WO2000061739A1 - Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle - Google Patents

Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle Download PDF

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Publication number
WO2000061739A1
WO2000061739A1 PCT/JP2000/002260 JP0002260W WO0061739A1 WO 2000061739 A1 WO2000061739 A1 WO 2000061739A1 JP 0002260 W JP0002260 W JP 0002260W WO 0061739 A1 WO0061739 A1 WO 0061739A1
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Prior art keywords
antibody
sugar chain
activity
cells
immune function
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English (en)
French (fr)
Japanese (ja)
Inventor
Nobuo Hanai
Kazuyasu Nakamura
Emi Shoji
Motoo Yamasaki
Kazuhisa Uchida
Toyohide Shinkawa
Susumu Imabeppu
Yutaka Kanda
Naoko Yamane
Hideharu Anazawa
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KH Neochem Co Ltd
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Kyowa Hakko Kogyo Co Ltd
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Priority to EP00915403.0A priority Critical patent/EP1176195B1/en
Priority to AU36728/00A priority patent/AU3672800A/en
Priority to CA2369292A priority patent/CA2369292C/en
Priority to JP2000611663A priority patent/JP4368530B2/ja
Priority to EP10180043.1A priority patent/EP2270150B2/en
Priority to ES00915403T priority patent/ES2418360T3/es
Priority to EP10180036.5A priority patent/EP2278003B2/en
Priority to EP10180034.0A priority patent/EP2270147B2/en
Priority to DK00915403.0T priority patent/DK1176195T3/da
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of WO2000061739A1 publication Critical patent/WO2000061739A1/ja
Anticipated expiration legal-status Critical
Priority to US11/126,299 priority patent/US20050272916A1/en
Priority to US11/126,176 priority patent/US7214775B2/en
Priority to US11/126,298 priority patent/US7708992B2/en
Priority to US11/686,458 priority patent/US7708997B2/en
Priority to US11/686,911 priority patent/US7655228B2/en
Priority to US11/686,920 priority patent/US7687061B2/en
Priority to US11/686,379 priority patent/US7718175B2/en
Priority to US11/686,915 priority patent/US7651688B2/en
Priority to US11/686,391 priority patent/US7682610B2/en
Priority to US11/686,404 priority patent/US7763246B2/en
Priority to US11/686,906 priority patent/US7682611B2/en
Priority to US12/645,613 priority patent/US8679491B2/en
Priority to US14/173,305 priority patent/US10233247B2/en
Priority to US15/460,790 priority patent/US20170240647A1/en
Priority to US16/517,776 priority patent/US20200017593A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Definitions

  • the present invention relates to a method for regulating the activity of an immune function molecule such as an antibody, a protein or a peptide, an agent for promoting the activity of an immune function molecule, and an immune function molecule having an enhanced immune function activity.
  • an immune function molecule such as an antibody, a protein or a peptide
  • an agent for promoting the activity of an immune function molecule and an immune function molecule having an enhanced immune function activity.
  • HAMA Human Anti Mouse Antibody
  • an antibody of a non-human animal can be used as a human-type chimeric antibody or a human-complementarity determining region (hereinafter referred to as CDR) transplanted antibody.
  • CDR human-complementarity determining region
  • a human chimeric antibody is an antibody in which the antibody variable region (hereinafter, referred to as V region) is an antibody of a non-human animal and the constant region (hereinafter, referred to as C region) is a human antibody. Ding's 'The' National 'Academy' of the Science (Proc. Natl. Acad. Sci.
  • the human CDR-grafted antibody is an antibody obtained by replacing the CDR of a human antibody with the CDR of an antibody from a non-human animal [Nature, 321, 522 (1986)]. It has been reported that immunogenicity is lower than that of antibodies, and the blood half-life is increased by 4 to 5 times [The 'Journal of Ob''Immunology (J. Immunol.), 147, 1352 (1991) ]. These reports show that a humanized antibody can be expected to be sufficiently effective even if it is not a completely human antibody as an antibody to be used for diagnosis, prevention and treatment of various human diseases.
  • tumor antibodies for example, anti-CD20 human chimeric antibody
  • Herceptin an anti-HER2 / neu human CDR-grafted antibody [Herceptin; Genentech, Inc.] has been clinically tested and is safe in B lymphoma and breast cancer, respectively. Sex and some therapeutic effects have been recognized [J. Clin. Oncol., 16, 2825 (1998), Journal of the National Kyansa. J. National Cancer Institute, 90, 882 (1998)]. In addition, already a fragment of anti-GPIIb / IIIa human chimeric antibody
  • ReoPro (Centocor), which is (Fab '), is marketed in Europe and the United States as a preventive drug for complications after percutaneous transluminal coronary angioplasty.
  • Fab ' ReoPro
  • Antibodies of the human IgG class are mainly used because of their functional properties such as having various effector functions [Monoclonal Antibodies: Principles and Applications, Wiley -Liss, Inc., Capter 1 (1995)].
  • Antibodies of the human IgG class are further divided into four subclasses, IgGl, IgG2, IgG3, and IgG4.
  • ADCC activity Antibody-dependent cytotoxicity
  • ADCC activity and CDC activity of human IgGl subclass antibodies requires the antibody Fc region and the antibody receptor existing on the surface of effector cells such as killer cells, natural killer cells, activated macrophages, etc. , FcaR) and binding to various complement components, and the binding is determined by the hinge domain of the antibody and the second domain of the C region (hereinafter referred to as the Ca2 domain). Importance of some amino acid residues in Eur. J. Immunol., 23, 1098 (1993), Immunology, 86, 319 (1995) ), Chemical Immunology (Chemical Immunology), 65, 88 (1997)], and the importance of sugar chains linked to the C2 domain [Chemical Immunology, 65, 88 (1997)] ] Has been suggested.
  • An object of the present invention is to provide a method for regulating the activity of an immune function molecule by identifying a sugar chain that enhances ADCC activity by praying for the sugar chain of a human IgGl subclass antibody produced in various animal cells.
  • Such antibodies have enhanced ADCC activity and can be used not only for anti-tumor antibodies, but also for other antibodies, and even proteins or peptides, for treatment of various human diseases. The effect is expected to increase. In particular, in the clinical application of antitumor antibodies, the antitumor effect of antibodies alone is often insufficient at present, and combination therapy with chemotherapy is used.
  • the present invention relates to the following (1) to (62).
  • rat myeloma cell is a rat myeloma cell YB2 / 3HL.P2.G11.16Ag.20 cell (ATCC CRL1662).
  • a sugar chain-containing immune function molecule activity promoter in which fucose is not present in N-acetylglucosamine at the reducing end of an N-glycoside-linked sugar chain.
  • the sugar chain contains a sugar chain synthesized by a cell having low or no enzyme activity for adding fucose to N-acetylglycosamine at the reducing end.
  • the rat myeloma cell is a YB2 / 3HL.P2.G11.16Ag.20 cell (3)
  • the tumor-associated antigen of the present invention means an antigen whose expression is enhanced in tumor cells as compared to normal cells.
  • gangliosides GD2, GD3, GM2 [Cancer 'Imnologi''Imnotherapy. (Cancer Immunol. Immunother.), 43, 152 (1996)], HER2 [Journal' Ob 'surgical' Research (J. Surgical Research) ), 77, 85 (1998)], CD52 [Leukemia Research, 22, 185 (1998)], MAGE [APMIS], 106, 665 (1998)].
  • factors that cause tumor cells to proliferate Offspring and their receptors are also included in tumor-associated antigens. Specifically, basic fibroblast growth factor and its receptor [Pancreas, 17, 169 (1998)], vascular endothelial cell growth factor and its receptor [Pasologi inn Yuichi National (Pathology International), 48, 499 (1998)].
  • the allergy or inflammation-related antigen of the present invention means an antigen that induces an allergic or inflammatory response, and an antigen that is induced in association with an allergic or inflammatory response. Yuichi [In Yuichi National Affairs, Zuofu, Paleregi-and-Immunology (International Archives. Allergy. Immunology), 117, 11 (1998)], Tumor necrosis Factors and their receptors Yuichi [Cytokine, 8, 651 (1996)].
  • the antigen relating to a circulatory disease of the present invention means an antigen relating to a circulatory disease induced by thrombus, vascular restenosis and the like. Specifically, GpIIb / IIIa on platelets [Thrombosis Research, 89, 129 (1998)], platelet-derived growth factor and its receptor Yuichi [American Journal of Physiology (American J. Physiology), 269, 1641 (1995)] and blood coagulation factors [Thrombosis and 'Hemostasis, 79, 14 (1998)].
  • the antigen associated with the autoimmune disease of the present invention means an autoantigen that causes an immune response that causes the disease and an antigen that enhances the reaction.
  • self DNA Specifically, self DNA [Ryu —Rheumatology International, 17, 223 (1998)], CD4 [Rhematic 'Dizzies' Clinics 'ob''North' America (Rheumatic Diseases Clinics. North America), 24, 567 ( 1998)].
  • the antigen related to the virus or bacterial infection of the present invention means an antigen related to the infection or growth of a virus or a bacterium into a target cell, and also a product of the virus or bacterium.
  • gP 120 [Uiroroji one (Virology), 248, 394 ( 1998)]
  • CXCR4 Journal. O blanking. Uiroroji one (J. Virology),, 8453 ( 1998)]
  • Vero toxin [di Yanaru ' Job “Clinical” microbiology (J. Clinical Microbiology), 34, 2053 (1996)].
  • a diagnostic agent for cancer comprising the immunological function molecule according to (36) as an active ingredient.
  • a therapeutic agent for cancer comprising the immune function molecule according to (36) as an active ingredient.
  • a prophylactic agent for cancer comprising the immunological function molecule according to (36) as an active ingredient.
  • a diagnostic agent for allergy or inflammation comprising the antibody according to (39) as an active ingredient.
  • a therapeutic drug for allergy or inflammation comprising the antibody according to (39) as an active ingredient.
  • a preventive drug for allergy or inflammation comprising the antibody according to (39) as an active ingredient.
  • a diagnostic agent for cardiovascular disease comprising the antibody according to (42) as an active ingredient.
  • a therapeutic agent for cardiovascular disease comprising the antibody according to (42) as an active ingredient.
  • a prophylactic agent for a cardiovascular disease comprising the antibody according to (42) above as an active ingredient.
  • a diagnostic drug for an autoimmune disease comprising the antibody according to (43) above as an active ingredient.
  • a prophylactic agent for an autoimmune disease comprising the antibody according to the above (43) as an active ingredient.
  • a diagnostic agent for a virus or bacterial infection comprising the antibody according to (44) as an active ingredient.
  • a therapeutic agent for virus or bacterial infection comprising the antibody according to (44) as an active ingredient.
  • a prophylactic agent for a viral or bacterial infection comprising the antibody according to (44) as an active ingredient.
  • a diagnostic agent for various diseases comprising the peptide or protein according to (26) or (27) as an active ingredient.
  • diseases in the present invention include diseases such as cancer, allergic diseases, inflammatory diseases, cardiovascular diseases, autoimmune diseases, and viral or bacterial infections.
  • a therapeutic agent for various diseases comprising the peptide or protein according to (60) as an active ingredient.
  • sugar chains are composed of sugar chains that bind to asparagine (referred to as N-glycoside-linked sugar chains) and sugar chains that bind to serine, threonine, etc. (referred to as 0-glycoside-linked sugar chains). It is roughly divided into two types.
  • the N-glycoside-linked sugar chain according to the present invention has various structures. [Biochemical experiment method 23-Glycoprotein sugar chain research method (Society Press Center), edited by Reiko Takahashi (1989)] In each case, it has the basic common core structure shown below.
  • the terminal of the sugar chain that binds to asparagine is called the reducing end, and the opposite non-reducing end.
  • the binding of fucose to N-acetylglucosamine at the reducing end includes: HI 1,3 bond, HI 1,6 bond, etc.
  • the N-glycoside-linked sugar chain has a high-mannose type in which only mannose is bonded to the non-reducing end of the core structure, and a galactose-N-acetylglucosamine (hereinafter, referred to as Gal-GlcNAc) on the non-reducing end side of the core structure. It has one or more branches in parallel, and further has a complex type having a structure such as N-acetylglucosamine of sialic acid isecting on the non-reducing terminal side of Ga to GlcNAc, and a high mannose type on the non-reducing terminal side of the core structure. And hybrid type having both branches of complex type.
  • the sugar chain of the present invention includes fucose not only in the above-described sugar chain but also in N-acetylcycloglucosamine. Any sugar chain that does not bind is included.
  • the immune function molecule is a molecule that originally exists in a living body and is involved in various immune reactions, and specifically includes an antibody, a protein, a peptide, and the like.
  • An antibody is a protein produced in vivo by an immune reaction as a result of stimulation with a foreign antigen and having an activity of specifically binding to an antigen.
  • Antibodies produced by immunizing animals with an antigen and secreted by hybridoma cells produced from spleen cells of the immunized animal, as well as antibodies produced by gene recombination techniques, that is, antibody expression vectors into which antibody genes have been inserted, can be used. Is introduced into a host cell. Specific examples include antibodies produced by hybridomas, humanized antibodies, and human antibodies.
  • a hybridoma is a monoclonal antibody having the desired antigen specificity obtained by cell fusion of B cells obtained by immunizing a non-human mammal with an antigen and myeloma cells derived from a mouse or the like. Means a producing cell.
  • humanized antibody examples include a human-type chimeric antibody, a human-type homology determining region (hereinafter abbreviated as CDR), and a grafted antibody.
  • CDR human-type homology determining region
  • the human chimeric antibody is composed of an antibody heavy chain variable region (hereinafter, the heavy chain is referred to as an H chain, the variable region is referred to as HV or VH as a V region) and an antibody light chain variable region (hereinafter, referred to as a light chain).
  • an L chain also referred to as LV or VL
  • a heavy chain constant region of a human antibody hereinafter, the constant region is also referred to as CH as a C region
  • CL light chain constant region of a human antibody
  • the human chimeric antibody is obtained by obtaining cDNAs encoding VH and VL from a hybridoma producing a monoclonal antibody, and encoding human antibodies CH and CL.
  • a human-type chimeric antibody expression vector can be constructed by inserting the gene into an expression vector for a host cell having a gene, and then expressing the vector by introducing it into a host cell.
  • the CH of the human chimeric antibody may be any CH as long as it belongs to human immunoglobulin (hereinafter, referred to as hlg), but is preferably a gG class, and furthermore, hIgGl, hIgG2, hIgG3 belonging to hlgG class , HIgG4 can be used.
  • the CL of the human chimeric antibody may be any CL as long as it belongs to hlg, and A: class or human class can be used.
  • the human CDR-grafted antibody refers to an antibody obtained by grafting the amino acid sequence of the CDRs of VH and VL of a non-human animal antibody to an appropriate position of VH and VL of a human antibody.
  • the human CDR-grafted antibody is constructed by constructing a cDNA encoding the V region obtained by grafting the VH and VL CDR sequences of an antibody of a non-human animal to the VH and VL CDR sequences of any human antibody.
  • the human-type CDR-grafted antibody expression vector is constructed by inserting the expression vector into a host cell expression vector for a host cell having the genes encoding CH and CL of the human antibody, and the expression vector is introduced into the host cell. CDR-grafted antibodies can be expressed and produced.
  • the CH of human CDR-grafted antibody may be any so long as it belongs to the hlg, are preferred those hlgG class, any further of hI g Gl, WgG2, WgG3, hIgG4 say subclasses belonging to hlgG class Can also be used.
  • the CL of the human CDR-grafted antibody may be any CL as long as it belongs to hlg, and a class or human class CL can be used.
  • Human antibodies originally mean antibodies naturally occurring in the human body, but human antibody phage libraries and human antibody production produced by recent advances in genetic, cell engineering, and developmental engineering technologies Antibodies obtained from transgenic animals or human antibody-producing transgenic plants are also included.
  • Antibodies present in the human body can be obtained, for example, by isolating human peripheral blood lymphocytes, infecting them with an EB virus, etc., immortalizing them, and cloning the cells, thereby culturing the lymphocytes producing the antibodies. Can be purified.
  • the human antibody phage library 1 is a library in which antibody fragments such as Fab and single-chain antibodies are expressed on the phage surface by inserting an antibody gene prepared from human B cells into the phage gene. From the library, phage expressing an antibody fragment having the desired antigen-binding activity can be recovered using the binding activity to the substrate on which the antigen is immobilized as an index. The antibody fragment was further subjected to two complete H It can also be converted into a human antibody molecule consisting of a chain and two complete light chains.
  • a human antibody-producing transgenic non-human animal refers to an animal in which a human antibody gene has been integrated into cells.
  • a human antibody-producing transgenic animal can be produced by introducing a human antibody gene into mouse ES cells, transplanting the ES cells into an early embryo of another mouse, and then developing the embryo.
  • Human antibody-producing transgenic animals can be prepared from human antibody-producing hybridomas by the usual method for producing hybridomas in mammals other than humans. Human antibodies can be produced and accumulated.
  • the activity of the antibody of the present invention means ADCC activity.
  • ADCC activity is defined as the antibody bound to tumor cells, etc., through the binding of the antibody Fc region to the Fc receptor existing on the surface of effector cells such as killer cells, natural killer cells, and activated macrophages. activating effector cells and means activity of damaging the tumor cells or the like [monoclonal Antibodies's: Principles 'and' ⁇ flop 1 RIQUET one Shiyonzu (monoclonal Antibodies: Principles and Applications) , Wiley-L iss, Inc , Capter 2.1 (1995)].
  • any protein and peptide can be used as long as it can activate various immune responses.
  • inferior ferron molecule inferior-kin-2 (IL-2) [Science, 193, 1007 (1976)]
  • the interleukin-12 IL-12
  • G-CSF granulocyte colony-stimulating factor
  • M-CSF macrophage colony stimulating factor
  • GM-CSF Granulocyte-macrophage colony stimulating factor
  • EP0 erythropoietin
  • TP0 Thrombopoi Echin
  • the activity of the protein and the peptide of the present invention refers to various immunities, including lymphocytes (T cells, B cells, etc.), macrophages, etc., when the protein and the peptide having the sugar chain are administered in vivo. It means the activity of the host cell or various immune response reactions.
  • Promotion of the activity of the proteins and peptides of the present invention refers to NK cells, T cells by IL-2 or IL-12. This means that the activation of cells and the action of promoting red blood cell production by EPO are further enhanced.
  • IgG sugar chains are composed of neutral sugars such as galactose, mannose and fucose, amino sugars such as N-acetylglycosamine, and acidic sugars such as sialic acid.
  • composition analysis of the sugar chain of an antibody neutral sugar or amino sugar is released by acid hydrolysis of the sugar chain with trifluoroacetic acid or the like, and the composition ratio can be analyzed.
  • BioLC sugar composition analyzer
  • BioLC uses a high performance anion-exchange chromatography-pulsed amperometric detection (HPAEC-PAD) method [Journal Leoff, Liquid Liquid Chromatography (J.Liq.Chromatogr.), 6, 1577 (1983)] It is a device for analysis.
  • the composition ratio can also be analyzed by a fluorescent labeling method using 2-aminoviridine. Specifically, a sample obtained by acid hydrolysis according to a known method [Agricultural 'and' Biological 'Chemistry (Agruc. Biol. Chem.), 55 (1), 283-284 (1991)] is used. -Fluorescent labeling by aminobilidylation and HPLC analysis to calculate composition ratio.
  • Structural analysis of the sugar chains of antibodies can be performed using the two-dimensional sugar map method [Analytical 'Biochemistry., 171, 73 (1988), Biochemistry Experimental Method 23-Glycoprotein sugar chain research method Kaiichi Sensen Yuichi) Takahashi Reiko (ed., 1989)].
  • the X-axis plots the retention time or elution position of reverse-phase chromatography sugar chains
  • the Y-axis plots the retention time or elution position of sugar chains by normal-phase chromatography. It is a method of estimating the sugar chain structure by comparing those results with known sugar chains.
  • the antibody is degraded by hydrazine to release a sugar chain from the antibody, and fluorescent labeling of the sugar chain with 2-aminoviridine (hereinafter abbreviated as PA) [Journal 'Ob' Biochemistry (J. Biochem.), 95, 197 (1984)], the sugar chain is separated from excess PA-forming reagent, etc. by gel filtration, and reversed-phase chromatography is performed. Next, normal phase chromatography is performed on each peak of the fractionated sugar chain.
  • PA 2-aminoviridine
  • mass spectrometry such as MALDI-TOF-MS of each sugar chain can be performed to confirm the structure estimated by the dimensional sugar chain map method.
  • immunoglobulin G (hereinafter abbreviated as IgG).
  • the N-glucoside-linked sugar chain that binds to IgG is mainly a biantennary complex type sugar chain having a structure represented by the following formula (denoted as biantennary).
  • sialic acid which is an acidic sugar
  • Gal may be added to Gal at the non-reducing end of the N-glucoside-linked sugar chain
  • bisecting N-acetylglycoscosamine may be added to the N-glucoside-linked sugar chain. is there.
  • IgG has an N-glucoside-linked sugar chain bound at one place in the Fc region. Since IgG is composed of two heavy chains, one antibody molecule has two Fc sites. Therefore, there are also two sugar chain binding sites.
  • the activity of IgG varies depending on the number of N-glucoside-linked sugar chains that do not bind fucose to N-acetylglucosamine to the above-mentioned two sugar chain binding sites. That is, when an N-glucoside-linked sugar chain in which fucose does not bind to N-acetylglucosamine is added to at least one place of the sugar chain binding site, the activity of the immune function molecule increases. An N-glycoside-linked sugar chain is not added to N-acetylglycosamine at both the sugar chain binding sites at two sites.
  • an antibody with an F0 structure Fucose does not bind to N-acetylglucosamine to N-glycoside-linked sugar chain
  • An antibody with F1 structure ⁇ antibody
  • fucose binds to N-acetylglucosamine to both the sugar chain binding site
  • F2 antibody the high IgG activity is as follows: F0 antibody> F1 antibody> F2 antibody.
  • the produced antibody does not necessarily have a single sugar chain structure, and even when attention is paid to the presence or absence of fucose, the F0 antibody, the F1 antibody, and the F2 antibody are present in a mixed state.
  • the sugar chain bound to the antibody is analyzed by the above-described method for analyzing the sugar chain of an immune function molecule, and the ADCC activity is regulated using the analysis result as an index. be able to.
  • the ratio of the F1 antibody and the F0 antibody may be increased.
  • the F1 antibody and the F0 antibody may be purified, or they may be purified from host cells so that N-darcoside-linked sugar chains, to which N-acetylglucosamine does not bind fucose, are added to the immune function molecule. Expression may be regulated.
  • the proportion of the F2 antibody may be increased.
  • the F2 antibody may be purified, or the expression in host cells may be regulated so that the N-glucoside-linked sugar chain in which fucose is bound to N-acetylglycosamine is added to the immune function molecule. May be.
  • the intensity of the desired activity can be adjusted by arbitrarily adjusting the abundance ratio of the F0 antibody, the F1 antibody, and the F2 antibody.
  • a method for producing an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose does not bind to N-acetylacetylglucosamine, or an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose binds to N-acetylglucosamine is described below. Will be described.
  • a gene encoding the desired antibody, peptide or protein can be introduced into a host cell and produced using the cell.
  • a gene encoding the antibody, peptide or protein of interest can be introduced into an animal or plant individual, and production can be performed using the individual.
  • Fucose does not bind to N-acetylglucosamine
  • Host cells or animal individuals for producing immunologically functional molecules having N-glucoside-linked sugar chains are plant individuals such as antibodies, which bind to the Fc region of the antibody. Any cell or individual having low or no enzymatic activity to add fucose to N-acetylglucosamine may be used.
  • Cells that have low or no enzymatic activity to add fucose to N-acetylglucosamine that binds to the Fc region of the antibody include rat myeloma cells, YB2 / 3HL.P2.G11.16Ag.20 cells (ATCC CRL 1662; hereinafter abbreviated as YB2 / 0 cell).
  • the host cells and the enzymes involved in the 1,6 binding of animal or plant individuals Generating cells or individuals with low or no enzymatic activity involved in the 1,6 bond by deleting the gene or mutating the gene to reduce or delete the enzymatic activity can be used as host cells or animal or plant individuals.
  • the enzyme involved in the 1,6 bond include fucosyltransferase, preferably 1,6-fucosyltransferase (hereinafter referred to as FUT8).
  • a host cell or animal individual for producing an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose binds to N-acetylglycosamine is a plant individual, for example, an antibody, and an antibody in the Fc region of the antibody. Any cell or individual having a high enzymatic activity to add fucose to N-acetylglucosamine to be bound may be used.
  • the enzyme can bind to the 1,6-linkage.
  • Cells or individuals with high enzyme activity involved can be prepared and used as host cells or animal or plant individuals.
  • the enzyme involved in the 1,6 bond include fucosyltransferase, preferably FUT8.
  • any cell that can express the gene of interest such as bacteria, yeast, animal cells, insect cells, and plant cells, can be used.
  • Bacterial host cells include microorganisms belonging to the genus Escherichia, Serratia, Bacillus, Brevibacterium, Corynebacterium, Microbacterium, Pseudomonas, etc., for example, Escherichia coli XLl-Blue ⁇ Escherichia coli XL2-Blue , Escherichia coli DH1, Escherichia coli MC1000, Escherichia coli KY3276,
  • microorganisms examples include Saccharomyces cerevisiae, Schizosaccharomyces pombe, Kluyveromyces lactis, Trichosporon pullulans s Schwanniomyces alluvius, and Candida utilis.
  • mouse myeloma cells such as NS0 cells, SP2 / 0 cells, Chinese Hams evening ovary cells CHO / dhfr- cells, CH0 / DG44 cells, rat myeloma YB2 / 0 cells, IR983F cells, monkeys COS cells, which are common cells, and Namalwa cells, which are human myeloma cells.
  • CH0 / DG44 cells which are Chinese hamster ovary cells, and the like can be mentioned.
  • Insect cell host cells include Spod9, Sf21 CBaculovirus Expression Vectors, A Laboratory Manual, WH Freeman and Company, New York (1992), which are ovarian cells of Spodoptera frugiperda, and High 5 (Invitrogen), which is an ovarian cell of Trichoplusia ⁇ _ And the like can be used.
  • Examples of the host cell of a plant cell include plant cells of tobacco, potato, tomato, carrot, soybean, rape, alf alfa, rice, wheat, wheat, and the like.
  • an immunologically functional molecule By culturing the transformant of the present invention obtained as described above in a medium, producing and accumulating an immunologically functional molecule in the culture, and collecting from the culture, an immunologically functional molecule can be produced. .
  • an animal or plant individual into which the gene has been introduced can be constructed, and these individuals can be used to produce an immune function molecule.
  • N-acetylglucosamine As an animal or plant individual for producing an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose does not bind to N-acetylglucosamine, for example, N-acetyl that binds to the Fc region of the antibody with an antibody Any animal or plant individual having low or no enzyme activity to add fucose to glucosamine may be used.
  • a knockout non-human animal or knockout plant having little or no enzyme activity involved in binding may be prepared and used.
  • the enzyme involved in the 1,6 bond include fucosyltransferase, preferably FUT8.
  • An animal or plant individual for producing an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose binds to N-acetylglucosamine is, for example, an antibody. Any animal or plant individual having a high enzymatic activity to add fucose to N-acetylglucosamine binding to the Fc region of the present invention may be used.
  • the activity of the enzyme involved in the 1,6 bond can be increased.
  • High transgenic non-human animals or transgenic plants may be produced and used.
  • the enzyme involved in the 1,6 bond include fucosyltransferase, preferably FUT8.
  • Transgenic non-human animals can be obtained by directly injecting a desired gene into a fertilized egg [Proc. Natl. Acad. Sci. USA, 77'7380 (1980)].
  • Transgenic non-human animals include mice, rats, egrets, chicks, goats, and eel.
  • a transgenic non-human or knockout non-human animal of the desired gene can be prepared by introducing the desired gene into embryonic stem cells and preparing an animal by the method of the assembly chimera method or the injection chimera method.
  • a transgenic non-human or knockout non-human animal of the desired gene can be prepared by introducing the desired gene into embryonic stem cells and preparing an animal by the method of the assembly chimera method or the injection chimera method.
  • Embryonic stem cells include mouse [Nature, 292, 154 (1981)], rat, chick, bush, monkey, goat, mouse, and the like.
  • transgenic non-human animals or knockout non-human animals can also be produced by using a cloning technique in which a nucleus into which a desired gene has been introduced is transferred to an enucleated egg [Science, 280, 1256]. , 1998; Science, 278, 824 (1997)].
  • a DNA encoding an immune function molecule is introduced into the animal individual prepared by the above method, the immune function molecule is produced and accumulated in the animal individual, and the immune function molecule is collected from the animal individual.
  • the immune function molecule can be produced. Examples of the storage location of the product in the animal include milk of the animal (JP-A-63-309192), eggs, and the like.
  • Methods for producing transgenic plants include the literature [Biol. Chem., 380, 825 (1999)]. Methods for producing knockout plants are described in the literature [Plant Journal, 11, 1195 (1997)]. can give.
  • the transgenic plant into which the DNA to be introduced has been introduced is cultivated according to a known method [tissue culture, ⁇ (1994), tissue culture, 21 (1995), Trends in Biotechnology, 15, 45 (1997)].
  • the immune function molecule can be produced by producing and accumulating the immune function molecule in the plant, and collecting the immune function molecule from the plant.
  • transgenic non-human animal or a knockout non-human animal of fucosyltransferase preferably FUT8
  • a transgenic animal of a desired immunologically functional molecule that is a syngeneic other strain
  • N- An immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose does not bind to acetylglycosamine or an immunologically functional molecule having an N-glucoside-linked sugar chain in which fucose binds to N-acetylglycosamine can be produced.
  • Genetically modified animals can be obtained. Methods of mating include natural mating and in vitro fertilization.
  • the isolated gene group of the enzyme or the like may be introduced into yeast, Escherichia coli, or the like, and the sugar chain may be mass-produced [Nature Biotechnology (Nature Biotechnology), 16, 847 (1998)]. it can.
  • the produced enzyme can also be used for modifying or producing an antibody, peptide or protein with the sugar chain.
  • a sugar chain that promotes the activity of the immune function molecule of the present invention can be replaced with a peptide [Journal 'Ob' Immunol. (J. Immunol.), 160, 293 (1998)].
  • the peptide is useful in the above-described method of using a sugar chain, and is also excellent in simplicity because it can be easily fused with an immune function molecule.
  • the humanized antibody expression vector refers to a human antibody heavy chain (hereinafter referred to as H chain) and a light chain (hereinafter referred to as L chain) for animal cells into which genes encoding the C region are incorporated. It is an expression vector and can be constructed by cloning the genes encoding the H chain and L chain C regions of a human antibody into an expression vector for animal cells.
  • the C region of the human antibody can be any of the H chain and L chain C regions of a human antibody.
  • the C region of the IgGl subclass of the H chain of a human antibody hereinafter, referred to as hCr1
  • the C region of the L chain class of a human antibody hereinafter referred to as hC.
  • chromosomal MA consisting of exon and intron can be used, and cDNA can also be used.
  • Any expression vector for animal cells can be used as long as it can incorporate and express a gene encoding the C region of a human antibody.
  • PAGE107 [Cytotechnology, 3, 133 (1990)]
  • pAGE103 [Journal, Ob 'Biochemistry (J. Biochem.), Dish, 1307 (1987)]
  • pHSG274 [Gene ), 223 (1984)]
  • pKCR Procedings of the National Academy of Sciences (Proc. Natl. Acad. Sci. USA), 78, 1527 (1981)]
  • pSGl ⁇ d2 -4 [Cytotechnology, 4, 173 (1990)].
  • the early promoters and enhancers used in animal cell expression vectors include the early promoters of SV40 — Yuichi and Enhancer [J. Biochem., 101, 1307 (1987) , Moroni murine leukemia virus LTR [Biochemical 'and' Biophysical 'Research' Communications (Biochem. Biophys. Res. Co. thigh un.), 149, 960 (1987)], promotion of immunoglobulin H chain Yuichi [Cell, 41, 79 (1985)] and Enhansa 1 [Cell, 33, 717 (1983)].
  • the vector for expressing humanized antibody can be either an evening Hv where the antibody H and L chains are present on separate vectors, or a type where the H and L chains are present on the same vector (hereinafter referred to as tandem type). Although it can be used, ease of construction of a humanized antibody expression vector, ease of introduction into animal cells, balance of antibody H chain and L chain expression levels in animal cells are balanced, etc. Therefore, a vector for expressing a tandem humanized antibody is preferable [Journal of Immunological Methods] (J. Immunol. Methods), 167, 271 (1994)].
  • the constructed humanized antibody expression vector can be used for expression of a human chimeric antibody and a human CDR-grafted antibody in animal cells.
  • CDNAs encoding the H chain and L chain V regions of non-human animal antibodies can be obtained as follows.
  • MRNA is extracted from hybridoma cells producing the desired mouse antibody, and cDNA is synthesized.
  • the synthesized cDNA is cloned into a vector such as phage or plasmid to prepare a cDNA library. From the library, using the C region or V region of the existing mouse antibody as a probe, a recombinant phage having cDNA encoding the H region V region or cDNA encoding the recombinant plasmid and L chain V region A recombinant phage or a recombinant plasmid having the following is isolated.
  • Recombination phage or recombination The entire nucleotide sequence of the H chain and L chain V regions of the target mouse antibody on the plasmid is determined, and the entire amino acid sequence of the H chain and L chain V regions is deduced from the base sequence.
  • any animal can be used as long as hybridoma cells can be produced, such as mouse, rat, Hamus Yuichi, and rabbit.
  • Methods for preparing total RNA from hybridoma cells include guanidine thiocyanate-cesium trifluoroacetate method [Methods in Enzymol., 154, 3 (1987)], and mRNA preparation from total RNA.
  • Examples of the method to be used include an oligo (dT) -immobilized cellulose column method [Molecular Cloning: Laboratory “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Lab. Press New York, 1989] and the like. can give.
  • kits for preparing mRNA from hybridoma cells include Fast Track mRNA Isolation Kit (manufactured by Invitrogen) and Quick Prep mRNA Purification Kit (manufactured by Pharmacia).
  • any vector can be used as a vector for incorporating a cDNA synthesized as a type III mRNA extracted from a hybridoma cell as long as the cDNA can be incorporated.
  • ZAP Express [Strategies, 5, 58 (1992)]
  • pBluescript II SK (+) [Nucleic Acids Research, 17, 9494 (1989)]
  • ⁇ zap II ⁇ gtlO, ⁇ gtll [DNA Cloning: A Practical Approach]
  • ⁇ , 49 (1985) Lambda BlueMid (Clontech), ⁇ ExCell, pT7T3 18U (Pharmacia)
  • pcD2 [Molecular 'and' Cellular 'biology (Mol. Cell. Biol.), 3, 280 (1983)]
  • pUC18 Gene, 33, 103 (1985)] Etc.
  • any Escherichia coli capable of introducing, expressing and maintaining the cDNA library can be used.
  • XL U Blue MR [Strategy (Strategies), 5, 81 (1992)], C600 [Genetics, 39, 440 (1954)], Y1088, Y1090 [Science, 222, 778 (1983)], NM522 [Journal. ⁇ Molecular 'Biology (J. Mol. Biol.), 166, 1 (1983)], K802 [Journal' ob Molecule 'Biology (J. Mol. Biol.), 16, 118 (1966)] And JM105 [Gene, 38, 275 (1985)].
  • Methods for selecting cDNA clones encoding the H chain and L chain V regions of non-human animal antibodies from the cDNA library include colony hybridization, plaque hybridization using an isotope or fluorescently labeled probe, etc. Hybridization method [Molecular Cloning: A Laboratory Manual], Cold Spring Harbor Lab. Press New York, 1989].
  • a primer or a cDNA synthesized from mRNA or a cDNA library is used as a type II, and is referred to as Polymerase Chain Reaction [hereinafter, referred to as PCR method; Molecular Cloning: A ⁇ Laboratory ⁇ Manual (Molecular Cloning: A Laboratory) Manual), Cold Spring Harbor Lab. Press New York, 1989; H-chain and L-chain V regions by Current Protocols in Molecular Biology, Supplement 1-34].
  • CDNA to be encoded can also be prepared.
  • the cDNA selected by the above method is cleaved with an appropriate restriction enzyme or the like, cloned into a plasmid such as pBluescript SK (-) (manufactured by Stratagene), and a commonly used nucleotide sequence analysis method, for example, Sangaichi ( Sanger) et al. [Procedures of the 'National' Academy 'of Science (Proc. Natl. Acad. Sci., USA), 74, 5463 (1977)].
  • the base sequence of the cDNA can be determined by analysis using an automatic base sequence analyzer such as ALF DNA Sequencer (Pharmacia).
  • the entire amino acid sequence of the H chain and the L chain V region was estimated, and the entire amino acid sequence of the H chain and the L chain V region of the known antibody [Sequences of protein and proteins]
  • the obtained cDNA was compared with that of the sequence of M. mori deer (Sequences oi Proteins oi Immunological Interest), US Dept. Health and Human Services, 1991]. It can be confirmed that the region encodes the complete amino acid sequence.
  • the length of the secretory signal sequence and the N-terminal amino acid sequence can be estimated, and the subgroup to which they belong can be known.
  • the amino acid sequences of the CDRs of the H chain and the L chain V region the amino acid sequences of the H chain and the L chain V region of the known antibody [sequences], [proteins], and Evening rest (Sequences of Proteins of Immunological Interest), US Dept. Health and Human Services, 1991].
  • the H-chain and L-chain V regions of a non-human animal antibody are located upstream of the gene encoding the H-chain and L-chain C regions of the human antibody in the humanized antibody expression vector described in 4 (1) of this section.
  • a human chimeric antibody expression vector can be constructed.
  • the cDNA encoding the H chain and L chain V regions of the antibody of a non-human animal can be obtained by combining the nucleotide sequence at the 3 'end of the H chain and L chain V regions of the non-human animal with the H chain and the human antibody. And the base sequence at the 5 'end of the C region of the L chain and linked to a synthetic DNA having an appropriate restriction enzyme recognition sequence at each end.
  • CDNA encoding the H chain and L chain V regions of the human CDR-grafted antibody can be constructed as follows. First, the amino acid sequence of the framework (hereinafter, referred to as FR) of the H chain and L chain V regions of the human antibody to which the CDRs of the H chain and L chain V regions of the target non-human animal antibody are transplanted is selected. . Any amino acid sequence can be used as the FR amino acid sequence of the H chain and L chain V regions of the human antibody, as long as it is derived from a human antibody.For example, the amino acid sequence registered with the Protein Data Bank, etc.
  • Amino acid sequence of FR in the V region of H chain and L chain of human antibody and common amino acid sequence of each subgroup of FR in the V region of H chain and L chain of human antibody [Sequences] Opportunistics, Sequences of Proteins of Immunological Interest, US Dept. Health and Human Services, 1991], among which human-type CDR-grafted antibodies with sufficient activity are To make it, the H chain of the desired non-human animal antibody It is desirable to select an amino acid sequence having the highest possible homology (at least 60% or more) with the FR amino acid sequence of the L chain V region.
  • the amino acid sequence of the CDR of the H chain and L chain V region of the antibody of the target non-human animal is transplanted into the FR amino acid sequence of the H chain and L chain V region of the selected human antibody.
  • the amplified product is cloned into a plasmid such as pBluescript SK (-) (manufactured by Stratagene), the nucleotide sequence is determined by the method described in (2) of this section 4, and the desired human CDR-grafted antibody is obtained.
  • a plasmid having a DNA sequence encoding the amino acid sequence of the H chain and L chain V regions is obtained.
  • a human CDR-grafted antibody has its antigen-binding activity only by grafting the CDRs of the H chain and L chain V region of the target non-human animal antibody into the FRs of the H chain and L chain V region of a human antibody. It is known that it is lower than that of the original non-human animal antibody [Bio / Technology-1 (BI0 / TECHN0L0GY), 9, 266 (1991)]. This is due to the fact that not only CDRs but also some amino acid residues of FRs are directly or indirectly involved in antigen binding activity in the V region of the H chain and L chain of the antibody of the non-human animal.
  • human-type CDR-grafted antibodies use amino acid residues or CDRs that are directly involved in binding to the antigen in the amino acid sequence of FRs in the H chain and L chain V regions of the human antibody. Identify amino acid residues that interact with amino acid residues or maintain the antibody's three-dimensional structure, and indirectly participate in antigen binding, and find them in the original non-human animal antibody It has been modified to amino acid residues to increase the decreased antigen binding activity [Bio / Technology-1 (BI0 / TECHN0L0GY), 9, 266 (1991)] o
  • the modification of the FR amino acid residue in the H chain and L chain V regions of a human antibody can be achieved by performing the PCR method described in 4 (5) of this section using the synthetic DNA for modification.
  • the nucleotide sequence of the amplified product after PCR is determined by the method described in (2) of this section 4 to confirm that the target modification has been performed.
  • the vector for expression of a humanized antibody described in (1) of Section 4 above was constructed in (5) and (6) of Section 4 upstream of the gene encoding the H chain and L chain C regions of the human antibody.
  • a cDNA encoding the H chain and L chain V regions of the human CDR-grafted antibody can be cloned to construct a human CDR-grafted antibody expression vector.
  • the 5 'end of the synthetic DNA located at both ends is used.
  • these can be located upstream of the gene encoding the H chain and L chain C regions of the human antibody in the humanized antibody expression vector described in (4) of this section 4. It can be cloned to express it in an appropriate form to construct a human CDR-grafted antibody expression vector.
  • Examples of a method for introducing an expression vector into an animal cell include an electroporation method [Japanese Patent Laid-Open No. 2-257891, Cytotechnology, 3, 133 (1990)].
  • an animal cell into which the humanized antibody expression vector is introduced any animal cell capable of producing a humanized antibody can be used, but preferably the Fc region of the antibody to be produced is used.
  • Cells with low or no enzyme activity that add fucose to N-acetylglycosamine added to the Fc region of an antibody are cells that have little or no enzyme involved in a 1,6 binding, Specific examples include cells having little or no fucosyltransferase activity, preferably FUT8 activity.
  • Cells with low or no enzymatic activity to add fucose to N-acetylglycosamine added to the Fc region of an antibody include rat myeloma cells, such as YB2 / 0 cells.
  • Cells in which the gene of an enzyme involved in 1,6 binding is deleted or a mutation is given to the gene to reduce or delete the enzyme activity can also be used as antibody-producing cells.
  • mouse myeloma cells NS0 cells, SP2 / 0 cells, Chinese hamster ovary cells CHO / dhfr- cells, CH0 / DG44 cells, rat myeloma YB2 / 0 cells, IR983F cells, and human myeloma cells Namalba cells and the like.
  • CH0 / DG44 cells which are Chinese hams evening ovary cells, and the like can be mentioned.
  • a transformant that stably produces a humanized antibody can be prepared by using a drug such as G418 sulfate (hereinafter, referred to as G418; manufactured by SIGMA) according to the method disclosed in JP-A-2-2577891. It can be selected depending on the animal cell culture medium contained.
  • G418 G418 sulfate
  • Animal cell culture media include RPMI1640 medium (Nissui Pharmaceutical), GIT medium (Nippon Pharmaceutical), EX-CELL302 medium (JRH), IMDM medium (GIBCO BRL), Hybridoma- An SFM medium (GIBCO BRL) or a medium obtained by adding various additives such as fetal calf serum (hereinafter referred to as FBS) to these mediums can be used.
  • FBS fetal calf serum
  • the amount of humanized antibody produced in the culture supernatant and the antigen-binding activity were determined by enzyme-linked immunosorbent assay [hereinafter referred to as ELISA; Antibodies: A Laboratory-Anibore (Antibodies: A Laboratory Manual)], Cold Spring Harbor Laboratory, Chapter 14, 1998, Monoclonal Antibodies: Principles and Practice, Academic Press Limited, 1996] and the like.
  • the transformant can increase the amount of humanized antibody produced using a DHFR gene amplification system or the like according to the method disclosed in Japanese Patent Application Laid-Open No. 2-257891.
  • Humanized antibodies can be purified from the culture supernatant of the transformant using a protein A column [Antibodies: A Laboratory Manual], Cold Spring Harbor Laboratory, Chapter 8, 1988, monochrome —Nal 'Antibodies: Principles and Practice, Academic Press Limited, 1996].
  • other purification methods usually used for protein purification can be used.
  • purification can be performed by a combination of gel filtration, ion exchange chromatography, and ultrafiltration.
  • the molecular weight of the purified humanized antibody H chain, L chain or whole antibody molecule can be determined by polyacrylamide gel electrophoresis [hereinafter referred to as SDS-PAGE; Nature, 227, 680 (1970)] or Western blotting.
  • SDS-PAGE polyacrylamide gel electrophoresis
  • the method for producing an antibody using an animal cell as a host has been described above.
  • the antibody can be produced in a bacterium, a yeast, an insect cell, a plant cell, or an animal or plant.
  • the binding activity of the purified humanized antibody to the antigen and the binding activity to the antigen-positive cultured cell line were determined by ELISA and immunofluorescence [Cancer-Immunology-Immunotherapy (Cancer Immunol. Immunother.), 36, 373 (1993)]. Can be measured. Cytotoxic activity against antigen-positive cultured cell lines can be evaluated by measuring CDC activity, ADCC activity, etc. [Cancer Immunol. Immunother., 36,
  • the safety and therapeutic effect of the humanized antibody in humans can be evaluated using an appropriate model of an animal species relatively close to humans, such as a cynomolgus monkey.
  • an antibody having a high ADCC activity is useful in the prevention and treatment of various diseases including cancer, allergy, cardiovascular disease, or viral or bacterial infection.
  • Cancer or malignant tumor, is a growth of cancer cells.
  • Ordinary anticancer drugs are characterized by inhibiting the growth of cancer cells.
  • an antibody having a high ADCC activity can treat cancer by damaging cancer cells by a cell-killing effect, and is therefore more effective as a therapeutic agent than ordinary anticancer drugs.
  • the allergic reaction is triggered by the release of mediator molecules by immune cells. Therefore, by removing the immune cells using an antibody having high ADCC activity, Response can be suppressed.
  • Cardiovascular diseases include arteriosclerosis. Atherosclerosis is currently treated with a balloon catheter.However, it is possible to prevent and treat cardiovascular diseases by suppressing the proliferation of arterial cells during restenosis after treatment with antibodies with high ADCC activity. it can. By suppressing the proliferation of cells infected with a virus or a bacterium by using an antibody having high ADCC activity, it is possible to prevent and treat various diseases including a virus or a bacterium infection.
  • antibodies with suppressed ADCC activity are useful in the prevention and treatment of autoimmune diseases.
  • antibodies with suppressed ADCC activity are useful in the prevention and treatment of autoimmune diseases, from the viewpoint of suppressing the immune response enhanced in autoimmune diseases.
  • the pharmaceutical containing the antibody of the present invention can be administered alone as a therapeutic agent, it is usually mixed with one or more pharmacologically acceptable carriers to obtain a pharmaceutical preparation. It is desirable to provide it as a pharmaceutical preparation manufactured by any method well known in the art.
  • the administration route is preferably the one that is most effective in treatment, and may be oral administration or parenteral administration such as buccal, respiratory, rectal, subcutaneous, intramuscular and intravenous administration.
  • parenteral administration such as buccal, respiratory, rectal, subcutaneous, intramuscular and intravenous administration.
  • intravenous administration can be preferably mentioned.
  • Dosage forms include sprays, capsules, tablets, granules, syrups, emulsions, suppositories, injections, ointments, tapes and the like.
  • Formulations suitable for oral administration include emulsions, syrups, capsules, tablets, powders, granules and the like.
  • Liquid preparations such as emulsions and syrups include water, sugars such as sucrose, sorbitol, fructose, glycols such as polyethylene glycol and propylene glycol, oils such as sesame oil, olive oil, soybean oil, p-hydroxybenzoic acid. It can be manufactured using preservatives such as acid esters and flavors such as stove beef flavor and peppermint as additives.
  • Capsules, tablets, powders, granules, etc. are excipients such as lactose, glucose, sucrose, mannitol, disintegrants such as starch, sodium alginate, lubricants such as magnesium stearate, talc, polyvinyl alcohol, hydroxy It can be produced using a binder such as propylcellulose and gelatin, a surfactant such as S-fatty acid ester, and a plasticizer such as glycerin as additives.
  • Formulations suitable for parenteral administration include injections, suppositories, sprays and the like.
  • Injectables are prepared using a carrier such as a salt solution, a glucose solution, or a mixture of both. Prepared. Alternatively, a powdered injection can be prepared by freeze-drying a humanized antibody according to a conventional method and adding sodium chloride thereto.
  • a carrier such as a salt solution, a glucose solution, or a mixture of both.
  • Suppositories are prepared using carriers such as cocoa butter, hydrogenated fats or carboxylic acids.
  • Sprays are prepared using the compound itself or a carrier that does not irritate the oral and respiratory tract mucosa of the recipient and disperses the compound as fine particles to facilitate absorption.
  • the carrier include lactose and glycerin.
  • Formulations such as aerosols and dry powders are possible depending on the properties of the compound and the carrier used.
  • the components exemplified as additives for oral preparations can be added.
  • the dose or frequency of administration varies depending on the desired therapeutic effect, administration method, treatment period, age, body weight, etc., but is usually 10 mg / kg to 20 mg / kg per day for an adult.
  • Methods for examining the antitumor effect of antibodies on various tumor cells include in vitro experiments such as CDC activity assay and ADCC activity assay.
  • In vivo experiments include tumor-based tumors in experimental animals such as mice. And antitumor experiments.
  • the activity of an immune function molecule can be promoted by producing an antibody, peptide or protein to which a sugar chain having no fucose is bound by the above method.
  • an immune function molecule By administering to the living body an immune function molecule whose activity has been promoted, a variety of cells including the effector cells responsible for ADCC activity, such as killer cells, natural killer cells, activated macrophages, etc. Immune cells are activated, and various immune responses can be regulated.
  • an immune function molecule can be suppressed by producing an antibody, peptide or protein to which a sugar chain containing fucose is bound by the method described above.
  • an immunologically functional molecule whose activity has been suppressed to the living body, the activity of various immune cells bearing ADCC activity is weakened in the living body, and it becomes possible to regulate various immune responses.
  • FIG. 1 is a diagram showing an SDS-PAGE (using a 4 to 15% gradient gel) electrophoresis pattern of five purified anti-GD3 chimeric antibodies.
  • the upper figure shows electrophoresis under non-reducing conditions, and the lower figure shows electrophoresis under reducing conditions.
  • Lane 1 is high molecular weight marker
  • 2 is YB2 / 0-GD3 quinula antibody
  • 3 is CH0 / DG44-GD3 chimeric antibody
  • 4 is SP2 / 0-GD3 quinula antibody
  • 5 is NS0-GD3 chimeric antibody (302)
  • 6 indicates the NS0-GD3 chimeric antibody (GIT)
  • 7 indicates the electrophoretic pattern of the low molecular weight marker.
  • FIG. 2 is a diagram showing the binding activity of five purified anti-GD3 chimeric antibodies to GD3, which was measured by changing the antibody concentration.
  • the vertical axis indicates the binding activity to GD3, and the horizontal axis indicates the antibody concentration.
  • ⁇ is YB2 / 0-GD3 chimeric antibody
  • Okina is CH0 / DG44-GD3 chimeric antibody
  • Mouth is SP2 / 0-GD3 chimeric antibody
  • Garden is NS0-GD3 chimeric antibody (302)
  • FIG. 3 is a diagram showing ADCC activities of five types of purified anti-GD3 quinula antibodies against human melanoma cell line G-361.
  • the vertical axis shows the cytotoxic activity, and the horizontal axis shows the antibody concentration.
  • ⁇ is the YB2 / 0-GD3 chimeric antibody
  • ⁇ is the CH0 / DG44-GD3 chimeric antibody
  • the mouth is the SP2 / 0-GD3 chimeric antibody
  • the garden is the NS0-GD3 chimeric antibody (302)
  • the mouse is the NS0-GD3 chimeric antibody (GIT ) Shows the respective activities.
  • FIG. 4 is a view showing an SDS-PAGE (4-: using a 15% gradient gel) electrophoresis pattern of three kinds of purified anti-hIL-5R CDR-grafted antibodies.
  • the upper figure shows the results of electrophoresis under non-reducing conditions, and the lower figure shows the results of electrophoresis under reducing conditions.
  • Lane 1 is a high molecular weight marker
  • 2 is a YB2 / 0-hIL-5RCDR antibody
  • 3 is a CH0 / d-hIL-5RCDR antibody
  • 4 is an NS0-hIL-5RCDR antibody
  • 5 is a migration pattern of a low molecular weight marker.
  • FIG. 5 is a diagram showing the binding activity of three types of purified anti-hIL-5R CDR-grafted antibodies to hIL-5Ra with varying antibody concentrations.
  • the vertical axis indicates the binding activity of ML-5R human, and the horizontal axis indicates the antibody concentration.
  • ⁇ indicates the activity of the YBZ / O-hll ⁇ SRCDR antibody, Hata indicates the activity of the CHO / d-hIL-5RCDR antibody, and the mouth indicates the activity of the NS0-hIL-5RCDR antibody.
  • FIG. 6 shows ADCC activities of three types of purified anti-hIL-5R CDR-grafted antibodies against hIL-5R-expressing mouse T cell line CTLL-2 (h5R).
  • the vertical axis shows the cytotoxic activity, and the horizontal axis shows the antibody concentration.
  • ⁇ indicates the activity of the YB2 / 0-hIL-5RCDR antibody
  • Hata indicates the activity of the CH0 / d-hIL-5RCDR antibody
  • the mouth indicates the activity of the NSO-hIL-5RCDR antibody.
  • FIG. 7 is a graph showing the inhibitory effect of three types of purified anti-hIL-5R CDR-grafted antibodies on hIL-5-induced eosinophilia model in cynomolgus monkeys.
  • the vertical axis is the number of peripheral blood eosinophils, the horizontal axis Shows the number of days (starting day of administration of antibody and hIL-5 was set to 0 day).
  • 101, 102 non-administered group, 301, 302, 303: YB2 / 0-hIL-5RCDR antibody group, 401, 402, 403: CH0 / d-hIL-5RCDR antibody group, 501, 502, 503
  • the results of the NS0-hIL-5RCDR antibody administration group are shown respectively.
  • Fig. 8 Reversed-phase HPLC elution of PA-glycans from purified anti-ML-5R a CDR-grafted antibody produced by YB2 / 0 (upper) and purified anti-hIL-5R-C CDR-grafted antibody produced by NS0 (lower)
  • Fig. 1 shows an elution diagram (left figure) and a separation diagram (right figure) obtained by analyzing the PA-linked glycan with hi-lefcosidase and analyzing it by reversed-phase HPLC.
  • the vertical axis indicates relative fluorescence intensity, and the horizontal axis indicates elution time.
  • FIG. 9 shows an elution diagram obtained by preparing a PA-linked sugar chain from a purified anti-hIL-5Ra CDR-grafted antibody produced by CHO / d cells and analyzing by reverse-phase HPLC.
  • the vertical axis indicates relative fluorescence intensity, and the horizontal axis indicates elution time.
  • FIG. 10 is a diagram in which the binding activity of a part of the non-adsorbed fraction and the adsorbed fraction to GD3 was measured by changing the antibody concentration.
  • the vertical axis indicates the binding activity to GD3, and the horizontal axis indicates the antibody concentration.
  • Indicates the non-adsorbed fraction and ⁇ indicates a part of the adsorbed fraction.
  • the figure below shows the ADCC activity of the non-adsorbed fraction and a part of the adsorbed fraction on human melanoma cell line G-361.
  • the vertical axis shows cytotoxic activity, and the horizontal axis shows antibody concentration. Hata indicates the non-adsorbed fraction and ⁇ indicates a part of the adsorbed fraction.
  • Fig. 11 shows an elution diagram obtained by analyzing a PA-linked sugar chain prepared from a part of the non-adsorbed fraction and the adsorbed fraction by reverse phase HPLC.
  • the left figure shows the elution diagram of the non-adsorbed fraction
  • the right figure shows the elution diagram of a part of the adsorbed fraction.
  • the vertical axis shows the relative fluorescence intensity
  • the horizontal axis shows the elution time.
  • Fig. 12 shows the amount of FUT8 transcript in each host cell line when the rat FUT8 sequence was used as a standard and internal control.
  • the garden shows the case where the CH0 cell line was used and the mouth used the YB2 / 0 cell line as the host cell.
  • the expression vector of the L chain of the anti-ganglioside GD3 human chimeric antibody (hereinafter, referred to as the anti-GD3 chimeric antibody) of pChiLHGM4.
  • PChi641LGM4 [Journal B. Immunol. Methods, 167, 271 (1994)]
  • L-chain cDNA obtained by cutting with restriction enzymes Mlul (Takara Shuzo) and Sail (Takara Shuzo).
  • the plasmid pChi641LGM40 constructed above is digested with the restriction enzyme Clal (Takara Shuzo), blunt-ended using the DNA Blunting Kit (Takara Shuzo), and further cut with Mlul (Takara Shuzo). Expression of about 5.68 kb fragment containing L chain cDNA and H chain of anti-GD3 chimera antibody Vector pChi641HGM4 [Journal of Immunol. Methods (J. Immunol.
  • tandem expression vector pChi641LHGM4 of the anti-GD3 chimeric antibody constructed in paragraph 1 of Example 1 above cells capable of stably producing the anti-GD3 chimeric antibody were produced as follows.
  • the cells were suspended in [RPMI1640 medium containing 10% FBS (GIBCO BRL)] and dispensed into 96-l culture plates (Sumitomo Belite) at 200 l / l. 5% C0 2 incubator - 37 ° in the (After culturing for 24 hours, colonies of transformants appeared showing the addition to 1 to 2 weeks of culture with G418-resistant so that the G418 to 0.5 mg / ml. The culture supernatant was recovered from the wells in which proliferation was observed, and the antigen-binding activity of the anti-GD3 quinula antibody in the supernatant was measured by the ELISA method described in Example 1, section 3.
  • RPMI1640- containing 0.5 mg / ml of G418 and 50 nM of methotrexet (hereinafter referred to as MTX; SIGMA), an inhibitor of DHFR, for the purpose of increasing antibody production using the DHFR gene amplification system
  • MTX methotrexet
  • a transformant capable of growing on an RPMI1640-FBS (10) medium containing MTX at a concentration of 200 nM and highly producing an anti-GD3 chimeric antibody was obtained.
  • the transformed cell obtained was subjected to two single cell dilutions (cloning) by the limiting dilution method.
  • the thus-obtained transformed cell clone 7-9-51 producing the anti-GD3 chimeric antibody was produced on April 5, 2001 by the Institute of Biotechnology, Industrial Science and Technology (Tsukuba, Ibaraki, Japan).
  • IMDM-dFBS (10) medium IMDM medium containing 10% of dialyzed fetal bovine serum (hereinafter referred to as dFBS; GIBC0 BRL)] to a concentration of l ⁇ 2 x 10 5 cells / ml, 0.5 ml was dispensed into 24-well plates (Iwaki Glass). After culturing at 37 ° C.
  • a transformant showing ⁇ resistance was induced.
  • the MTX concentration was increased to 100 n by the same method as above, and finally IMDM-dFBS containing G418 at 0.5 mg / ml and MTX at a concentration of ⁇ Propagated in (10) medium A transformant capable of producing a high anti-GD3 chimeric antibody was obtained.
  • the obtained transformant was subjected to two single cell dilutions (cloning) by the limiting dilution method.
  • EX-CELL302-dFBS (10) medium EX-CELL302 medium containing 10% dFBS and 2 mM L-Gln
  • EX-CELL302 medium containing 10% dFBS and 2 mM L-Gln EX-CELL302 medium containing 10% dFBS and 2 mM L-Gln
  • the antigen-binding activity of the anti-GD3 quinula antibody in the culture supernatant of the gel in which the growth of the transformed strain was observed was measured by the ELISA method described in Example 1, section 3.
  • the MTX concentration was gradually increased to 100 nM and 200 ⁇ in the same manner as above, and finally G418 was 0.5 mg / ml.
  • a transformant capable of growing on an EX-CELL302-dFBS (10) medium containing MTX at a concentration of 200 nM and highly producing an anti-GD3 chimeric antibody was obtained.
  • the resulting transformant was transformed into a single cell (cloning) by the limiting dilution method twice.
  • the binding activity of the antibody to GD3 was measured as follows.
  • GD3 dipalmitoylphosphatidylcholine
  • SIGMA dipalmitoylphosphatidylcholine
  • SIGMA cholesterol
  • 20 n 1 (40 pmol / well) of this solution was dispensed into each well of a 96-well ELISA plate (manufactured by Greiner), air-dried, and 1% bovine serum albumin (hereinafter referred to as BSA).
  • BSA bovine serum albumin
  • ABTS substrate solution [2,2, -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) ammonium is added to 1 L of 0.1 M citrate buffer ( pH 4.2), and immediately before use, a solution in which hydrogen peroxide was added at 1 UL 1 / ml) was added at 50 z1 / Pell to develop color, and the absorbance at 415 nm (hereinafter referred to as 0D415) was measured. It was measured.
  • the transformed cell clone producing the anti-GD3 chimeric antibody obtained in the above-mentioned Example 1, paragraph 2 (1) was obtained by using BSA at 0.2%, MTX at 200 nM, and triiodothyronine (hereinafter referred to as T3; manufactured by SIGMA). ) was suspended in Hybridoma-SFM medium containing ⁇ at a concentration of 3 x 10 5 cells / ml, and cultured with stirring at 50 rpm using a 2.0 L spinner-bottle (Iwaki Glass). After culturing for 10 days in a thermostat at 37 ° C, the culture supernatant was collected. Prosep-A from culture supernatant
  • the anti-GD3 chimeric antibody was purified using a column (manufactured by Bioprocessing) according to the attached instructions.
  • the purified anti-GD3 chimeric antibody was named YB2 / 0-GD3 chimeric antibody.
  • the transformed cell clone producing the anti-GD3 chimeric antibody obtained in the section 2 (2) of Example 1 was treated with 3 mM of L-Gln and a fatty acid concentrate (hereinafter referred to as CDLC; manufactured by GIBCO BRL).
  • CDLC a fatty acid concentrate
  • PF68 pull port nick F68
  • GIBC0 BRL Co. the pull port nick F68
  • the anti-GD3 chimeric antibody was purified from the culture supernatant using a Prosep-A (manufactured by Bioprocessing) column according to the attached instructions.
  • the purified anti-GD3 chimeric antibody was named CH0 / DG44-GD3 quinula antibody.
  • the transformed cell clone producing the anti-GD3 chimeric antibody obtained in the section 2 (3) of Example 1 was L-Gln at 2 mM, G418 at 0.5 mg / ml, MTX at 200 nM, and FBS at 1%. It was suspended in a lx lO 6 cells / ml in EX- cell 302 medium containing at, aliquoted 200ml min to 175 thigh 2 flasks (Greiner Co.). 5% C0 4 days after culturing at 37 ° C for 2 incubator within one, the culture supernatant was recovered.
  • the anti-GD3 chimeric antibody was purified from the culture supernatant using a Prosep-A (Bioprocessing) column according to the attached instructions.
  • the purified anti-GD3 chimeric antibody was named S0-GD3 chimeric antibody (302).
  • the transformed cell clone was suspended in a GIT medium containing G418 at a concentration of 0.5 mg / ml and MTX at a concentration of 200 nM at a concentration of 3 ⁇ 10 5 cells / ml, and placed in a 175 band 2 flask (Greiner). Each 200 ml was dispensed. 5 C0 10 days after cultivation at 37 ° C for within 2 incubator, the culture supernatant was recovered.
  • the anti-GD3 chimeric antibody was purified from the culture supernatant using a Prosep-A (Bioprocessing) column according to the attached instructions.
  • the purified anti-GD3 chimeric antibody was named NS0-GD3 chimeric antibody (GIT).
  • a transformed cell clone producing the anti-GD3 chimeric antibody described in JP-A-5-304989 was suspended in a GIT medium containing G418 at a concentration of 0.5 mg / ml and MTX at a concentration of 200 nM at a concentration of 310 5 cells / ml. 200 ml was dispensed into two flasks of 175 each (Greiner). 5 C0 2 incubator evening 8 days after incubation at 37 ° C for in the primary, the culture supernatant was recovered.
  • the anti-GD3 chimeric antibody was purified from the culture supernatant using a Prosep-A (Bioprocessing) column according to the attached instructions.
  • the purified anti-GD3 chimeric antibody was named SP2 / 0-GD3 chimeric antibody.
  • each purified anti-GD3 chimeric antibody had a single band with a molecular weight of about 150 kilodaltons (Kd) under non-reducing conditions, Two bands of about 50Kd and about 25Kd were observed.
  • FIG. 2 shows the results of examining the binding activity by changing the concentration of the added anti-GD3 chimeric antibody.
  • the five types of anti-GD3 chimeric antibodies exhibited almost the same binding activity to GD3. This result indicates that the antigen-binding activity of the antibody is constant irrespective of the animal cell producing the antibody and the culture method.
  • a comparison between the NS0-GD3 chimeric antibody (302) and the NS0-GD3 chimeric antibody (GIT) suggested that the antigen-binding activity was constant irrespective of the culture medium used.
  • ADCC activity In vitro cytotoxic activity of anti-GD3 chimeric antibody
  • ADCC activity was measured according to the method described below.
  • RPMI 1640-FBS (10) to 1 X 10 6 cells of human melanoma cell line G-361 was cultured in a medium (ATCC CRL1424) were prepared, 37 ° by addition of Na 2 51 Cr0 4 is a radioactive substance 3.7MBq equivalents The cells were allowed to react for 1 hour and radiolabeled. After the reaction, the suspension was washed three times with RPMI1640-FBS (10) medium by suspending and centrifuging, resuspended in the medium, and left on ice at 4 ° C for 30 minutes to allow natural dissociation of radioactive substances. After centrifugation, RPMI1640-FBS (10) medium was added 5 ml, adjusted to 2 x l0 5 cells / ml, and a target cell solution.
  • the amount of spontaneously dissociated 51 Cr was determined by performing the same operation as above using only the medium instead of the effector cell solution and the antibody solution, and measuring the amount of 51 Cr in the supernatant.
  • the total amount of dissociated 51 Cr was determined by adding the medium alone instead of the antibody solution and adding 1 N hydrochloric acid instead of the effector cell solution, and performing the same operation as above, and measuring the amount of 51 Cr in the supernatant.
  • ADCC activity was determined by the following equation.
  • Total dissociation 51 Cr-Spontaneous dissociation 51 A result is shown in Fig. 3.
  • the YB2 / 0-GD3 quinula antibody showed the highest ADCC activity, followed by the SP2 / 0-GD3 chimeric antibody, the NS0-GD3 quinula antibody, The ADC0 activity was higher in the order of the CH0-GD3 chimeric antibody.
  • the above results indicate that the ADCC activity of the antibody varies greatly depending on the animal cell used for production. The mechanism was assumed to be due to the difference in the structure of the Fc region of the antibody, since the antigen binding activities were equivalent.
  • Example 3 Preparation of Anti-Human Inulin Leukin 5 Receptor Single Chain Human CDR-grafted Antibody 1. Preparation of Stable Cell Producing Anti-Human Inulin Leukin 5 Receptor Single Chain Human CDR-grafted Antibody
  • W097 / 10354 Anti-human in evening leukin 5 receptor evening single chain human CDR-grafted antibody
  • a cell stably producing an anti-hIL-5Ra CDR-grafted antibody was prepared as follows.
  • Anti hIL-5R a CDR-grafted antibody expression base Kuta one pKANTEX1259HV3LV0 5 ⁇ g of 4 x l0 6 cells
  • suspended in 40 ml of RPMI1640-FBS (10) and dispensed into a 96-well culture plate (manufactured by Sumitomo Beilkrite) at 200/1 / well.
  • G418 was added at 0.5 mg / ml in order to increase antibody production using the DHFR gene amplification system.
  • the MTX was suspended at l ⁇ 2 x l0 5 cells / ml in RPMI1640-FBS (10) medium comprising 50 nM, was dispensed at 2ml 24 Uwerupureto (Greiner Co.). 53 ⁇ 4C0 2 incubator base - evening and cultured for 1-2 weeks at 37 ° C for within one to induce transformants showing 50 nM MTX resistance.
  • the antigen binding activity of the anti-ML-5R CDR-grafted antibody in the culture supernatant of the gel in which the growth of the transformant was observed was measured by the ELISA method described in Example 3, paragraph 2.
  • the MTX concentration was increased to 100 nM and 200 nM in the same manner as described above, and finally G418 was obtained in an RPMI1640-FBS (10) medium containing 0.5 mg / ml of MTX at a concentration of 200 nM and high production of an anti-ML-5R CDR-grafted antibody.
  • the obtained transformant was transformed into a single cell (cloning) by limiting dilution twice.
  • the transformed cell clone No. 3 that produces the anti-ML-5R CDR-grafted antibody obtained in this manner was awarded on April 5, 2001 by the National Institute of Bioscience and Biotechnology, Institute of Biotechnology, Japan (Tsukuba, Ibaraki, Japan). It has been deposited as FERM BP-6690 at Higashi 1-3-1, 1-3.
  • G418 was added at 0.5 mg / m MTX in order to increase the amount of antibody production using the DHFR gene amplification system.
  • the MTX concentration was increased to 100 nM and 500 nM by the same method as described above, and finally, G418 was contained at a concentration of 0.5 mg / ml and MTX at a concentration of 500 nM.
  • a transformed strain capable of growing in IMDM-dFBS (10) medium and highly producing anti-ML-5Ra CDR-grafted antibody was obtained.
  • the obtained transformant was subjected to single cell cloning (cloning) by the limiting dilution method twice.
  • An anti-hIL-5R CDR-grafted antibody expression vector was prepared using the chain and L-chain cDNA, and NS0 cells were transformed to obtain a transformant which highly produced the anti-hIL-5Ra CDR-grafted antibody. The resulting transformant was subjected to two single dilutions (cloning) by the limiting dilution method.
  • the binding activity of the antibody to ML-5R was measured as follows.
  • the solution was dissolved in a liquid (PH4.2) and immediately before use, a solution in which hydrogen peroxide was added at 1 a1 / ml] was added at 50 ⁇ 1 / ⁇ ⁇ to develop color, and 0D415 was measured.
  • the transformed cell clone producing the anti-hIL-5R / CDR-grafted antibody obtained in paragraph (1) of Example 3 above was transformed into a GIT medium containing G418 at a concentration of 0.5 mg / ml and MTX at a concentration of 200 nM.
  • the cells were suspended at a concentration of 3 ⁇ 10 5 cells / ml, and 200 ml of the suspension was dispensed into 175 awake 2 flasks (manufactured by Greiner). 5% C0 8 days after incubation at 37 ° C for within 2 incubator, the culture supernatant was recovered. Culture supernatant
  • the anti-hIL-5R CDR-grafted antibody was purified by ion exchange chromatography and gel filtration.
  • the purified anti-hIL-5R a CDR-grafted antibody was named as YB2 / 0-hIL-5RCDR antibody.
  • the transformed cell clone producing the anti-hi5R / CDR-grafted antibody obtained in Section 1 (2) of Example 3 above contains L-Gln at a concentration of 3 M, CDLC at a concentration of 0.5%, and PF68 at a concentration of 0.3%.
  • the cells were suspended in EX-CELL302 medium so as to have a concentration of 3 ⁇ 10 5 cells / ml, and cultured with stirring at 100 rpm using a 4.0 L spinner bottle (manufactured by Iwaki Glass Co., Ltd.). After culturing for 10 days in a thermostat at 37 ° C, the culture supernatant was collected.
  • the anti-hIL-5R CDR-grafted antibody was purified from the culture supernatant using ion exchange chromatography and gel filtration.
  • the purified anti-hIL-5R CDR-grafted antibody was named CHO / d-hIL-5RCDR antibody.
  • the transformed cell clone producing the anti-ML-5R / CDR-grafted antibody obtained in Section 1 (3) of Example 3 was cloned by the method of Yarranton et al. [Bio / Technology (BI0 / TECHN0L0GY), 10 , 169 (1992)], and after culturing, the culture supernatant was recovered.
  • the anti-ML-5R a CDR-grafted antibody was purified from the culture supernatant by ion exchange chromatography and gel filtration.
  • the purified anti-ML-5R a CDR-grafted antibody was named NSO-hIL-5RCDR antibody.
  • each of the purified anti-hIL-5R and CDR-grafted antibodies had a single band with a molecular weight of about 150 Kd under non-reducing conditions, and about 50 Kd and about 25 Kd under reducing conditions. 2 bands were observed.
  • An IgG-type antibody has a molecular weight of about 150 Kd under non-reducing conditions. Under reducing conditions, disulfide bonds (hereinafter referred to as S-S bonds) in the molecule are cleaved, and H molecules having a molecular weight of about 50 Kd are obtained.
  • S-S bonds disulfide bonds
  • FIG. 5 shows the results of examining the binding activity by changing the concentration of the added anti-hIL-5Ra CDR-grafted antibody.
  • the three types of anti-hIL-5R a CDR-grafted antibodies exhibited almost the same binding activity to hIL-5R. This result indicates that the antigen-binding activity of the antibody is constant irrespective of the animal cell producing the antibody and the culture method thereof, as in the result of item 1 of Example 2.
  • ADCC activity was measured according to the following method.
  • the mouse T cell line CTLL-2 (h5R) expressing the hIL-5R heavy chain and 5 chain described in W097 / 10354 was cultured in RPMI1640-FBS (IO) medium, and 1 x 10 6 cells / 0.5 ml. so as to prepare a Na 2 51 Cr0 4 is a radioactive substance 3.7MBq equivalents added by 1.5 hour at 37 ° C, labeled radiate cells. After the reaction, the cells were washed three times by suspending and centrifuging with RPMI1640-FBS (IO) medium, resuspended in the medium, and left on ice at 4 ° C for 30 minutes to spontaneously dissociate the radioactive substance. After centrifugation, 5 ml of RPMI1640-FBS (10) medium was added to adjust to 2 ⁇ 10 5 cells / ml, which was used as a target cell solution.
  • RPMI1640-FBS (IO) RPMI1640-FBS
  • the amount of spontaneously dissociated 51 Cr was determined by performing the same operation as above using only the medium instead of the effector cell solution and the antibody solution, and measuring the amount of 51 Cr in the supernatant.
  • the total amount of dissociated 51 Cr can be determined by adding only the medium instead of the antibody solution and adding 1N hydrochloric acid instead of the effector cell solution, and performing the same operation as above, and measuring the amount of 51 Cr in the supernatant. I asked.
  • ADCC activity was determined by the following equation. Amount in sample supernatant-amount of spontaneously dissociated 51 Cr
  • ADDC activity (%) X100
  • hIL-5 (preparation method described in W097 / 10354) was administered subcutaneously at a dose of 1 g / kg once a day, 14 times in total, to the cynomolgus monkeys.
  • Various anti-hIL-5R a CDR-grafted antibodies were intravenously administered once at 0.3 mg / kg 1 hour before the administration of hIL-5 on day 0.
  • the group not administered with the antibody was used as a control.
  • Antibody-administered group 3 animals (No.301, No.302, No.303, No.401, No.402, No.403, No.501, No.502, No.503) Used two (No. 101, No. 102) force monkeys.
  • FIG. 7 shows the results. As shown in FIG. 7, in the group to which the YB2 / 0-hIL-5RCDR antibody was administered, the increase in blood eosinophils was completely suppressed. On the other hand, in the group to which the CH0 / d-hIL-5RCDR antibody was administered, complete inhibition was observed in one animal, but the inhibitory effect was insufficient in two animals Met. In the NSO-hIL-5RCDR antibody administration group, no complete inhibitory effect was observed, and the effect was insufficient.
  • Sialic acid was removed from the humanized antibody of the present invention by acid hydrolysis using hydrochloric acid. After complete removal of hydrochloric acid, the sugar chains were cleaved from the protein by hydrazinolysis [Method of Enzymology, 83, 263, 1982]. After removing the hydrazine, N-acetylation was performed by adding an aqueous solution of ammonium acetate and acetic anhydride. After lyophilization, fluorescent labeling with 2-aminoviridine was performed [Journal 'OB' Biochemistry.
  • the fluorescently labeled sugar chain was separated from impurities using a Surperdex Peptide HR 10/30 column (Pharmacia). The sugar chain fraction was dried with a centrifugal concentrator to obtain a purified PA sugar chain.
  • Antibody-producing cells a 1-6 fucose-linked sugar chain (%)
  • NS0 73 About 47% of the anti-hIL-5RCDR-grafted antibody produced in YB2 / 0 cells and about 73% of the anti-hIL-5RCDR-grafted antibody produced in NS0 cells were sugar chains having 1-6 fucose. Therefore, the antibody produced in YB 2/0 cells had more sugar chains without 1-6 fucose than the antibody produced in NS0 cells.
  • Anti-hIL-5R / CDR-grafted antibody produced in YB2 / 0 cells, NS0 cells and CHO / d cells is hydrolyzed into monosaccharides by acid hydrolysis with trifluoroacetic acid, and the resulting product is degraded using BioLC (Dionex). The monosaccharide composition analysis was performed.
  • the relative ratio of fucose was YB2 / 0 ⁇ CHO / d ⁇ NS0.
  • the sugar chain of the antibody produced in YB2 / 0 cells also had the lowest fucose content.
  • PA-glycans were prepared from purified anti-M1-5Ra CDR-grafted antibodies produced in CHO / dhfr-cells, and subjected to reverse-phase HPLC analysis using a CLC-0DS column (Shimadzu) (Fig. 9). ).
  • the sugar chains without fucose were eluted for 35 to 45 minutes, and the sugar chains with fucose were eluted for 45 to 60 minutes.
  • the anti-hIl-5R and CDR-grafted antibodies produced in CHO / dhfr-cells produced more fucose than the antibodies produced in rat myeloma YB2 / 0 cells, similar to the antibodies produced in mouse myeoma-ma NS0 cells.
  • the content of sugar chains not possessed was low.
  • Example 7 Separation of High ADCC Activity Antibody Using a lectin column that binds to a sugar chain having fucose, anti-hIl-5R a CDR-grafted antibody produced in rat myeloma YB2 / 0 cells was separated.
  • HPLC was performed using LC-6A manufactured by Shimadzu Corporation at a flow rate of 1 ml / min and a column temperature of room temperature. After injecting the purified anti-ML-5R antibody CDR-grafted antibody equilibrated with 50 mM Tris-sulfate buffer (pH 7.3), a linear concentration gradient (0.2 min.) Of 0.2 M methyl-mannoside (Nacalai Tesque) was used. ).
  • Anti-hn-5R a CDR-transplanted antibody was separated into a non-adsorbed fraction and an adsorbed fraction.
  • the non-adsorbed fraction and a part of the adsorbed fraction were taken and the binding activity to hIL-5R was measured, the same binding activity was shown (Fig. 10, upper panel).
  • the ADCC activity was measured, the non-adsorbed fraction showed higher ADCC activity than part of the adsorbed fraction (Fig. 10, lower panel).
  • PA-linked sugar chains were prepared from the non-adsorbed fraction and a part of the adsorbed fraction, and subjected to reverse-phase HPLC analysis using a CLC-0DS column (manufactured by Shimadzu) (Fig. 11).
  • the non-adsorbed fraction was mainly an antibody having a sugar chain without fucose
  • a part of the adsorbed fraction was mainly an antibody having a sugar chain with fucose.
  • CH0 / DG44 cells derived from Chinese hamster ovary were suspended in IMDM medium (Life Technologies) supplemented with 10% FBS (Life Technologies) and 1-fold concentration of HT supplement (Life Technologies), and 2 x 10 5 cells / The cells were seeded at a density of ml in T75 flasks for adherent cell culture (Greiner).
  • the cells were seeded at a density on a T75 flask for suspension cell culture (Greiner). These were cultured in 5% C0 2 incubator within one 37 ° C, 1 day of culture, 2 days, 3 days, each host cell lx l0 7 cells on day 4 and day 5 were collected, RNAeasy (QIAGEN) to extract total RNA.
  • a reverse transcription reaction was carried out using a oligo (dT) as a primer and a SUPERSCRIPT TM Preamplification System for First Strand cDNA Synthesis (Life Technologies) in a 20 ⁇ l system to synthesize cDNA.
  • a 1-fold concentration of the solution after the reverse transcription reaction was used for competitive PCR.
  • the amount of each gene transcript was determined by diluting the solution after the reverse transcription reaction 50-fold with water, and stored at -80 ° C until use.
  • PCR was performed at 94 ° C for 1 minute, followed by 30 cycles at 94 ° C for 30 seconds, 55 ° C for 30 seconds, and 72 ° C for 2 minutes. For 10 minutes. 979 bp of each specific amplified fragment obtained by PCR was ligated to plasmid PCR2.1 using T0P0 TA cloning Kit (Invitrogen), and a plasmid containing each partial fragment of Chinese Hams Yuichi FUT8 and rat FUT8 (CHFT8-pCR2 .1 and YBFT8-pCR2.1).
  • the nucleotide sequence of each cDNA obtained was determined using DNA Sequencer 377 (Parkin Elmer) and BigDye Terminator Cycle Sequencing FS Ready Reaction Kit (Parkin Elmer). (Shown in SEQ ID NOs: 3 and 4).
  • Chinese hamster ⁇ -actin and rat ⁇ -actin were obtained by the following method.
  • Each sequence-specific reverse primer shown in SEQ ID NO: 6 and SEQ ID NO: 7, including the translation stop codon, was designed.
  • PCR was performed for 25 cycles, with a reaction consisting of 98 ° C for 15 seconds, 65 ° C for 2 seconds, and 74 ° C for 30 seconds as one cycle.
  • Each specific amplified fragment obtained by PCR After phosphorylating the 5 'end of 1128 bp with MEGALABEL (Takara Shuzo), fragment it into pBluescriptl KS (+) (Strategene) and cut it with the restriction enzyme EcoRV ( 2.9 Kb) were ligated with Ligation High (Toyobo Co., Ltd.) to obtain plasmids (CHAc-pBS, YBAc-pBS) containing the full-length 0RF of each cDNA of ⁇ -actin and rat ⁇ -actin of Chinese Hams.
  • the nucleotide sequences of the obtained cDNAs were determined using DNA Sequencer-377 (Parkin Elmer) and BigDye Terminator Cycle Sequencing FS Ready Reaction Kit (Parkin Elmer), respectively. Chinese Hams Yuichi ⁇ -actin and rat It was confirmed that each cDNA of ⁇ -actin encodes the 0RF full-length sequence.
  • a calibration curve was created to measure the amount of mRNA transcribed from the FUT8 gene in production cells.
  • the FUT8 standards used in the calibration curve include plasmids CHFT8-pCR2.1 and YBFT8-pCR2.1, which are plasmids obtained by incorporating the respective partial fragments of Chinese Hams Yuichi FUT8 and rat FUT8 obtained in (2) into pCR2.1. Was digested with the restriction enzyme EcoRI, and the resulting DNA was used for linearization.
  • An internal control for FUT8 quantification was obtained by deleting 203 bp between Scal-Hindllll of the internal nucleotide sequences of Chinese Hams Yuichi FUT8 and rat FUT8 in CHFT8-pCR2.1 and YBFT8-pCR2.1.
  • DNA obtained by digesting CHFT8d-pCR2.1 and YBFT8d-pCR2.1 with the restriction enzyme EcoRI was used linearly.
  • the total 0RF of the cDNA of each of the Chinese hamster ⁇ -actin and rat ⁇ -actin obtained in (3) was calculated using pBluescriptl KS (+)
  • CHAc-pBS and YBAc-pBS Chinese Hams Yuichi CHAcd-pBS and YBAcd-pBS obtained by deleting 180 bp between ⁇ -actin and rat ⁇ -actin between Dral l and Drall II, the former being Hindi 11 and Pst I
  • Hind 111 and Kpnl were used, and ⁇ obtained by digesting each was linearized.
  • the quantification of the FUT8 transcript was performed as follows. First, a common sequence-specific primer set (shown in SEQ ID NOs: 8 and 9) was designed for the internal sequence of the 0RF partial sequence of Chinese hamster FUT8 and rat FUT8 obtained in (2).
  • a total volume of 20 ⁇ l of the reaction solution containing 5 ⁇ l of a 50-fold diluted solution of the cDNA solution derived from each host cell strain obtained in (1) and 5 ⁇ l (lOf) of the internal control plasmid [ExTaq buffer (Takara Shuzo) PCR was performed using 0.2 mM dNTPs, 0.5 ⁇ , the above gene-specific primers (SEQ ID NO: 8 and SEQ ID NO: 9), and 5% DMS0] using DNA polymerase ExTaq (Takara Shuzo). PCR was performed at 94 ° C for 3 minutes, followed by 32 cycles of 1 cycle at 94 ° C, 1 minute at 60 ° C, and 1 minute at 72 ° C.
  • the quantification of the transcription product of ⁇ -actin was performed as follows.
  • a set of primers specific to each gene (the former is represented by SEQ ID NO: 10 and SEQ ID NO: 11, and the latter is represented by SEQ ID NO: 12 and SEQ ID NO: 13) were designed respectively.
  • FUT8 F 5'-GTCCATGGTGATCCTGCAGTGTGG-3 '638 431
  • ⁇ -actin F 5'-GATATCGCTGCGCTCGTCGTCGAC-3 '789 609, (rat) R: 5'-CAGGAAGGAAGGCTGGAAGAGAGC-3'
  • Quantitative PCR was performed using the primer sets shown in Table 3. As a result, from each gene transcript and each standard, a DNA fragment of the size shown in the evening column of Table 3 was obtained, and from each internal control, a DNA fragment of the size shown in the competition column of Table 3 was obtained. The fragment could be amplified.
  • PCR was performed using the amounts of the standard plasmids prepared in (4) of 0.1 fg, 1 fg, 5 fg, 10 fg, 50 fg, 100 fg and 500 fg, respectively, and the amount of amplification products was measured. Then, a calibration curve was prepared by plotting the measured values and the amount of the standard plasmid.
  • FIG. 12 shows the amount of FUT8 transcript in each host cell line when the rat FUT8 sequence was used as a standard and internal control. Throughout the culture period, the CH0 cell line showed a transcription level more than 10 times that of the YB2 / 0 cell line. This tendency was also observed when the Chinese hamster FUT8 sequence was used as a standard and internal control.
  • Table 4 shows the FUT8 transcript amount as a relative value to the amount of ⁇ -actin transcript.
  • the FUT8 transcript level of the YB2 / 0 cell line was around 0.1 for ⁇ -actin, while the CH0 cell line was 0.5 to 2%.
  • the present invention relates to a sugar chain that regulates the activity of an immune function molecule such as an antibody, protein or peptide, and an antibody, protein or peptide having a sugar chain.
  • the present invention further relates to a method for producing the sugar chain, an antibody having the sugar chain, a protein or a peptide, and a diagnostic, prophylactic or therapeutic agent containing them as an active ingredient.

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EP10180034.0A EP2270147B2 (en) 1999-04-09 2000-04-07 Method for controlling the activity of immunologically functional molecule
EP10180036.5A EP2278003B2 (en) 1999-04-09 2000-04-07 Method for controlling the activity of immunologically functional molecule
CA2369292A CA2369292C (en) 1999-04-09 2000-04-07 Method of modulating the activity of functional immune molecules
JP2000611663A JP4368530B2 (ja) 1999-04-09 2000-04-07 免疫機能分子の活性を調節する方法
EP10180043.1A EP2270150B2 (en) 1999-04-09 2000-04-07 Method for controlling the activity of immunologically functional molecule
ES00915403T ES2418360T3 (es) 1999-04-09 2000-04-07 Procedimiento para controlar la actividad de una molécula inmunofuncional
DK00915403.0T DK1176195T3 (da) 1999-04-09 2000-04-07 Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle
EP00915403.0A EP1176195B1 (en) 1999-04-09 2000-04-07 Method for controlling the activity of immunologically functional molecule
AU36728/00A AU3672800A (en) 1999-04-09 2000-04-07 Method for controlling the activity of immunologically functional molecule
US11/126,176 US7214775B2 (en) 1999-04-09 2005-05-11 Method of modulating the activity of functional immune molecules
US11/126,298 US7708992B2 (en) 1999-04-09 2005-05-11 Methods for producing antibody compositions with increased ADCC
US11/126,299 US20050272916A1 (en) 1999-04-09 2005-05-11 Method of modulating the activity of functional immune molecules
US11/686,906 US7682611B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to CXCR4 protein
US11/686,458 US7708997B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules
US11/686,404 US7763246B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to platelet-derived growth factor receptor
US11/686,391 US7682610B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules
US11/686,911 US7655228B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to GM2
US11/686,920 US7687061B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to Her-2
US11/686,379 US7718175B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to interleukin-5 receptor protein
US11/686,915 US7651688B2 (en) 1999-04-09 2007-03-15 Method of modulating the activity of functional immune molecules to CD52
US12/645,613 US8679491B2 (en) 1999-04-09 2009-12-23 Method of modulating the activity of functional immune molecules
US14/173,305 US10233247B2 (en) 1999-04-09 2014-02-05 Method of modulating the activity of functional immune molecules
US15/460,790 US20170240647A1 (en) 1999-04-09 2017-03-16 Method of modulating the activity of functional immune molecules
US16/517,776 US20200017593A1 (en) 1999-04-09 2019-07-22 Method of producing antibodies with n-glycoside-linked sugar chains lacking fucosylation

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