 (en) * | 2004-03-25 | 2005-10-20 | California Institute Of Technology | Hybridization chain reaction |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| HRP20130782T1 (en) | 2004-04-02 | 2013-09-30 | The Regents Of The University Of California, Office Of Technology Transfer | Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin |
| EP3372614B1 (en) * | 2004-04-07 | 2022-06-08 | Rinat Neuroscience Corp. | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| MXPA06011694A (es) | 2004-04-09 | 2006-12-14 | Monsanto Technology Llc | Composiciones y metodos para el control de infestaciones de insectos en plantas. |
| WO2005117938A2 (en) * | 2004-04-13 | 2005-12-15 | Regents Of The University Of Minnesota | Methods of treating ocular conditions |
| US20070031417A2 (en) * | 2004-04-14 | 2007-02-08 | University Of Massachusetts | Dicer interacting proteins and uses therefor |
| US20050233994A1 (en) * | 2004-04-16 | 2005-10-20 | Ajamete Kaykas | Methods and vectors for expressing siRNA |
| EP1773998A2 (en) * | 2004-04-20 | 2007-04-18 | Nastech Pharmaceutical Company Inc. | Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells |
| CA2562673A1 (en) * | 2004-04-22 | 2005-11-03 | Yissum Research Development Company Of The Hebrew University Of Jerusal Em | Universal target sequences for sirna gene silencing |
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| AU2005243277A1 (en) | 2004-04-23 | 2005-11-24 | Ceres Inc. | Methods for modifying plant characteristics |
| WO2005105157A2 (en) | 2004-04-23 | 2005-11-10 | The Trustees Of Columbia University In The City Ofnew York | INHIBITION OF HAIRLESS PROTEIN mRNA |
| US8076304B2 (en) * | 2004-04-26 | 2011-12-13 | The Regents Of The University Of Colorado | Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions |
| EP1747462A2 (en) * | 2004-04-27 | 2007-01-31 | Galapagos N.V. | Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| US20060035815A1 (en) * | 2004-05-04 | 2006-02-16 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
| US20060040882A1 (en) * | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| WO2005111246A1 (en) * | 2004-05-11 | 2005-11-24 | Wyeth | Oligonucleotide arrays to monitor gene expression and methods for making and using same |
| US7605250B2 (en) * | 2004-05-12 | 2009-10-20 | Dharmacon, Inc. | siRNA targeting cAMP-specific phosphodiesterase 4D |
| WO2005113571A2 (en) * | 2004-05-13 | 2005-12-01 | The University Of North Carolina At Chapel Hill | Methods for the delivery of oligomeric compounds |
| EP2336363A1 (en) | 2004-05-14 | 2011-06-22 | Rosetta Genomics Ltd | MicroRNAs and uses thereof |
| JP5697297B2 (ja) | 2004-05-14 | 2015-04-08 | ロゼッタ ジノミクス リミテッド | マイクロnasおよびその使用 |
| US8563252B2 (en) * | 2004-05-14 | 2013-10-22 | Rosetta Genomics Ltd. | Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers |
| US20050265927A1 (en) * | 2004-05-17 | 2005-12-01 | Yale University | Intranasal delivery of nucleic acid molecules |
| US7563885B1 (en) * | 2004-05-24 | 2009-07-21 | Isis Pharmaceuticals, Inc. | Modulation of Tudor-SN expression |
| US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| WO2006033679A2 (en) * | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US8394947B2 (en) * | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
| CA2568735A1 (en) * | 2004-06-03 | 2005-12-22 | Isis Pharmaceuticals, Inc. | Double strand compositions comprising differentially modified strands for use in gene modulation |
| US7858323B2 (en) | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
| US20060003410A1 (en) | 2004-06-10 | 2006-01-05 | Lee-Ming Chuang | Prostaglandin reductase |
| ES2461857T3 (es) | 2004-06-16 | 2014-05-21 | Dsm Ip Assets B.V. | Composiciones y métodos para la decoloración enzimática de clorofila |
| US20060156421A1 (en) * | 2004-06-18 | 2006-07-13 | Cagan Ross L | High throughput screening methods for anti-metastatic compounds |
| US20060010505A1 (en) * | 2004-06-18 | 2006-01-12 | Washington University | High throughput cancer pharmaceutical screening using drosophila |
| WO2005123048A2 (en) | 2004-06-21 | 2005-12-29 | Proteome Sciences Plc | Screening methods using c-abl, fyn and syk in combination with tau protein |
| DE602005026811D1 (de) | 2004-06-22 | 2011-04-21 | Univ Illinois | Verfahren zur inhibierung von tumorzellwachstum mit foxm1 sirns |
| CA2559760A1 (en) | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8680062B2 (en) | 2004-07-06 | 2014-03-25 | Deliversir Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
| US7968762B2 (en) * | 2004-07-13 | 2011-06-28 | Van Andel Research Institute | Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF) |
| US20060073496A1 (en) * | 2004-07-20 | 2006-04-06 | O'toole Margot | Methods of identifying patients at risk of developing encephalitis following immunotherapy for Alzheimer's disease |
| US20060024677A1 (en) | 2004-07-20 | 2006-02-02 | Morris David W | Novel therapeutic targets in cancer |
| CA2579574A1 (en) | 2004-07-23 | 2007-01-04 | The University Of North Carolina At Chapel Hill | Methods and materials for determining pain sensitivity and predicting and treating related disorders |
| JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
| DE102004036456A1 (de) * | 2004-07-28 | 2006-03-23 | Basf Plant Science Gmbh | Verfahren zur Herstellung von transgenen Pflanzen mit erhöhter Pathogenresistenz durch Veränderung des Gehalts und/oder der Aktivität von Actin-depolymerisierenden Faktoren |
| US20060075522A1 (en) | 2004-07-31 | 2006-04-06 | Jaclyn Cleveland | Genes and uses for plant improvement |
| AU2005268917B2 (en) | 2004-08-02 | 2010-05-20 | Basf Plant Science Gmbh | Method for isolation of transcription termination sequences |
| WO2006017673A2 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| WO2006020821A2 (en) | 2004-08-13 | 2006-02-23 | Basf Plant Science Gmbh | Compositions and methods using rna interference for control of nematodes |
| KR100939274B1 (ko) | 2004-08-16 | 2010-01-29 | 쿠아크 파마수티칼스 인코퍼레이티드 | 알티피801 억제제의 치료적 용도 |
| ATE518954T1 (de) * | 2004-08-18 | 2011-08-15 | Lorus Therapeutics Inc | Kleine interferierende rna-moleküle gegen ribonukleotidreduktase und ihre verwendungen |
| WO2006033756A2 (en) | 2004-08-23 | 2006-03-30 | Nucleonics, Inc. | Multiple rna polymerase iii promoter expression constructs |
| US20060046247A1 (en) * | 2004-08-25 | 2006-03-02 | Rapp Jeffrey C | Protecting avians from pathogens |
| US20080222743A1 (en) * | 2004-08-25 | 2008-09-11 | Avigenics, Inc. | RNA interference and disease resistance in avians |
| US20090313712A1 (en) * | 2004-08-25 | 2009-12-17 | Leandro Christmann | RNA interference and disease resistance in avians |
| WO2006026238A2 (en) * | 2004-08-25 | 2006-03-09 | Avigenics, Inc. | Rna interference in avians |
| US7323310B2 (en) * | 2004-08-31 | 2008-01-29 | Qiagen North American Holdings, Inc. | Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase |
| US7884086B2 (en) * | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
| US20060059585A1 (en) | 2004-09-14 | 2006-03-16 | Boris Jankowski | Modulating plant sugar levels |
| WO2006031859A2 (en) | 2004-09-14 | 2006-03-23 | Ceres Inc. | Modulation of amino acid and sugar content in plants |
| FI20041204A0 (fi) | 2004-09-16 | 2004-09-16 | Riikka Lund | Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi |
| EP2359832A3 (en) | 2004-09-18 | 2011-11-23 | University of Maryland, Baltimore | Therapeutic agents targeting the NCCA-ATP channel and methods of use thereof |
| US7456338B2 (en) | 2004-09-22 | 2008-11-25 | Arborgen Llc | Modification of plant lignin content |
| US7799906B1 (en) | 2004-09-22 | 2010-09-21 | Arborgen, Llc | Compositions and methods for modulating lignin of a plant |
| US7402428B2 (en) | 2004-09-22 | 2008-07-22 | Arborgen, Llc | Modification of plant lignin content |
| JP4991547B2 (ja) * | 2004-09-28 | 2012-08-01 | クアーク・ファーマスーティカルス、インコーポレイテッド | 脱毛症、急性腎不全および他の疾患の治療のためのオリゴリボヌクレオチドおよびその使用の方法 |
| WO2006039399A2 (en) * | 2004-09-29 | 2006-04-13 | University Of Rochester | Staufen 1 (stau1) - mediated mrna decay |
| US20090163406A1 (en) * | 2004-09-30 | 2009-06-25 | The Regents Of The University Of California | Compositions and methods for diagnosing and treating brain cancer and identifying neural stem cells |
| US8765704B1 (en) | 2008-02-28 | 2014-07-01 | Novartis Ag | Modified small interfering RNA molecules and methods of use |
| EP1796732B1 (en) * | 2004-10-01 | 2013-10-30 | Novartis Vaccines and Diagnostics, Inc. | Modified small interfering rna molecules and methods of use |
| WO2006070227A2 (en) * | 2004-10-04 | 2006-07-06 | Devgen Nv | Method for down-regulating gene expression in fungi |
| CN101056981A (zh) * | 2004-10-04 | 2007-10-17 | 德福根有限公司 | 负调节真菌中基因表达的方法 |
| US20060247197A1 (en) | 2004-10-04 | 2006-11-02 | Van De Craen Marc | Method for down-regulating gene expression in fungi |
| EP2166097B1 (en) | 2004-10-05 | 2014-08-06 | SunGene GmbH | Constitutive expression cassettes for regulation of plant expression |
| BRPI0516874A (pt) * | 2004-10-12 | 2008-09-23 | Univ Rockefeller | micrornas |
| EP1807093A2 (en) * | 2004-10-13 | 2007-07-18 | Isis Pharmaceuticals, Inc. | Antisense modulation of ptp1b expression |
| JP2008515458A (ja) * | 2004-10-13 | 2008-05-15 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 線虫抵抗性の遺伝子組換え植物 |
| US7429692B2 (en) | 2004-10-14 | 2008-09-30 | Ceres, Inc. | Sucrose synthase 3 promoter from rice and uses thereof |
| ES2444001T3 (es) | 2004-10-21 | 2014-02-21 | Venganza Inc. | Procedimientos y materiales para conferir resistencia a plagas y patógenos de plantas |
| US7790878B2 (en) * | 2004-10-22 | 2010-09-07 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| US7592322B2 (en) * | 2004-10-22 | 2009-09-22 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| WO2006045591A2 (en) * | 2004-10-25 | 2006-05-04 | Devgen N.V. | Method and constructs for delivering double stranded rna to pest organisms |
| SG158921A1 (en) * | 2004-10-27 | 2010-02-26 | Schering Corp | Compositions and methods for short interfering nucleic acid inhibition of nav1.8 |
| US9492400B2 (en) * | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| EP2314688B1 (en) * | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| JP2008520209A (ja) * | 2004-11-17 | 2008-06-19 | ユニヴァーシティ・オブ・メリーランド,バルチモア | siRNAの有効なキャリアとしての高度に枝分かれしたHKペプチド |
| JP4851940B2 (ja) * | 2004-11-19 | 2012-01-11 | 宮城県 | がんまたは糖尿病治療のための医薬組成物 |
| US7935811B2 (en) * | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| US7923206B2 (en) * | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
| EP1662000B1 (en) | 2004-11-25 | 2011-03-30 | SunGene GmbH | Expression cassettes for guard cell-preferential expression in plants |
| WO2006060454A2 (en) * | 2004-12-02 | 2006-06-08 | B-Bridge International, Inc. | Methods of designing small interfering rnas, antisense polynucleotides, and other hybridizing polynucleotides |
| EP1666599A3 (en) | 2004-12-04 | 2006-07-12 | SunGene GmbH | Expression cassettes for mesophyll- and/or epidermis-preferential expression in plants |
| WO2006062971A2 (en) | 2004-12-08 | 2006-06-15 | Ceres Inc. | Modulating plant carbon levels |
| WO2008069878A2 (en) | 2006-10-27 | 2008-06-12 | Ceres, Inc. | Modulating lignin in plants |
| US9758790B2 (en) | 2004-12-08 | 2017-09-12 | Ceres, Inc. | Modulating the level of components within plants |
| EP2072620B1 (en) | 2004-12-08 | 2013-05-08 | SunGene GmbH | Expression casstettes for vascular tissue-preferential expression in plants |
| EP1669456A3 (en) | 2004-12-11 | 2006-07-12 | SunGene GmbH | Expression cassettes for meristem-preferential expression in plants |
| US7335510B2 (en) | 2004-12-16 | 2008-02-26 | Ceres, Inc. | Modulating plant nitrogen levels |
| CA2585798A1 (en) | 2004-12-17 | 2006-06-17 | Metanomics Gmbh | Process for the control of production of fine chemicals |
| US8404927B2 (en) * | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
| US20060200878A1 (en) * | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| WO2006069064A2 (en) | 2004-12-22 | 2006-06-29 | Nucleonics, Inc. | Conserved hbv and hcv sequences useful for gene silencing |
| US7335760B2 (en) | 2004-12-22 | 2008-02-26 | Ceres, Inc. | Nucleic acid sequences encoding zinc finger proteins |
| US20090022708A1 (en) * | 2004-12-22 | 2009-01-22 | Lobie Peter E | Trefoil Factors and Methods of Treating Proliferation Disorders Using Same |
| US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術 |
| TWI401316B (zh) * | 2004-12-23 | 2013-07-11 | Alcon Inc | 用於治療青光眼之血清澱粉樣蛋白A的RNAi抑制作用 |
| WO2006071219A1 (en) | 2004-12-28 | 2006-07-06 | Pioneer Hi-Bred International, Inc. | Improved grain quality through altered expression of seed proteins |
| EP1838875A4 (en) * | 2004-12-30 | 2010-08-25 | Todd M Hauser | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| US8137907B2 (en) | 2005-01-03 | 2012-03-20 | Cold Spring Harbor Laboratory | Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof |
| JP5081630B2 (ja) | 2005-01-07 | 2012-11-28 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | RSVのRNAi調節及びその治療上の使用方法 |
| ATE462726T1 (de) | 2005-01-07 | 2010-04-15 | Diadexus Inc | Ovr110-antikörperzusammensetzungen und verwendungsverfahren dafür |
| EP3059306A1 (en) | 2005-01-12 | 2016-08-24 | Monsanto Technology LLC | Genes and uses for plant improvement |
| MX2007008486A (es) | 2005-01-13 | 2008-02-15 | Pioneer Hi Bred Int | Gen y promotor cyclo1 de maiz. |
| MX2007008568A (es) | 2005-01-14 | 2008-01-11 | Univ Guelph | Gen y proteina de deteccion de azucar regulados por nitrogeno y modulacion de los mismos. |
| US7718625B2 (en) * | 2005-01-27 | 2010-05-18 | University Of South Florida | Polynucleotides targeted against the extended 5′-UTR region of argininosuccinate synthase and uses thereof |
| TW200639253A (en) * | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular targets |
| CA2596412A1 (en) | 2005-02-03 | 2006-12-21 | Coda Therapeutics Limited | Anti-connexin compounds and uses thereof |
| AU2006212223B2 (en) | 2005-02-09 | 2010-11-25 | Basf Plant Science Gmbh | Expression cassettes for regulation of expression in monocotyledonous plants |
| EP2357257B1 (en) | 2005-02-14 | 2019-07-31 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| US7704503B2 (en) * | 2005-02-14 | 2010-04-27 | Wyeth Llc | Use of IL-17F in diagnosis and therapy of airway inflammation |
| TW200641353A (en) | 2005-02-14 | 2006-12-01 | Wyeth Corp | Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor |
| US20060211004A1 (en) | 2005-02-15 | 2006-09-21 | Ilsley Diane D | Methods and compositions for determining non-specific cytotoxicity of a transfection agent |
| US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| BRPI0607378A2 (pt) | 2005-02-26 | 2010-03-23 | Basf Plant Science Gmbh | cassetes de expressço, seqÜÊncia nucleotÍdica isolada, vetor, cÉlula hospedeira transgÊnica ou organismo nço humano, cÉlula de planta ou planta transgÊnica, mÉtodos para identificar e/ou isolar uma seqÜÊncia nucleotÍdica reguladora da transcriÇço, para prover ou produzir um cassete de expressço transgÊnica, e para prover uma seqÜÊncia nucleotÍdica reguladora de transcriÇço sintÉtica, e, seqÜÊncia reguladora de transcriÇço sintÉtica |
| EP2166099B1 (en) | 2005-03-08 | 2012-12-19 | BASF Plant Science GmbH | Expression enhancing intron sequences |
| US7727721B2 (en) | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
| EP1869174B1 (en) | 2005-03-10 | 2015-02-18 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
| EP1869076A2 (en) | 2005-03-10 | 2007-12-26 | Genentech, Inc. | Methods and compositions for modulating vascular integrity |
| BRPI0609206A2 (pt) | 2005-03-11 | 2010-03-02 | Alcon Inc | inibiÇço mediada por rnai de proteÍna relacionada frizzled-1 para tratamento de glaucoma |
| DE202005004135U1 (de) * | 2005-03-11 | 2005-05-19 | Klocke Verpackungs-Service Gmbh | Mehrkomponentenverpackung mit Applikator |
| DE102005011648A1 (de) * | 2005-03-14 | 2006-09-21 | IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung | Verfahren zur Erhöhung der Pilzresistenz in transgenen Pflanzen durch wirtsinduzierte Unterdrückung der Genexpression in Pilzpathogenen |
| WO2006130201A1 (en) * | 2005-03-14 | 2006-12-07 | Board Of Regents, The University Of Texas System | Antigene oligomers inhibit transcription |
| CA2611859C (en) | 2005-03-15 | 2015-03-31 | Verenium Corporation | Cellulases, nucleic acids encoding them and methods for making and using them |
| EA015584B1 (ru) | 2005-03-23 | 2011-10-31 | Генмаб А/С | Антитело к cd38 человека и его применение |
| US20060223777A1 (en) * | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| JP4131271B2 (ja) * | 2005-03-30 | 2008-08-13 | ソニー株式会社 | 情報処理装置および方法、並びにプログラム |
| US7427605B2 (en) | 2005-03-31 | 2008-09-23 | Calando Pharmaceuticals, Inc. | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof |
| RU2533804C2 (ru) * | 2005-03-31 | 2014-11-20 | Ронен КАХАНА | Получение домашней птицы и других животных, устойчивых к вирусному заболеванию |
| JP2008535853A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌関連遺伝子 |
| JP2008535857A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌の診断、検出および処置におけるcacna1e |
| US20060234973A1 (en) * | 2005-04-14 | 2006-10-19 | Kevin Fitzgerald | Transcription factor RNA interference reagents and methods of use thereof |
| WO2006112879A2 (en) * | 2005-04-15 | 2006-10-26 | The Trustees Of The University Of Pennsylvania | Hunk, a snf1-related kinase essential for mammary tumor metastasis |
| JP4982757B2 (ja) | 2005-04-15 | 2012-07-25 | 国立大学法人鳥取大学 | hTERT発現調節遺伝子 |
| US8895717B2 (en) * | 2005-04-15 | 2014-11-25 | The Board Of Regents Of The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
| US20060269556A1 (en) * | 2005-04-18 | 2006-11-30 | Karl Nocka | Mast cell activation using siglec 6 antibodies |
| WO2006113743A2 (en) * | 2005-04-18 | 2006-10-26 | Massachusetts Institute Of Technology | Compositions and methods for rna interference with sialidase expression and uses thereof |
| US8034994B2 (en) | 2005-04-19 | 2011-10-11 | Basf Plant Science Gmbh | Starchy-endosperm and/or germinating embryo-specific expression in mono-cotyledonous plants |
| WO2006111512A1 (en) | 2005-04-19 | 2006-10-26 | Basf Plant Science Gmbh | Improved methods controlling gene expression |
| AU2006245701B2 (en) | 2005-05-10 | 2011-04-28 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
| WO2006124699A2 (en) | 2005-05-12 | 2006-11-23 | Wisconsin Alumni Research Foundation | Blockade of pin1 prevents cytokine production by activated immune cells |
| US8669236B2 (en) * | 2005-05-12 | 2014-03-11 | The General Hospital Corporation | Biotinylated compositions |
| FR2885808B1 (fr) | 2005-05-19 | 2007-07-06 | Oreal | Vectorisation de dsrna par des particules cationiques et utilisation topique. |
| WO2007001684A2 (en) * | 2005-05-19 | 2007-01-04 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inhibiting dna polymerase beta to enhance efficacy of anticancer agents |
| US20070044164A1 (en) | 2005-05-31 | 2007-02-22 | Cold Spring Harbor Laboratory | Methods for producing microRNAs |
| US8759306B2 (en) * | 2005-05-31 | 2014-06-24 | Devgen N.V. | RNAi for the control of insects and arachnids |
| WO2006128739A1 (en) * | 2005-06-01 | 2006-12-07 | Polyplus-Transfection Sa | Oligonucleotides for rna interference and biological applications thereof |
| EP1888789A2 (en) * | 2005-06-06 | 2008-02-20 | Wyeth a Corporation of the State of Delaware | Expression profiles of peripheral blood mononuclear cells for inflammatory bowel diseases |
| US20070299029A1 (en) * | 2005-06-09 | 2007-12-27 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| WO2006132606A1 (en) * | 2005-06-09 | 2006-12-14 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| US20070014776A1 (en) * | 2005-06-09 | 2007-01-18 | Gimeno Ruth E | Identification of adiponutrin-related proteins as esterases and methods of use for the same |
| WO2006135862A2 (en) * | 2005-06-10 | 2006-12-21 | Children's Hospital And Research Center At Oakland | Immunomodulation by altering sphingosine 1-phosphate lyase (spl) activity |
| US20100266574A1 (en) * | 2005-06-10 | 2010-10-21 | Orna Mor | Oligoribonucleotides and Methods of Use Thereof for Treatment of Fibrotic Conditions and Other Diseases |
| WO2006138275A2 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| ES2267390B1 (es) * | 2005-06-16 | 2008-03-16 | Universidad Politecnica De Valencia | Aislamiento y caracterizacion de mutante csb3-1 de arabidopsis thaliana, y su uso como regulador de la resistencia en plantas a enfermedades producidas por patogenos biotroficos. |
| EP2159289A3 (en) | 2005-06-23 | 2010-03-24 | BASF Plant Science GmbH | Improved methods for the production of stably transformed plants |
| US20080280843A1 (en) | 2006-05-24 | 2008-11-13 | Van Bilsen Paul | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
| US20070015191A1 (en) * | 2005-07-01 | 2007-01-18 | Promega Corporation | Network of buoyant particles for biomolecule purification and use of buoyant particles or network of buoyant particles for biomolecule purification |
| ES2435774T3 (es) * | 2005-07-07 | 2013-12-23 | Yissum Research Development Company, Of The Hebrew University Of Jerusalem | Agentes de ácido nucleico para la regulación negativa de H19, y métodos de uso del mismo |
| WO2007011702A2 (en) | 2005-07-15 | 2007-01-25 | The University Of North Carolina At Chapel Hill | Use of egfr inhibitors to prevent or treat obesity |
| WO2007014275A2 (en) | 2005-07-26 | 2007-02-01 | Sangamo Biosciences, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| WO2007013575A2 (en) * | 2005-07-28 | 2007-02-01 | Oncotherapy Science, Inc. | Method for diagnosing and treating renal cell carcinoma |
| US20090176725A1 (en) * | 2005-08-17 | 2009-07-09 | Sirna Therapeutics Inc. | Chemically modified short interfering nucleic acid molecules that mediate rna interference |
| EP1937066A4 (en) | 2005-08-18 | 2008-12-24 | Alnylam Pharmaceuticals Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF NERVOUS DISEASES |
| EP1947942B1 (en) | 2005-08-18 | 2015-07-29 | Accelalox, Inc. | Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway |
| WO2007025079A2 (en) * | 2005-08-23 | 2007-03-01 | Illumigen Biosciences, Inc. | Detection of mutations in a gene associated with resistance to viral infection, oas2 or oas3 |
| US8029989B2 (en) * | 2005-08-26 | 2011-10-04 | The Trustees Of The University Of Pennsylvania | Method using snail transcriptional repressor |
| US7666584B2 (en) * | 2005-09-01 | 2010-02-23 | Philadelphia Health & Education Coporation | Identification of a pin specific gene and protein (PIN-1) useful as a diagnostic treatment for prostate cancer |
| WO2007026958A1 (ja) | 2005-09-01 | 2007-03-08 | Suntory Limited | トリプトファントランスポーター遺伝子及びその用途 |
| WO2007030167A1 (en) * | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| WO2007030510A2 (en) | 2005-09-08 | 2007-03-15 | Chromatin Inc. | Plants modified with mini-chromosomes |
| US7718369B2 (en) | 2005-09-12 | 2010-05-18 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| WO2007031333A2 (en) | 2005-09-15 | 2007-03-22 | Novosom Ag | Improvements in or relating to amphoteric liposomes |
| ES2557512T3 (es) | 2005-09-16 | 2016-01-26 | Devgen N.V. | Métodos basados en plantas transgénicas para plagas de plantas usando ARNi |
| CN102409050A (zh) | 2005-09-16 | 2012-04-11 | 孟山都技术有限公司 | 用于在植物中遗传控制昆虫侵袭的方法和组合物 |
| EP1931789B1 (en) | 2005-09-20 | 2016-05-04 | BASF Plant Science GmbH | Methods for controlling gene expression using ta-siran |
| AU2006292278B2 (en) | 2005-09-20 | 2012-03-08 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| EP1965814A4 (en) | 2005-09-26 | 2012-01-11 | Univ Columbia | SIDE POPULATION CELLS IN CARDIAL REPAIR |
| EP1928916A2 (en) * | 2005-09-29 | 2008-06-11 | Viral Logic Systems Technology Corp. | Immunomodulatory compositions and uses therefor |
| BRPI0616848A8 (pt) * | 2005-10-03 | 2017-09-19 | Monsanto Technology Llc | Semente de planta transgênica com maior teor de lisina |
| WO2007044727A2 (en) * | 2005-10-07 | 2007-04-19 | California Institute Of Technology | Pkr activation via hybridization chain reaction |
| WO2007043049A1 (en) * | 2005-10-11 | 2007-04-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compositions for silencing the expression of vdac1 and uses thereof |
| US20090304641A1 (en) * | 2005-10-17 | 2009-12-10 | Children's Hospital Boston | Methods and Compositions for Regulating Gene Expression |
| US7794951B2 (en) * | 2005-10-18 | 2010-09-14 | University Of Massachusetts Medical School | SREBP2gc transcription factors and uses thereof |
| WO2007045040A1 (en) | 2005-10-20 | 2007-04-26 | Commonwealth Scientific And Industrial Research Organisation | Cereals with altered dormancy |
| NZ568385A (en) | 2005-10-21 | 2012-07-27 | Univ California | C-kit oncogene mutations in melanoma |
| DK1945665T3 (da) * | 2005-10-21 | 2012-02-06 | Genzyme Corp | Antistof-baserede terapimidler med forhøjet ADCC-aktivitet |
| US7723314B1 (en) | 2005-10-28 | 2010-05-25 | Transderm, Inc. | Methods and compositions for treating pachyonychia congenita |
| US7320965B2 (en) | 2005-10-28 | 2008-01-22 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of Huntingtin gene |
| PT2500360E (pt) | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| AU2006308847C1 (en) * | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) * | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CA2626584A1 (en) | 2005-11-04 | 2007-05-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of nav1.8 gene |
| US8362323B2 (en) | 2005-11-08 | 2013-01-29 | Basf Plant Science Gmbh | Use of armadillo repeat (ARM1) polynucleotides for obtaining pathogen resistance in plants |
| AU2006311730B2 (en) | 2005-11-09 | 2010-12-02 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of Factor V Leiden mutant gene |
| CN100447243C (zh) * | 2005-11-15 | 2008-12-31 | 中国人民解放军第四军医大学 | HBV特异性干涉靶位点基因及其siRNA和其在抗HBV感染中的应用 |
| EP2431467A3 (en) | 2005-11-17 | 2012-05-02 | Board Of Regents, The University Of Texas | Modulation of gene expression by oligomers targeted to chromosomal DNA |
| US8603991B2 (en) | 2005-11-18 | 2013-12-10 | Gradalis, Inc. | Individualized cancer therapy |
| US8916530B2 (en) * | 2005-11-18 | 2014-12-23 | Gradalis, Inc. | Individualized cancer therapy |
| EP1960778A2 (fr) * | 2005-11-25 | 2008-08-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Procede pour la mise en evidence de la presence ou de l'absence de marqueurs (eef1a1 ou mark3 ) associes a la presence et/ou a la chimiosensibilite des tumeurs |
| WO2007064759A2 (en) * | 2005-11-29 | 2007-06-07 | The Scripps Research Institute | Inhibiting tumour cell invasion, metastasis and angiogenesis through targetting legumain |
| JP4737531B2 (ja) | 2005-12-05 | 2011-08-03 | サントリーホールディングス株式会社 | 形質転換酵母を用いるセラミドの製造方法 |
| EP2311856A1 (en) | 2005-12-09 | 2011-04-20 | BASF Plant Science GmbH | Polypeptides involved in regulation of sugar and lipid metabolism and methods of use VIII |
| WO2007070381A2 (en) | 2005-12-09 | 2007-06-21 | Promega Corporation | Nucleic acid purification with a binding matrix |
| US20090317802A1 (en) * | 2005-12-09 | 2009-12-24 | Bhatia Sangeeta N | Compositions and Methods to Monitor RNA Delivery to Cells |
| US9267937B2 (en) * | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| EP2330202A3 (en) | 2006-01-06 | 2011-09-14 | University Of Georgia Research Foundation, Inc. | Cyst nematode resistant transgenic plants |
| WO2007080143A1 (en) * | 2006-01-12 | 2007-07-19 | Basf Plant Science Gmbh | Use of stomatin (stm1) polynucleotides for achieving a pathogen resistance in plants |
| EP2374462A3 (en) | 2006-01-12 | 2011-12-14 | deVGen N.V. | Methods for controlling pests using RNAi |
| US8906876B2 (en) | 2006-01-12 | 2014-12-09 | Devgen Nv | Methods for controlling pests using RNAi |
| JP5474355B2 (ja) | 2006-01-12 | 2014-04-16 | デブジェン エヌブイ | RNAiを利用する植物害虫のための遺伝子組換え植物系方法 |
| WO2007084922A2 (en) | 2006-01-17 | 2007-07-26 | Biolex Therapeutics, Inc. | Compositions and methods for humanization and optimization of n-glycans in plants |
| CN100562342C (zh) * | 2006-01-17 | 2009-11-25 | 奥林格斯技术有限公司 | 防治流感病毒感染的寡核苷酸药物 |
| US20090060921A1 (en) * | 2006-01-17 | 2009-03-05 | Biolex Therapeutics, Inc. | Glycan-optimized anti-cd20 antibodies |
| US7825099B2 (en) * | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| NL2000439C2 (nl) * | 2006-01-20 | 2009-03-16 | Quark Biotech | Therapeutische toepassingen van inhibitoren van RTP801. |
| US8222482B2 (en) | 2006-01-26 | 2012-07-17 | Ceres, Inc. | Modulating plant oil levels |
| CA2638837A1 (en) * | 2006-01-27 | 2007-08-02 | Santaris Pharma A/S | Lna modified phosphorothiolated oligonucleotides |
| WO2007089601A2 (en) | 2006-01-27 | 2007-08-09 | Biogen Idec Ma Inc. | Nogo receptor antagonists |
| US20090324574A1 (en) | 2006-02-02 | 2009-12-31 | Verenium Corporation | Esterases and Related Nucleic Acids and Methods |
| US20080022423A1 (en) * | 2006-02-03 | 2008-01-24 | Monsanto Technology Llc | IN PLANTA RNAi CONTROL OF FUNGI |
| EP2444487B1 (en) | 2006-02-10 | 2018-04-18 | BP Corporation North America Inc. | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
| PL2044109T3 (pl) | 2006-02-10 | 2014-11-28 | Monsanto Technology Llc | Identyfikacja i zastosowanie genów docelowych do zwalczania nicieni pasożytów roślin |
| EP1984511A2 (en) | 2006-02-13 | 2008-10-29 | Monsanto Technology LLP | Selecting and stabilizing dsrna constructs |
| CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
| CA2946924A1 (en) | 2006-02-14 | 2007-08-23 | Bp Corporation North America Inc. | Xylanases, nucleic acids encoding them and methods for making and using them |
| US20070293657A1 (en) * | 2006-02-17 | 2007-12-20 | Nastech Pharmaceutical Company Inc. | Complexes and methods of forming complexes of ribonucleic acids and peptides |
| WO2007120989A2 (en) | 2006-02-24 | 2007-10-25 | Ceres, Inc. | Shade regulatory regions |
| BRPI0608595A2 (pt) | 2006-02-24 | 2017-07-25 | Suntory Ltd | Polinecleotídeo, proteína, vetor, levedura, métodos para produzir uma bebida alcoólica, para avaliar uma levedura de teste quanto a sua propriedade de floculação, e para selecionar uma levedura, e, bebida alcoólica |
| JP2009165352A (ja) * | 2006-02-24 | 2009-07-30 | Suntory Liquors Ltd | アシルCoA:エタノールO−アシルトランスフェラーゼ/エステラーゼ遺伝子及びその用途 |
| ATE548379T1 (de) | 2006-02-24 | 2012-03-15 | Suntory Holdings Ltd | Gen, das das für die flockungseigenschaften von hefe verantwortliche protein kodiert, und seine verwendung |
| CA2638762A1 (en) | 2006-02-24 | 2007-08-30 | Suntory Limited | Ammonia transporter gene and use thereof |
| JPWO2007097093A1 (ja) * | 2006-02-27 | 2009-07-09 | サントリーホールディングス株式会社 | 分枝アミノ酸トランスポーター遺伝子及びその用途 |
| WO2007097095A1 (ja) * | 2006-02-27 | 2007-08-30 | Suntory Limited | 芳香族アミノ酸トランスポーター遺伝子及びその用途 |
| JP2009528845A (ja) * | 2006-03-08 | 2009-08-13 | プロメガ・コーポレーション | 低分子量rnaの精製方法 |
| US7910566B2 (en) * | 2006-03-09 | 2011-03-22 | Quark Pharmaceuticals Inc. | Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA |
| US20100068172A1 (en) * | 2006-03-16 | 2010-03-18 | Devgen N.V. | Nematode Control |
| US8143482B2 (en) | 2006-03-20 | 2012-03-27 | Novozymes, Inc. | Polypeptides having endoglucanase activity and polynucleotides encoding same |
| WO2007107162A2 (en) * | 2006-03-23 | 2007-09-27 | Santaris Pharma A/S | Small internally segmented interfering rna |
| FR2898908A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence |
| EP2004817A2 (en) | 2006-03-30 | 2008-12-24 | Novozymes, Inc. | Polypeptides having endoglucanase activity and polynucleotides encoding same |
| US8968702B2 (en) | 2006-03-30 | 2015-03-03 | Duke University | Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses |
| WO2007115168A2 (en) | 2006-03-31 | 2007-10-11 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of eg5 gene |
| WO2008105773A2 (en) | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| EP2090662A3 (en) | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
| US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| EP2010226B1 (en) | 2006-04-07 | 2014-01-15 | The Research Foundation of State University of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| DE602007005366D1 (de) * | 2006-04-07 | 2010-04-29 | Chimeros Inc | Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen |
| US7625874B2 (en) * | 2006-04-11 | 2009-12-01 | The Regents Of The University Of California | Compositions and methods for treating diseases associated with T-box and N-Myc |
| AU2007238636A1 (en) | 2006-04-13 | 2007-10-25 | Novartis Vaccines & Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancer |
| WO2007120842A2 (en) * | 2006-04-13 | 2007-10-25 | Cornell Research Foundation, Inc. | Methods and compositions for targeting c-rel |
| WO2007124376A2 (en) * | 2006-04-19 | 2007-11-01 | Wyeth | Short interfering rna duplexes targeting an ires sequence and uses thereof |
| MX2008013397A (es) * | 2006-04-21 | 2009-03-27 | Wyeth Corp | Analisis de perfilamiento de expresion diferencial de fenotipos de cultivo celular y usos de los mismos. |
| CA2656990A1 (en) * | 2006-04-28 | 2007-11-08 | University Of South Florida | Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| US20070281900A1 (en) * | 2006-05-05 | 2007-12-06 | Nastech Pharmaceutical Company Inc. | COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY |
| EP2032134B1 (en) | 2006-05-09 | 2015-06-24 | Genzyme Corporation | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis |
| SG171676A1 (en) | 2006-05-11 | 2011-06-29 | Alnylam Pharmaceuticals Inc | Compositions and methods for inhibiting expression of the pcsk9 gene |
| GB0609498D0 (en) * | 2006-05-12 | 2006-06-21 | Oncomethylome Sciences S A | Novel methylation marker |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| EP2025347A4 (en) | 2006-05-15 | 2010-08-11 | Takeda Pharmaceutical | PROPHYLACTIC AND THERAPEUTIC AGENTS AGAINST CANCER |
| US7888552B2 (en) | 2006-05-16 | 2011-02-15 | Monsanto Technology Llc | Use of non-agrobacterium bacterial species for plant transformation |
| US20110052697A1 (en) * | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| US20070286863A1 (en) * | 2006-05-17 | 2007-12-13 | Christopher Sinal | CMKLR regulation of adipogenesis and adipocyte metabolic function |
| US20070269892A1 (en) * | 2006-05-18 | 2007-11-22 | Nastech Pharmaceutical Company Inc. | FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA |
| AU2007253776B2 (en) | 2006-05-19 | 2012-04-26 | Arrowhead Research Corporation | RNAi-mediated inhibition of tumor necrosis factor alpha-related conditions |
| ATE528008T1 (de) | 2006-05-19 | 2011-10-15 | Alnylam Pharmaceuticals Inc | Rnai-modulation von aha und ihre therapeutische verwendung |
| EP2018443A4 (en) | 2006-05-22 | 2009-11-11 | Alnylam Pharmaceuticals Inc | COMPOSITIONS AND METHODS INHIBITING EXPRESSION OF IKK-B GENE |
| US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
| US20070275923A1 (en) * | 2006-05-25 | 2007-11-29 | Nastech Pharmaceutical Company Inc. | CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY |
| AU2007267864A1 (en) * | 2006-05-25 | 2007-12-06 | Wyeth | Expression of the cysteine protease legumain in vascular and inflammatory diseases |
| CA2654165A1 (en) | 2006-06-05 | 2007-12-13 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| EP2044204B1 (en) | 2006-06-07 | 2014-04-30 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Plant expression constructs and methods of utilizing same |
| EP2026843A4 (en) * | 2006-06-09 | 2011-06-22 | Quark Pharmaceuticals Inc | THERAPEUTIC USES OF RTP801L INHIBITORS |
| JP2009540011A (ja) * | 2006-06-12 | 2009-11-19 | エクセジェニックス、インク.ディー/ビー/エー オプコ ヘルス、インク. | 血管新生のsiRNA阻害のための組成物及び方法 |
| JP5554564B2 (ja) | 2006-06-13 | 2014-07-23 | ザ ロックフェラー ユニヴァーシティ | 新規治療用および診断用生成物および方法 |
| WO2007147067A2 (en) * | 2006-06-14 | 2007-12-21 | Rosetta Inpharmatics Llc | Methods and compositions for regulating cell cycle progression |
| CA2655990A1 (en) * | 2006-06-22 | 2007-12-27 | Tai June Yoo | Restoration of hearing loss |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US8097596B2 (en) * | 2006-06-30 | 2012-01-17 | Lakewood-Amedex, Inc. | Compositions and methods for the treatment of muscle wasting |
| US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
| DK2038432T3 (en) | 2006-06-30 | 2017-04-03 | Rosetta Genomics Ltd | METHOD OF DETECTING AND QUANTIFYING A TARGET NUCLEIC ACID GENERATED BY RT-PCR BY MIRNA |
| US20130191941A1 (en) | 2006-07-05 | 2013-07-25 | Shing Kwok | Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants |
| EP2046110A4 (en) | 2006-07-07 | 2010-10-27 | Univ Washington State | GENES THAT CODE FOR THE CHAVICOL / EUGENOL SYNTHASE FROM THE KREOSOTBUSCH LARREA TRIDENTATA |
| EP2471809B1 (en) | 2006-07-11 | 2015-09-02 | University Of Medicine And Dentistry Of New Jersey | Proteins, nucleic acids encoding the same and associated methods of use |
| AU2007272314B2 (en) | 2006-07-12 | 2014-05-01 | Commonwealth Scientific And Industrial Research Organisation | Polynucleotides and methods for enhancing salinity tolerance in plants |
| NZ574046A (en) | 2006-07-13 | 2012-09-28 | Univ Iowa Res Found | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
| EP2412383A1 (en) | 2006-07-28 | 2012-02-01 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| PL380335A1 (pl) * | 2006-07-31 | 2008-02-04 | Instytut Chemii Bioorganicznej Pan W Poznaniu | Sekwencja dwunicowego ATN-RNA, interwencja interferencyjnym RNA ( iRnAi) oraz zastosowanie sekwencji dwunicowego ATN-RNA w terapii guzów mózgu |
| BRPI0714876B1 (pt) | 2006-08-04 | 2022-04-19 | Verenium Corporation | Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos |
| WO2008021207A2 (en) | 2006-08-11 | 2008-02-21 | Dow Agrosciences Llc | Zinc finger nuclease-mediated homologous recombination |
| EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
| US9580515B2 (en) | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| WO2008025711A2 (de) * | 2006-08-30 | 2008-03-06 | Basf Plant Science Gmbh | Verfahren zur erhöhung der pathogenresistenz in transgenen pflanzen |
| WO2008028121A1 (en) | 2006-08-31 | 2008-03-06 | Monsanto Technology Llc | Plant transformation without selection |
| WO2008030605A2 (en) * | 2006-09-08 | 2008-03-13 | The Regents Of The University Of Michigan | Herv group ii viruses in lymphoma and cancer |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| US20100158894A1 (en) | 2006-09-15 | 2010-06-24 | Tokai University | Preventive or remedy for er-negative and her2-negative breast cancer and method of screening the same |
| WO2008036638A2 (en) | 2006-09-18 | 2008-03-27 | Alnylam Pharmaceuticals, Inc. | Rnai modulation of scap and therapeutic uses thereof |
| JP2010510964A (ja) * | 2006-09-19 | 2010-04-08 | アシュラジェン インコーポレイテッド | 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路 |
| CA2663878A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| EP2617823B1 (en) | 2006-09-21 | 2015-07-01 | BASF Enzymes LLC | Phytases, nucleic acids encoding them and methods for making and using them |
| PL2057274T3 (pl) | 2006-09-21 | 2014-05-30 | Dsm Ip Assets Bv | Fosfolipazy, kodujące je kwasy nukleinowe i sposoby ich wytwarzania i stosowania |
| CA2663581C (en) | 2006-09-21 | 2016-03-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the hamp gene |
| EP2064223B1 (en) * | 2006-09-22 | 2013-04-24 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| WO2008040787A2 (de) | 2006-10-06 | 2008-04-10 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| EP3378953A1 (en) | 2006-10-12 | 2018-09-26 | Monsanto Technology LLC | Plant micrornas and methods of use thereof |
| EP2462924A3 (en) | 2006-10-13 | 2013-01-23 | Marina Biotech, Inc. | Improvements in or relating to amphoteric liposomes. |
| AU2007310982A1 (en) | 2006-10-18 | 2008-04-24 | Marina Biotech, Inc. | Nicked or gapped nucleic acid molecules and uses thereof |
| US9532980B2 (en) | 2006-10-25 | 2017-01-03 | The Rockefeller University | Methods for the treatment of A-β related disorders and compositions therefor |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のsiRNAおよびその使用方法 |
| ATE508191T1 (de) * | 2006-11-01 | 2011-05-15 | Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct | Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase |
| DK2094086T3 (da) * | 2006-11-08 | 2013-11-25 | Veritas Bio LLC | Indgivelse in vivo af dobbeltstrenget rna til en målcelle |
| US8758998B2 (en) | 2006-11-09 | 2014-06-24 | Gradalis, Inc. | Construction of bifunctional short hairpin RNA |
| US8906874B2 (en) | 2006-11-09 | 2014-12-09 | Gradalis, Inc. | Bi-functional shRNA targeting Stathmin 1 and uses thereof |
| US8252526B2 (en) | 2006-11-09 | 2012-08-28 | Gradalis, Inc. | ShRNA molecules and methods of use thereof |
| EP2433635A1 (en) | 2006-11-10 | 2012-03-28 | Massachusetts Institute Of Technology | PAK Modulators |
| KR20150072458A (ko) * | 2006-11-15 | 2015-06-29 | 코다 테라퓨틱스, 인크. | 상처 치유를 위한 개선 방법 및 조성물 |
| WO2008147456A2 (en) * | 2006-11-20 | 2008-12-04 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
| US8222388B2 (en) | 2006-11-22 | 2012-07-17 | Ceres, Inc. | Broadly expressing regulatory regions |
| AU2007325283B2 (en) | 2006-11-27 | 2012-08-30 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| CA2683287A1 (en) | 2006-11-27 | 2008-12-18 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
| US7820408B2 (en) | 2006-11-29 | 2010-10-26 | Novozymes, Inc. | Methods of improving the introduction of DNA into bacterial cells |
| WO2008066931A2 (en) | 2006-11-29 | 2008-06-05 | Novozymes, Inc. | Bacillus licheniformis chromosome |
| CN101195821A (zh) * | 2006-12-04 | 2008-06-11 | 中国科学院上海生命科学研究院 | 利用RNAi技术改良植物抗虫性的方法 |
| US8481506B2 (en) * | 2006-12-05 | 2013-07-09 | Rosetta Genomics, Ltd. | Nucleic acids involved in viral infection |
| US20080213377A1 (en) * | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
| CA2671294A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| WO2008067840A1 (en) | 2006-12-08 | 2008-06-12 | Swetree Technologies Ab | Plants having improved growth characteristics and method for making the same |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| CA2671299A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| EP2092068B1 (en) * | 2006-12-14 | 2014-10-08 | Dow AgroSciences LLC | Optimized non-canonical zinc finger proteins |
| WO2008080093A2 (en) | 2006-12-21 | 2008-07-03 | Verenium Corporation | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
| EP2097445A1 (en) * | 2006-12-22 | 2009-09-09 | F. Hoffmann-Roche AG | Shrna-mediated inhibition of expression of alpha-1. 6-fucosyltransferase |
| EP2097448A4 (en) | 2006-12-22 | 2010-07-21 | Univ Utah Res Found | PROCEDURE FOR THE EVIDENCE OF EYE DISEASES AND SUFFERINGS AND THEIR TREATMENT |
| EP3103451A1 (en) | 2007-01-12 | 2016-12-14 | University of Maryland, Baltimore | Targetting ncca-atp channel for organ protection following ischemic episode |
| CA2673361A1 (en) | 2007-01-15 | 2008-07-24 | Basf Plant Science Gmbh | Use of subtilisin (rnr9) polynucleotides for achieving a pathogen resistance in plants |
| US20100086526A1 (en) * | 2007-01-16 | 2010-04-08 | Abraham Hochberg | Nucleic acid constructs and methods for specific silencing of h19 |
| WO2008089265A2 (en) * | 2007-01-17 | 2008-07-24 | University Of Georgia Research Foundation, Inc. | Anti-viral methods and compositions |
| EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| AU2008207735B2 (en) | 2007-01-26 | 2013-10-03 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| WO2008092099A2 (en) * | 2007-01-26 | 2008-07-31 | Rosetta Genomics, Ltd. | Compositions and methods for treating hematopoietic malignancies |
| WO2008094937A2 (en) * | 2007-01-29 | 2008-08-07 | Joslin Diabetes Center, Inc. | Methods of modulating angiogenesis |
| CA2674721C (en) | 2007-01-30 | 2018-04-03 | Verenium Corporation | Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them |
| CN101686641B (zh) | 2007-02-05 | 2014-05-07 | 新加坡国立大学 | 推定的细胞激动素受体和其应用方法 |
| BRPI0807428A2 (pt) | 2007-02-06 | 2014-07-22 | Basf Plant Science Gmbh | Molécula de dsrna, coleção de moléculas dsrna, planta transgênica, métodos para preparar uma planta transgênica, e para conceder resistência a nematódeo a uma planta, e, vetor de expressão |
| EP2111452B1 (en) | 2007-02-08 | 2012-04-11 | BASF Plant Science GmbH | Compositions and methods using rna interference of opr3-like gene for control of nematodes |
| US9217129B2 (en) * | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| MX2009007766A (es) | 2007-02-09 | 2009-07-30 | Basf Plant Science Gmbh | Composiciones y metodos que utilizan arn de interferencia de tipo cdpk para el control de nematodos. |
| DE102007008596B4 (de) | 2007-02-15 | 2010-09-02 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung |
| KR20090119910A (ko) | 2007-02-16 | 2009-11-20 | 바스프 플랜트 사이언스 게엠베하 | 외떡잎 식물에서 배-특이적 발현의 조절을 위한 핵산 서열 |
| AU2008218813B2 (en) | 2007-02-20 | 2014-04-17 | Monsanto Technology, Llc | Invertebrate microRNAs |
| US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| EP2137205A2 (en) * | 2007-02-26 | 2009-12-30 | Quark Pharmaceuticals, Inc. | Inhibitors of rtp801 and their use in disease treatment |
| US9006206B2 (en) | 2007-02-27 | 2015-04-14 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| ATE553196T1 (de) * | 2007-02-27 | 2012-04-15 | Rosetta Genomics Ltd | Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod |
| US20100292301A1 (en) * | 2007-02-28 | 2010-11-18 | Elena Feinstein | Novel sirna structures |
| US9340601B2 (en) * | 2007-03-01 | 2016-05-17 | The Board Of Trustees Of The Leland Stanford Junior University | Splice variants of the EGF receptor |
| US8318921B2 (en) * | 2007-03-01 | 2012-11-27 | California Institute Of Technology | Triggered RNAi |
| WO2008109432A2 (en) * | 2007-03-02 | 2008-09-12 | The Board Of Regents Of The University Of Texas System | Therapeutic targeting of interleukins using sirna in neutral liposomes |
| WO2008106785A1 (en) | 2007-03-05 | 2008-09-12 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| US8080648B1 (en) | 2007-03-09 | 2011-12-20 | The United States Of America, As Represented By The Secretary Of Agriculture | Pesticidal double stranded RNA composition and method of use thereof |
| US20090060889A1 (en) * | 2007-03-12 | 2009-03-05 | Von Hofe Eric | Ii-RNAi involved Ii suppression in cancer immunotherapy |
| EP2125898B1 (en) | 2007-03-14 | 2013-05-15 | Novartis AG | Apcdd1 inhibitors for treating, diagnosing or detecting cancer |
| CA2681323A1 (en) | 2007-03-21 | 2008-09-25 | Brookhaven Science Associates, Llc | Combined hairpin-antisense compositions and methods for modulating expression |
| US7812002B2 (en) * | 2007-03-21 | 2010-10-12 | Quark Pharmaceuticals, Inc. | Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer |
| EP2129771B1 (en) | 2007-03-26 | 2018-09-12 | The Government of the U.S.A. as represented by the Secretary of the Department of Health & Human Services | Methods for modulating embryonic stem cell differentiation |
| PE20090064A1 (es) | 2007-03-26 | 2009-03-02 | Novartis Ag | Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende |
| US20100273172A1 (en) * | 2007-03-27 | 2010-10-28 | Rosetta Genomics Ltd. | Micrornas expression signature for determination of tumors origin |
| CL2008000883A1 (es) * | 2007-03-28 | 2008-10-03 | Wyeth6 3 | Metodo de deteccion de compuestos capaces de antagonizar la senalizacion de il-17f/il-17a; compuesto identificado por dicho metodo; uso de una cantidad de un antagonista de senalizacion de il-17f/il-17a, composicion farmaceutica que comprende dicho a |
| AP3018A (en) | 2007-03-29 | 2014-10-31 | Alnylam Pharmaceuticals Inc | Compositions and methods for inhibiting expressionof a gene from the ebola |
| EP1985295A1 (en) * | 2007-04-04 | 2008-10-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Selective inhibitors of CB2 receptor expression and/or activity for the treatment of obesity and obesity-related disorders |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
| WO2008124165A2 (en) * | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
| WO2008130921A1 (en) * | 2007-04-16 | 2008-10-30 | Modgene, Llc | Methods and compositions for diagnosis and treatment of depression and anxiety |
| MX2009011218A (es) * | 2007-04-17 | 2010-02-11 | Baxter Int | Microparticulas de acido nucleico para administracion pulmonar. |
| CA2584934A1 (en) | 2007-04-17 | 2008-10-17 | University Of Guelph | Nitrogen-regulated sugar sensing gene and protein and modulation thereof |
| ES2516827T3 (es) | 2007-04-23 | 2014-10-31 | Deliversir Ltd | Un sistema para entregar agentes terapéuticos a células vivas y núcleos de células |
| US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
| US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
| WO2009014565A2 (en) | 2007-04-26 | 2009-01-29 | Ludwig Institute For Cancer Research, Ltd. | Methods for diagnosing and treating astrocytomas |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US8916745B2 (en) | 2007-04-27 | 2014-12-23 | The Regents Of The University Of California | Plant CO2 sensors, nucleic acids encoding them, and methods for making and using them |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
| US20100197763A1 (en) * | 2007-05-02 | 2010-08-05 | Merck & Co., Inc. | RNA Interference Mediated Inhibition of Cyclic Nucleotide Type 4 Phosphodiesterase (PDE4B) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US20100251392A1 (en) * | 2007-05-04 | 2010-09-30 | Abbott Laboratories | Methods for assessing the delivery of exogenous agents |
| US20100115635A1 (en) * | 2007-05-04 | 2010-05-06 | Abbott Laboratories | Methods for Assessing the Delivery of Exogenous Agents |
| JP5475643B2 (ja) | 2007-05-04 | 2014-04-16 | マリーナ バイオテック,インコーポレイテッド | アミノ酸脂質およびその使用 |
| US8426676B2 (en) | 2007-05-04 | 2013-04-23 | Basf Plant Science Gmbh | Seed enhancement by combinations of pyruvate kinases |
| US8298781B2 (en) * | 2007-05-08 | 2012-10-30 | Duke University | Compositions and methods for characterizing and regulating olfactory sensation |
| CA2687079A1 (en) | 2007-05-11 | 2008-11-20 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
| KR101461659B1 (ko) | 2007-05-11 | 2014-11-17 | 토마스 제퍼슨 유니버시티 | 신경변성 질환 및 장애의 치료 및 예방 방법 |
| WO2008143786A1 (en) * | 2007-05-14 | 2008-11-27 | The Rockefeller University | Production of artificial micrornas using synthetic microrna precursors |
| EP1992699A1 (en) * | 2007-05-15 | 2008-11-19 | Genoplante-Valor | Method for increasing the resistance of a plant to endoparasitic nematodes |
| US9217151B2 (en) | 2007-05-16 | 2015-12-22 | California Institute Of Technology | Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| BRPI0811170B8 (pt) | 2007-05-22 | 2021-05-25 | Arcturus Therapeutics Inc | oligonucleotídeos de rna e complexos de rna substituídos por hidroximetila |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008142036A2 (en) | 2007-05-22 | 2008-11-27 | Basf Plant Science Gmbh | Plant cells and plants with increased tolerance and/or resistance to environmental stress and increased biomass production-ko |
| CA2687760C (en) | 2007-05-23 | 2017-10-31 | Syngenta Participations Ag | Sugar beet polynucleotide markers |
| CA2688417C (en) | 2007-05-24 | 2017-04-25 | Calcimedica, Inc. | Calcium channel proteins and uses thereof |
| IN2009KN04568A (enExample) | 2007-06-01 | 2015-08-28 | Univ Princeton | |
| WO2008154333A2 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | Mir-34 regulated genes and pathways as targets for therapeutic intervention |
| EP2164863A4 (en) | 2007-06-15 | 2010-07-28 | Univ Arkansas | METHOD FOR THE ADMINISTRATION OF MOLECULES IN CELLS USING A RICIN SUB-UNIT AND RELATED COMPOSITIONS THEREOF |
| WO2008152636A2 (en) * | 2007-06-15 | 2008-12-18 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting nadph oxidase expression |
| WO2008157299A2 (en) * | 2007-06-15 | 2008-12-24 | Wyeth | Differential expression profiling analysis of cell culture phenotypes and uses thereof |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| DE102007029471A1 (de) | 2007-06-20 | 2008-12-24 | Novosom Ag | Neue fakultativ kationische Sterole |
| CA2974689C (en) | 2007-06-22 | 2020-02-25 | The United States Of America As Represented By The Department Of Veters Affairs | Inhibitors of ncca-atp channels for therapy |
| WO2009001359A2 (en) * | 2007-06-27 | 2008-12-31 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of pro-apoptotic genes |
| US10745701B2 (en) | 2007-06-28 | 2020-08-18 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
| US20090324596A1 (en) | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
| CA2728575A1 (en) * | 2007-06-29 | 2009-01-08 | Boston Biomedical, Inc. | Enabling the use of long dsrna for gene targeting in mammalian and other selected animal cells |
| CA2692320A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Methods of treating bone disorders with modulators of axl |
| WO2009005095A1 (ja) | 2007-07-03 | 2009-01-08 | Kyorin Pharmaceutical Co., Ltd | インフルエンザ治療 |
| WO2009004085A2 (en) | 2007-07-05 | 2009-01-08 | Novartis Ag | Dsrna for treating viral infection |
| JP5529732B2 (ja) | 2007-07-06 | 2014-06-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌における再発性遺伝子融合 |
| CA2692632A1 (en) * | 2007-07-06 | 2009-01-15 | Intradigm Corporation | Methods and compositions for treatment of cancer and other angiogenesis-related diseases |
| AU2008273713B2 (en) * | 2007-07-10 | 2014-07-03 | Neurim Pharmaceuticals (1991) Ltd. | CD44 splice variants in neurodegenerative diseases |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| WO2009012263A2 (en) | 2007-07-18 | 2009-01-22 | The Trustees Of Columbia University In The City Of New York | Tissue-specific micrornas and compositions and uses thereof |
| EP2185719B1 (en) | 2007-08-02 | 2013-11-13 | NovImmune SA | Anti-rantes antibodies and methods of use thereof |
| US20090044296A1 (en) * | 2007-08-07 | 2009-02-12 | Cornell Research Foundation, Inc. | Hrpn interactors and uses thereof |
| MX2010001734A (es) | 2007-08-13 | 2010-08-04 | Commw Scient Ind Res Org | Cebada con bajos niveles de hordeinas. |
| WO2009021288A1 (en) | 2007-08-14 | 2009-02-19 | Commonwealth Scientific And Industrial Research Organisation | Improved gene silencing methods |
| US20090047269A1 (en) | 2007-08-16 | 2009-02-19 | The Regents Of The University Of Michigan | Metabolomic cancer targets |
| CA2697363A1 (en) | 2007-08-23 | 2009-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptogenesis |
| BRPI0815848A2 (pt) | 2007-08-30 | 2017-06-06 | The Burnet Inst | composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit. |
| WO2009033027A2 (en) * | 2007-09-05 | 2009-03-12 | Medtronic, Inc. | Suppression of scn9a gene expression and/or function for the treatment of pain |
| WO2009036332A1 (en) * | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| JP2010538678A (ja) * | 2007-09-18 | 2010-12-16 | イントラドイグム コーポレーション | K−rassiRNA含有組成物及びそれらの使用法 |
| US20100280097A1 (en) * | 2007-09-18 | 2010-11-04 | Intradigm Corporation | Compositions comprising hif-1 alpha sirna and methods of use thereof |
| DK2195428T3 (en) | 2007-09-19 | 2014-03-03 | Applied Biosystems Llc | SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF |
| ES2585157T3 (es) | 2007-09-27 | 2016-10-04 | Dow Agrosciences Llc | Proteínas de dedo de cinc de diseño que se dirigen a los genes de 5-enolpiruvil shikimato-3-fosfato sintasa |
| CA2701845A1 (en) | 2007-10-03 | 2009-04-09 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
| CN101952437B (zh) | 2007-10-03 | 2014-04-09 | 维莱尼姆公司 | 木聚糖酶、编码它们的核酸以及其制备和应用方法 |
| AU2008308499A1 (en) * | 2007-10-04 | 2009-04-09 | Board Of Regents, The University Of Texas System | Modulating gene expression with agRNA and gapmers targeting antisense transcripts |
| US20100280098A1 (en) * | 2007-10-05 | 2010-11-04 | Juliano Rudolph L | Receptor targeted oligonucleotides |
| BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| CA2702494A1 (en) | 2007-10-19 | 2009-04-23 | The Regents Of The University Of California | Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss |
| PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| US8097712B2 (en) * | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| CA2705488C (en) | 2007-11-12 | 2018-01-16 | Curtis C. Harris | Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer |
| EP2065037A1 (en) | 2007-11-27 | 2009-06-03 | DKFZ Deutsches Krebsforschungszentrum | Means and methods for treating or preventing brain tumors based on the nuclear receptor tailless (Tlx) |
| UA113829C2 (uk) | 2007-11-27 | 2017-03-27 | Коммонвелс Сайнтіфік Енд Індастріал Рісерч Організейшн | Генетично модифікована рослина зі збільшеним потенціалом продуктивності |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| US7968525B1 (en) | 2007-12-03 | 2011-06-28 | University Of Florida Research Foundation, Inc. | Use of RNA interference to validate new termiticide target sites and a method of termite control |
| DK2224822T3 (da) | 2007-12-06 | 2014-08-25 | Novozymes As | Polypeptider med acetylxylanesterase-aktivitet og polynukleotider, der koder for disse |
| US7871985B2 (en) | 2007-12-10 | 2011-01-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of factor VII gene |
| US20100204305A1 (en) * | 2007-12-11 | 2010-08-12 | Lorus Therapeutics Inc. | Small interfering rna molecules against ribonucleotide reductase and uses thereof |
| US20110105584A1 (en) * | 2007-12-12 | 2011-05-05 | Elena Feinstein | Rtp80il sirna compounds and methods of use thereof |
| US8614311B2 (en) | 2007-12-12 | 2013-12-24 | Quark Pharmaceuticals, Inc. | RTP801L siRNA compounds and methods of use thereof |
| EP2229459B1 (en) * | 2007-12-13 | 2014-08-27 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| EP2225380A2 (en) * | 2007-12-17 | 2010-09-08 | BASF Plant Science GmbH | Lipid metabolism protein and uses thereof i (bzip transcription factor) |
| EP2072528A1 (en) | 2007-12-19 | 2009-06-24 | Labeit, Mr. Siegfried | A host cell deficient for MuRF1 and MuRF2 |
| BRPI0821230A2 (pt) | 2007-12-19 | 2019-09-24 | Novozymes As | "constructo de ácido nucleico, cédula microbiana hospedeira recombinante, métodos para priduzir um polipeptídeo tendo atividade intensificadora celulolítica, para produzir um mutante de uma cédula precursora, para inibir a expressão de um polipeptídeo com atividade de intensificação celulolítica em uma célula, para produzir uma proteína, para degradar ou converter um material celulósico, e, para fermentar um material celulósico" |
| US20090186358A1 (en) * | 2007-12-21 | 2009-07-23 | Wyeth | Pathway Analysis of Cell Culture Phenotypes and Uses Thereof |
| EP2252689A2 (en) * | 2007-12-21 | 2010-11-24 | Coda Therapeutics, Inc. | Use of anti-connexin polynucleotides for the treatment of surgical adhesions |
| CA2710387A1 (en) * | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| EP2554674B1 (en) | 2007-12-21 | 2014-11-05 | Keygene N.V. | Trichome specific promoters |
| AU2008340002A1 (en) | 2007-12-21 | 2009-07-02 | Basf Plant Science Gmbh | Plants with increased yield (KO NUE) |
| WO2009085270A2 (en) * | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions |
| WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
| NZ586643A (en) | 2007-12-28 | 2012-10-26 | Swetree Technologies Ab | Woody plants having improved growth characteristics and method for making the same using transcription factors |
| US20090226914A1 (en) * | 2007-12-31 | 2009-09-10 | Bates Paula J | Methods and products to target, capture and characterize stem cells |
| US8541220B2 (en) | 2008-01-03 | 2013-09-24 | Verenium Corporation | Isomerases, nucleic acids encoding them and methods for making and using them |
| WO2009088949A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| EP2240583A2 (en) * | 2008-01-07 | 2010-10-20 | Coda Therapeutics, Inc. | Wound healing compositions and treatments |
| TW200930398A (en) * | 2008-01-11 | 2009-07-16 | Univ Chang Gung | RNAi sequence, inhibitor, and inhibition method that specifically inhibits expression of 78-kDA glucose-regulated protein |
| WO2009090639A2 (en) * | 2008-01-15 | 2009-07-23 | Quark Pharmaceuticals, Inc. | Sirna compounds and methods of use thereof |
| DK2245464T3 (en) | 2008-01-25 | 2017-02-20 | Multivir Inc | P53 BIOMARKETS |
| JP2011510623A (ja) * | 2008-01-27 | 2011-04-07 | ロゼッタ ゲノミックス エルティーディー. | 妊娠の合併症を診断するための方法及び組成物 |
| BRPI0822284A2 (pt) | 2008-02-05 | 2014-11-11 | Pioner Hi Bred International Inc | Mólecula de ácido nucléico isolada, construção de dna, vetor de dna, método para expressar uma sequência de nucleotídeos em uma planta, método para expressar uma sequência de nucleotídeos em uma célula vegetal e método para expressar seletivamente uma sequência de nucleotídeos na folha de milho, bainha, colar e nervura central |
| US20090263803A1 (en) * | 2008-02-08 | 2009-10-22 | Sylvie Beaudenon | Mirnas differentially expressed in lymph nodes from cancer patients |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| EP3643782A1 (en) | 2008-02-11 | 2020-04-29 | Phio Pharmaceuticals Corp. | Modified rnai polynucleotides and uses thereof |
| DE102009043743B4 (de) | 2009-03-13 | 2016-10-13 | Friedrich-Schiller-Universität Jena | Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung |
| US8497364B2 (en) * | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
| KR101397407B1 (ko) | 2008-03-05 | 2014-06-19 | 알닐람 파마슈티칼스 인코포레이티드 | Eg5 및 VEGF 유전자의 발현을 억제하기 위한 조성물 및 방법 |
| WO2009111643A2 (en) * | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
| CA2717496A1 (en) * | 2008-03-12 | 2009-09-17 | Intradigm Corporation | Compositions comprising notch1 sirna and methods of use thereof |
| WO2009116037A2 (en) * | 2008-03-20 | 2009-09-24 | Quark Pharmaceuticals, Inc. | NOVEL siRNA COMPOUNDS FOR INHIBITING RTP801 |
| WO2009154835A2 (en) * | 2008-03-26 | 2009-12-23 | Asuragen, Inc. | Compositions and methods related to mir-16 and therapy of prostate cancer |
| KR20100127880A (ko) | 2008-04-04 | 2010-12-06 | 카란도 파마슈티칼즈, 인코포레이티드 | Epas1 억제제의 조성물 및 용도 |
| WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| US8802923B2 (en) | 2008-04-10 | 2014-08-12 | A.B. Seeds Ltd. | Compositions and methods for enhancing oil content in plants |
| CN102027121B (zh) | 2008-04-10 | 2017-08-08 | 孟山都技术公司 | 用于根结线虫防治的方法和组合物 |
| WO2009131632A1 (en) | 2008-04-14 | 2009-10-29 | Sangamo Biosciences, Inc. | Linear donor constructs for targeted integration |
| WO2009144704A2 (en) * | 2008-04-15 | 2009-12-03 | Quark Pharmaceuticals, Inc. | siRNA COMPOUNDS FOR INHIBITING NRF2 |
| GB0807018D0 (en) | 2008-04-17 | 2008-05-21 | Fusion Antibodies Ltd | Antibodies and treatment |
| US8518884B2 (en) | 2008-04-25 | 2013-08-27 | Northwestern University | Methods for treating atrial or ventricular arrhythmias by administering a G-protein alpha inhibitor |
| EP2285960B1 (en) | 2008-05-08 | 2015-07-08 | Asuragen, INC. | Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis |
| US20090291073A1 (en) * | 2008-05-20 | 2009-11-26 | Ward Keith W | Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same |
| US20100021904A1 (en) * | 2008-05-21 | 2010-01-28 | Pierce Niles A | Shielded cross-linking probes |
| US8241854B2 (en) * | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
| US20100021901A1 (en) * | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
| WO2009143391A2 (en) * | 2008-05-22 | 2009-11-26 | Isis Pharmaceuticals, Inc | Methods for modulation expression of creb |
| CA2726052A1 (en) | 2008-06-04 | 2009-12-10 | The Board Of Regents Of The University Of Texas System | Modulation of gene expression through endogenous small rna targeting of gene promoters |
| US8431692B2 (en) | 2008-06-06 | 2013-04-30 | Quark Pharmaceuticals, Inc. | Compositions and methods for treatment of ear disorders |
| WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
| WO2010008582A2 (en) | 2008-07-18 | 2010-01-21 | Rxi Pharmaceuticals Corporation | Phagocytic cell drug delivery system |
| US8512944B2 (en) | 2008-08-27 | 2013-08-20 | Oncotherapy Science, Inc. | PRMT1 for target genes of cancer therapy and diagnosis |
| US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8357503B2 (en) | 2008-08-29 | 2013-01-22 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8153391B2 (en) | 2008-08-29 | 2012-04-10 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| EP2690175B1 (en) | 2008-09-02 | 2016-12-28 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for combined inhibition of mutant EGFR gene and IL-6 expression |
| US8883725B2 (en) | 2008-09-10 | 2014-11-11 | University Of Bradford | Compositions and methods for modulating skin pigmentation |
| HRP20180738T1 (hr) | 2008-09-15 | 2018-06-15 | F. Hoffmann - La Roche Ag | Pripravci i postupci za regulaciju stanične osmolarnosti |
| WO2010033560A2 (en) | 2008-09-16 | 2010-03-25 | University Of Maryland, Baltimore | Sur1 inhibitors for therapy |
| EP2165710A1 (en) | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
| CN108165548B (zh) | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| WO2010036962A1 (en) | 2008-09-25 | 2010-04-01 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene |
| MX2011003183A (es) | 2008-09-26 | 2011-04-21 | Oncomed Pharm Inc | Agentes que se unen a receptor encrespado y usos de los mismos. |
| JP5767585B2 (ja) | 2008-09-29 | 2015-08-19 | モンサント テクノロジー エルエルシー | 大豆遺伝子組換え事象mon87705およびその検出方法 |
| US8298794B2 (en) | 2008-10-09 | 2012-10-30 | Ceres, Inc. | Cinnamyl-alcohol dehydrogenases |
| WO2010042933A2 (en) | 2008-10-10 | 2010-04-15 | Northwestern University | Inhibition and treatment of prostate cancer metastasis |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8277812B2 (en) * | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| KR20110084254A (ko) | 2008-10-16 | 2011-07-21 | 사이토닉스 코포레이션 | 척추 및 관절 통증을 탐지하고 치료하는 생체표식 및 방법 |
| EP2349210B1 (en) | 2008-10-16 | 2015-03-18 | Marina Biotech, Inc. | Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics |
| HRP20150796T1 (hr) | 2008-10-20 | 2015-09-11 | Alnylam Pharmaceuticals, Inc. | Pripravci i postupci za inhibiciju ekspresije transtiretina |
| WO2010048590A1 (en) * | 2008-10-23 | 2010-04-29 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules |
| WO2010050584A1 (ja) | 2008-10-31 | 2010-05-06 | 独立行政法人科学技術振興機構 | ヘルパーt細胞の選択的機能制御法 |
| EP2350291A4 (en) | 2008-11-03 | 2012-02-22 | Swetree Technologies Ab | PLANT MATERIAL, PLANTS AND METHOD FOR PRODUCING A PLANT WITH CHANGED LIGNIN PROPERTIES |
| WO2010054221A2 (en) | 2008-11-06 | 2010-05-14 | The Johns Hopkins University | Treatment of chronic inflammatory respiratory disorders |
| CN102272157B (zh) | 2008-11-07 | 2015-11-25 | 研究发展基金会 | 用于抑制cripto/grp78复合物形成和信号的组合物和方法 |
| CA2742986C (en) * | 2008-11-07 | 2015-03-31 | Triact Therapeutics, Inc. | Use of catecholic butane derivatives in cancer therapy |
| EP2352847B1 (en) | 2008-11-10 | 2014-01-08 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Gene signature for predicting prognosis of patients with solid tumors |
| JP2012508026A (ja) * | 2008-11-10 | 2012-04-05 | ワイス・エルエルシー | 温度誘導型ポリヌクレオチドおよびその使用 |
| WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
| WO2010057203A2 (en) | 2008-11-17 | 2010-05-20 | The Board Of Regents Of The University Of Texas System | Hdl particles for delivery of nucleic acids |
| WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
| CN102292444A (zh) | 2008-11-20 | 2011-12-21 | 诺维信股份有限公司 | 具有淀粉分解增强活性的多肽和编码该多肽的多核苷酸 |
| US9340789B2 (en) | 2008-12-03 | 2016-05-17 | Arcturus Therapeutics, Inc. | UNA oligomer structures for therapeutic agents |
| EP2370092A1 (en) | 2008-12-03 | 2011-10-05 | Research Development Foundation | Modulation of olfml-3 mediated angiogenesis |
| WO2010065830A1 (en) | 2008-12-04 | 2010-06-10 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| MX2011005851A (es) | 2008-12-04 | 2011-07-29 | Opko Opthalmics Llc | Composiciones y metodos para la inhibicion selectiva de isoformas vegf proangiogenicas. |
| US8497075B2 (en) | 2008-12-09 | 2013-07-30 | Novartis Ag | Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands |
| CA2746514C (en) | 2008-12-10 | 2018-11-27 | Alnylam Pharmaceuticals, Inc. | Gnaq targeted dsrna compositions and methods for inhibiting expression |
| EP2198879A1 (en) | 2008-12-11 | 2010-06-23 | Institut Curie | CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell |
| US20110296557A1 (en) | 2008-12-12 | 2011-12-01 | Novozymes, Inc. | Polypeptides Having Lipase Activity And Polynucleotides Encoding Same |
| DE112009003708T5 (de) | 2008-12-12 | 2012-09-13 | Basf Plant Science Gmbh | Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenenOrganismen |
| US9493759B2 (en) | 2008-12-12 | 2016-11-15 | Novozymes, Inc. | Polypeptides having aspartic endopeptidase activity and polynucleotides encoding same |
| US20110269206A1 (en) | 2008-12-15 | 2011-11-03 | Novozymes, Inc | Polypeptides Having Catalase Activity And Polynucleotides Encoding Same |
| US8633030B2 (en) | 2008-12-16 | 2014-01-21 | Novozymes, Inc. | Polypeptides having carboxypeptidase activity and polynucleotides encoding same |
| US20110271407A1 (en) | 2008-12-16 | 2011-11-03 | Novozymes, Inc. | Polypeptides Having Alpha-Mannosidase Activity And Polynucleotides Encoding Same |
| US20100233172A1 (en) * | 2008-12-16 | 2010-09-16 | Bristol-Myers Squibb Company | Methods of inhibiting quiescent tumor proliferation |
| SI2370575T1 (en) | 2008-12-17 | 2018-07-31 | Dow Agrosciences, Llc | Targeted integration in the Zp15 locus |
| US20110288155A1 (en) | 2008-12-18 | 2011-11-24 | Elena Feinstein | Sirna compounds and methods of use thereof |
| CN105907756A (zh) * | 2008-12-18 | 2016-08-31 | 戴瑟纳制药公司 | 延长的dicer酶底物和特异性抑制基因表达的方法 |
| EP2379076B1 (en) | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2010074783A1 (en) | 2008-12-23 | 2010-07-01 | The Trustees Of Columbia University In The City Of New York | Phosphodiesterase inhibitors and uses thereof |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
| JP5801205B2 (ja) * | 2009-01-08 | 2015-10-28 | ノースウェスタン ユニバーシティ | 多価オリゴヌクレオチド修飾ナノ粒子コンジュゲートによる細菌タンパク質産生の阻害 |
| BRPI1004572A2 (pt) | 2009-01-09 | 2016-04-05 | Univ Michigan | "fusões genéticas recorrentes em câncer |
| US8604277B2 (en) | 2009-01-28 | 2013-12-10 | Novozymes, Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| US8629324B2 (en) | 2009-01-30 | 2014-01-14 | Novozymes, Inc. | Polypeptides having expansin activity and polynucleotides encoding same |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| US8309530B2 (en) * | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
| CN102341106A (zh) | 2009-02-13 | 2012-02-01 | 印第安那大学科技研究公司 | 用于抑制mmp2和mmp9的化合物和方法 |
| ES2625891T3 (es) | 2009-02-13 | 2017-07-20 | The Regents Of The University Of California | Control de la tolerancia al estrés, eficiencia del uso de agua y expresión génica en plantas mediante el uso de nuevas proteínas receptoras de ABA y agonistas sintéticos |
| EP2400985A2 (en) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor |
| JP2012519170A (ja) | 2009-02-26 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 生体内の腫瘍細胞のemtステータスをモニターするためのinsitu法 |
| WO2010099341A1 (en) | 2009-02-26 | 2010-09-02 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of mig-12 gene |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2012519281A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| CN102421900B (zh) | 2009-03-12 | 2015-07-22 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因表达的脂质配制的组合物以及方法 |
| SG174452A1 (en) | 2009-03-19 | 2011-10-28 | Merck Sharp & Dohme | RNA INTERFERENCE MEDIATED INHIBITION OF BTB AND CNC HOMOLOGY 1, BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR 1 (BACH 1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SEQUENCE LISTING |
| EP2408458A1 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120029054A1 (en) | 2009-03-19 | 2012-02-02 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA) |
| EP2408916A2 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2010106187A2 (en) | 2009-03-20 | 2010-09-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibitors of cathepsin s for prevention or treatment of obesity-associated disorders |
| EP2408904B1 (en) | 2009-03-20 | 2017-10-18 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| DE112010001772T5 (de) | 2009-03-20 | 2012-10-18 | Basf Plant Science Company Gmbh | Nematodenresistente transgene pflanzen |
| US20110045080A1 (en) * | 2009-03-24 | 2011-02-24 | William Marsh Rice University | Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto |
| US20120022143A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA) |
| CN102439152A (zh) | 2009-03-27 | 2012-05-02 | 默沙东公司 | 使用短干扰核酸(siNA)的RNA干扰介导的细胞间粘附分子1(ICAM-1)基因表达的抑制 |
| WO2010111471A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120010272A1 (en) | 2009-03-27 | 2012-01-12 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| US20100257634A1 (en) * | 2009-04-03 | 2010-10-07 | Venganza Inc. | Bioassay for gene silencing constructs |
| KR101791702B1 (ko) | 2009-04-03 | 2017-10-30 | 다이서나 파마수이티컬, 인크. | 비대칭 이중가닥 rna에 의한 kras의 특이적 저해를 위한 방법 및 조성물 |
| WO2010115874A1 (en) | 2009-04-07 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and the diagnosis ofpulmonary arterial hypertension |
| WO2010118243A2 (en) | 2009-04-08 | 2010-10-14 | Genentech, Inc. | Use of il-27 antagonists to treat lupus |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| US8283332B2 (en) | 2009-04-17 | 2012-10-09 | University Of Louisville Research Foundation, Inc. | PFKFB4 inhibitors and methods of using the same |
| CA2759332A1 (en) * | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| CN102575257B (zh) | 2009-04-22 | 2014-11-05 | 巴斯夫植物科学有限公司 | 全种子特异性启动子 |
| EP2243828A1 (en) | 2009-04-24 | 2010-10-27 | DKFZ Deutsches Krebsforschungszentrum | Use of mixed lineage like kinase polypeptides (MLKL polypeptides) in cancer therapy |
| US8815586B2 (en) * | 2009-04-24 | 2014-08-26 | The Board Of Regents Of The University Of Texas System | Modulation of gene expression using oligomers that target gene regions downstream of 3′ untranslated regions |
| US8822426B2 (en) | 2009-05-05 | 2014-09-02 | Beeologics Inc. | Prevention and treatment of nosema disease in bees |
| MY186558A (en) * | 2009-05-13 | 2021-07-27 | Malaysian Palm Oil Board | A constitutive promoter from oil palm type 2 |
| US20100298697A1 (en) * | 2009-05-19 | 2010-11-25 | Medtronic, Inc. | Method and devices for improved efficiency of rna delivery to cells |
| US8207138B2 (en) | 2009-05-19 | 2012-06-26 | Medtronic, Inc. | Methods and devices for improved efficiency of RNA delivery to cells |
| PL2432467T3 (pl) | 2009-05-20 | 2018-07-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Zastosowanie antagonistów receptora 5-ht3 serotoniny w leczeniu zaburzeń przedsionkowych ze zmianami chorobowymi |
| EP2432499A2 (en) | 2009-05-20 | 2012-03-28 | Schering Corporation | Modulation of pilr receptors to treat microbial infections |
| ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| AU2010249500B2 (en) | 2009-05-21 | 2016-03-24 | Basf Enzymes Llc | Phytases, nucleic acids encoding them and methods for making and using them |
| WO2010141511A2 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| CN104480088A (zh) | 2009-06-02 | 2015-04-01 | 诺维信股份有限公司 | 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸 |
| EP2258858A1 (en) | 2009-06-05 | 2010-12-08 | Universitätsklinikum Freiburg | Transgenic LSD1 animal model for cancer |
| BRPI1012003A2 (pt) | 2009-06-05 | 2015-09-22 | Univ Florida | "isolamento e supressão direcionada de genes biossintéticos de lignina da cana-de-açúcar" |
| EP2440664B1 (en) | 2009-06-08 | 2021-04-21 | Nunhems B.V. | Drought tolerant plants |
| CA2765034A1 (en) | 2009-06-09 | 2010-12-23 | Pioneer Hi-Bred International, Inc. | Early endosperm promoter and methods of use |
| EP2266550A1 (en) | 2009-06-15 | 2010-12-29 | Institut Curie | Antagonists of ß-catenin for preventing and/or treating neurodegenerative disorders |
| WO2010147992A1 (en) | 2009-06-15 | 2010-12-23 | Alnylam Pharmaceuticals, Inc. | Methods for increasing efficacy of lipid formulated sirna |
| EP2442792A4 (en) | 2009-06-15 | 2015-12-23 | Alnylam Pharmaceuticals Inc | TESTING GENE PCSK9 LIPID-FORMULATED DSRNA |
| US20100324124A1 (en) * | 2009-06-17 | 2010-12-23 | Massachusetts Institute Of Technology | Compositions and methods relating to DNA-based particles |
| US20100323018A1 (en) * | 2009-06-17 | 2010-12-23 | Massachusetts Institute Of Technology | Branched DNA/RNA monomers and uses thereof |
| EP2445334A1 (en) | 2009-06-26 | 2012-05-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Non human animal models for increased retinal vascular permeability |
| CA2764073A1 (en) | 2009-06-30 | 2011-01-20 | E. I. Du Pont De Nemours And Company | Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding cytosolic pyrophosphatase |
| EP2451957B1 (en) | 2009-07-07 | 2017-11-15 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| AU2010270337B2 (en) | 2009-07-09 | 2016-09-22 | Biontech Delivery Technologies Gmbh | Amphoteric liposomes comprising imino lipids |
| CA2766858A1 (en) | 2009-07-10 | 2011-01-13 | Basf Plant Science Company Gmbh | Expression cassettes for endosperm-specific expression in plants |
| ES2562463T3 (es) | 2009-07-14 | 2016-03-04 | Mayo Foundation For Medical Education And Research | Administración no covalente, mediada por péptidos, de agentes activos a través de la barrera hematoencefálica |
| DK2769737T3 (en) | 2009-07-20 | 2017-07-24 | Bristol Myers Squibb Co | COMBINATION OF ANTI-CTLA4 ANTIBODY WITH ETOPOSIDE FOR SYNERGISTIC TREATMENT OF PROLIFERATIVE DISEASES |
| EA036343B1 (ru) | 2009-07-20 | 2020-10-29 | Серес, Инк. | Увеличение биомассы трансгенных растений |
| US9409983B2 (en) | 2009-07-23 | 2016-08-09 | The Board Of Trustess Of The University Of Illinois | Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases |
| EP2456460A4 (en) | 2009-07-24 | 2013-02-20 | Univ California | METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASES ASSOCIATED WITH AVB5 INTEGRIN |
| WO2011014458A1 (en) | 2009-07-28 | 2011-02-03 | Novozymes, Inc. | Polypeptides having phytase activity and polynucleotides encoding same |
| WO2011017137A2 (en) * | 2009-08-03 | 2011-02-10 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating insects |
| NZ598457A (en) * | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
| US9029338B2 (en) | 2009-08-14 | 2015-05-12 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| WO2011021177A2 (en) | 2009-08-19 | 2011-02-24 | Rosetta Genomics Ltd. | Compositions and methods for prognosis and treatment of prostate cancer |
| WO2011020874A1 (en) | 2009-08-20 | 2011-02-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
| CN102481311A (zh) | 2009-08-21 | 2012-05-30 | 比欧洛吉科斯公司 | 经由植物转录的分子预防和治疗有益昆虫的疾病 |
| US8222397B2 (en) * | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| EP2473598B1 (en) | 2009-09-04 | 2017-03-22 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methods for enhancing genome stability and telomere elongation in embryonic stem cells |
| WO2011031600A1 (en) | 2009-09-10 | 2011-03-17 | Schering Corporation | Use of il-33 antagonists to treat fibrotic disease |
| WO2011032100A1 (en) | 2009-09-11 | 2011-03-17 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of kshv vil6 and human il6 |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| BR112012006032A2 (pt) | 2009-09-17 | 2015-09-08 | Novozymes Inc | polipetídeo isolado, composição, célula hospedeira recombinante, métodos para produzir o polipetídeo, um polipetídeo tendo atividade realçadora celulolítica, um mutante de uma célula precursora, uma proteína e um produto de fermentação, planta transgênica, parte de planta ou célula de planta, molécula de rna inibidora de filamento duplo(rsrna), e, métodos para inibir a expressão de um polipetídeo tendo atividade realçadora celulolítica em uma célula, degradar ou converter um polipetídeo isolado, composição, célula hospedeira recombinante, métodos para produzir o polipetídeo, um polipetídeo tendo atividade realçadora celulolítica, um mutante de uma célula precursora, uma proteína e um produto de fermentação, planta transgênica, parte de planta ou célula de planta, molécula de rna inibidora de filamento duplo (dsrna), e, métodos para inibir a expressão de um polipetídeo tendo atividade realçadora celulolítica em uma célula, degradar ou converter um material celulósico e fermentar um material celulósico. |
| EP2478095A1 (en) | 2009-09-18 | 2012-07-25 | Novozymes Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| US20120244170A1 (en) * | 2009-09-22 | 2012-09-27 | Rafal Ciosk | Treating cancer by modulating mex-3 |
| US8211665B2 (en) | 2009-09-29 | 2012-07-03 | Novozymes, Inc. | Polypeptides having xylanase activity and polynucleotides encoding same |
| WO2011041397A1 (en) | 2009-09-29 | 2011-04-07 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US8586829B2 (en) | 2009-09-30 | 2013-11-19 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| EP2977382A3 (en) | 2009-09-30 | 2016-05-11 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
| UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
| EP2490696A1 (en) | 2009-10-20 | 2012-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of disorders of glucose homeostasis |
| CA2775146A1 (en) | 2009-10-26 | 2011-05-12 | Pioneer Hi-Bred International, Inc. | Somatic ovule specific promoter and methods of use |
| BR112012006847A2 (pt) | 2009-10-29 | 2015-09-08 | Novozymes As | polipeptídeo polinucleotídeo, célula hospedeira recombinante, métodos para produzir o polipeptídeo para produzir um mutante de uma célula parental, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, para produzir um produto de fermentação e pra fermentar um material celulósico, planta transgênica, parte da planta ou célula da planta, molécula de rna inibitória de filamento duplo, e, composição. |
| US20120311728A1 (en) | 2009-11-06 | 2012-12-06 | Ziad Mallat | Methods and pharmaceutical composition for the treatment of atherosclerosis |
| BR112012008260A2 (pt) | 2009-11-06 | 2015-09-15 | Novozymes Inc E Novozymes As | polipeptídeo, polinucleotídeo, métodos para produzir o polipeptídeo, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, para fermentar um material celulósico, planta transgênica, parte da planta ou célula da planta,e, molécula de rna inibitória de filamento duplo. |
| US9799416B2 (en) * | 2009-11-06 | 2017-10-24 | Terrapower, Llc | Methods and systems for migrating fuel assemblies in a nuclear fission reactor |
| ES2574054T3 (es) | 2009-11-06 | 2016-06-14 | Novozymes, Inc. | Polipéptidos con actividad de xilanasa y polinucleótidos que los codifican |
| CN102666856B (zh) | 2009-11-08 | 2016-04-06 | 夸克制药公司 | 定向至RhoA靶基因的双链RNA化合物在制造治疗神经性疼痛的药物中的用途 |
| EP2322927A1 (en) | 2009-11-16 | 2011-05-18 | Deutsches Krebsforschungszentrum | Compounds inhibiting CD95 signaling for the treatment of pancreatic cancer |
| EP2322619A1 (en) | 2009-11-17 | 2011-05-18 | Deutsches Krebsforschungszentrum | Inhibitors of centrosomal clustering |
| JP6174320B2 (ja) | 2009-11-17 | 2017-08-02 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | ヒトヌクレオリンに対するヒトモノクローナル抗体 |
| WO2011062962A2 (en) | 2009-11-17 | 2011-05-26 | The Trustees Of The University Of Pennsylvania | Smndelta7 degron: novel compositions and methods of use |
| AU2010324658A1 (en) | 2009-11-26 | 2012-05-03 | Quark Pharmaceuticals, Inc. | siRNA compounds comprising terminal substitutions |
| WO2011065389A1 (ja) | 2009-11-27 | 2011-06-03 | 独立行政法人科学技術振興機構 | 高脂血症治療剤のスクリーニング方法 |
| EP2507375A4 (en) | 2009-12-03 | 2013-04-24 | Basf Plant Science Co Gmbh | EXPRESSION CASSETTES FOR EMBRYOSPECIFIC EXPRESSION IN PLANTS |
| EP2509628B1 (en) | 2009-12-07 | 2017-10-25 | The Johns Hopkins University | Sr-bi as a predictor of human female infertility and responsiveness to treatment |
| US20120283190A1 (en) | 2009-12-09 | 2012-11-08 | Institut National de la Santé et de la Recherche Medicale (INSERM) | Endothelin inhibitors for the treatment of rapidly progressive glomerulonephritis |
| ES2562499T3 (es) | 2009-12-09 | 2016-03-04 | Nitto Denko Corporation | Modulación de la expresión de HSP47 |
| US8778904B2 (en) | 2009-12-09 | 2014-07-15 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the CNS |
| WO2011069953A1 (en) | 2009-12-09 | 2011-06-16 | Basf Plant Science Company Gmbh | Methods for increasing the resistance of plants to fungi by silencing the fungal smt1-gene |
| EP3632901B1 (en) | 2009-12-10 | 2022-02-02 | The Trustees of Columbia University in the City of New York | Histone acetyltransferase activators and uses thereof |
| US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| WO2011084357A1 (en) | 2009-12-17 | 2011-07-14 | Schering Corporation | Modulation of pilr to treat immune disorders |
| KR101605932B1 (ko) * | 2009-12-18 | 2016-03-24 | 노파르티스 아게 | Hsf1-관련 질환을 치료하기 위한 유기 조성물 |
| SG181881A1 (en) | 2009-12-23 | 2012-07-30 | Gradalis Inc | Furin-knockdown bi-functional rna |
| EP3721943A1 (en) | 2009-12-23 | 2020-10-14 | Novartis AG | Lipids, lipid compositions and methods of using them |
| SG10201606680QA (en) | 2009-12-23 | 2016-10-28 | Gradalis Inc | Furin-knockdown and gm-csf-augmented (fang) cancer vaccine |
| WO2011080261A1 (en) | 2009-12-28 | 2011-07-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for improved cardiomyogenic differentiation of pluripotent cells |
| BR112012015959A2 (pt) | 2009-12-29 | 2019-09-24 | Hills Pet Nutrition Inc | composições incluindo gengibre para a melhora ou prevenção de condições inflamatórias |
| HUE045270T2 (hu) | 2010-01-05 | 2019-12-30 | Inst Nat Sante Rech Med | FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére |
| WO2011084193A1 (en) | 2010-01-07 | 2011-07-14 | Quark Pharmaceuticals, Inc. | Oligonucleotide compounds comprising non-nucleotide overhangs |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| DE102010004957A1 (de) | 2010-01-14 | 2011-07-21 | Universitätsklinikum Jena, 07743 | Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung |
| HUE034866T2 (hu) | 2010-01-15 | 2018-03-28 | Inst Nat Sante Rech Med | NKCC inhibitorok az autizmus kezelésére |
| DK2529033T3 (en) | 2010-01-26 | 2017-08-07 | Nat Jewish Health | PROCEDURES FOR PREVENTING THE RISK OF, DIAGNOSTICATION AND PROJECTING OF LUNG DISEASES |
| WO2011100058A1 (en) | 2010-02-09 | 2011-08-18 | Sangamo Biosciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| BR112012019609A2 (pt) | 2010-02-23 | 2019-09-24 | Basf Plant Science Gmbh | vetor de expressão isolado , plantas,transgenicas metodo para produzir uma planta transgenica e metodo para conferir a resistencia a nematoides em uma planta |
| AU2011223643A1 (en) | 2010-03-03 | 2012-06-28 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| US20110217309A1 (en) | 2010-03-03 | 2011-09-08 | Buck Elizabeth A | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| EP2860254A1 (en) | 2010-03-03 | 2015-04-15 | E. I. du Pont de Nemours and Company | Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides |
| DK3231872T3 (da) | 2010-03-08 | 2020-07-20 | Monsanto Technology Llc | Polynukleotidmolekyler til genregulering i planter |
| WO2011116209A2 (en) | 2010-03-17 | 2011-09-22 | The Regents Of The University Of Michigan | Using phage epitopes to profile the immune response |
| US9080171B2 (en) | 2010-03-24 | 2015-07-14 | RXi Parmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
| KR102453078B1 (ko) | 2010-03-24 | 2022-10-11 | 피오 파마슈티칼스 코프. | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| WO2011120023A1 (en) | 2010-03-26 | 2011-09-29 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting survivin gene expression uses thereof |
| EP2552460A1 (en) | 2010-03-29 | 2013-02-06 | Universite De Strasbourg | Polymers for delivering molecules of interest |
| JP5860029B2 (ja) | 2010-03-29 | 2016-02-16 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | トランスチレチン(TTR)関連眼アミロイドーシスのためのsiRNA療法 |
| KR20130043102A (ko) | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
| CA2792561C (en) | 2010-04-06 | 2021-10-26 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of cd274/pd-l1 gene |
| WO2011133584A2 (en) | 2010-04-19 | 2011-10-27 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting hras gene expression and uses thereof |
| WO2011133931A1 (en) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Use of il-27 antagonists for treating inflammatory bowel disease |
| EP2563922A1 (en) | 2010-04-26 | 2013-03-06 | Marina Biotech, Inc. | Nucleic acid compounds with conformationally restricted monomers and uses thereof |
| WO2011139842A2 (en) | 2010-04-28 | 2011-11-10 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof |
| EP2566967B1 (en) | 2010-05-04 | 2016-07-06 | The Brigham and Women's Hospital, Inc. | Cadherin-11 antagonist for the treatment of fibrosis |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| EP2977084B1 (en) | 2010-05-10 | 2017-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| CA2798886A1 (en) | 2010-05-11 | 2011-11-17 | Dow Agrosciences Llc | Saccharopolyspora spinosa with modified spnk |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
| KR101223660B1 (ko) | 2010-05-20 | 2013-01-17 | 광주과학기술원 | HIF-2α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 |
| JP6033218B2 (ja) | 2010-05-21 | 2016-11-30 | ペプティメド, インコーポレイテッド | がんを治療するための試薬および方法 |
| US20110293700A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| WO2011147968A1 (en) | 2010-05-28 | 2011-12-01 | Nunhems B.V. | Plants with increased fruit size |
| WO2011151321A1 (en) | 2010-05-31 | 2011-12-08 | Institut Curie | Asf1b as a prognosis marker and therapeutic target in human cancer |
| EP3456827A3 (en) | 2010-06-02 | 2019-05-08 | Alnylam Pharmaceuticals, Inc. | Compositions and methods directed to treating liver fibrosis |
| DE102010022937A1 (de) | 2010-06-04 | 2011-12-08 | Universitätsklinikum Jena | Zellspezifisch aktivierbare biologisch wirksame Moleküle auf Grundlage von siRNA, Verfahren zu deren Aktivierung sowie Applikationskit zur Verabreichung |
| GB201009601D0 (en) | 2010-06-08 | 2010-07-21 | Devgen Private Ltd | Method for down-grading gene expression in fungi |
| WO2011157798A1 (en) | 2010-06-16 | 2011-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for stimulating reepithelialisation during wound healing |
| BR112012029891A2 (pt) | 2010-06-21 | 2021-07-06 | Novozymes Inc | polipeptídeo isolado, uso do mesmo, composição, polinucleotídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira, e, métodos para produzir e para aumentar a produção de um ácido dicarboxílico c4. |
| WO2011163466A1 (en) | 2010-06-23 | 2011-12-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Regulation of skin pigmentation by neuregulin-1 (nrg-1) |
| EP2585071A1 (en) | 2010-06-28 | 2013-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical composition for use in the treatment of glaucoma |
| US8581042B2 (en) | 2010-06-30 | 2013-11-12 | Novozymes A/S | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| BR112012033668A2 (pt) | 2010-07-01 | 2017-06-13 | Du Pont | planta e semente transgênica, método para a produção de um planta transgênica, produto e/ou subproduto obtido a partir da semente transgênica, polinucleotídeo isolado e planta ou semente compreendendo uma cosntrução de dna recombinante |
| US9512188B2 (en) | 2010-07-12 | 2016-12-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Isolated polynucleotides and methods and plants using same for regulating plant acidity |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US9040671B2 (en) | 2010-07-23 | 2015-05-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for cancer management targeting Co-029 |
| US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| JP5903718B2 (ja) | 2010-08-09 | 2016-04-13 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Hiv−1感染の処置のための方法及び医薬的組成物 |
| AU2011289283B2 (en) | 2010-08-13 | 2015-04-30 | Pioneer Hi-Bred International, Inc. | Chimeric promoters and methods of use |
| EP3587574B1 (en) | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| US10865445B2 (en) | 2010-08-18 | 2020-12-15 | Fred Hutchinson Cancer Research Center | Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL |
| JP6106085B2 (ja) | 2010-08-24 | 2017-03-29 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| EP2609106A4 (en) * | 2010-08-26 | 2014-03-19 | Merck Sharp & Dohme | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2012030858A2 (en) | 2010-08-30 | 2012-03-08 | Novozymes A/S | Polypeptides having hemicellulolytic activity and polynucleotides encoding same |
| WO2012030799A1 (en) | 2010-08-30 | 2012-03-08 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US9187742B2 (en) | 2010-08-30 | 2015-11-17 | Novozymes, Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| WO2012030844A1 (en) | 2010-08-30 | 2012-03-08 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
| US8624082B2 (en) | 2010-08-30 | 2014-01-07 | Novozymes A/S | Polypeptides having xylanase activity and polynucleotides encoding same |
| WO2012030845A2 (en) | 2010-08-30 | 2012-03-08 | Novozymes A/S | Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same |
| US20130224192A1 (en) | 2010-09-02 | 2013-08-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for the prognosis of the progression of cancer |
| EP2621511A1 (en) | 2010-09-28 | 2013-08-07 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of bone density related diseases |
| US20140079769A1 (en) | 2010-10-01 | 2014-03-20 | Fabiola Terzi | Methods for predicting the progression and treating a chronic kidney disease in a patient |
| JP2014502144A (ja) | 2010-10-06 | 2014-01-30 | ビーピー・コーポレーション・ノース・アメリカ・インコーポレーテッド | バリアントcbhiポリペプチド |
| US20140134231A1 (en) | 2010-10-11 | 2014-05-15 | Sanford-Burnham Medical Research Institute | Mir-211 expression and related pathways in human melanoma |
| WO2012051491A1 (en) | 2010-10-14 | 2012-04-19 | The United States Of America, As Represented By The Secretary National Institutes Of Health | Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting |
| CN108404115A (zh) | 2010-10-15 | 2018-08-17 | 纽约市哥伦比亚大学理事会 | 肥胖症-相关的基因和它们的蛋白和其用途 |
| EP2633049B1 (en) | 2010-10-27 | 2018-10-10 | Harrisvaccines Inc | Methods and compositions to protect aquatic invertebrates from disease |
| CN107828820B (zh) | 2010-10-27 | 2022-06-07 | 学校法人自治医科大学 | 用于向神经系统细胞导入基因的腺相关病毒粒子 |
| US10004797B2 (en) | 2010-10-27 | 2018-06-26 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
| US8822427B2 (en) | 2010-10-27 | 2014-09-02 | Harrisvaccines | Methods and compositions to protect aquatic invertebrates from disease |
| BR112013010278B1 (pt) | 2010-10-27 | 2020-12-29 | Ceres, Inc | método para produzir uma planta, método para modular a composição de biomassa em uma planta, ácido nucleico isolado e método para alterar a composição de biomassa em uma planta |
| US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| WO2012058566A1 (en) | 2010-10-29 | 2012-05-03 | Novozymes A/S | Polypeptides having succinyl-coa:aceto acetate transferase activity and polynucleotides encoding same |
| EP2635308A2 (en) | 2010-11-01 | 2013-09-11 | Peptimed, Inc. | Compositions of a peptide targeting system for treating cancer |
| EP2635299B1 (en) | 2010-11-02 | 2019-07-31 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| US9212354B2 (en) | 2010-11-04 | 2015-12-15 | Novozymes Inc. | Polypeptides having cellobiohydrolase activitiy and polynucleotides encoding same |
| ES2950027T3 (es) | 2010-11-04 | 2023-10-04 | Arista Cereal Tech Pty Ltd | Trigo con alto contenido en amilosa |
| AU2011325871B2 (en) | 2010-11-05 | 2016-02-04 | Medvet Science Pty Ltd | Markers of endothelial progenitor cells and uses thereof |
| CN103370054A (zh) | 2010-11-09 | 2013-10-23 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
| WO2012062220A1 (en) | 2010-11-12 | 2012-05-18 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
| EP2455456A1 (en) | 2010-11-22 | 2012-05-23 | Institut Curie | Use of kinesin inhibitors in HIV infection treatment and a method for screening them |
| EP2643479B1 (en) | 2010-11-22 | 2017-09-13 | Rosetta Genomics Ltd | Methods and materials for classification of tissue of origin of tumor samples |
| US20130336979A1 (en) | 2010-12-01 | 2013-12-19 | Fatima Smih | Diagnostic and treatment of chronic heart failure |
| US9533041B2 (en) | 2010-12-03 | 2017-01-03 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of heart failure |
| CA2820706C (en) | 2010-12-03 | 2018-05-22 | Ms Technologies, Llc | Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells |
| EP2649181B1 (en) | 2010-12-06 | 2016-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
| US9150926B2 (en) | 2010-12-06 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Diagnosis and treatment of adrenocortical tumors using human microRNA-483 |
| US10202615B2 (en) | 2010-12-10 | 2019-02-12 | Vanderbilt University | Mammalian genes involved in toxicity and infection |
| US8575328B2 (en) * | 2010-12-14 | 2013-11-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Formicidae (ant) control using double-stranded RNA constructs |
| EP2655635A1 (en) | 2010-12-22 | 2013-10-30 | Pioneer Hi-Bred International, Inc. | Viral promoter, truncations thereof, and methods of use |
| EP2654428B1 (en) | 2010-12-22 | 2018-02-14 | The Trustees of Columbia University in the City of New York | Histone acetyltransferase modulators and usese thereof |
| BR112013014698A2 (pt) | 2010-12-22 | 2017-03-07 | E I Du Point De Nemours & Company | constructo de dna, vetor, célula vegetal, planta, semente transgênica proveniente da planta, método para expressão de uma sequência de nucleotídeos em uma planta, método para expressão de uma sequência de nucleotídeos em uma célula vegetal, método para expressar seletivamente uma sequência de nucleotídeos em tecidos de raiz, caule, grão e pendão de milho |
| WO2012093384A1 (en) | 2011-01-03 | 2012-07-12 | Rosetta Genomics Ltd. | Compositions and methods for treatment of ovarian cancer |
| KR102119187B1 (ko) | 2011-01-10 | 2020-06-08 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 줄기 세포 인자 억제제 |
| US20150018408A1 (en) | 2013-07-10 | 2015-01-15 | The Regents Of The University Of Michigan | Therapeutic antibodies and uses thereof |
| WO2012103350A1 (en) | 2011-01-26 | 2012-08-02 | Novozymes A/S | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| EP3235903B1 (en) | 2011-01-26 | 2021-07-07 | Novozymes A/S | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| EP2487242A1 (en) | 2011-02-09 | 2012-08-15 | Ruprecht-Karls-Universität Heidelberg | B-type plexin antagonists and uses thereof |
| WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
| NZ759163A (en) | 2011-02-14 | 2023-03-31 | Revivicor Inc | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
| BR112013020824A8 (pt) | 2011-02-15 | 2018-07-10 | Pioneer Hi Bred Int | molécula de ácido nucleico isolada, cassete de expressão, vetor, célula vegetal, planta, semente transgênica, método para expressar uma sequência de nucleotídeos em uma planta ou uma célula vegetal |
| WO2012116040A1 (en) | 2011-02-22 | 2012-08-30 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma |
| SG192961A1 (en) | 2011-03-03 | 2013-09-30 | Quark Pharmaceuticals Inc | Compositions and methods for treating lung disease and injury |
| AU2012223366B2 (en) | 2011-03-03 | 2017-02-23 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| US9796979B2 (en) | 2011-03-03 | 2017-10-24 | Quark Pharmaceuticals Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| WO2012120130A1 (en) | 2011-03-09 | 2012-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods to characterize patients suffering from hemolysis |
| US9409958B2 (en) | 2011-03-10 | 2016-08-09 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| JP2014515012A (ja) | 2011-03-15 | 2014-06-26 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 血管関連黄斑症およびその症状の診断および治療方法 |
| US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
| WO2012129145A1 (en) | 2011-03-18 | 2012-09-27 | OSI Pharmaceuticals, LLC | Nscle combination therapy |
| US8648230B2 (en) | 2011-03-18 | 2014-02-11 | Ms Technologies, Llc | Regulatory regions preferentially expressing in non-pollen plant tissue |
| WO2012140516A2 (en) | 2011-04-13 | 2012-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Non human animal model for ulcerative colitis and its main complications |
| JP5951752B2 (ja) | 2011-04-13 | 2016-07-13 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | Ptp1b発現のアンチセンス調節 |
| KR101291668B1 (ko) | 2011-04-21 | 2013-08-01 | 서울대학교산학협력단 | 미코박테리아―대장균용 셔틀 벡터 및 이의 용도 |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2012146702A1 (en) | 2011-04-28 | 2012-11-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing accessory cells and uses thereof for preparing activated nk cells |
| DK2702153T3 (en) | 2011-04-28 | 2019-03-18 | Novozymes Inc | Polypeptides with endoglucanase activity and polynucleotides encoding them |
| US9677084B2 (en) * | 2011-04-29 | 2017-06-13 | Pioneer Hi-Bred International, Inc. | Down-regulation of a homeodomain-leucine zipper I-class homeobox gene for improved plant performance |
| EP2520658B1 (en) | 2011-05-03 | 2015-10-07 | Dow AgroSciences LLC | Enhancing spinosyn production with oxygen binding proteins |
| JP6347743B2 (ja) | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
| EP2527448A1 (en) | 2011-05-23 | 2012-11-28 | Novozymes A/S | Simultaneous site-specific integrations of multiple gene-copies in filamentous fungi |
| EP2527432A1 (en) | 2011-05-23 | 2012-11-28 | Novozymes A/S | Bi-directional cytosine deaminase-encoding selection marker |
| EP2714934B1 (en) | 2011-05-24 | 2018-09-19 | Rosetta Genomics Ltd | Methods and compositions for determining heart failure or a risk of heart failure |
| ES2597052T3 (es) | 2011-05-25 | 2017-01-13 | Université Paris Descartes | Inhibidores de ERK para su uso en el tratamiento de atrofia muscular espinal |
| WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
| WO2012170304A2 (en) | 2011-06-02 | 2012-12-13 | The Regents Of The University Of California | Plants with elevated levels of glucan |
| WO2012167173A1 (en) | 2011-06-02 | 2012-12-06 | The University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
| US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
| TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Hsp47表現調控強化用類視色素脂質體 |
| GB201109966D0 (en) | 2011-06-10 | 2011-07-27 | Cancer Res Inst Royal | Materials and methods for treating pten mutated or deficient cancer |
| SG10201604726YA (en) | 2011-06-10 | 2016-07-28 | Temasek Life Sciences Lab Ltd | Genetic manipulation and expression systems for pucciniomycotina and ustilaginomycotina subphyla |
| GB201109965D0 (en) | 2011-06-10 | 2011-07-27 | Cancer Res Inst Royal | Materials and methods for treating estrogen receptor alpher(ER) positive cancer |
| CA2838246C (en) | 2011-06-13 | 2018-07-10 | Csl Limited | Antibodies against g-csfr and uses thereof |
| US9228188B2 (en) | 2011-06-21 | 2016-01-05 | Alnylam Pharmaceuticals, Inc. | Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression |
| MX344807B (es) | 2011-06-21 | 2017-01-09 | Alnylam Pharmaceuticals Inc | Composiciones y metodos para inhibicion de genes para alipoproteina c-iii (apoc3). |
| CA2839896A1 (en) | 2011-06-21 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
| EP2723351B1 (en) | 2011-06-21 | 2018-02-14 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibition of expression of protein c (proc) genes |
| EP3366312A1 (en) | 2011-06-23 | 2018-08-29 | Alnylam Pharmaceuticals, Inc. | Serpina 1 sirnas: compositions of matter and methods of treatment |
| WO2012175711A1 (en) | 2011-06-24 | 2012-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the responsiveness of a patient affected with an osteosarcoma to a chemotherapy |
| WO2013003697A1 (en) | 2011-06-30 | 2013-01-03 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
| WO2013001372A2 (en) | 2011-06-30 | 2013-01-03 | University Of Oslo | Methods and compositions for inhibition of activation of regulatory t cells |
| LT2729173T (lt) | 2011-07-06 | 2016-10-10 | Sykehuset Sorlandet Hf | Egfr taikinių terapija |
| EP2734632A1 (en) | 2011-07-21 | 2014-05-28 | The Regents of the University of California | Transcription factors for the production of cellulose degrading enzymes |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| WO2013015152A1 (ja) | 2011-07-22 | 2013-01-31 | 公立大学法人横浜市立大学 | mRNAのpoly(A)鎖および/または3'末端配列の一部を切断し、翻訳反応を抑制する技術 |
| WO2013014262A1 (en) | 2011-07-27 | 2013-01-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating myhre syndrome |
| US9487761B2 (en) | 2011-08-10 | 2016-11-08 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| WO2013021064A1 (en) | 2011-08-10 | 2013-02-14 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| WO2013021060A1 (en) | 2011-08-10 | 2013-02-14 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| WO2013021065A1 (en) | 2011-08-10 | 2013-02-14 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| WO2013021062A1 (en) | 2011-08-10 | 2013-02-14 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| WO2013021059A1 (en) | 2011-08-10 | 2013-02-14 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| US9382559B2 (en) | 2011-08-10 | 2016-07-05 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| BR112014002988A2 (pt) * | 2011-08-12 | 2017-03-01 | Bayer Cropscience Nv | expressão específica de célula de proteção de transgenes em algodão |
| EP2741777B1 (en) | 2011-08-12 | 2017-01-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| WO2013028928A1 (en) | 2011-08-24 | 2013-02-28 | Novozymes, Inc. | Cellulolytic enzyme compositions and uses thereof |
| US9663772B2 (en) | 2011-08-24 | 2017-05-30 | Novozymes, Inc. | Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof |
| WO2013033380A1 (en) | 2011-08-31 | 2013-03-07 | Genentech, Inc. | Diagnostic markers |
| EP3098314B1 (en) | 2011-09-02 | 2019-03-13 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat hsf1-related diseases |
| CA2857374A1 (en) | 2011-09-02 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Camkii, ip3r, calcineurin, p38 and mk2/3 inhibitors to treat metabolic disturbances of obesity |
| US9593062B2 (en) | 2011-09-07 | 2017-03-14 | Deutschland Krebsforschungszentrum | Means and methods for treating and/or preventing natural AHR ligand-dependent cancer |
| CN104136451A (zh) | 2011-09-07 | 2014-11-05 | 玛瑞纳生物技术有限公司 | 具有构象限制的单体的核酸化合物的合成和用途 |
| AU2012305714A1 (en) | 2011-09-09 | 2014-03-27 | Biomed Realty, L.P. | Methods and compositions for controlling assembly of viral proteins |
| WO2013036799A2 (en) | 2011-09-09 | 2013-03-14 | Fred Hutchinson Cancer Research Center | Methods and compositions involving nkg2d inhibitors and cancer |
| AU2012308753B2 (en) * | 2011-09-13 | 2018-05-17 | Monsanto Technology Llc | Methods and compositions for weed control |
| BR112014005958A2 (pt) | 2011-09-13 | 2020-10-13 | Monsanto Technology Llc | métodos e composições químicas agrícolas para controle de planta, método de redução de expressão de um gene accase em uma planta, cassete de expressão microbiana, método para fazer um polinucleotídeo, método de identificação de polinucleotídeos úteis na modulação de expressão do gene accase e composição herbicida |
| US9840715B1 (en) | 2011-09-13 | 2017-12-12 | Monsanto Technology Llc | Methods and compositions for delaying senescence and improving disease tolerance and yield in plants |
| AU2012308737B2 (en) * | 2011-09-13 | 2018-06-14 | Monsanto Technology Llc | Methods and compositions for weed control |
| UA115534C2 (uk) * | 2011-09-13 | 2017-11-27 | Монсанто Текнолоджи Ллс | Спосіб та композиція для боротьби з бур'янами (варіанти) |
| US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
| WO2013040049A1 (en) | 2011-09-13 | 2013-03-21 | Monsanto Technology Llc | Methods and compositions for weed control |
| MX350771B (es) | 2011-09-13 | 2017-09-15 | Monsanto Technology Llc | Métodos y composiciones para el control de malezas. |
| CN103958539B (zh) * | 2011-09-13 | 2019-12-17 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
| CA2848695A1 (en) | 2011-09-13 | 2013-03-21 | Monsanto Technology Llc | Methods and composition for weed control comprising inhibiting ppg oxidase |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| US9920326B1 (en) | 2011-09-14 | 2018-03-20 | Monsanto Technology Llc | Methods and compositions for increasing invertase activity in plants |
| WO2013043910A1 (en) | 2011-09-20 | 2013-03-28 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US9352312B2 (en) | 2011-09-23 | 2016-05-31 | Alere Switzerland Gmbh | System and apparatus for reactions |
| BR112014007569A2 (pt) | 2011-09-30 | 2017-04-18 | Genentech Inc | marcadores de metilação diagnósticos fenótipo epitelial ou mesenquimal e a resposta ao inibidor da quinase de egfr em tumores ou células tumorais |
| US20150038496A1 (en) | 2011-10-03 | 2015-02-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and pharmaceutical compositions for the treatment of th2 mediated diseases |
| EA028662B1 (ru) | 2011-10-04 | 2017-12-29 | Байер Интеллекчуал Проперти Гмбх | Рнк-интерференция для борьбы с грибами и оомицетами путем ингибирования гена сахаропиндегидрогеназы |
| PE20141562A1 (es) | 2011-10-14 | 2014-11-12 | Genentech Inc | Anticuerpos anti-htra1 y metodos de uso |
| US20150018383A1 (en) | 2011-10-14 | 2015-01-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Biomarkers of renal disorders |
| WO2013059496A1 (en) | 2011-10-18 | 2013-04-25 | Dicerna Pharmaceuticals, Inc. | Amine cationic lipids and uses thereof |
| WO2013057313A1 (en) | 2011-10-20 | 2013-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the detection and the treatment of cardiac remodeling |
| BR122020026837B1 (pt) | 2011-11-02 | 2021-04-13 | Ceres, Inc | Método de aumento do rendimento de planta em solo contendo níveis elevados de al3+, método de aumento da tolerância de uma planta |
| AU2012332517B9 (en) | 2011-11-03 | 2017-08-10 | Quark Pharmaceuticals, Inc. | Methods and compositions for neuroprotection |
| US9357722B2 (en) | 2011-11-04 | 2016-06-07 | Arista Cereal Technologies Pty Limited | High amylose wheat-II |
| EP2776130A1 (en) | 2011-11-07 | 2014-09-17 | Institut National de la Sante et de la Recherche Medicale (INSERM) | A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis |
| US20140323549A1 (en) | 2011-11-08 | 2014-10-30 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
| WO2013075644A1 (en) | 2011-11-22 | 2013-05-30 | Novozymes, Inc. | Polypeptides having beta-xylosidase activity and polynucleotides encoding same |
| US20140328864A1 (en) | 2011-11-22 | 2014-11-06 | Inserm (Institut National De La Sente Et De La Recherche Medicale) | Methods and pharmaceutical compositions for reducing airway hyperresponse |
| US9624481B2 (en) | 2011-12-01 | 2017-04-18 | Novozymes, Inc. | Polypeptides having beta-xylosidase activity and polynucleotides encoding same |
| WO2013079531A2 (en) | 2011-12-02 | 2013-06-06 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| US9404093B2 (en) | 2011-12-02 | 2016-08-02 | Novozymes A/S | Polypeptides having peroxygenase activity and polynucleotides encoding same |
| BR112014013853A2 (pt) | 2011-12-09 | 2020-01-14 | Ceres Inc | uso de um ácido nucleico isolado, método de obtenção de uma célula vegetal transgênica, método de obtenção de uma planta transgênica, método de produção de uma planta, método de produção de biomassa, método de processamento de biomassa, método de alteração da composição de biomassa, método de modulação de composição de biomassa, método de produção de um produto de forragem |
| UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
| EP3272862A1 (en) | 2011-12-16 | 2018-01-24 | Novozymes, Inc. | Polypeptides having laccase activity and polynucleotides encoding same |
| CA2860416C (en) | 2011-12-27 | 2024-04-30 | Commonwealth Scientific And Industrial Research Organisation | Production of dihydrosterculic acid and derivatives thereof |
| WO2013096992A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Reserach Organisation | Simultaneous gene silencing and supressing gene silencing in the same cell |
| WO2013096993A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
| WO2013101783A2 (en) | 2011-12-30 | 2013-07-04 | Bio-Rad Laboratories, Inc. | Methods and compositions for performing nucleic acid amplification reactions |
| MX355636B (es) | 2012-01-06 | 2018-04-25 | Pioneer Hi Bred Int | Composiciones y métodos para la expresión de una secuencia en un tejido reproductor de una planta. |
| CA2860783A1 (en) | 2012-01-06 | 2013-07-11 | Pioneer Hi-Bred International, Inc. | Ovule specific promoter and methods of use |
| US9006515B2 (en) | 2012-01-06 | 2015-04-14 | Pioneer Hi Bred International Inc | Pollen preferred promoters and methods of use |
| BR112014016870A2 (pt) | 2012-01-09 | 2017-06-27 | Huesken Dieter | composições orgânicas para tratar doenças relacionadas com beta-catenina |
| CA2860864A1 (en) | 2012-01-11 | 2013-07-18 | The Australian National University | Method for modulating plant root architecture |
| WO2013109738A1 (en) | 2012-01-17 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | Novel phosphodiesterase inhibitors and uses thereof |
| GB201201332D0 (en) | 2012-01-26 | 2012-03-14 | Imp Innovations Ltd | Method |
| WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
| CN107119060A (zh) | 2012-02-01 | 2017-09-01 | 陶氏益农公司 | 草甘膦抗性植物和相关方法 |
| WO2013121034A1 (en) | 2012-02-17 | 2013-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reducing adipose tissue inflammation |
| BR112014018876A2 (pt) | 2012-02-20 | 2017-07-04 | Novozymes As | polipeptídeo isolado com atividade endoglicanase, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, método de produção de um polipeptídeo |
| US9663560B2 (en) * | 2012-02-28 | 2017-05-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Cotton PHYA1 RNAi improves fiber quality, root elongation, flowering, maturity and yield potential in Gossypium hirsutum L |
| CN104168898A (zh) | 2012-03-16 | 2014-11-26 | 霍夫曼-拉罗奇有限公司 | 以pak1抑制剂治疗黑色素瘤的方法 |
| KR102135601B1 (ko) | 2012-03-29 | 2020-07-20 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 탈모 질환의 치료 방법 |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| EP2650013A1 (en) | 2012-04-10 | 2013-10-16 | Deutsches Krebsforschungszentrum | Inhibitors of Receptor for Advanced Glycation-End products (RAGE) for use in treating and/or preventing inflammation- and/or damage-induced cancer |
| US10100321B2 (en) | 2012-04-19 | 2018-10-16 | Temasek Life Sciences Laboratory Limited | Methods for increasing cotton fiber length |
| BR112014025983A2 (pt) | 2012-04-20 | 2018-07-03 | Futuragene Israel Ltd | molécula de ácido ribonucleico, dsrna, vetor, célula hospedeira, tecido vegetal, ácido nucleico e métodos de produção de plantas e de inibição de infestação de pragas |
| BR112014024804A2 (pt) | 2012-04-23 | 2017-07-11 | Novozymes As | polipeptídeo isolado tendo atividade de glucuronil esterase, composição, polinucleotídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, métodos para a produção de um polipeptídeo, para a degradação ou conversão de um material celulósico e para a produção de um produto de fermentação |
| BR112014026268A2 (pt) | 2012-04-23 | 2017-07-18 | Novozymes As | polipeptídeo isolado, composição, polinucleotídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, métodos de produção de um polipeptídeo e de degradação ou conversão de um material celulósico |
| WO2013163085A2 (en) | 2012-04-23 | 2013-10-31 | Futuragene Israel Ltd. | Glycaspis brimblecombei control agents |
| CN104619164B (zh) | 2012-04-25 | 2018-11-16 | 联邦科学技术研究组织 | 高油酸油 |
| EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| WO2013164444A1 (en) | 2012-05-03 | 2013-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment and diagnotic of anemia of inflammation |
| US20150126573A1 (en) | 2012-05-09 | 2015-05-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| WO2013171296A1 (en) | 2012-05-16 | 2013-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic and treatment of sarcoidosis |
| EP2852679A1 (en) | 2012-05-22 | 2015-04-01 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosing and treating focal segmental glomerulosclerosis |
| IN2014MN02404A (enExample) | 2012-05-24 | 2015-08-21 | Seeds Ltd Ab | |
| ES2683380T3 (es) | 2012-06-08 | 2018-09-26 | Sensorion | Inhibidores del receptor H4 para tratar el tinnitus |
| WO2013187556A1 (en) | 2012-06-14 | 2013-12-19 | Scripps Korea Antibody Institute | Novel antibody specific for clec14a and uses thereof |
| EP2864485A4 (en) | 2012-06-22 | 2016-03-02 | Univ California | COMPOSITIONS AND METHODS FOR IMPROVING PLANT STATE DEVELOPMENT AS A RESPONSE TO CARBON DIOXIDE AND APPLICATIONS FOR MANIPULATING THE NON-RESISTANCE OF PLANTS |
| WO2014001451A1 (en) | 2012-06-27 | 2014-01-03 | Metanomics Health Gmbh | Methods for identifying diabetes drugs |
| WO2014006025A2 (en) | 2012-07-02 | 2014-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Marker of pathogenicity in salmonella |
| PL2875049T3 (pl) | 2012-07-18 | 2019-07-31 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Sposoby zapobiegania i leczenia przewlekłej choroby nerek (ckd) |
| US20150175979A1 (en) | 2012-07-23 | 2015-06-25 | La Jolla Institute For Allergy And Immunology | Ptprs and proteoglycans in autoimmune disease |
| US9655977B2 (en) | 2012-08-31 | 2017-05-23 | The General Hospital Corporation | Biotin complexes for treatment and diagnosis of alzheimer's disease |
| EP2897633B1 (en) | 2012-09-18 | 2020-01-01 | UTI Limited Partnership | Treatment of pain by inhibition of usp5 de-ubiquitinase |
| BR112015006176B1 (pt) | 2012-09-21 | 2023-04-18 | Intensity Therapeutics, Inc | Uso de um agente terapêutico e de um agente de intensificação de permeação intracelular |
| US20150259701A1 (en) * | 2012-10-03 | 2015-09-17 | Futuragene Israel Ltd. | Gall wasp control agents |
| WO2014055825A1 (en) | 2012-10-04 | 2014-04-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | A formulation of mycobacterial components as an adjuvant for inducing th17 responses |
| WO2014053871A1 (en) | 2012-10-04 | 2014-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for screening a compound capable of inhibiting the notch1 transcriptional activity |
| EP2905337A4 (en) | 2012-10-05 | 2016-10-12 | Bioneer Corp | AMPHIREGULIN SPECIFIC DOUBLE HELIX OLIGO RNA, DOUBLE HELIX OLIGO RNA STRUCTURE WITH THE DOUBLE HELIX OLIGO RNA AND COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASES THEREWITH |
| WO2014058896A1 (en) | 2012-10-08 | 2014-04-17 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| ES2776029T3 (es) | 2012-10-08 | 2020-07-28 | St Jude Childrens Res Hospital | Terapias basadas en el control de la estabilidad y función de las células T reguladoras por medio de un eje neuropilina-1:semaforina |
| EP2906589A1 (en) | 2012-10-10 | 2015-08-19 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for treatment of gastrointestinal stromal tumors |
| US20150259696A1 (en) | 2012-10-11 | 2015-09-17 | Shane E. Abbitt | Guard cell promoters and uses thereof |
| WO2014056920A2 (en) | 2012-10-12 | 2014-04-17 | Novozymes A/S | Polypeptides having peroxygenase activity |
| US9458435B2 (en) | 2012-10-12 | 2016-10-04 | Novozymes A/S | Polypeptides having peroxygenase activity |
| WO2014056922A2 (en) | 2012-10-12 | 2014-04-17 | Novozymes A/S | Polypeptides having peroxygenase activity |
| CN104718287B (zh) | 2012-10-12 | 2018-02-06 | 诺维信公司 | 具有过氧合酶活性的多肽 |
| CN104704116B (zh) | 2012-10-12 | 2018-09-28 | 诺维信公司 | 具有过氧合酶活性的多肽 |
| WO2014056927A2 (en) | 2012-10-12 | 2014-04-17 | Novozymes A/S | Polypeptides having peroxygenase activity |
| EP2906685B1 (en) | 2012-10-12 | 2018-08-15 | Novozymes A/S | Polypeptides having peroxygenase activity |
| WO2014062989A2 (en) | 2012-10-18 | 2014-04-24 | Monsanto Technology Llc | Methods and compositions for plant pest control |
| EP2908864B1 (en) | 2012-10-22 | 2019-12-11 | Sabag-Rfa Ltd. | Phosphate compounds for delivering therapeutic agents into living cells and cells nuclei |
| HK1212216A1 (en) | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| US20150275194A1 (en) | 2012-10-24 | 2015-10-01 | Novozymes A/S | Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same |
| IN2015DN03795A (enExample) | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
| WO2014064203A1 (en) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
| WO2014064192A1 (en) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment and prediction of myocardial infraction |
| EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
| EP2917347B1 (en) | 2012-11-08 | 2019-01-02 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of bone metastases |
| EP2732815A1 (en) | 2012-11-16 | 2014-05-21 | Neurochlore | Modulators of intracellular chloride concentration for treating fragile X syndrome |
| HUE035887T2 (en) | 2012-12-05 | 2018-05-28 | Alnylam Pharmaceuticals Inc | PCSK9 iRNA preparations and methods for their use |
| AR093909A1 (es) | 2012-12-12 | 2015-06-24 | Bayer Cropscience Ag | Uso de ingredientes activos para controlar nematodos en cultivos resistentes a nematodos |
| US9486473B2 (en) | 2012-12-13 | 2016-11-08 | Ymir Genomics, Llc | MicroRNAs and uses thereof |
| WO2014091466A2 (en) | 2012-12-14 | 2014-06-19 | Indian Agricultural Research Institute | A method for the control of nematodes in plants |
| WO2014093835A1 (en) | 2012-12-14 | 2014-06-19 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US20150337280A1 (en) | 2012-12-19 | 2015-11-26 | Novozymes A/S | Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same |
| CA2891855A1 (en) | 2012-12-21 | 2014-06-26 | Sykehuset Sorlandet Hf | Egfr targeted therapy of neurological disorders and pain |
| BR112015014624A2 (pt) | 2012-12-24 | 2017-10-10 | Novozymes As | polipeptídeo isolado, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, método para tratamento de têxtil |
| US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
| UY35251A (es) | 2013-01-01 | 2014-07-31 | Seeds Ltd Ab | MOLÉCULAS DE dsRNA AISLADAS Y MÉTODOS PARA USARLAS PARA SILENCIAR MOLÉCULAS DIANA DE INTERÉS |
| US10258682B2 (en) | 2013-01-16 | 2019-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Attenuated chlamydia vaccine |
| US10000767B2 (en) | 2013-01-28 | 2018-06-19 | Monsanto Technology Llc | Methods and compositions for plant pest control |
| EP2951589A1 (en) | 2013-02-01 | 2015-12-09 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting and preventing metastasis in triple negative breast cancers |
| HK1211887A1 (en) | 2013-02-04 | 2016-06-03 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| WO2014122199A1 (en) | 2013-02-06 | 2014-08-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of chronic intestinal pseudo-obstruction |
| EP2767594A1 (en) | 2013-02-19 | 2014-08-20 | Deutsches Krebsforschungszentrum | The signature of Wnt/ß-catenin signaling in Cancer |
| WO2014128127A1 (en) | 2013-02-19 | 2014-08-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of prostate cancer |
| CA2941010A1 (en) | 2013-02-26 | 2014-09-04 | Triact Therapeutics, Inc. | Cancer therapy |
| CN105143470B (zh) | 2013-02-28 | 2020-06-09 | 德克萨斯大学系统董事会 | 用于将癌症分类为易感于tmepai定向疗法以及治疗所述癌症的方法 |
| WO2014135655A1 (en) | 2013-03-06 | 2014-09-12 | Institut Curie | Compositions and methods for treating muscle-invasive bladder cancer |
| CN107879960B (zh) | 2013-03-08 | 2021-06-22 | 诺华股份有限公司 | 用于传递活性成分的脂质和脂质组合物 |
| US9243258B2 (en) | 2013-03-12 | 2016-01-26 | Pioneer Hi Bred International Inc | Root-preferred promoter and methods of use |
| US9273322B2 (en) | 2013-03-12 | 2016-03-01 | Pioneer Hi Bred International Inc | Root-preferred promoter and methods of use |
| CA2905027A1 (en) | 2013-03-13 | 2014-10-09 | Monsanto Technology Llc | Methods and compositions for weed control |
| MX2015012334A (es) | 2013-03-13 | 2016-02-05 | Monsanto Technology Llc | Metodos y composiciones para el control de malezas. |
| EP3699592A1 (en) | 2013-03-13 | 2020-08-26 | Geneweave Biosciences Inc. | Non-replicative transduction particles and transduction particle-based reporter systems |
| WO2014140167A1 (en) | 2013-03-14 | 2014-09-18 | Dsm Ip Assets B.V. | Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof |
| US20140283211A1 (en) | 2013-03-14 | 2014-09-18 | Monsanto Technology Llc | Methods and Compositions for Plant Pest Control |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| WO2014140165A1 (en) | 2013-03-14 | 2014-09-18 | Dsm Ip Assets B.V. | Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof |
| US9688767B2 (en) | 2013-03-15 | 2017-06-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of predicting survival time in myocardial infarction patients by measuring BAFF levels |
| US9546364B2 (en) | 2013-03-15 | 2017-01-17 | Carnegie Mellon University | Synthetic lariat RNA for RNA interference |
| EP2968551B1 (en) | 2013-03-15 | 2021-05-05 | The Trustees of Columbia University in the City of New York | Fusion proteins and methods thereof |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| CA2907184C (en) | 2013-03-15 | 2022-12-06 | Sutter West Bay Hospitals | Falz for use as a target for therapies to treat cancer |
| US20160051556A1 (en) | 2013-03-21 | 2016-02-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and Pharmaceutical Composition for use in the Treatment of Chronic Liver Diseases Associated with a Low Hepcidin Expression |
| WO2014170712A1 (en) | 2013-04-15 | 2014-10-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Rac-1 inhibitors or pi3k inhibitors for preventing intestinal barrier dysfunction |
| CA2909434A1 (en) | 2013-04-18 | 2014-10-23 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof |
| US20160083424A1 (en) | 2013-04-26 | 2016-03-24 | Oslo Universitetssykehus Hf | Compositions and methods for targeting antigen-presenting cells |
| EP2810952A1 (en) | 2013-06-03 | 2014-12-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Novel pest control methods |
| NZ631602A (en) | 2013-06-13 | 2019-09-27 | Grains Res & Dev Corp | Barley with very low levels of hordeins |
| US10155001B2 (en) | 2013-06-14 | 2018-12-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | RAC1 inhibitors for inducing bronchodilation |
| WO2014203189A1 (en) | 2013-06-18 | 2014-12-24 | Rosetta Genomics Ltd. | Nanocarrier system for micrornas and uses thereof |
| ES2982449T3 (es) | 2013-06-25 | 2024-10-16 | Walter & Eliza Hall Inst Medical Res | Miméticos Smac para su uso en el tratamiento de una infección persistente por VIH |
| US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
| CA2917102A1 (en) | 2013-07-03 | 2015-01-08 | City Of Hope | Anticancer combinations |
| WO2015001053A1 (en) | 2013-07-03 | 2015-01-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the screening of substances that may be useful for the prevention and treatment of infections by enterobacteriaceae family |
| US10899756B2 (en) | 2013-07-17 | 2021-01-26 | The Trustees Of Columbia University In The City Of New York | Phosphodiesterase inhibitors and uses thereof |
| JP6668236B2 (ja) | 2013-07-19 | 2020-03-18 | モンサント テクノロジー エルエルシー | Leptinotarsa防除用組成物及びその方法 |
| US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
| US20160208247A1 (en) | 2013-07-31 | 2016-07-21 | Qbi Enterprises Ltd. | Methods of use of sphingolipid polyalkylamine oligonucleotide compounds |
| EP3027222A1 (en) | 2013-07-31 | 2016-06-08 | QBI Enterprises Ltd. | Sphingolipid-polyalkylamine-oligonucleotide compounds |
| EP2835423A1 (en) | 2013-08-09 | 2015-02-11 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Ligase E3 RNF185 inhibitors and uses thereof |
| EP3044593A4 (en) | 2013-09-09 | 2017-05-17 | Triact Therapeutics, Inc. | Cancer therapy |
| CA2923629A1 (en) | 2013-09-11 | 2015-03-19 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
| WO2015036618A1 (en) | 2013-09-16 | 2015-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of epilepsy |
| US20160250249A1 (en) | 2013-10-03 | 2016-09-01 | Inserm ( Institute National De Lasanté Et De La Re Cherche Médicale) | Methods and pharmaceutical compositions for modulating autophagy in a subject in need thereof |
| WO2015051366A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Novel formats for organic compounds for use in rna interference |
| WO2015051044A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Novel formats for organic compounds for use in rna interference |
| EP3052107B1 (en) | 2013-10-04 | 2018-05-02 | Novartis AG | Organic compounds to treat hepatitis b virus |
| CN105683163B (zh) | 2013-10-04 | 2018-11-09 | 诺华股份有限公司 | RNA干扰中使用的RNAi剂的3’端帽 |
| WO2015054451A1 (en) | 2013-10-09 | 2015-04-16 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma |
| JP2016537965A (ja) | 2013-10-11 | 2016-12-08 | ジェネンテック, インコーポレイテッド | Nsp4阻害剤及び使用方法 |
| EP3057434A4 (en) | 2013-10-16 | 2017-05-03 | The Australian National University | Method for modulating plant growth |
| EP2862928A1 (en) | 2013-10-18 | 2015-04-22 | Université de Strasbourg | Dynamin 2 inhibitor for the treatment of centronuclear myopathies |
| US9540642B2 (en) | 2013-11-04 | 2017-01-10 | The United States Of America, As Represented By The Secretary Of Agriculture | Compositions and methods for controlling arthropod parasite and pest infestations |
| BR102014027442B1 (pt) | 2013-11-04 | 2022-09-27 | Dow Agrosciences Llc | Molécula de ácido nucleico recombinante, uso de uma planta de milho, parte de planta de milho ou célula de planta de milho compreendendo a mesma e método para produzir uma célula vegetal transgênica compreendendo um dna de interesse |
| EP3862434A1 (en) | 2013-11-04 | 2021-08-11 | Dow AgroSciences LLC | Optimal soybean loci |
| WO2015066638A2 (en) | 2013-11-04 | 2015-05-07 | Dow Agrosciences Llc | Optimal maize loci |
| WO2015069459A1 (en) | 2013-11-05 | 2015-05-14 | Novartis Ag | Organic compounds |
| WO2015070009A2 (en) | 2013-11-08 | 2015-05-14 | The Board Of Regents Of The University Of Texas System | Vh4 antibodies against gray matter neuron and astrocyte |
| US10004814B2 (en) | 2013-11-11 | 2018-06-26 | Sirna Therapeutics, Inc. | Systemic delivery of myostatin short interfering nucleic acids (siNA) conjugated to a lipophilic moiety |
| US9932588B2 (en) | 2013-11-15 | 2018-04-03 | Northwestern University | Inhibition of oxidative stress in atrial fibrillation |
| EP3074513A1 (en) | 2013-11-26 | 2016-10-05 | Novozymes A/S | Enzyme compositions and uses thereof |
| DK3074038T3 (en) | 2013-11-28 | 2019-03-11 | Csl Ltd | METHOD OF TREATING DIABETIC NEPHROPATHY |
| CN113151180A (zh) | 2013-12-02 | 2021-07-23 | 菲奥医药公司 | 癌症的免疫治疗 |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
| EP3079475B1 (en) | 2013-12-11 | 2020-10-07 | Sloan-kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| JP6553618B2 (ja) | 2013-12-18 | 2019-07-31 | シーエスエル リミティド | 創傷を治療する方法 |
| WO2015095346A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| PT3083556T (pt) | 2013-12-19 | 2020-03-05 | Novartis Ag | Lípidos e composições lipídicas para a entrega de agentes ativos |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| US9822368B2 (en) | 2013-12-20 | 2017-11-21 | Fondazione Istituto Italiano Di Tecnologia | Modulators of intracellular chloride concentration for treating down syndrome |
| US9274117B2 (en) | 2013-12-21 | 2016-03-01 | Catholic University Industry Academic | Use of SIRT7 as novel cancer therapy target and method for treating cancer using the same |
| EP3088001B1 (en) | 2013-12-27 | 2020-02-12 | National University Corporation Kochi University | Anti-lipolysis stimulated liporotein receptor antibodies for treatment of ovarian cancer |
| TW201527314A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子(三) |
| TW201527313A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子(二) |
| TW201527312A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子(一) |
| TW201527316A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子(五) |
| US9944648B2 (en) | 2014-01-09 | 2018-04-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN105979770B (zh) | 2014-01-15 | 2019-07-05 | 孟山都技术公司 | 用于使用epsps多核苷酸的杂草控制的方法和组合物 |
| WO2015118167A1 (en) | 2014-02-10 | 2015-08-13 | Institut Curie | Use of mcoln-1 modulators to regulate cell migration |
| TW201538518A (zh) | 2014-02-28 | 2015-10-16 | Dow Agrosciences Llc | 藉由嵌合基因調控元件所賦予之根部特異性表現 |
| ES2782125T3 (es) | 2014-03-11 | 2020-09-10 | Cellectis | Método para generar linfocitos T compatibles para trasplante alogénico |
| WO2015140351A1 (en) | 2014-03-21 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing myelination |
| US9856475B2 (en) | 2014-03-25 | 2018-01-02 | Arcturus Therapeutics, Inc. | Formulations for treating amyloidosis |
| JP6771387B2 (ja) | 2014-03-25 | 2020-10-21 | アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. | 遺伝子サイレンシング用トランスサイレチン対立遺伝子選択的unaオリゴマー |
| AU2015236215B2 (en) | 2014-03-25 | 2020-03-19 | Arcturus Therapeutics, Inc. | UNA oligomers having reduced off-target effects in gene silencing |
| CN106413390B (zh) | 2014-04-01 | 2019-09-27 | 孟山都技术公司 | 用于控制虫害的组合物和方法 |
| EP3128008B1 (en) | 2014-04-04 | 2024-05-29 | Bioneer Corporation | Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| WO2015158760A1 (en) | 2014-04-16 | 2015-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | ApoO FOR USE IN A METHOD FOR TREATING CANCER AND VARIOUS PATHOPHYSIOLOGICAL SITUATIONS |
| EP2932969A1 (en) | 2014-04-17 | 2015-10-21 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Pancreatic cancer therapy and diagnosis |
| CA2947270A1 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic acids targeting mdm2 or mycn |
| US9101100B1 (en) | 2014-04-30 | 2015-08-11 | Ceres, Inc. | Methods and materials for high throughput testing of transgene combinations |
| US9545417B2 (en) | 2014-05-01 | 2017-01-17 | The Johns Hopkins University | Methods of inhibiting cancer stem cells with HMGA1 inhibitors |
| US10258639B2 (en) | 2014-05-06 | 2019-04-16 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy |
| KR101633881B1 (ko) | 2014-05-08 | 2016-06-28 | 고려대학교 산학협력단 | 도파민 의존성 신경장애 치료를 위한 REV-ERBα 유전자의 용도 |
| KR101633876B1 (ko) | 2014-05-08 | 2016-06-28 | 고려대학교 산학협력단 | 정서장애 및 중독질환 치료를 위한 REV-ERBα 유전자의 용도 |
| DK3152315T3 (en) | 2014-06-06 | 2018-11-26 | Novozymes As | ENZYME COMPOSITIONS AND APPLICATIONS THEREOF |
| EP3158067B1 (en) | 2014-06-23 | 2020-08-12 | Monsanto Technology LLC | Compositions and methods for regulating gene expression via rna interference |
| CN106460022B (zh) | 2014-06-24 | 2018-06-05 | 加州大学董事会 | 木糖甙木糖醇寡聚物的生产方法 |
| US11807857B2 (en) | 2014-06-25 | 2023-11-07 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
| PH12016502588B1 (en) | 2014-07-07 | 2024-01-17 | Commw Scient Ind Res Org | Processes for producing industrial products from plant lipids |
| WO2016005422A1 (en) | 2014-07-09 | 2016-01-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating neuropathic pain |
| CA2955191C (en) | 2014-07-15 | 2024-03-12 | Ceres, Inc. | Methods of increasing crop yield under abiotic stress |
| WO2016010840A1 (en) | 2014-07-16 | 2016-01-21 | Novartis Ag | Method of encapsulating a nucleic acid in a lipid nanoparticle host |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| AR101348A1 (es) | 2014-07-29 | 2016-12-14 | Monsanto Technology Llc | Composiciones y métodos para el control de pestes por insectos |
| WO2016022947A1 (en) | 2014-08-07 | 2016-02-11 | The Johns Hopkins University | Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases |
| US20170218384A1 (en) | 2014-08-08 | 2017-08-03 | Pioneer Hi-Bred International, Inc. | Ubiquitin promoters and introns and methods of use |
| US11466061B2 (en) | 2014-08-22 | 2022-10-11 | Yingfang Liu | Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins |
| JP6683686B2 (ja) | 2014-08-22 | 2020-04-22 | オークランド ユニサービシーズ リミティド | チャネル調節剤 |
| JP6731912B2 (ja) | 2014-09-05 | 2020-07-29 | ノバルティス アーゲー | 活性物質の送達用の脂質および脂質組成物 |
| WO2016037157A2 (en) | 2014-09-05 | 2016-03-10 | The Johns Hopkins University | Targeting capn9/capns2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies |
| KR102689262B1 (ko) | 2014-09-05 | 2024-07-30 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
| KR102473092B1 (ko) | 2014-09-15 | 2022-12-01 | 칠드런'즈 메디컬 센터 코포레이션 | 히스톤 h3-리신 트리메틸화를 제거함으로써 체세포 핵 이식(scnt) 효율을 증가시키는 방법 및 조성물 |
| AU2015317330B2 (en) | 2014-09-19 | 2021-01-14 | Memorial Sloan-Kettering Cancer Center | Methods for treating brain metastasis |
| US20170296561A1 (en) | 2014-09-25 | 2017-10-19 | Cold Spring Harbor Laboratory | Treatment of rett syndrome |
| WO2016046414A2 (en) | 2014-09-26 | 2016-03-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cdc25a inhibitor for the treatment of drug resistant cancer or for the prevention of tumor relapse |
| WO2016050680A1 (en) | 2014-09-29 | 2016-04-07 | Novozymes A/S | Yoqm-inactivation in bacillus |
| US9705501B2 (en) * | 2014-10-01 | 2017-07-11 | Maxim Integrated Products, Inc. | Systems and methods for enhancing confidentiality via logic gate encryption |
| MX391478B (es) | 2014-10-10 | 2025-03-21 | Idera Pharmaceuticals Inc | Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer. |
| WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
| EP3009147A1 (en) | 2014-10-16 | 2016-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant glioblastoma |
| SG11201703132UA (en) | 2014-10-22 | 2017-05-30 | Temasek Life Sciences Lab Ltd | Terpene synthases from ylang ylang (cananga odorata var. fruticosa) |
| WO2016066608A1 (en) | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
| WO2016066671A1 (en) | 2014-10-29 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant cancers using progastrin inhibitors |
| WO2016077624A1 (en) | 2014-11-12 | 2016-05-19 | Nmc, Inc. | Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| AU2015360794B2 (en) | 2014-12-08 | 2021-07-08 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| EP3865576A1 (en) | 2014-12-15 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| EP3925979A3 (en) | 2014-12-23 | 2022-03-23 | The Trustees of Columbia University in the City of New York | Fgfr-tacc fusion proteins and methods thereof |
| KR102360028B1 (ko) * | 2014-12-26 | 2022-02-08 | 삼성전자주식회사 | Smurf2의 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| US9434947B2 (en) * | 2015-01-20 | 2016-09-06 | Oregon Health & Science University | Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome |
| US10968449B2 (en) | 2015-01-22 | 2021-04-06 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
| WO2016128523A1 (en) | 2015-02-12 | 2016-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| WO2016131944A1 (en) | 2015-02-20 | 2016-08-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating cardiovascular diseases |
| CA2978449A1 (en) | 2015-03-02 | 2016-09-09 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using an il-33 antagonist |
| MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
| WO2016139331A1 (en) | 2015-03-05 | 2016-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of melanoma |
| CN111961103B (zh) | 2015-03-09 | 2023-06-16 | 肯塔基大学研究基金会 | 用于脑肿瘤治疗的rna纳米颗粒 |
| WO2016145008A2 (en) | 2015-03-09 | 2016-09-15 | University Of Kentucky Research Foundation | Mirna for treatment of breast cancer |
| WO2016145003A1 (en) | 2015-03-09 | 2016-09-15 | University Of Kentucky Research Foundation | Rna nanoparticle for treatment of gastric cancer |
| WO2016142427A1 (en) | 2015-03-10 | 2016-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method ank kit for reprogramming somatic cells |
| EP3268027B1 (en) | 2015-03-13 | 2022-11-02 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Hepcidin antagonists for use in the treatment of inflammation |
| KR101797569B1 (ko) | 2015-03-18 | 2017-11-22 | 한국교통대학교산학협력단 | 금속 나노입자 기반 간 표적성 핵산 전달체 및 이의 제조방법 |
| US10519447B2 (en) | 2015-04-01 | 2019-12-31 | Arcturus Therapeutics, Inc. | Therapeutic UNA oligomers and uses thereof |
| US11279768B1 (en) | 2015-04-03 | 2022-03-22 | Precision Biologics, Inc. | Anti-cancer antibodies, combination therapies, and uses thereof |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| EP3283108B1 (en) | 2015-04-13 | 2020-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of haemorrhagic diseases |
| CN107614685B (zh) | 2015-04-17 | 2021-10-19 | 肯塔基大学研究基金会 | Rna纳米颗粒及其使用方法 |
| EP3085785A1 (en) | 2015-04-22 | 2016-10-26 | Université de Strasbourg | Dynamin 2 inhibitor for the treatment of duchenne's muscular dystrophy |
| JP2018519248A (ja) | 2015-04-22 | 2018-07-19 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Th17媒介性疾患の処置のための方法及び医薬組成物 |
| WO2016170382A1 (en) | 2015-04-23 | 2016-10-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions comprising a bradykinin 2 receptor antagonist for prevention or treatment of impaired skin wound healing |
| EP3289104B1 (en) | 2015-04-29 | 2020-11-04 | New York University | Method for treating high-grade gliomas |
| WO2016179394A1 (en) | 2015-05-05 | 2016-11-10 | Malik Mohammad Tariq | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents |
| WO2016187486A1 (en) | 2015-05-19 | 2016-11-24 | Fred Hutchinson Cancer Research Center | Biomarkers and uses thereof for selecting pancreas cancer intervention |
| WO2016185026A1 (en) | 2015-05-20 | 2016-11-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for modulation polarization and activation of macrophages |
| EP3303391A1 (en) | 2015-05-26 | 2018-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions (ntsr1 inhibitors) for the treatment of hepatocellular carcinomas |
| WO2016191734A1 (en) | 2015-05-28 | 2016-12-01 | University Of California Berkeley | Monofunctional aldehyde and alcohol dehydrogenases for production of fuels and commodity chemicals |
| JP7001586B2 (ja) | 2015-05-29 | 2022-01-19 | アルカディア バイオサイエンシーズ | グルテン減少穀粒及びその組成物 |
| CN107750125A (zh) | 2015-06-02 | 2018-03-02 | 孟山都技术有限公司 | 用于将多核苷酸递送至植物中的组合物和方法 |
| AU2016270913A1 (en) | 2015-06-03 | 2018-01-04 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
| CN107922480B (zh) | 2015-06-12 | 2022-09-23 | 艾利妥 | 抗cd33抗体及其使用方法 |
| HK1252675A1 (zh) | 2015-06-12 | 2019-05-31 | Alector Llc | 抗cd33抗体及其使用方法 |
| CA2985490A1 (en) | 2015-06-17 | 2016-12-22 | E.I. Du Pont De Nemours And Company | Plant regulatory elements and methods of use thereof |
| US10087455B2 (en) | 2015-06-19 | 2018-10-02 | Arcadia Biosciences, Inc. | Wheat with reduced lipoxygenase activity |
| EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| US10808247B2 (en) | 2015-07-06 | 2020-10-20 | Phio Pharmaceuticals Corp. | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
| EP3862005A1 (en) | 2015-07-06 | 2021-08-11 | Phio Pharmaceuticals Corp. | Nucleic acid molecules targeting superoxide dismutase 1 (sod1) |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| WO2017015671A1 (en) | 2015-07-23 | 2017-01-26 | Arcturus Therapeutics, Inc. | Compositions for treating amyloidosis |
| WO2017029391A1 (en) | 2015-08-20 | 2017-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating cancer |
| US10072065B2 (en) | 2015-08-24 | 2018-09-11 | Mayo Foundation For Medical Education And Research | Peptide-mediated delivery of immunoglobulins across the blood-brain barrier |
| WO2017035278A1 (en) | 2015-08-24 | 2017-03-02 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotide nanoparticles for the modulation of gene expression and uses thereof |
| JP7525980B2 (ja) | 2015-08-28 | 2024-07-31 | アレクトル エルエルシー | 抗Siglec-7抗体及びその使用方法 |
| SG10202007937SA (en) | 2015-09-02 | 2020-09-29 | Alnylam Pharmaceuticals Inc | PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| CA2996806A1 (en) | 2015-09-04 | 2017-03-09 | Keygene N.V. | Diplospory gene |
| MA44908A (fr) * | 2015-09-08 | 2018-07-18 | Sylentis Sau | Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène nrarp |
| CA2997947A1 (en) | 2015-09-09 | 2017-03-16 | The Trustees Of Columbia University In The City Of New York | Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease |
| EP3349802B1 (en) | 2015-09-14 | 2021-08-04 | The Board of Regents of the University of Texas System | Lipocationic dendrimers and uses thereof |
| US10086063B2 (en) | 2015-09-23 | 2018-10-02 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| US10383935B2 (en) | 2015-09-23 | 2019-08-20 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| WO2017059113A1 (en) | 2015-09-29 | 2017-04-06 | Duke University | Compositions and methods for identifying and treating dystonia disorders |
| US10358497B2 (en) | 2015-09-29 | 2019-07-23 | Amgen Inc. | Methods of treating cardiovascular disease with an ASGR inhibitor |
| US11021707B2 (en) | 2015-10-19 | 2021-06-01 | Phio Pharmaceuticals Corp. | Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA |
| WO2017067944A1 (en) | 2015-10-19 | 2017-04-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of subjects suffering from triple negative breast cancer |
| JP7060502B2 (ja) | 2015-10-29 | 2022-04-26 | アレクトル エルエルシー | 抗Siglec-9抗体及びその使用方法 |
| SI3368578T1 (sl) | 2015-10-30 | 2021-08-31 | F. Hoffmann-La Roche Ag | Protitelesa proti HtrA1 in postopki uporabe |
| AU2016355920B2 (en) | 2015-11-18 | 2020-11-12 | Commonwealth Scientific And Industrial Research Organisation | Rice grain with thickened aleurone |
| WO2017085566A1 (en) | 2015-11-20 | 2017-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for increase/induction of immune responses |
| WO2017093354A1 (en) | 2015-11-30 | 2017-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nmdar antagonists for the treatment of diseases associated with angiogenesis |
| WO2017091952A1 (zh) | 2015-11-30 | 2017-06-08 | 谢彦晖 | Akt2在诊断和治疗肿瘤中的用途 |
| CN115786368A (zh) | 2015-11-30 | 2023-03-14 | 先锋国际良种公司 | 植物调节元件及其使用方法 |
| US20180353486A1 (en) | 2015-12-01 | 2018-12-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of darier disease |
| US20180371551A1 (en) | 2015-12-03 | 2018-12-27 | Agios Pharmaceuticals, Inc. | Mat2a inhibitors for treating mtap null cancer |
| PT3386519T (pt) | 2015-12-13 | 2021-04-27 | Nitto Denko Corp | Estruturas de sirna para atividade elevada e redução de alvos extra |
| GB201522186D0 (en) | 2015-12-16 | 2016-01-27 | Singapore Health Services Pte Ltd And Nat University Of Singapore The | Treatment of fibrosis |
| US11104911B2 (en) | 2015-12-22 | 2021-08-31 | Pioneer Hi-Bred International, Inc. | Embryo-preferred Zea mays promoters and methods of use |
| WO2017129558A1 (en) | 2016-01-25 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting or treating myelopoiesis-driven cardiometabolic diseases and sepsis |
| CN117942405A (zh) | 2016-02-25 | 2024-04-30 | 应用生物实验室公司 | 保护空气传播的病原体和刺激物的组合物和方法 |
| US12447166B2 (en) | 2016-02-25 | 2025-10-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
| US11072777B2 (en) | 2016-03-04 | 2021-07-27 | University Of Louisville Research Foundation, Inc. | Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs) |
| CA3016474A1 (en) | 2016-03-15 | 2017-09-21 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
| DK3429603T3 (da) | 2016-03-15 | 2022-03-14 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller |
| WO2017158043A1 (en) | 2016-03-15 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Early and non invasive method for assessing a subject's risk of having pancreatic ductal adenocarcinoma and methods of treatement of such disease |
| WO2017158396A1 (en) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
| EP3433615A1 (en) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for diagnosis and treatment of solar lentigo |
| US10639384B2 (en) | 2016-03-23 | 2020-05-05 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Targeting the neuronal calcium sensor 1 for treating wolfram syndrome |
| BR112018069506A2 (pt) | 2016-03-24 | 2019-01-29 | Academisch Ziekenhuis Leiden | métodos para transfectar plantas e para reduzir eventos de integração aleatória |
| US10883108B2 (en) | 2016-03-31 | 2021-01-05 | The Schepens Eye Research Institute, Inc. | Endomucin inhibitor as an anti-angiogenic agent |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| MA45469A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques de bêta-caténine et leurs utilisations |
| MA45470A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques kras et leurs utilisations |
| MA45349A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques egfr et leurs utilisations |
| WO2017182834A1 (en) | 2016-04-19 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating resistant glioblastoma |
| US10550398B2 (en) | 2016-04-19 | 2020-02-04 | Novozymes A/S | RlmA-inactivated filamentous fungal host cell |
| US20190119364A1 (en) | 2016-04-29 | 2019-04-25 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and compositions useful for treating metabolic syndrome, and methods using same |
| CN109476707B (zh) | 2016-05-13 | 2022-12-02 | 4D分子治疗有限公司 | 腺相关病毒变体衣壳和其使用方法 |
| US10562849B2 (en) | 2016-05-16 | 2020-02-18 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
| EP3464357A1 (en) | 2016-05-24 | 2019-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections |
| PT109454A (pt) | 2016-06-14 | 2017-12-14 | Phyzat Biopharmaceuticals Lda | Ácidos nucleicos de interferência e composições que os compreendem |
| EP3471757A1 (en) | 2016-06-16 | 2019-04-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of gut inflammatory diseases such as inflammatory bowel diseases (ibd) or irritable bowel syndrome (ibs) |
| EP3475430B1 (en) | 2016-06-24 | 2022-06-01 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
| EP3478321A4 (en) | 2016-06-30 | 2020-04-22 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| IL290679B2 (en) | 2016-07-05 | 2023-10-01 | California Inst Of Techn | Hybridization chain reaction based on a minimal initiator |
| US11292801B2 (en) | 2016-07-05 | 2022-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CN109477110B (zh) * | 2016-07-08 | 2022-11-25 | Tak循环株式会社 | 抑制mex3b基因的表达的核酸、试剂、及疾病的预防或治疗剂 |
| US11279935B2 (en) | 2016-07-08 | 2022-03-22 | Tak-Circulator Co, Ltd | Method for screening prophylactic or therapeutic agents for diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 and agent for the prevention or treatment of diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 |
| KR102619496B1 (ko) | 2016-07-19 | 2023-12-29 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Stat3를 타겟으로 하는 종양용해성 바이러스 |
| ES2973248T3 (es) | 2016-07-26 | 2024-06-19 | Inst Nat Sante Rech Med | Antagonista del receptor mineralocorticoide para el tratamiento de la osteoartritis |
| JP2019528437A (ja) | 2016-07-28 | 2019-10-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 腫瘍関連マクロファージをターゲティングすることによるガン疾患の処置方法 |
| EP3519582A1 (en) | 2016-07-29 | 2019-08-07 | Danmarks Tekniske Universitet | Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides |
| US20190183114A1 (en) | 2016-08-05 | 2019-06-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for the preservationof organs |
| WO2018044939A1 (en) | 2016-08-30 | 2018-03-08 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
| WO2018046610A1 (en) | 2016-09-08 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating nephrotic syndrome |
| US10933081B2 (en) | 2016-09-21 | 2021-03-02 | Alnylam Pharmaceuticals, Inc. | Myostatin iRNA compositions and methods of use thereof |
| WO2018055023A1 (en) | 2016-09-22 | 2018-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of lung cancer |
| AU2017336523B2 (en) | 2016-09-28 | 2022-07-21 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2018069232A1 (en) | 2016-10-10 | 2018-04-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of having cardiac hypertrophy |
| WO2018078083A1 (en) | 2016-10-28 | 2018-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating multiple myeloma |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
| CA3043030A1 (en) | 2016-11-10 | 2018-05-17 | Jose Baselga BASELGA | Inhibition of kmt2d for the treatment of cancer |
| WO2018087391A1 (en) | 2016-11-14 | 2018-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating stem cells proliferation or differentiation |
| US20190276833A1 (en) | 2016-11-17 | 2019-09-12 | Deutsches Krebsforschungszentrum | Cancer treatment by glycerol-3-phosphate dehydrogenase 1 inhibition |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| US11147249B2 (en) | 2016-12-08 | 2021-10-19 | Alector Llc | Siglec transgenic mice and methods of use thereof |
| US20200054660A1 (en) | 2016-12-09 | 2020-02-20 | St. Jude Children's Research Hospital | Dna methylation profiling for t-cell immunotherapy |
| WO2018112232A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device |
| TW201834711A (zh) | 2016-12-14 | 2018-10-01 | 美商寶珍那提公司 | 以tnf抑制劑治療胃腸道疾病 |
| WO2018112256A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| WO2018112235A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor |
| EP4190318A1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
| JP7150723B2 (ja) | 2016-12-14 | 2022-10-11 | ビオラ・セラピューティクス・インコーポレイテッド | 消化管疾病のインテグリン阻害薬による治療 |
| US10894837B2 (en) | 2016-12-16 | 2021-01-19 | Université De Bordeaux | MMP9 inhibitors and uses thereof in the prevention or treatment of a depigmenting disorder |
| WO2018115083A1 (en) | 2016-12-21 | 2018-06-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of gut diseases such as irritable bowel syndrome (ibs) |
| WO2018115477A1 (en) | 2016-12-23 | 2018-06-28 | Universite De Strasbourg | Dynamin 2 inhibitor for the treatment of myotonic dystrophy |
| US20230190958A1 (en) | 2017-01-13 | 2023-06-22 | Jichi Medical University | AAV Vector for Disrupting Coagulation Factor-Related Gene on Liver Genome |
| WO2018134386A1 (en) | 2017-01-23 | 2018-07-26 | Novozymes A/S | Host cells and methods for producing double-stranded rna |
| WO2018138106A1 (en) | 2017-01-27 | 2018-08-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of heart failure |
| WO2018141753A1 (en) | 2017-01-31 | 2018-08-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating squamous cell carcinomas |
| AU2018219895C1 (en) | 2017-02-09 | 2024-10-03 | Indapta Therapeutics, Inc. | Engineered Natural Killer (NK) cells and compositions and methods thereof |
| US20180271996A1 (en) | 2017-02-28 | 2018-09-27 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
| WO2018162676A1 (en) | 2017-03-08 | 2018-09-13 | Université De Strasbourg | DISINTEGRATABLE POROUS ORGANOSILICA OR ORGANOMETALOXIDE NANOPARTICLES AND USES THEREOF AS VEHICLE FOR CONTROLLED DELIVERY OF siRNA |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| WO2018172155A1 (en) | 2017-03-23 | 2018-09-27 | Novozymes A/S | Improved filamentous fungal host cells |
| US20210138213A1 (en) | 2017-03-30 | 2021-05-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| WO2018183934A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor |
| WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
| WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
| EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
| WO2018189403A1 (en) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
| US20210283068A1 (en) | 2017-04-19 | 2021-09-16 | St. Jude Children's Research Hospital | Tumor suppression by modulation of non-canonical autophagy (lap) in myeloid cells |
| CN106942162A (zh) * | 2017-04-25 | 2017-07-14 | 遵义医学院 | 一种适用于白背飞虱饲喂法rna干扰实验的装置及其使用方法 |
| CN111201247A (zh) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | 治疗方法和新颖构建体 |
| EP3615662A1 (en) | 2017-04-28 | 2020-03-04 | Precision Biosciences, Inc. | Methods for reducing dna-induced cytotoxicity and enhancing gene editing in primary cells |
| WO2018208837A1 (en) | 2017-05-08 | 2018-11-15 | Precision Biosciences, Inc. | Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof |
| US11359014B2 (en) | 2017-05-16 | 2022-06-14 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| WO2018211018A1 (en) | 2017-05-17 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
| EP3630740A4 (en) | 2017-05-25 | 2021-03-31 | The Governors of the University of Alberta | METHODS FOR THE PREVENTION OR TREATMENT OF ATHEROSCLEROSIS WITH ISOENZYME INHIBITORS SPECIFIC TO HUMAN NEURAMINIDASE |
| EP3412288A1 (en) | 2017-06-08 | 2018-12-12 | Galderma Research & Development | Vegf inhibitors for use for preventing and/or treating acne |
| JP2020524157A (ja) | 2017-06-20 | 2020-08-13 | アンスティテュート キュリー | がん併用療法における使用のためのsuv39h1ヒストンメチルトランスフェラーゼの阻害剤 |
| JP7388798B2 (ja) | 2017-06-20 | 2023-11-29 | アンスティテュート キュリー | Suv39h1を欠損する免疫細胞 |
| WO2018234538A1 (en) | 2017-06-23 | 2018-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Hepcidin antagonist or agonist for use in the treatment of dysregulation of mo and/or mn metabolism |
| WO2019012030A1 (en) | 2017-07-13 | 2019-01-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | DHODH INHIBITOR AND CHK1 INHIBITOR FOR THE TREATMENT OF CANCER |
| WO2019014656A1 (en) | 2017-07-14 | 2019-01-17 | Han Si Ping | METALLIC OLIGONUCLEOTIDE JONCTIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS |
| PE20200486A1 (es) | 2017-08-03 | 2020-03-03 | Alector Llc | Anticuerpos anti-cd33 y metodos para utilizarlos |
| EP3665281A4 (en) | 2017-08-10 | 2021-05-05 | City of Hope | CONDITIONAL SIRNA AND ITS USE IN THE TREATMENT OF CARDIAC HYERTROPHY |
| EP3444347A1 (en) | 2017-08-18 | 2019-02-20 | Universität Heidelberg | Use of anti-crispr polypeptides for specific activation of cas nucleases |
| CN111433360B (zh) | 2017-09-07 | 2024-01-12 | 北京泰德制药股份有限公司 | 靶向ckip-1的双链rna分子及其用途 |
| KR20250035034A (ko) | 2017-09-15 | 2025-03-11 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | Rna 분자 |
| FI3684423T3 (fi) | 2017-09-20 | 2023-06-15 | 4D Molecular Therapeutics Inc | Adenoassesioidun viruksen kapsidivariantteja ja niiden käyttömenetelmiä |
| BR112020006045A2 (pt) | 2017-09-25 | 2020-10-06 | Pioneer Hi-Bred International, Inc. | molécula de ácido nucleico, cassete de expressão, vetor, célula vegetal, planta, semente da planta, método para produzir uma planta transgênica, planta transgênica, semente da planta transgênica, método para aprimorar a eficiência de maturação de embrião somático e método para produzir uma planta dicotiledônea transgênica ou uma planta gimnosperma transgênica |
| US20200237864A1 (en) | 2017-10-10 | 2020-07-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating fibrotic interstitial lung disease |
| WO2019072885A1 (en) | 2017-10-11 | 2019-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | MAGNETIC NANOPARTICLES FOR THE TREATMENT OF CANCER |
| EP3701027A1 (en) | 2017-10-26 | 2020-09-02 | Les Laboratoires Servier SAS | Methods and pharmaceutical compositions for treating tubulin carboxypeptidases associated diseases |
| JP7551496B2 (ja) | 2017-10-31 | 2024-09-17 | カリヴィル イムノセラピューティクス, インコーポレイテッド | 全身送達のためのプラットフォーム腫瘍溶解性ベクター |
| JP7461886B2 (ja) | 2017-11-13 | 2024-04-04 | サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 標的遺伝子の発現を抑制するためのジチオリン酸結合を含む核酸 |
| JP7271539B2 (ja) | 2017-11-14 | 2023-05-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | リンホトキシンアルファ遺伝子について遺伝的に改変された調節性t細胞及びその使用 |
| EP3713603A1 (en) | 2017-11-23 | 2020-09-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | New method for treating dengue virus infection |
| EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| AU2018372235B9 (en) | 2017-11-27 | 2022-03-10 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and use for inhibiting angiogenesis |
| WO2019108835A1 (en) | 2017-11-29 | 2019-06-06 | The Trustees Of Columbia University In The City Of New York | Delta-2-tubulin as a biomarker and therapeutic target for peripheral neuropathy |
| PL3717011T3 (pl) | 2017-11-29 | 2023-03-27 | Csl Limited | Sposób leczenia lub zapobiegania uszkodzeniu niedokrwienno- reperfuzyjnemu |
| WO2019106126A1 (en) | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mdm2 modulators for the diagnosis and treatment of liposarcoma |
| CN118667812A (zh) | 2017-12-06 | 2024-09-20 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| US11470827B2 (en) | 2017-12-12 | 2022-10-18 | Alector Llc | Transgenic mice expressing human TREM proteins and methods of use thereof |
| EP3502259A1 (en) | 2017-12-19 | 2019-06-26 | Universiteit Leiden | A combinational strategy for reducing random integration events when transfecting plants |
| WO2019121872A1 (en) | 2017-12-20 | 2019-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of liver cancer |
| EP3727463A1 (en) | 2017-12-21 | 2020-10-28 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| AU2019207703B2 (en) | 2018-01-09 | 2024-11-14 | Cibus Europe B.V. | Shatterproof genes and mutations |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| US20210363587A1 (en) | 2018-02-07 | 2021-11-25 | St. Jude Children's Research Hospital | EPIGENETIC HISTONE REGULATION MEDIATED BY CXorf67 |
| WO2019158512A1 (en) | 2018-02-13 | 2019-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prognosis and the treatment of glioblastoma |
| CN111867679A (zh) | 2018-03-06 | 2020-10-30 | 居里研究所 | 用于癌症联合治疗的setdb1组蛋白甲基转移酶抑制剂 |
| AU2019234474B2 (en) | 2018-03-12 | 2025-05-15 | Pioneer Hi-Bred International, Inc. | Methods for plant transformation |
| WO2019178645A1 (en) | 2018-03-23 | 2019-09-26 | Csl Limited | Method of treating asthma |
| US20210047696A1 (en) | 2018-03-28 | 2021-02-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| JP7474702B2 (ja) | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法 |
| JP7607872B2 (ja) | 2018-03-30 | 2025-01-06 | ユニバーシティ オブ ジュネーブ | マイクロrna発現構築物及びその使用 |
| US20210010013A1 (en) | 2018-04-04 | 2021-01-14 | Cibus Us Llc | Fad2 genes and mutations |
| WO2019199673A1 (en) | 2018-04-09 | 2019-10-17 | President And Fellows Of Harvard College | Modulating nuclear receptors and methods of using same |
| WO2019207066A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of sjögren's syndrome |
| WO2019211369A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| WO2019211370A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| US11702668B2 (en) | 2018-05-22 | 2023-07-18 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
| JP7512207B2 (ja) | 2018-05-24 | 2024-07-08 | サーナオミクス インコーポレイテッド | 核酸治療薬のための調節可能な共カップリングポリペプチドナノ粒子送達系の組成物および方法 |
| WO2019227091A1 (en) | 2018-05-25 | 2019-11-28 | The Penn State Research Foundation | Nanoparticle for protein delivery |
| GB201808927D0 (en) | 2018-05-31 | 2018-07-18 | Institute Of Cancer Res Royal Cancer Hospital | Materials and methods for monitoring the development of resistance of cancers to treatment |
| WO2019234099A1 (en) | 2018-06-06 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, predicting the outcome and treating a patient suffering from heart failure with preserved ejection fraction |
| WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
| CN119841953A (zh) | 2018-06-08 | 2025-04-18 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| US20210277409A1 (en) | 2018-06-28 | 2021-09-09 | Pioneer Hi-Bred International, Inc. | Methods for selecting transformed plants |
| WO2020016160A1 (en) | 2018-07-16 | 2020-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat neurological diseases |
| EP3823672A1 (en) | 2018-07-19 | 2021-05-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Combination for treating cancer |
| SG11202100555PA (en) | 2018-07-27 | 2021-02-25 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| WO2020026968A1 (ja) | 2018-07-30 | 2020-02-06 | 株式会社遺伝子治療研究所 | Aavベクターによる遺伝子発現を増強する方法 |
| JP7566741B2 (ja) | 2018-08-10 | 2024-10-15 | シティ・オブ・ホープ | プログラム可能なsiRNA及びその使用 |
| BR112021003016A2 (pt) | 2018-08-31 | 2021-05-18 | Alector Llc | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica |
| WO2020049026A1 (en) | 2018-09-05 | 2020-03-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating asthma and allergic diseases |
| JP2022501388A (ja) | 2018-09-19 | 2022-01-06 | ラホヤ インスティチュート フォー イミュノロジー | 関節リウマチにおけるptprs及びプロテオグリカン |
| CN113056552A (zh) | 2018-10-09 | 2021-06-29 | 诺维信公司 | 经修饰的丝状真菌宿主细胞 |
| EP3866807A1 (en) | 2018-10-16 | 2021-08-25 | F. Hoffmann-La Roche AG | Use of akt inhibitors in ophthalmology |
| EP3867269A1 (en) | 2018-10-18 | 2021-08-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of a big-h3 antagonist and an immune checkpoint inhibitor for the treatment of solid tumor |
| AU2019369340A1 (en) | 2018-10-29 | 2021-05-20 | Mersana Therapeutics, Inc. | Cysteine engineered antibody-drug conjugates with peptide-containing linkers |
| US20220000893A1 (en) | 2018-10-31 | 2022-01-06 | |Nserm (Institut National De La Santé Et De La Recherche Médicale) | Method for treating t-helper type 2 mediated disease |
| JP2022512817A (ja) | 2018-10-31 | 2022-02-07 | パイオニア ハイ-ブレッド インターナショナル, インコーポレイテッド | オクロバクテリウム(Ochrobactrum)媒介植物形質転換のための組成物及び方法 |
| AU2019371161A1 (en) | 2018-10-31 | 2021-06-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Biomarkers and methods of use for radiation-induced lung injury |
| EP3650040A1 (en) | 2018-11-07 | 2020-05-13 | Galderma Research & Development | Vegf inhibitors for use for preventing and/or treating atopic dermatitis |
| WO2020102668A1 (en) | 2018-11-16 | 2020-05-22 | Nitto Denko Corporation | Rna interference delivery formulation and methods for malignant tumors |
| BR112021010338A2 (pt) | 2018-11-28 | 2021-11-16 | Novozymes As | Células hospedeiras fúngicas filamentosas modificadas |
| CN114144423B (zh) | 2018-12-27 | 2025-04-04 | 圣诺制药公司 | 使用与免疫检查点抑制剂组合递送的siRNA沉默TGF-BETA 1和COX2以治疗癌症 |
| US11883401B2 (en) | 2019-01-08 | 2024-01-30 | Duke University | Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same |
| WO2020148310A1 (en) | 2019-01-17 | 2020-07-23 | F. Hoffmann-La Roche Ag | E3 ubiquitin ligase (ube3a) protein targets |
| AU2020211695A1 (en) | 2019-01-21 | 2021-09-02 | National University Of Singapore | Treatment of hepatotoxicity |
| JP2022519577A (ja) | 2019-02-01 | 2022-03-24 | ウニベルシテート バーゼル | 養子細胞移植療法における使用のためのカルシニューリン阻害剤耐性免疫細胞 |
| WO2020161083A1 (en) | 2019-02-04 | 2020-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for modulating blood-brain barrier |
| AU2020217747B2 (en) | 2019-02-08 | 2025-01-02 | Board Of Regents, The University Of Texas System | Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction |
| WO2020169707A1 (en) | 2019-02-21 | 2020-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Foxo1 inhibitor for use in the treatment of latent virus infection |
| GB201902419D0 (en) | 2019-02-22 | 2019-04-10 | Singapore Health Serv Pte Ltd | Treatment of kidney injury |
| US12215382B2 (en) | 2019-03-01 | 2025-02-04 | The General Hospital Corporation | Liver protective MARC variants and uses thereof |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| BR112021017998A2 (pt) | 2019-03-11 | 2021-11-16 | Pioneer Hi Bred Int | Métodos para a produção de plantas clonais |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| CA3128376A1 (en) | 2019-03-27 | 2020-10-01 | Pioneer Hi-Bred International, Inc. | Plant explant transformation |
| WO2020193740A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
| WO2020198496A1 (en) | 2019-03-28 | 2020-10-01 | Pioneer Hi-Bred International, Inc. | Modified agrobacterium strains and use thereof for plant transformation |
| WO2020208082A1 (en) | 2019-04-09 | 2020-10-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating cmv related diseases |
| CA3137224A1 (en) | 2019-04-19 | 2020-10-22 | Sorbonne Universite | P16ink4a inhibitor for preventing or treating huntington's disease |
| CN114364693A (zh) | 2019-05-03 | 2022-04-15 | 新加坡保健服务私人有限公司 | 代谢性疾病的治疗和预防 |
| GB201906291D0 (en) | 2019-05-03 | 2019-06-19 | Singapore Health Serv Pte Ltd | Treatment and prevention of metabolic diseases |
| IL287801A (en) | 2019-05-07 | 2022-07-01 | Immunicom Inc | Increasing responses to checkpoint inhibitors by extracorporeal apheresis |
| US20220227859A1 (en) | 2019-05-16 | 2022-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat type 2 inflammation or mast-cell dependent disease |
| WO2020249769A1 (en) | 2019-06-14 | 2020-12-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating ocular diseases related to mitochondrial dna maintenance |
| US11473086B2 (en) | 2019-06-19 | 2022-10-18 | Ut-Battelle, Llc | Loss of function alleles of PtEPSP-TF and its regulatory targets in rice |
| WO2021001539A1 (en) | 2019-07-04 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy to detect and treat eosinophilic fasciitis |
| WO2021005223A1 (en) | 2019-07-10 | 2021-01-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of epilepsy |
| JP7371954B2 (ja) | 2019-07-12 | 2023-10-31 | 株式会社遺伝子治療研究所 | ヒト肝臓への遺伝子導入のためのアデノ随伴ウイルスビリオン |
| US20220251581A1 (en) | 2019-07-26 | 2022-08-11 | Novozymes A/S | Modified filamentous fungal host cell |
| CA3148950A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| WO2021028335A1 (en) | 2019-08-14 | 2021-02-18 | Vanarix Sa | Method for in vitro production of hyaline cartilage tissue |
| EP4022061A1 (en) | 2019-08-27 | 2022-07-06 | Sanofi | Compositions and methods for inhibiting pcsk9 |
| WO2021044012A1 (en) | 2019-09-05 | 2021-03-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment and pronostic of acute myeloid leukemia |
| GB201913030D0 (en) | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
| KR102100163B1 (ko) | 2019-09-24 | 2020-04-13 | 테고사이언스 (주) | 켈로이드 또는 비후성 반흔 예방 또는 치료용 조성물 |
| US20220290151A1 (en) | 2019-09-27 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of müllerian inhibiting substance inhibitors for treating cancer |
| EP3825408A1 (en) | 2019-11-19 | 2021-05-26 | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. | Methods of multi-species insect pest control |
| WO2021099394A1 (en) | 2019-11-19 | 2021-05-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antisense oligonucleotides and their use for the treatment of cancer |
| WO2021105391A1 (en) | 2019-11-27 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination comprising nupr1 inhibitors to treat cancer |
| WO2021105384A1 (en) | 2019-11-27 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Targeting the nls region of nupr1 protein to treat cancer |
| EP4077676A1 (en) | 2019-12-18 | 2022-10-26 | Novartis AG | Compositions and methods for the treatment of hemoglobinopathies |
| IL293530A (en) | 2019-12-18 | 2022-08-01 | Novartis Ag | Derivatives of 3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione and their uses |
| KR20220139886A (ko) | 2020-01-08 | 2022-10-17 | 리제너론 파아마슈티컬스, 인크. | 진행성 골화성 섬유이형성증의 치료 |
| US12178902B1 (en) | 2020-01-12 | 2024-12-31 | University Of Southern California | Methods and compositions for fluid drainage by Piezo ion channel activation |
| WO2021150300A1 (en) | 2020-01-22 | 2021-07-29 | Massachusetts Institute Of Technology | Inducible tissue constructs and uses thereof |
| WO2021156329A1 (en) | 2020-02-05 | 2021-08-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment of cancer disease by targeting an epigenetic factor |
| WO2021163079A1 (en) | 2020-02-10 | 2021-08-19 | Biomarin Pharmaceutical Inc. | Virus-free cell cultures |
| WO2021173965A1 (en) | 2020-02-28 | 2021-09-02 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
| EP4121063A4 (en) | 2020-03-19 | 2024-07-03 | Avidity Biosciences, Inc. | COMPOSITIONS AND METHODS FOR TREATING FACIO-SCAPULO-HUMERAL MUSCULAR DYSTROPHY |
| US20220023204A1 (en) | 2020-04-20 | 2022-01-27 | Board Of Regents, The University Of Texas System | Biologically active dry powder compositions and method of their manufacture and use |
| IL297442A (en) | 2020-04-22 | 2022-12-01 | Iovance Biotherapeutics Inc | Systems and methods for coordinating production of cells for patient-specific immunotherapy |
| US20210332364A1 (en) | 2020-04-28 | 2021-10-28 | Phyzat Biopharmaceuticals, Lda | siNA MOLECULES, METHODS OF PRODUCTION AND USES THEREOF |
| WO2021224401A1 (en) | 2020-05-07 | 2021-11-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for determining a reference range of β-galactose exposure platelet |
| US20210348167A1 (en) | 2020-05-09 | 2021-11-11 | Phyzat Biopharmaceuticals, Lda | siNA MOLECULES, METHODS OF PRODUCTION AND USES THEREOF |
| EP4153192B8 (en) | 2020-05-19 | 2024-09-04 | Institut Curie | Antagonist of cd44/hyaluronic acid pathway for use in a method for the treatment of cytokine release syndrome |
| JP2023537558A (ja) | 2020-05-27 | 2023-09-04 | アンチオン バイオサイエンシーズ エスアー | 目的の抗原にcar t細胞をリダイレクトするためのアダプター分子 |
| EP3919062A1 (en) | 2020-06-02 | 2021-12-08 | Institut Gustave-Roussy | Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom |
| WO2021245107A2 (en) | 2020-06-02 | 2021-12-09 | Institut Gustave Roussy | Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom |
| EP4162417A1 (en) | 2020-06-03 | 2023-04-12 | Xenotherapeutics, Inc. | Selection and monitoring methods for xenotransplantation |
| EP4161583A1 (en) | 2020-06-05 | 2023-04-12 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for treating ocular diseases |
| CN116194121A (zh) | 2020-06-09 | 2023-05-30 | 吉尼松公司 | 用于治疗扩张型心肌病的cilp-1抑制剂 |
| WO2021250076A1 (en) | 2020-06-09 | 2021-12-16 | Genethon | Treatment of genetic dilated cardiomyopathies |
| WO2021255204A1 (en) | 2020-06-18 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
| GB202009292D0 (en) | 2020-06-18 | 2020-08-05 | Singapore Health Serv Pte Ltd | Treatment and prevention of disease caused by type IV collagen dysfunction |
| US20230305023A1 (en) | 2020-06-25 | 2023-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment and diagnostic of pathological conditions associated with intense stress |
| US20230266325A1 (en) | 2020-06-30 | 2023-08-24 | Lunglife Ai, Inc. | Methods for detecting lung cancer |
| IL299771A (en) | 2020-07-10 | 2023-03-01 | Inst Nat Sante Rech Med | Methods and compounds for the treatment of epilepsy |
| WO2022018667A1 (en) | 2020-07-24 | 2022-01-27 | Pfizer Inc. | Combination therapies using cdk2 and cdc25a inhibitors |
| US20230303974A1 (en) | 2020-07-30 | 2023-09-28 | Institut Curie | Immune Cells Defective for SOCS1 |
| US20230340149A1 (en) | 2020-09-07 | 2023-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment of inflammatory bowel diseases |
| AU2021355365A1 (en) | 2020-09-30 | 2023-04-06 | Corteva Agriscience Llc | Rapid transformation of monocot leaf explants |
| US20220218622A1 (en) | 2020-10-14 | 2022-07-14 | George Mason Research Foundation, Inc. | Ionizable lipids and methods of manufacture and use thereof |
| GB202017244D0 (en) | 2020-10-30 | 2020-12-16 | Nat Univ Singapore | Methods to extend health-span and treat age-related diseases |
| WO2022109133A1 (en) | 2020-11-19 | 2022-05-27 | Kalivir Immunotherapeutics, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
| US20230416754A1 (en) | 2020-11-23 | 2023-12-28 | Phyzat Biopharmaceuticals, Lda | Sina molecules, methods of production and uses thereof |
| EP4263822A1 (en) | 2020-12-15 | 2023-10-25 | Novozymes A/S | Mutated host cells with reduced cell motility |
| WO2022147481A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma Inc. | Combination therapy of an oncolytic virus delivering a foreign antigen and an engineered immune cell expressing a chimeric receptor targeting the foreign antigen |
| US20240083990A1 (en) | 2021-01-26 | 2024-03-14 | Universite Brest Bretagne Occidentale | Novel stim1 splicing variants and uses thereof |
| EP4284925A4 (en) | 2021-01-26 | 2025-08-13 | California Inst Of Techn | ALLOSTERIC CONDITIONAL GUIDE RNAS FOR SELECTIVE REGULATION OF CRISPR/CAS CELLS |
| US20250127811A1 (en) | 2021-01-28 | 2025-04-24 | Precision Biosciences, Inc. | Modulation of tgf beta signaling in genetically-modified eukaryotic cells |
| WO2022171777A1 (en) | 2021-02-12 | 2022-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for prognosis and treating a patient suffering from cancer |
| WO2022218998A1 (en) | 2021-04-13 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating hepatitis b and d virus infection |
| EP4322938A1 (en) | 2021-04-14 | 2024-02-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | New method to improve nk cells cytotoxicity |
| US20240190993A1 (en) | 2021-04-14 | 2024-06-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method to improve the anti-tumoral activity of macrophages |
| US20250339480A1 (en) | 2021-04-21 | 2025-11-06 | Jichi Medical University | Adeno-associated virus virion for treating ornithine transcarbamylase deficiency |
| WO2022232375A1 (en) | 2021-04-30 | 2022-11-03 | Kalivir Immunotherapeutics, Inc. | Oncolytic viruses for modified mhc expression |
| MX2023014041A (es) | 2021-05-28 | 2023-12-15 | Shanghai Regenelead Therapies Co Ltd | Virus adenoasociado recombinante que tiene una capsida variante y su aplicacion. |
| WO2022253910A1 (en) | 2021-06-02 | 2022-12-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new method to treat an inflammatory skin disease |
| WO2022269518A2 (en) | 2021-06-23 | 2022-12-29 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
| US11593428B2 (en) | 2021-07-08 | 2023-02-28 | Bank Of America Corporation | System and method for detecting errors in a task workflow from a video stream |
| US20250092126A1 (en) | 2021-07-26 | 2025-03-20 | Boehringer Ingelheim International Gmbh | Treatment and prevention of alcoholic liver disease |
| EP4381069A1 (en) | 2021-08-02 | 2024-06-12 | Universite De Montpellier | Compositions and methods for treating cmt1a or cmt1e diseases with rnai molecules targeting pmp22 |
| CN118019548A (zh) | 2021-08-06 | 2024-05-10 | 蒙彼利埃癌症研究所 | 用于治疗癌症的方法 |
| WO2023020980A1 (en) | 2021-08-16 | 2023-02-23 | F. Hoffmann-La Roche Ag | E3 ubiquitin ligase (ube3a) protein targets |
| US20240316061A1 (en) | 2021-09-17 | 2024-09-26 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
| US20250134952A1 (en) | 2021-09-20 | 2025-05-01 | Institut National de la Santé et de la Recherche Médicale | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
| WO2023057484A1 (en) | 2021-10-06 | 2023-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy |
| CA3232968A1 (en) | 2021-10-14 | 2023-04-20 | Jasper Williams | Immune cells having co-expressed shrnas and logic gate systems |
| WO2023073099A1 (en) | 2021-10-28 | 2023-05-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to improve phagocytosis |
| WO2023078906A1 (en) | 2021-11-03 | 2023-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating acute myeloid leukemia |
| WO2023078900A1 (en) | 2021-11-03 | 2023-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating triple negative breast cancer (tnbc) |
| WO2023081767A1 (en) | 2021-11-05 | 2023-05-11 | Precision Biosciences, Inc. | Methods for immunotherapy |
| EP4433089A1 (en) | 2021-11-19 | 2024-09-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
| WO2023089159A1 (en) | 2021-11-22 | 2023-05-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy targeting stroma/tumor cell crosstalk to treat a cancer |
| WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
| EP4446419A1 (en) | 2021-12-06 | 2024-10-16 | Jichi Medical University | Recombinant adeno-associated virus vector for treatment of iron-accumulating neurodegenerative diseases |
| WO2023111173A1 (en) | 2021-12-16 | 2023-06-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An ezh2 degrader or inhibitor for use in the treatment of resistant acute myeloid leukemia |
| EP4448096A1 (en) | 2021-12-16 | 2024-10-23 | Singapore Health Services Pte. Ltd. | Treatment and prevention of glomerular disease |
| WO2023122805A1 (en) | 2021-12-20 | 2023-06-29 | Vestaron Corporation | Sorbitol driven selection pressure method |
| US20250051759A1 (en) | 2021-12-23 | 2025-02-13 | Boehringer Ingelheim International Gmbh | METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi) |
| EP4215614A1 (en) | 2022-01-24 | 2023-07-26 | Dynacure | Combination therapy for dystrophin-related diseases |
| US12004476B2 (en) | 2022-01-26 | 2024-06-11 | Monsanto Technology Llc. | Cotton variety 20R750B3XF |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics Inc | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| GB202206507D0 (en) | 2022-05-04 | 2022-06-15 | Antion Biosciences Sa | Expression construct |
| WO2023230531A1 (en) | 2022-05-24 | 2023-11-30 | Lunglife Ai, Inc. | Methods for detecting circulating genetically abnormal cells |
| WO2024003350A1 (en) | 2022-06-30 | 2024-01-04 | Universite De Strasbourg | Combination therapy for melanoma |
| EP4299742A1 (en) | 2022-06-30 | 2024-01-03 | Université de Strasbourg | Combination therapy for melanoma |
| EP4558149A1 (en) | 2022-07-21 | 2025-05-28 | Institut National de la Santé et de la Recherche Médicale | Methods and compositions for treating chronic pain disorders |
| EP4311546A1 (en) | 2022-07-26 | 2024-01-31 | Dynacure | Combination therapy for myopathies |
| WO2024028794A1 (en) | 2022-08-02 | 2024-02-08 | Temple Therapeutics BV | Methods for treating endometrial and ovarian hyperproliferative disorders |
| WO2024028476A1 (en) | 2022-08-05 | 2024-02-08 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of th2-mediated diseases |
| WO2024037910A1 (en) | 2022-08-17 | 2024-02-22 | Institut National de la Santé et de la Recherche Médicale | Syk inhibitors for use in the treatment of cancer |
| GB202212077D0 (en) | 2022-08-18 | 2022-10-05 | Tribune Therapeutics Ab | Agents that inhibit ccn ligand-induced signalling for treating disease |
| EP4580658A1 (en) | 2022-08-31 | 2025-07-09 | Institut National de la Santé et de la Recherche Médicale | Method to generate more efficient car-t cells |
| WO2024052503A1 (en) | 2022-09-08 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to ltbp2 and uses thereof |
| WO2024056659A1 (en) | 2022-09-13 | 2024-03-21 | Institut National de la Santé et de la Recherche Médicale | Method for treating prostate cancer and other epithelial cancers |
| CN120112638A (zh) | 2022-09-13 | 2025-06-06 | 阿森纳生物科学公司 | 具有共表达的TGFBR shRNA的免疫细胞 |
| CN119968464A (zh) | 2022-09-16 | 2025-05-09 | 阿森纳生物科学公司 | 具有组合基因扰动的免疫细胞 |
| WO2024074713A1 (en) | 2022-10-07 | 2024-04-11 | Institut National de la Santé et de la Recherche Médicale | Method to generate improving car-t cells |
| KR20250094703A (ko) | 2022-10-25 | 2025-06-25 | 아블린쓰 엔.브이. | 향상된 효과기 기능을 갖는 당조작된 Fc 변이체 폴리펩타이드 |
| IL320733A (en) | 2022-11-21 | 2025-07-01 | Iovance Biotherapeutics Inc | Two-dimensional processes for expanding tumor-infiltrating lymphocytes and treatments thereof |
| EP4623106A1 (en) | 2022-11-22 | 2025-10-01 | Institut Curie | Lnc-znf30-3 as cancer biomarker and therapeutic target |
| GB202219829D0 (en) | 2022-12-29 | 2023-02-15 | Ivy Farm Tech Limited | Genetically manipulated cells |
| WO2024161015A1 (en) | 2023-02-03 | 2024-08-08 | Institut National de la Santé et de la Recherche Médicale | Method to treat age-related diseases |
| WO2024170505A1 (en) | 2023-02-13 | 2024-08-22 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of iron overload associated diseases |
| TW202442689A (zh) | 2023-03-03 | 2024-11-01 | 美商亞森諾生物科學公司 | 靶向psma及ca9之系統 |
| CN120858176A (zh) | 2023-03-07 | 2025-10-28 | 居里研究所 | Brca相关癌症中的ung/udg抑制 |
| WO2024184479A1 (en) | 2023-03-08 | 2024-09-12 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of food allergy |
| WO2024191808A1 (en) | 2023-03-10 | 2024-09-19 | University Of Rochester | Etiological therapeutics for fragile x syndrome |
| GB202303784D0 (en) | 2023-03-15 | 2023-04-26 | Institute Of Cancer Res Royal Cancer Hospital | Cancer treatment |
| WO2024194401A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Vps4b inhibitor for use in methods for the treatment of hrd cancer |
| WO2024194402A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Farnesyl transferase inhibitor for use in methods for the treatment of hrd cancer |
| WO2024194673A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Methods for the treatment of dedifferentiated liposarcoma |
| WO2024223877A1 (en) | 2023-04-26 | 2024-10-31 | Institut National de la Santé et de la Recherche Médicale | Method for modulating the differentiation and functions of human dendritic cells |
| GB202306619D0 (en) | 2023-05-04 | 2023-06-21 | Antion Biosciences Sa | Cell |
| WO2024236336A1 (en) | 2023-05-17 | 2024-11-21 | Institut National de la Santé et de la Recherche Médicale | Lipc variant in the treatment of hypercholesterolemia and atherosclerotic cardiovascular disease |
| WO2024236131A1 (en) | 2023-05-17 | 2024-11-21 | Institut National de la Santé et de la Recherche Médicale | Stratificate and method to treat a patient suffering from a cancer |
| WO2024246162A1 (en) | 2023-05-30 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of focal cortical dysplasia |
| WO2024256527A1 (en) | 2023-06-13 | 2024-12-19 | Institut National de la Santé et de la Recherche Médicale | Use of a cxcl 10 inhibitor for the treatment of transplant vasculopathy |
| WO2024256635A1 (en) | 2023-06-15 | 2024-12-19 | Institut National de la Santé et de la Recherche Médicale | Dpm1 inhibitor for treating cancer |
| WO2025003461A1 (en) | 2023-06-30 | 2025-01-02 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of metabolic disorders |
| WO2025008406A1 (en) | 2023-07-04 | 2025-01-09 | Institut National de la Santé et de la Recherche Médicale | Antisense oligonucleotides and their use for the treatment of cancer |
| WO2025007195A1 (en) | 2023-07-05 | 2025-01-09 | CSL Innovation Pty Ltd | Methods of treating or preventing a complication of sickle cell disease |
| WO2025021839A1 (en) | 2023-07-25 | 2025-01-30 | Institut National de la Santé et de la Recherche Médicale | Method to treat metabolic disorders |
| WO2025032112A1 (en) | 2023-08-08 | 2025-02-13 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of type 2-mediated diseases |
| GB202313465D0 (en) | 2023-09-04 | 2023-10-18 | Univ Court Univ Of Glasgow | Methods for the treatment of heart failure with preserved ejection fraction |
| WO2025052001A1 (en) | 2023-09-07 | 2025-03-13 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| EP4520334A1 (en) | 2023-09-07 | 2025-03-12 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| NL2035852B1 (en) | 2023-09-21 | 2025-03-28 | Academisch Ziekenhuis Leiden | Enhancement of t cell mediated therapies |
| WO2025068157A1 (en) | 2023-09-25 | 2025-04-03 | Stromacare | COMBINATION OF A βIG-H3 ANTAGONIST AND A PDFG-AA ANTAGONIST FOR THE TREATMENT OF CANCER |
| WO2025068180A1 (en) | 2023-09-25 | 2025-04-03 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of cancer by targetting cancer - associated fibroblasts |
| WO2025068393A1 (en) | 2023-09-27 | 2025-04-03 | Institut Curie | Methods for the treatment of fibrotic related diseases |
| WO2025068418A1 (en) | 2023-09-27 | 2025-04-03 | Institut National de la Santé et de la Recherche Médicale | Inhibitor of the transcription factor ap-1 for use in the treatment of age-related diseases |
| WO2025073765A1 (en) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from melanoma |
| WO2025078851A1 (en) | 2023-10-11 | 2025-04-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods of treating cognitive deficit |
| WO2025082944A1 (en) | 2023-10-16 | 2025-04-24 | Institut National de la Santé et de la Recherche Médicale | Inhibitor of the low-density lipoprotein receptor family (ldl-r family) and/or apolipoprotein e (apoe) for use in the treatment of crimean-congo hemorrhagic fever virus (cchfv) infection |
| WO2025088546A1 (en) | 2023-10-25 | 2025-05-01 | Ablynx N.V. | Fc domain variants with enhanced fc receptor binding |
| WO2025114512A1 (en) | 2023-11-29 | 2025-06-05 | Cnrs Dsi | Therapeutic use of surf2 modulators |
| WO2025114453A1 (en) | 2023-11-30 | 2025-06-05 | Institut National de la Santé et de la Recherche Médicale | Method of prevention and/or treatment of nairoviridae family infections |
| WO2025162980A1 (en) | 2024-01-30 | 2025-08-07 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of breast cancer using a jnk-1 inhibitor |
| WO2025163107A1 (en) | 2024-02-01 | 2025-08-07 | Institut Gustave Roussy | Immune cells defective for znf217 and uses thereof |
| WO2025176679A1 (en) | 2024-02-19 | 2025-08-28 | Institut National de la Santé et de la Recherche Médicale | Inhibitor of the flavin-containing monooxygenase (fmo) for use in the treatment of cancer |
| WO2025176777A1 (en) | 2024-02-20 | 2025-08-28 | Institut Curie | Dut inhibition in homologous recombination deficiency cancer |
| GB202402745D0 (en) | 2024-02-27 | 2024-04-10 | Antion Biosciences Sa | Cell |
| WO2025191002A1 (en) | 2024-03-12 | 2025-09-18 | National University Of Singapore | Treatment and prevention of disease by il-7r inhibition |
| WO2025191018A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Mrgpre binding agent for use in the treatment of inflammatory and pain disorders |
| US20250297255A1 (en) | 2024-03-20 | 2025-09-25 | Arsenal Biosciences, Inc. | Systems targeting tmprss4 and slc34a2 |
| WO2025213127A1 (en) | 2024-04-05 | 2025-10-09 | Indapta Therapeutics, Inc. | Treatment of autoimmune diseases or conditions with natural killer cells |
| WO2025215354A1 (en) | 2024-04-08 | 2025-10-16 | Ivy Farm Technologies Limited | Method of culturing an animal cell |
| WO2025217379A1 (en) | 2024-04-10 | 2025-10-16 | University Of Rochester | Drug treatment for macular degeneration |
| WO2025224297A1 (en) | 2024-04-26 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to tgfbi and uses thereof |
| WO2025237990A1 (en) | 2024-05-14 | 2025-11-20 | Institut National de la Santé et de la Recherche Médicale | Antisense oligonucleotides and their use for the treatment of pulmonary fibrosis |
| WO2025245399A1 (en) | 2024-05-23 | 2025-11-27 | Indapta Therapeutics, Inc. | Method of treating cancer with natural killer cells |
| WO2025248505A1 (en) | 2024-05-31 | 2025-12-04 | Wayne State University | Methods for treating endometrial and ovarian hyperproliferative disorders |
Family Cites Families (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931397A (en) * | 1971-11-05 | 1976-01-06 | Beecham Group Limited | Biologically active material |
| US4024222A (en) | 1973-10-30 | 1977-05-17 | The Johns Hopkins University | Nucleic acid complexes |
| US4283393A (en) * | 1979-03-13 | 1981-08-11 | Merck & Co., Inc. | Topical application of interferon inducers |
| US6130206A (en) * | 1980-07-07 | 2000-10-10 | Hem Research, Inc. | Treating viral infections associated with chronic fatigue with dsRNA |
| US4511713A (en) | 1980-11-12 | 1985-04-16 | The Johns Hopkins University | Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4605394A (en) | 1982-12-03 | 1986-08-12 | Simon V. Skurkovich | Methods for the treatment of pathological conditions by removing interferon from the organism |
| JPS5936698A (ja) | 1982-08-20 | 1984-02-28 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞 |
| US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5208149A (en) | 1983-10-20 | 1993-05-04 | The Research Foundation Of State University Of New York | Nucleic acid constructs containing stable stem and loop structures |
| US5173410A (en) | 1984-02-15 | 1992-12-22 | Lubrizol Genetics Inc. | Transfer vector |
| US4766072A (en) * | 1985-07-17 | 1988-08-23 | Promega Corporation | Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence |
| US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
| US4795744A (en) * | 1986-07-17 | 1989-01-03 | Hem Research, Inc. | Modulation of AIDS virus-related events by double-stranded RNAS |
| CA1326450C (en) | 1985-08-26 | 1994-01-25 | William A. Carter | Modulation of aids virus-related events by double stranded rnas (dsrnas) |
| US4945082A (en) | 1985-08-26 | 1990-07-31 | Hem Research, Inc. | Controlled dsRNA therapy for human viral infections |
| US4820696A (en) * | 1985-08-26 | 1989-04-11 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAS |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US5120657A (en) * | 1986-12-05 | 1992-06-09 | Agracetus, Inc. | Apparatus for genetic transformation |
| PH24467A (en) | 1987-03-03 | 1990-07-18 | Hem Res Inc | Synergistics interplay of lymphokines and dsrnas |
| US4950652A (en) | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
| US5091374A (en) * | 1987-07-17 | 1992-02-25 | Hem Research Inc. | Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function |
| US5906980A (en) | 1987-07-17 | 1999-05-25 | Hem Research Inc. | Treatment of hepatitis with mismatched dsRNA |
| AU1820588A (en) | 1987-07-17 | 1989-01-19 | Hem Research, Inc. | Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function |
| IE66830B1 (en) | 1987-08-12 | 1996-02-07 | Hem Res Inc | Topically active compositions of double-stranded RNAs |
| IE72103B1 (en) | 1987-08-12 | 1997-03-12 | Hem Res Inc | Promotion of host defense by systemic dsRNA treatment |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| US5712257A (en) * | 1987-08-12 | 1998-01-27 | Hem Research, Inc. | Topically active compositions of mismatched dsRNAs |
| US5593973A (en) * | 1987-09-04 | 1997-01-14 | Hemispherx Biopharma Inc. | Treatment of viral hepatitis with mismatched dsRNA |
| DE3853755T2 (de) | 1987-09-04 | 1995-12-14 | Hem Pharma Corp | Diagnose von Mangelzuständen doppelsträngiger RNS. |
| US5874555A (en) | 1987-10-30 | 1999-02-23 | California Institute Of Technology | Triple helices and processes for making same |
| US4963532A (en) | 1987-11-25 | 1990-10-16 | Hem Research, Inc. | dsRNA-based prevention of viral escape |
| PH25365A (en) | 1987-12-23 | 1991-05-13 | Hem Research | Rhase l inhibitor as a marker for virus infections |
| US5922602A (en) | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
| US5789214A (en) | 1988-03-08 | 1998-08-04 | Novartis Finance Corporation | Method of inducing gene transcription in a plant |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| CA1320446C (en) | 1988-06-20 | 1993-07-20 | William A. Carter | Modulation of lymphokine-resistant cellular states by dsrnas |
| EP0350151B1 (en) | 1988-07-07 | 1994-03-30 | Hem Pharmaceuticals Corp. | Diagnosing and treating chronic fatigue syndrome |
| US5258369A (en) | 1988-08-29 | 1993-11-02 | Hem Pharmaceuticals Corporation | Treatment of chronic cerebral dysfunction by dsRNA methodology |
| ES2090049T3 (es) | 1989-03-16 | 1996-10-16 | Boehringer Ingelheim Int | Unidades geneticas para la inhibicion de la funcion de arn. |
| US5034323A (en) | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| WO1990012488A2 (en) | 1989-04-05 | 1990-11-01 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast |
| WO1990012094A1 (en) | 1989-04-05 | 1990-10-18 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | A clone of double-stranded rna virus and applications thereof |
| EP0473576A4 (en) | 1989-05-19 | 1993-03-10 | Hem Research, Inc. | Short therapeutic dsrna of defined structure |
| GB8916213D0 (en) * | 1989-07-14 | 1989-08-31 | Ici Plc | Dna constructs,cells and plants derived therefrom |
| BR9007757A (pt) | 1989-10-16 | 1992-08-11 | Hem Res Inc | Diagnostico e tratamento de disturbios neuro-cognitivos associados com disfuncoes imunologicas sistemicas |
| US5132292A (en) | 1990-05-25 | 1992-07-21 | Hem Research, Inc. | Treatment of viral hepatitis |
| US5194245A (en) * | 1990-05-25 | 1993-03-16 | Hem Research Inc. | Diagnosis of viral hepatitis |
| US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| ATE191931T1 (de) | 1990-11-23 | 2000-05-15 | Plant Genetic Systems Nv | Verfahren zur transformation monokotyler pflanzen |
| US5145323A (en) * | 1990-11-26 | 1992-09-08 | Tecumseh Products Company | Liquid level control with capacitive sensors |
| WO1992018522A1 (en) | 1991-04-18 | 1992-10-29 | The Salk Institute For Biological Studies | Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| US6010908A (en) | 1992-08-21 | 2000-01-04 | The Regents Of The University Of California | Gene therapy by small fragment homologous replacement |
| US6136601A (en) | 1991-08-21 | 2000-10-24 | Epoch Pharmaceuticals, Inc. | Targeted mutagenesis in living cells using modified oligonucleotides |
| CA2073630C (en) | 1991-08-30 | 2007-12-11 | Atsushi Ohshima | Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor |
| FR2685346B1 (fr) | 1991-12-18 | 1994-02-11 | Cis Bio International | Procede de preparation d'arn double-brin, et ses applications. |
| DE4208107A1 (de) * | 1992-03-13 | 1993-09-16 | Bayer Ag | Pseudorabies-virus (prv)-polynukleotide und ihre verwendung zur herstellung von virusresistenten eukaryotischen zellen |
| US5593874A (en) | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| AU687736B2 (en) | 1992-05-11 | 1998-03-05 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
| US5693535A (en) * | 1992-05-14 | 1997-12-02 | Ribozyme Pharmaceuticals, Inc. | HIV targeted ribozymes |
| WO1994001550A1 (en) * | 1992-07-02 | 1994-01-20 | Hybridon, Inc. | Self-stabilized oligonucleotides as therapeutic agents |
| US5489519A (en) * | 1992-10-27 | 1996-02-06 | Queen's University At Kingston | Multidrug resistance protein |
| US6372965B1 (en) * | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| CA2159639A1 (en) | 1993-04-02 | 1994-10-13 | Vincent J. Miles | Method for selective inactivation of viral replication |
| US5739309A (en) * | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
| KR960704034A (ko) | 1993-07-19 | 1996-08-31 | 다니엘 엘. 캐시앙 | 단백질 생산, 세포 증식 및(또는) 전염병 병원균의 증식에 대한 올리고뉴클레오티드 저해의 향상법(Enhancement of Oligonucleotide Inhibition of Protein Production, Cell Proliferation, and/or Multiplication of Infectious Disease Pathogens) |
| CA2105364A1 (en) * | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5808036A (en) * | 1993-09-01 | 1998-09-15 | Research Corporation Technologies Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5578716A (en) * | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US5908779A (en) | 1993-12-01 | 1999-06-01 | University Of Connecticut | Targeted RNA degradation using nuclear antisense RNA |
| FR2714383B1 (fr) * | 1993-12-29 | 1996-02-09 | Centre Nat Rech Scient | Contrôle de l'expression de gènes. |
| DK1298208T3 (da) | 1994-01-05 | 2006-07-24 | Gene Shears Pty Ltd | Ribozymer der er målrettet mod en HIV-tat-sekvens |
| US5583034A (en) * | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| WO1995023225A2 (en) | 1994-02-23 | 1995-08-31 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting the expression of disease related genes |
| US5631148A (en) | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| US6054299A (en) * | 1994-04-29 | 2000-04-25 | Conrad; Charles A. | Stem-loop cloning vector and method |
| US6291742B1 (en) | 1994-09-26 | 2001-09-18 | Carnegie Institution Of Washington | Production of hydroxylated fatty acids in genetically modified plants |
| US5674683A (en) * | 1995-03-21 | 1997-10-07 | Research Corporation Technologies, Inc. | Stem-loop and circular oligonucleotides and method of using |
| AU5741396A (en) | 1995-05-11 | 1996-11-29 | Hybridon, Inc. | Pyrimidine targeting hairpin triplex-forming oligonucleotide s |
| US5691140A (en) | 1995-05-18 | 1997-11-25 | New England Biolabs, Inc. | Bidirectional in vitro transcription vectors utilizing a single RNA polymerase for both directions |
| US5693773A (en) * | 1995-06-07 | 1997-12-02 | Hybridon Incorporated | Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidines |
| EP0850318A1 (en) | 1995-09-13 | 1998-07-01 | Chiron Corporation | Method and construct for screening for inhibitors of transcriptional activation |
| EP0851919A1 (en) | 1995-09-20 | 1998-07-08 | University of Massachusetts Worcester | Antisense oligonucleotide chemotherapy for benign hyperplasia or cancer of the prostate |
| JPH09110894A (ja) | 1995-10-17 | 1997-04-28 | Soyaku Gijutsu Kenkyusho:Kk | ハイブリッドdna/rnaオリゴヌクレオチド及び抗ウイルス剤 |
| JP3847366B2 (ja) | 1996-02-22 | 2006-11-22 | アンジェスMg株式会社 | アンチセンスオリゴヌクレオチドを用いた固定性分裂終了細胞増殖剤 |
| US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
| US6022863A (en) | 1996-05-21 | 2000-02-08 | Yale University | Regulation of gene expression |
| US5850026A (en) | 1996-07-03 | 1998-12-15 | Cargill, Incorporated | Canola oil having increased oleic acid and decreased linolenic acid content |
| ES2256893T3 (es) * | 1996-08-02 | 2006-07-16 | Genesense Technologies Inc. | Secuencias antisentido antitumorales dirigidas contra componentes r1 y r2 de la reductasa ribonucleica. |
| DE19631919C2 (de) | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US5747338A (en) * | 1996-08-15 | 1998-05-05 | Chiron Corporation | Method and construct for screening for inhibitors of transcriptional activation |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| GB9703146D0 (en) | 1997-02-14 | 1997-04-02 | Innes John Centre Innov Ltd | Methods and means for gene silencing in transgenic plants |
| WO1998040489A1 (en) | 1997-03-10 | 1998-09-17 | Japan Tobacco Inc. | Antisense base sequences |
| GB9710475D0 (en) * | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| WO1999009045A1 (en) | 1997-08-20 | 1999-02-25 | Somagenics, Inc. | Antisense and antigene therapeutics with improved binding properties and methods for their use |
| GB9720148D0 (en) * | 1997-09-22 | 1997-11-26 | Innes John Centre Innov Ltd | Gene silencing materials and methods |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU9522501A (en) | 1998-03-20 | 2002-01-31 | Benitec Australia Ltd | Control of gene expression |
| ES2374290T3 (es) * | 1998-03-20 | 2012-02-15 | Commonwealth Scientific And Industrial Research Organisation | Genes sintéticos y constructos genéticos que comprenden los mismos. |
| AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| EP1068311B2 (en) | 1998-04-08 | 2020-12-09 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| EP1104492B1 (en) | 1998-08-20 | 2004-02-11 | The Johns Hopkins University School Of Medicine | Subtle mitochondrial mutations as tumor markers |
| WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| WO2000063364A2 (en) | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| US20040138168A1 (en) | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| KR20020030780A (ko) | 1999-07-09 | 2002-04-25 | 이곤 이 버그 | 플라스미드 서열의 전사 동안 비정상적인 rna 형성을예방하기 위한 방법 및 조성물 |
| US6423885B1 (en) * | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6291504B1 (en) | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| GB9930691D0 (en) | 1999-12-24 | 2000-02-16 | Devgen Nv | Improvements relating to double-stranded RNA inhibition |
| JP2003527856A (ja) | 2000-03-17 | 2003-09-24 | ベニテック オーストラリア リミテッド | 遺伝子のサイレンシング |
| EP1309726B2 (en) * | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| GB2362383B (en) | 2000-05-19 | 2003-12-31 | Devgen Nv | Gene expression system |
| ATE507300T1 (de) * | 2000-06-23 | 2011-05-15 | Du Pont | Rekombinante konstrukte und ihre verwendung bei der reduzierung der genexpression |
| US7109393B2 (en) * | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
| RU2322500C2 (ru) | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| EP1229134A3 (en) | 2001-01-31 | 2004-01-28 | Nucleonics, Inc | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| US6506059B2 (en) * | 2001-03-29 | 2003-01-14 | Avx Corporation | Electrical connectors for display devices |
| ES2566561T3 (es) | 2001-07-12 | 2016-04-13 | University Of Massachusetts | Producción in vivo de ARN pequeños de interferencia que median el silenciamiento génico |
| AU2002326906C1 (en) | 2001-09-13 | 2009-01-29 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
| EP1436401A4 (en) | 2001-09-27 | 2006-06-14 | Timothy Albert Holton | STEM-LOOP VECTOR SYSTEM |
| GB0130955D0 (en) | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| EP1341144B1 (en) * | 2002-03-01 | 2006-06-21 | Magnetek S.p.A. | Power circuit for a plasma display |
| US20040022748A1 (en) * | 2002-03-12 | 2004-02-05 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Method of enhancing skin lightening |
| AU2002951347A0 (en) | 2002-09-09 | 2002-09-26 | Benitec Australia Ltd | Genetic silencing |
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| US20030056235A1 (en) | 2003-03-20 |
| US20160208280A1 (en) | 2016-07-21 |
| US6506559B1 (en) | 2003-01-14 |
| AU1938099A (en) | 1999-07-12 |
| US7538095B2 (en) | 2009-05-26 |
| JP2002516062A (ja) | 2002-06-04 |
| US20080248576A1 (en) | 2008-10-09 |
| CA2311999A1 (en) | 1999-07-01 |
| US20030051263A1 (en) | 2003-03-13 |
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| US20130029425A1 (en) | 2013-01-31 |
| JP2009291209A (ja) | 2009-12-17 |
| US20030055020A1 (en) | 2003-03-20 |
| US20140350083A1 (en) | 2014-11-27 |
| AU743798B2 (en) | 2002-02-07 |
| US20130230492A1 (en) | 2013-09-05 |
| US10358653B2 (en) | 2019-07-23 |
| US7560438B2 (en) | 2009-07-14 |
| EP2267131A1 (en) | 2010-12-29 |
| JP2013048629A (ja) | 2013-03-14 |
| AU743798C (en) | 2006-02-09 |
| US8283329B2 (en) | 2012-10-09 |
| EP1042462A1 (en) | 2000-10-11 |
| US9102939B2 (en) | 2015-08-11 |
| EP2267131B1 (en) | 2017-04-19 |
| US8580754B2 (en) | 2013-11-12 |
| WO1999032619A1 (en) | 1999-07-01 |
| JP2015133993A (ja) | 2015-07-27 |
| CA2311999C (en) | 2016-02-23 |
| JP5969889B2 (ja) | 2016-08-17 |
| US7622633B2 (en) | 2009-11-24 |
| US20080081373A1 (en) | 2008-04-03 |
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