MX2019007963A - Expansion de linfocitos infiltrantes de tumor (til) con agonistas de la superfamilia de recptor de factor de necrosis tumoral (tnfrsf) y combinaciones terapeuticas de til- y agonistas de tnfrsf. - Google Patents

Expansion de linfocitos infiltrantes de tumor (til) con agonistas de la superfamilia de recptor de factor de necrosis tumoral (tnfrsf) y combinaciones terapeuticas de til- y agonistas de tnfrsf.

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Publication number
MX2019007963A
MX2019007963A MX2019007963A MX2019007963A MX2019007963A MX 2019007963 A MX2019007963 A MX 2019007963A MX 2019007963 A MX2019007963 A MX 2019007963A MX 2019007963 A MX2019007963 A MX 2019007963A MX 2019007963 A MX2019007963 A MX 2019007963A
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Mexico
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tils
tnfrsf
agonists
agonist
necrosis factor
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MX2019007963A
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English (en)
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T Lotze Michael
Ritthipichai Krit
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Iovance Biotherapeutics Inc
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Publication of MX2019007963A publication Critical patent/MX2019007963A/es

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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
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Abstract

En la presente se describen métodos para expandir linfocitos infiltrantes de tumor (TIL) usando un agonista de la superfamilia del receptor de factor de necrosis tumoral (TNFRSF), como por ejemplo un agonista 4-IBB, un agonista CD27, un agonista relacionado con el receptor TNF inducido por glucocorticoide, un agonista OX40, un agonista HVEM o un agonista CD95, y usos de estos TIL expandidos en el tratamiento de enfermedades como por ejemplo cáncer. Además, en algunas modalidades se describen en la presente combinaciones terapéuticas de los TIL y agonistas de TNFRSF útiles en el tratamiento de enfermedades como por ejemplo cáncer, que incluye composiciones, usos y regímenes de dosificación de los mismos.
MX2019007963A 2017-01-06 2018-01-05 Expansion de linfocitos infiltrantes de tumor (til) con agonistas de la superfamilia de recptor de factor de necrosis tumoral (tnfrsf) y combinaciones terapeuticas de til- y agonistas de tnfrsf. MX2019007963A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762443556P 2017-01-06 2017-01-06
US201762460477P 2017-02-17 2017-02-17
US201762532807P 2017-07-14 2017-07-14
US201762567151P 2017-10-02 2017-10-02
PCT/US2018/012605 WO2018129332A1 (en) 2017-01-06 2018-01-05 Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists

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MX2019007963A true MX2019007963A (es) 2019-10-21

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US (2) US20200121719A1 (es)
EP (1) EP3565888A1 (es)
JP (2) JP2020514289A (es)
KR (1) KR20190104048A (es)
CN (1) CN110462027A (es)
AU (2) AU2018205234B2 (es)
BR (1) BR112019013940A2 (es)
CA (1) CA3049163A1 (es)
IL (1) IL267780B1 (es)
MA (1) MA47236A (es)
MX (1) MX2019007963A (es)
TW (1) TW201837168A (es)
WO (1) WO2018129332A1 (es)

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