AU2009204501B2 - Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects - Google Patents

Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects Download PDF

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Publication number
AU2009204501B2
AU2009204501B2 AU2009204501A AU2009204501A AU2009204501B2 AU 2009204501 B2 AU2009204501 B2 AU 2009204501B2 AU 2009204501 A AU2009204501 A AU 2009204501A AU 2009204501 A AU2009204501 A AU 2009204501A AU 2009204501 B2 AU2009204501 B2 AU 2009204501B2
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Australia
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igg
amino acid
containing polypeptide
heterodimeric protein
replacement
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AU2009204501A
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AU2009204501A1 (en
Inventor
Gunasekaran Kannan
Martin Pentony
Michael Wittekind
Wei Yan
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009204501A 2008-01-07 2009-01-06 Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects Active AU2009204501B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015202560A AU2015202560B2 (en) 2008-01-07 2015-05-12 Method for Making Antibody Fc-Heterodimeric Molecules Using Electrostatic Steering Effects

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1956908P 2008-01-07 2008-01-07
US61/019,569 2008-01-07
US12030508P 2008-12-05 2008-12-05
US61/120,305 2008-12-05
PCT/US2009/000071 WO2009089004A1 (en) 2008-01-07 2009-01-06 Method for making antibody fc-heterodimeric molecules using electrostatic steering effects

Related Child Applications (1)

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AU2015202560A Division AU2015202560B2 (en) 2008-01-07 2015-05-12 Method for Making Antibody Fc-Heterodimeric Molecules Using Electrostatic Steering Effects

Publications (2)

Publication Number Publication Date
AU2009204501A1 AU2009204501A1 (en) 2009-07-16
AU2009204501B2 true AU2009204501B2 (en) 2015-02-12

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AU2009204501A Active AU2009204501B2 (en) 2008-01-07 2009-01-06 Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects

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US (2) US8592562B2 (https=)
EP (3) EP3061770B8 (https=)
JP (3) JP6157046B2 (https=)
AU (1) AU2009204501B2 (https=)
CA (1) CA2709847C (https=)
CY (1) CY1117162T1 (https=)
DK (1) DK2235064T3 (https=)
ES (2) ES2774337T3 (https=)
HU (1) HUE028536T2 (https=)
MX (1) MX350962B (https=)
PL (1) PL2235064T3 (https=)
PT (1) PT2235064E (https=)
SI (1) SI2235064T1 (https=)
WO (1) WO2009089004A1 (https=)

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