PE20210687A1 - Anticuerpos de union a vista a ph acido - Google Patents
Anticuerpos de union a vista a ph acidoInfo
- Publication number
- PE20210687A1 PE20210687A1 PE2021000018A PE2021000018A PE20210687A1 PE 20210687 A1 PE20210687 A1 PE 20210687A1 PE 2021000018 A PE2021000018 A PE 2021000018A PE 2021000018 A PE2021000018 A PE 2021000018A PE 20210687 A1 PE20210687 A1 PE 20210687A1
- Authority
- PE
- Peru
- Prior art keywords
- antibodies
- sight
- binding
- acid
- acidic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente solicitud se relaciona con anticuerpos que se unen especificamente al supresor de activacion de linfocitos T que contiene inmunoglobulina con dominio V (VISTA) a pH acido y su uso en el tratamiento del cancer. En algunas modalidades, los anticuerpos se unen especificamente a VISTA humano a pH acido, pero no se unen significativamente a VISTA humano a pH neutro o fisiologico
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862696622P | 2018-07-11 | 2018-07-11 | |
US201862733450P | 2018-09-19 | 2018-09-19 | |
US201962826330P | 2019-03-29 | 2019-03-29 | |
PCT/US2019/041154 WO2020014327A2 (en) | 2018-07-11 | 2019-07-10 | Antibodies binding to vista at acidic ph |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20210687A1 true PE20210687A1 (es) | 2021-04-08 |
Family
ID=67470712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000018A PE20210687A1 (es) | 2018-07-11 | 2019-07-10 | Anticuerpos de union a vista a ph acido |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220073617A1 (es) |
EP (1) | EP3820902A2 (es) |
JP (1) | JP2022513421A (es) |
KR (1) | KR20210031722A (es) |
CN (1) | CN112638948A (es) |
AU (1) | AU2019301120A1 (es) |
BR (1) | BR112021000303A2 (es) |
CA (1) | CA3104536A1 (es) |
CL (5) | CL2021000012A1 (es) |
CO (1) | CO2021000046A2 (es) |
IL (1) | IL279944A (es) |
MX (1) | MX2021000213A (es) |
PE (1) | PE20210687A1 (es) |
SG (1) | SG11202100102VA (es) |
TW (1) | TW202028235A (es) |
WO (1) | WO2020014327A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND USES THEREOF |
CN110740749A (zh) | 2017-03-14 | 2020-01-31 | 戊瑞治疗有限公司 | 在酸性pH下与VISTA结合的抗体 |
CN114729043A (zh) * | 2019-09-19 | 2022-07-08 | 百时美施贵宝公司 | 在酸性pH下结合至VISTA的抗体 |
US20230272082A1 (en) * | 2021-11-09 | 2023-08-31 | Sensei Biotherapeutics, Inc. | Anti-vista antibodies and uses thereof |
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WO2018008555A1 (ja) | 2016-07-07 | 2018-01-11 | 日本ゼオン株式会社 | 非水系二次電池電極用バインダー組成物、非水系二次電池電極用スラリー組成物、非水系二次電池用電極および非水系二次電池 |
EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND USES THEREOF |
CN110740749A (zh) * | 2017-03-14 | 2020-01-31 | 戊瑞治疗有限公司 | 在酸性pH下与VISTA结合的抗体 |
TW201945393A (zh) * | 2018-03-21 | 2019-12-01 | 美商戊瑞治療有限公司 | 在酸性pH結合至VISTA之抗體 |
US20190300610A1 (en) * | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
-
2019
- 2019-07-10 CA CA3104536A patent/CA3104536A1/en active Pending
- 2019-07-10 PE PE2021000018A patent/PE20210687A1/es unknown
- 2019-07-10 SG SG11202100102VA patent/SG11202100102VA/en unknown
- 2019-07-10 EP EP19745902.7A patent/EP3820902A2/en active Pending
- 2019-07-10 CN CN201980057653.4A patent/CN112638948A/zh active Pending
- 2019-07-10 JP JP2021500886A patent/JP2022513421A/ja active Pending
- 2019-07-10 TW TW108124306A patent/TW202028235A/zh unknown
- 2019-07-10 AU AU2019301120A patent/AU2019301120A1/en active Pending
- 2019-07-10 KR KR1020217003857A patent/KR20210031722A/ko unknown
- 2019-07-10 WO PCT/US2019/041154 patent/WO2020014327A2/en active Application Filing
- 2019-07-10 BR BR112021000303-7A patent/BR112021000303A2/pt unknown
- 2019-07-10 MX MX2021000213A patent/MX2021000213A/es unknown
- 2019-07-10 US US17/258,866 patent/US20220073617A1/en active Pending
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2021
- 2021-01-04 IL IL279944A patent/IL279944A/en unknown
- 2021-01-05 CL CL2021000012A patent/CL2021000012A1/es unknown
- 2021-01-06 CO CONC2021/0000046A patent/CO2021000046A2/es unknown
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2022
- 2022-10-25 CL CL2022002946A patent/CL2022002946A1/es unknown
- 2022-10-25 CL CL2022002944A patent/CL2022002944A1/es unknown
- 2022-10-25 CL CL2022002945A patent/CL2022002945A1/es unknown
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2023
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CL2023002543A1 (es) | 2024-01-19 |
CN112638948A (zh) | 2021-04-09 |
WO2020014327A2 (en) | 2020-01-16 |
WO2020014327A3 (en) | 2020-02-27 |
AU2019301120A1 (en) | 2021-02-25 |
SG11202100102VA (en) | 2021-02-25 |
CL2022002946A1 (es) | 2023-04-21 |
CO2021000046A2 (es) | 2021-04-19 |
TW202028235A (zh) | 2020-08-01 |
CL2022002944A1 (es) | 2023-04-21 |
KR20210031722A (ko) | 2021-03-22 |
CL2021000012A1 (es) | 2021-05-24 |
EP3820902A2 (en) | 2021-05-19 |
IL279944A (en) | 2021-03-01 |
CL2022002945A1 (es) | 2023-04-21 |
US20220073617A1 (en) | 2022-03-10 |
JP2022513421A (ja) | 2022-02-08 |
CA3104536A1 (en) | 2020-01-16 |
MX2021000213A (es) | 2021-03-25 |
BR112021000303A2 (pt) | 2021-04-13 |
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