MX360352B - Cromatografia de afinidad basada en receptores fc. - Google Patents
Cromatografia de afinidad basada en receptores fc.Info
- Publication number
- MX360352B MX360352B MX2014009622A MX2014009622A MX360352B MX 360352 B MX360352 B MX 360352B MX 2014009622 A MX2014009622 A MX 2014009622A MX 2014009622 A MX2014009622 A MX 2014009622A MX 360352 B MX360352 B MX 360352B
- Authority
- MX
- Mexico
- Prior art keywords
- affinity chromatography
- based affinity
- receptor based
- antibody
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
- B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient, chromatofocusing, i.e. separation according to the isoelectric point pI
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere a el uso de un complejo no covalente, inmovilizado de un receptor Fc neonatal (FcRn) y una beta-2-microglobulina (b2m) como ligando de cromatografía de afinidad en general y, por ejemplo, para la determinación de la semivida in vivo de un anticuerpo al determinar la relación de los tiempos de retención del anticuerpo y un anticuerpo de referencia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12155630 | 2012-02-15 | ||
PCT/EP2013/052932 WO2013120929A1 (en) | 2012-02-15 | 2013-02-14 | Fc-receptor based affinity chromatography |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009622A MX2014009622A (es) | 2014-11-10 |
MX360352B true MX360352B (es) | 2018-10-30 |
Family
ID=47720509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009622A MX360352B (es) | 2012-02-15 | 2013-02-14 | Cromatografia de afinidad basada en receptores fc. |
Country Status (16)
Country | Link |
---|---|
US (3) | US20150018241A1 (es) |
EP (1) | EP2814587B1 (es) |
JP (3) | JP6152120B2 (es) |
KR (1) | KR102069397B1 (es) |
CN (1) | CN104125852B9 (es) |
BR (1) | BR112014018005B1 (es) |
CA (2) | CA3159061A1 (es) |
ES (1) | ES2676031T3 (es) |
HK (1) | HK1203435A1 (es) |
HR (1) | HRP20180966T1 (es) |
MX (1) | MX360352B (es) |
PL (1) | PL2814587T3 (es) |
RU (1) | RU2624128C2 (es) |
SI (1) | SI2814587T1 (es) |
TR (1) | TR201808458T4 (es) |
WO (1) | WO2013120929A1 (es) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9783570B2 (en) | 2011-07-01 | 2017-10-10 | Hoffmann-La Roche Inc. | Method for separation of monomeric polypeptides from aggregated polypeptides |
RU2727639C2 (ru) * | 2014-01-15 | 2020-07-22 | Ф.Хоффманн-Ля Рош Аг | Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а |
CN106103478B (zh) * | 2014-03-21 | 2020-04-03 | 豪夫迈·罗氏有限公司 | 抗体体内半寿期的体外预测 |
CN106574261B (zh) * | 2014-06-27 | 2021-02-05 | 东曹株式会社 | 改良Fc结合蛋白、及制造方法、使用该蛋白的抗体吸附剂和使用该吸附剂的抗体分离方法 |
SG11201701423RA (en) | 2014-09-03 | 2017-03-30 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
BR112017006178A2 (pt) | 2014-11-06 | 2018-05-02 | F. Hoffmann-La Roche Ag | região fc, anticorpos, formulação farmacêutica e usos dos anticorpos |
UA125433C2 (uk) | 2015-07-23 | 2022-03-09 | Бьорінґер Інґельхайм Інтернаціональ Ґмбх | Націлена на іl-23а і фактор активації в-лімфоцитів (baff) сполука та її застосування |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
WO2017079637A1 (en) | 2015-11-04 | 2017-05-11 | Biogen Ma Inc. | Conjugation methods for modifying or immobilizing proteins |
JP2018039735A (ja) * | 2016-09-05 | 2018-03-15 | 東ソー株式会社 | 補体依存性細胞傷害活性が異なる抗体の分離方法 |
CN109689682B (zh) | 2016-09-19 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 基于补体因子的亲和层析 |
TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
ES2847973T3 (es) | 2016-12-20 | 2021-08-04 | Hoffmann La Roche | Politerapia de anticuerpos biespecíficos anti-CD20/anti-CD3 y agonistas de 4-1BB (CD137) |
RS63663B1 (sr) | 2017-04-03 | 2022-11-30 | Hoffmann La Roche | Imunokonjugati anti-pd-1 antitela sa mutantom il-2 ili sa il-15 |
WO2018184966A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Antibodies binding to steap-1 |
WO2018184965A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
KR102294136B1 (ko) | 2017-04-05 | 2021-08-26 | 에프. 호프만-라 로슈 아게 | 항-lag3 항체 |
CN110505883A (zh) | 2017-04-13 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂 |
EP3615678B1 (en) | 2017-04-28 | 2024-07-31 | F. Hoffmann-La Roche AG | Antibody selection method |
GB201717446D0 (en) * | 2017-10-24 | 2017-12-06 | Evox Therapeutics Ltd | Affinity purification of engineering extracellular vesicles |
JP6977536B2 (ja) * | 2017-12-19 | 2021-12-08 | 東ソー株式会社 | ゲル濾過クロマトグラフィを用いた抗体の変性度合評価方法 |
SG11202005632SA (en) | 2017-12-21 | 2020-07-29 | Hoffmann La Roche | Antibodies binding to hla-a2/wt1 |
CN111511400A (zh) | 2017-12-29 | 2020-08-07 | 豪夫迈·罗氏有限公司 | 抗vegf抗体及其使用方法 |
TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
BR112020015568A2 (pt) | 2018-03-13 | 2020-12-29 | F. Hoffmann-La Roche Ag | Agonista de 4-1bb (cd137), produto farmacêutico, composição farmacêutica, uso de uma combinação de um agonista de 4-1bb e método para tratar ou retardar a progressão do câncer |
JP2021519073A (ja) | 2018-03-29 | 2021-08-10 | ジェネンテック, インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
AR115052A1 (es) | 2018-04-18 | 2020-11-25 | Hoffmann La Roche | Anticuerpos multiespecíficos y utilización de los mismos |
JP7469584B2 (ja) | 2018-06-20 | 2024-04-17 | 東ソー株式会社 | 抗体の分離方法および疾患の検査方法 |
JP7159642B2 (ja) * | 2018-06-26 | 2022-10-25 | 東ソー株式会社 | カラムの抗体に対する保持力の測定方法 |
US20200047085A1 (en) | 2018-08-09 | 2020-02-13 | Regeneron Pharmaceuticals, Inc. | Methods for assessing binding affinity of an antibody variant to the neonatal fc receptor |
WO2020084032A1 (en) | 2018-10-25 | 2020-04-30 | F. Hoffmann-La Roche Ag | Modification of antibody fcrn binding |
BR112021012022A2 (pt) | 2018-12-21 | 2021-11-03 | Hoffmann La Roche | Anticorpo que se liga ao vegf e à il-1beta e métodos de uso |
EP3897847A1 (en) | 2018-12-21 | 2021-10-27 | F. Hoffmann-La Roche AG | Antibodies binding to cd3 |
CN109725159B (zh) * | 2018-12-28 | 2021-10-08 | 江苏众红生物工程创药研究院有限公司 | 人β2-微球蛋白的定量检测试纸卡与临床应用 |
EP3903102B1 (en) | 2018-12-30 | 2023-04-12 | F. Hoffmann-La Roche AG | Ph-gradient spr-based binding assay |
SG11202109391PA (en) | 2019-03-29 | 2021-09-29 | Hoffmann La Roche | Method for the generation of an fcrn expressing cell by targeted integration of multiple expression cassettes in a defined organization |
EP3994169A1 (en) | 2019-07-02 | 2022-05-11 | F. Hoffmann-La Roche AG | Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody |
AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
CN114174338A (zh) | 2019-07-31 | 2022-03-11 | 豪夫迈·罗氏有限公司 | 与gprc5d结合的抗体 |
PE20220394A1 (es) | 2019-07-31 | 2022-03-18 | Hoffmann La Roche | Anticuerpos que se fijan a gprc5d |
JP2022549087A (ja) | 2019-09-18 | 2022-11-24 | ジェネンテック, インコーポレイテッド | 抗klk7抗体、抗klk5抗体、多重特異性抗klk5/klk7抗体および使用方法 |
AU2020406085A1 (en) | 2019-12-18 | 2022-05-26 | F. Hoffmann-La Roche Ag | Antibodies binding to HLA-A2/MAGE-A4 |
WO2021123173A1 (en) | 2019-12-20 | 2021-06-24 | F. Hoffmann-La Roche Ag | Il-37 fusion proteins and uses thereof |
CN115315512A (zh) | 2020-03-26 | 2022-11-08 | 基因泰克公司 | 具有降低的宿主细胞蛋白质的经修饰的哺乳动物细胞 |
EP4126940A1 (en) | 2020-03-30 | 2023-02-08 | F. Hoffmann-La Roche AG | Antibody that binds to vegf and pdgf-b and methods of use |
WO2021209402A2 (en) | 2020-04-15 | 2021-10-21 | F. Hoffmann-La Roche Ag | Immunoconjugates |
IL298302A (en) | 2020-06-08 | 2023-01-01 | Hoffmann La Roche | Antibodies against hbv and methods of use |
KR20230025673A (ko) | 2020-06-19 | 2023-02-22 | 에프. 호프만-라 로슈 아게 | CD3 및 FolR1에 결합하는 항체 |
CR20220637A (es) | 2020-06-19 | 2023-01-31 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y cd19 |
WO2021255146A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea |
CA3176579A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 |
EP4172192A1 (en) | 2020-06-24 | 2023-05-03 | Genentech, Inc. | Apoptosis resistant cell lines |
IL298921A (en) | 2020-07-10 | 2023-02-01 | Hoffmann La Roche | Antibodies that bind to cancer cells and direct radionuclides to said cells |
MX2023000617A (es) | 2020-07-17 | 2023-02-13 | Genentech Inc | Anticuerpos anti-notch2 y metodos de uso. |
JP2023539201A (ja) | 2020-08-28 | 2023-09-13 | ジェネンテック, インコーポレイテッド | 宿主細胞タンパク質のCRISPR/Cas9マルチプレックスノックアウト |
PE20230986A1 (es) | 2020-09-04 | 2023-06-21 | Hoffmann La Roche | Anticuerpo que se une a vegf-a y ang2, y metodos de uso |
WO2022086957A1 (en) | 2020-10-20 | 2022-04-28 | Genentech, Inc. | Peg-conjugated anti-mertk antibodies and methods of use |
EP4256336A1 (en) * | 2020-12-06 | 2023-10-11 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
JP7326584B2 (ja) | 2020-12-17 | 2023-08-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗hla-g抗体及びその使用 |
WO2022148853A1 (en) | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
JP2024504931A (ja) | 2021-01-12 | 2024-02-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | がん細胞に結合し、放射性核種を前記細胞に標的化するスプリット抗体 |
KR20230131205A (ko) | 2021-01-13 | 2023-09-12 | 에프. 호프만-라 로슈 아게 | 병용 요법 |
EP4288458A1 (en) | 2021-02-03 | 2023-12-13 | Genentech, Inc. | Multispecific binding protein degrader platform and methods of use |
CN117062839A (zh) | 2021-03-12 | 2023-11-14 | 基因泰克公司 | 抗klk7抗体、抗klk5抗体、多特异性抗klk5/klk7抗体和使用方法 |
US20240218046A1 (en) | 2021-04-14 | 2024-07-04 | Anjarium Biosciences Ag | Fc-derived polypeptides |
IL307501A (en) | 2021-04-19 | 2023-12-01 | Hoffmann La Roche | Modified mammalian cells |
EP4341385A1 (en) | 2021-05-21 | 2024-03-27 | Genentech, Inc. | Modified cells for the production of a recombinant product of interest |
JP2024530402A (ja) | 2021-07-12 | 2024-08-21 | ジェネンテック, インコーポレイテッド | 抗体-リパーゼ結合を減少させるための構造 |
IL309856A (en) | 2021-07-14 | 2024-02-01 | Genentech Inc | Antibodies anti-C-C motif receptor 8 (CCR8) and methods of use |
AU2022315528A1 (en) | 2021-07-22 | 2023-10-19 | F. Hoffmann-La Roche Ag | Heterodimeric fc domain antibodies |
JPWO2023013618A1 (es) * | 2021-08-02 | 2023-02-09 | ||
EP4380980A1 (en) | 2021-08-03 | 2024-06-12 | F. Hoffmann-La Roche AG | Bispecific antibodies and methods of use |
EP4429706A1 (en) | 2021-10-14 | 2024-09-18 | F. Hoffmann-La Roche AG | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
KR20240082349A (ko) | 2021-10-14 | 2024-06-10 | 에프. 호프만-라 로슈 아게 | 새로운 인터루킨-7 면역접합체 |
AR127887A1 (es) | 2021-12-10 | 2024-03-06 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y plap |
IL313169A (en) | 2021-12-15 | 2024-07-01 | Genentech Inc | Stabilized IL-18 polypeptides and their uses |
TW202340251A (zh) | 2022-01-19 | 2023-10-16 | 美商建南德克公司 | 抗notch2抗體及結合物及其使用方法 |
AR129268A1 (es) | 2022-05-11 | 2024-08-07 | Hoffmann La Roche | Anticuerpo que se une a vegf-a e il6 y métodos de uso |
WO2024077239A1 (en) | 2022-10-07 | 2024-04-11 | Genentech, Inc. | Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies |
TW202423970A (zh) | 2022-10-10 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | Gprc5d tcb及cd38抗體之組合療法 |
WO2024079015A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and imids |
TW202423969A (zh) | 2022-10-10 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | Gprc5d tcb及蛋白酶體抑制劑之組合療法 |
WO2024100170A1 (en) | 2022-11-11 | 2024-05-16 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a*02/foxp3 |
WO2024104933A1 (en) | 2022-11-15 | 2024-05-23 | F. Hoffmann-La Roche Ag | Antigen binding molecules |
WO2024155807A1 (en) | 2023-01-18 | 2024-07-25 | Genentech, Inc. | Multispecific antibodies and uses thereof |
WO2024153722A1 (en) | 2023-01-20 | 2024-07-25 | F. Hoffmann-La Roche Ag | Immunoconjugates |
WO2024156672A1 (en) | 2023-01-25 | 2024-08-02 | F. Hoffmann-La Roche Ag | Antibodies binding to csf1r and cd3 |
WO2024184287A1 (en) | 2023-03-06 | 2024-09-12 | F. Hoffmann-La Roche Ag | Combination therapy of an anti-egfrviii/anti-cd3 antibody and an tumor-targeted 4-1bb agonist |
WO2024191785A1 (en) | 2023-03-10 | 2024-09-19 | Genentech, Inc. | Fusions with proteases and uses thereof |
US20240327522A1 (en) | 2023-03-31 | 2024-10-03 | Genentech, Inc. | Anti-alpha v beta 8 integrin antibodies and methods of use |
WO2024208777A1 (en) | 2023-04-03 | 2024-10-10 | F. Hoffmann-La Roche Ag | All-in-one agonistic antibodies |
WO2024208776A1 (en) | 2023-04-03 | 2024-10-10 | F. Hoffmann-La Roche Ag | Agonistic split antibodies |
Family Cites Families (134)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4900660A (en) * | 1985-11-25 | 1990-02-13 | University Of Florida | Streptococcal fc rc |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
US5169936A (en) * | 1989-04-14 | 1992-12-08 | Biogen, Inc. | Protein purification on immobilized metal affinity resins effected by elution using a weak ligand |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US5623053A (en) * | 1992-01-10 | 1997-04-22 | California Institute Of Technology | Soluble mammal-derived Fc receptor which binds at a pH ranging from about 5.5 to 6.5 and releases at a pH ranging from about 7.5 to 8.5 |
CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
ATE196606T1 (de) | 1992-11-13 | 2000-10-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörpern, die gegen ein differenzierung-antigen gerichtet sind, dessen expression auf menschliche b lymphozyt beschränkt ist, für die behandlung von b-zell-lymphoma |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
ATE296315T1 (de) | 1997-06-24 | 2005-06-15 | Genentech Inc | Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
EP1028751B1 (en) | 1997-10-31 | 2008-12-31 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
DK1034298T3 (da) | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanisering af murint antistof |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
DK1068241T3 (da) | 1998-04-02 | 2008-02-04 | Genentech Inc | Antistofvarianter og fragmenter deraf |
AU3657899A (en) * | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US20030175884A1 (en) | 2001-08-03 | 2003-09-18 | Pablo Umana | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
PT1082341E (pt) * | 1998-06-01 | 2011-02-15 | Agensys Inc | Antigénio de tumor útil em diagnóstico e terapêutica de cancro da próstata e do cólon |
KR101155191B1 (ko) | 1999-01-15 | 2012-06-13 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
ES2571230T3 (es) | 1999-04-09 | 2016-05-24 | Kyowa Hakko Kirin Co Ltd | Procedimiento para controlar la actividad de una molécula inmunofuncional |
NZ517906A (en) | 1999-10-04 | 2003-01-31 | Medicago Inc | Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
WO2001029246A1 (fr) | 1999-10-19 | 2001-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un polypeptide |
IL149809A0 (en) | 1999-12-15 | 2002-11-10 | Genentech Inc | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
AU767394C (en) | 1999-12-29 | 2005-04-21 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
DK2857516T3 (en) | 2000-04-11 | 2017-08-07 | Genentech Inc | Multivalent antibodies and uses thereof |
EA013224B1 (ru) | 2000-10-06 | 2010-04-30 | Киова Хакко Кирин Ко., Лтд. | Клетки, продуцирующие композиции антител |
US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP1916303B1 (en) | 2000-11-30 | 2013-02-27 | Medarex, Inc. | Nucleic acids encoding rearranged human immunoglobulin sequences from transgenic transchromosomal mice |
CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
PL373256A1 (en) | 2002-04-09 | 2005-08-22 | Kyowa Hakko Kogyo Co, Ltd. | Cells with modified genome |
WO2003084569A1 (fr) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Medicament contenant une composition anticorps |
JP4628679B2 (ja) | 2002-04-09 | 2011-02-09 | 協和発酵キリン株式会社 | Gdp−フコースの輸送に関与する蛋白質の活性が低下または欠失した細胞 |
JP4832719B2 (ja) | 2002-04-09 | 2011-12-07 | 協和発酵キリン株式会社 | FcγRIIIa多型患者に適応する抗体組成物含有医薬 |
CA2481658A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to fcy receptor iiia |
WO2003085118A1 (fr) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production de composition anticorps |
EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
EP2301966A1 (en) | 2002-12-16 | 2011-03-30 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
CA2510003A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
CA2542046A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Fused protein composition |
US20070134759A1 (en) | 2003-10-09 | 2007-06-14 | Harue Nishiya | Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase |
LT2348051T (lt) | 2003-11-05 | 2019-02-25 | Roche Glycart Ag | Cd20 antikūnai su padidintu fc receptoriaus prisijungimo giminingumu ir efektorine funkcija |
BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
CN101124245A (zh) * | 2003-11-12 | 2008-02-13 | 比奥根艾迪克Ma公司 | 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法 |
WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
WO2005053742A1 (ja) | 2003-12-04 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | 抗体組成物を含有する医薬 |
WO2005097832A2 (en) | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
EP2357201B1 (en) | 2004-04-13 | 2017-08-30 | F. Hoffmann-La Roche AG | Anti-P-selectin antibodies |
KR20070057839A (ko) | 2004-08-19 | 2007-06-07 | 제넨테크, 인크. | 변경된 이펙터 기능을 갖는 폴리펩티드 변이체 |
TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
NZ553500A (en) | 2004-09-23 | 2009-11-27 | Genentech Inc Genentech Inc | Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
CN117534755A (zh) | 2005-05-09 | 2024-02-09 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
EP2465870A1 (en) | 2005-11-07 | 2012-06-20 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
US20070237764A1 (en) | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
AR060871A1 (es) | 2006-05-09 | 2008-07-16 | Genentech Inc | Union de polipeptidos con supercontigos optimizados |
EP1878739A1 (en) * | 2006-07-14 | 2008-01-16 | LEK Pharmaceuticals D.D. | One step IMAC (MCAC) purification of proteins |
EP2471816A1 (en) | 2006-08-30 | 2012-07-04 | Genentech, Inc. | Multispecific antibodies |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
WO2008103474A1 (en) * | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
WO2008143199A1 (ja) * | 2007-05-21 | 2008-11-27 | Nomadic Bioscience Co., Ltd. | 新規ポリペプチド,アフィニティークロマトグラフィー用材,及びイムノグロブリンの分離及び/又は精製方法 |
CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
HUE029635T2 (en) | 2007-09-26 | 2017-03-28 | Chugai Pharmaceutical Co Ltd | A method for modifying an isoelectric point of an antibody by amino acid substitution in CDR |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
EP4269443A3 (en) | 2007-12-26 | 2023-12-27 | Xencor, Inc. | Fc variants with altered binding to fcrn |
HUE028536T2 (en) | 2008-01-07 | 2016-12-28 | Amgen Inc | Method for producing antibody to FC heterodimer molecules using electrostatic control effects |
DK2708559T3 (en) | 2008-04-11 | 2018-06-14 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of repeatedly binding two or more antigen molecules |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
PE20110707A1 (es) | 2008-10-14 | 2011-10-11 | Genentech Inc | Variantes de inmunoglobulinas |
EP2365979A2 (en) | 2008-10-22 | 2011-09-21 | Biogen Idec MA Inc. | Recombinant fcrn and variants thereof for purification of fc-containing fusion proteins |
SG175004A1 (en) | 2009-04-02 | 2011-11-28 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
WO2010115589A1 (en) | 2009-04-07 | 2010-10-14 | Roche Glycart Ag | Trivalent, bispecific antibodies |
PE20120540A1 (es) | 2009-05-27 | 2012-05-09 | Hoffmann La Roche | Anticuerpos triespecificos o tetraespecificos |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
WO2011106272A1 (en) * | 2010-02-23 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel binding assays useful in identifying antibodies with altered half-lives |
TWI667257B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
CA2802344C (en) | 2010-06-18 | 2023-06-13 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
ES2692268T3 (es) * | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
US10221210B2 (en) * | 2011-07-20 | 2019-03-05 | Zepteon, Incorporated | Polypeptide separation methods |
WO2013087913A1 (en) | 2011-12-16 | 2013-06-20 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
RS62509B1 (sr) | 2012-07-13 | 2021-11-30 | Roche Glycart Ag | Bispecifična anti-vegf/anti-ang-2 antitela i njihova upotreba u lečenju očnih vaskularnih bolesti |
KR102282761B1 (ko) | 2013-02-26 | 2021-07-30 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
CN106103478B (zh) | 2014-03-21 | 2020-04-03 | 豪夫迈·罗氏有限公司 | 抗体体内半寿期的体外预测 |
WO2015175874A2 (en) | 2014-05-16 | 2015-11-19 | Medimmune, Llc | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
BR112017006178A2 (pt) | 2014-11-06 | 2018-05-02 | F. Hoffmann-La Roche Ag | região fc, anticorpos, formulação farmacêutica e usos dos anticorpos |
JP6288332B2 (ja) * | 2017-03-06 | 2018-03-07 | 東洋紡株式会社 | 新規なグルコース脱水素酵素 |
-
2013
- 2013-02-14 MX MX2014009622A patent/MX360352B/es active IP Right Grant
- 2013-02-14 CN CN201380009724.6A patent/CN104125852B9/zh active Active
- 2013-02-14 CA CA3159061A patent/CA3159061A1/en active Pending
- 2013-02-14 RU RU2014136223A patent/RU2624128C2/ru active
- 2013-02-14 JP JP2014557032A patent/JP6152120B2/ja active Active
- 2013-02-14 ES ES13704599.3T patent/ES2676031T3/es active Active
- 2013-02-14 SI SI201331082T patent/SI2814587T1/en unknown
- 2013-02-14 KR KR1020147022694A patent/KR102069397B1/ko active IP Right Grant
- 2013-02-14 US US14/378,808 patent/US20150018241A1/en not_active Abandoned
- 2013-02-14 WO PCT/EP2013/052932 patent/WO2013120929A1/en active Application Filing
- 2013-02-14 TR TR2018/08458T patent/TR201808458T4/tr unknown
- 2013-02-14 EP EP13704599.3A patent/EP2814587B1/en active Active
- 2013-02-14 PL PL13704599T patent/PL2814587T3/pl unknown
- 2013-02-14 BR BR112014018005-9A patent/BR112014018005B1/pt active IP Right Grant
- 2013-02-14 CA CA2860600A patent/CA2860600C/en active Active
-
2015
- 2015-04-27 HK HK15104045.0A patent/HK1203435A1/xx unknown
-
2017
- 2017-05-26 JP JP2017104130A patent/JP6360232B2/ja active Active
-
2018
- 2018-06-21 JP JP2018117501A patent/JP6713020B2/ja active Active
- 2018-06-26 HR HRP20180966TT patent/HRP20180966T1/hr unknown
-
2019
- 2019-01-25 US US16/258,294 patent/US11814409B2/en active Active
-
2023
- 2023-08-17 US US18/235,015 patent/US20240124519A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2013120929A1 (en) | 2013-08-22 |
BR112014018005A2 (pt) | 2018-06-26 |
BR112014018005B1 (pt) | 2021-06-29 |
CA2860600C (en) | 2022-07-26 |
US20240124519A1 (en) | 2024-04-18 |
CN104125852B (zh) | 2017-03-22 |
EP2814587B1 (en) | 2018-05-02 |
HK1203435A1 (en) | 2015-10-30 |
KR102069397B1 (ko) | 2020-01-22 |
JP6713020B2 (ja) | 2020-06-24 |
JP6152120B2 (ja) | 2017-06-21 |
HRP20180966T1 (hr) | 2018-08-10 |
KR20140127251A (ko) | 2014-11-03 |
CN104125852B9 (zh) | 2017-05-17 |
TR201808458T4 (tr) | 2018-07-23 |
MX2014009622A (es) | 2014-11-10 |
EP2814587A1 (en) | 2014-12-24 |
CA2860600A1 (en) | 2013-08-22 |
PL2814587T3 (pl) | 2018-10-31 |
JP2018188442A (ja) | 2018-11-29 |
CN104125852A (zh) | 2014-10-29 |
RU2624128C2 (ru) | 2017-06-30 |
CA3159061A1 (en) | 2013-08-22 |
JP6360232B2 (ja) | 2018-07-18 |
ES2676031T3 (es) | 2018-07-16 |
US20190276492A1 (en) | 2019-09-12 |
RU2014136223A (ru) | 2016-04-10 |
JP2017207494A (ja) | 2017-11-24 |
JP2015512034A (ja) | 2015-04-23 |
US20150018241A1 (en) | 2015-01-15 |
SI2814587T1 (en) | 2018-08-31 |
US11814409B2 (en) | 2023-11-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX360352B (es) | Cromatografia de afinidad basada en receptores fc. | |
UA117801C2 (uk) | Лікування неврологічного порушення за допомогою антитіла, яке має низьку афінність до рецептора гематоенцефалічного бар'єру | |
EP3549956A3 (en) | Therapeutic antigen-binding molecule with a fcrn-binding domain that promotes antigen clearance | |
MX343659B (es) | Proteínas de unión receptoras fc. | |
PH12015502470A1 (en) | Human fcrn-binding modified antibodies and methods of use | |
MA34927B1 (fr) | Anticorps anti-cea | |
CR20140585A (es) | Proteinas de union a antigeno st2 | |
EA201591652A1 (ru) | ТАНДЕМНЫЕ БИСПЕЦИФИЧЕСКИЕ Fc-АНТИТЕЛА ПРОТИВ c-MET | |
EP3786183A3 (en) | Antigen binding constructs to cd3 | |
EA201490745A1 (ru) | Полипептиды антител, которые вызывают антагонизм cd40l | |
EA201391564A1 (ru) | Полипептиды антитела, которые антагонизируют cd40 | |
PT2552955T (pt) | Anticorpos com afinidade modificada para fcrn que promovem a depuração de antigénios | |
NZ598713A (en) | Insulin receptor binding antibodies | |
WO2009128963A3 (en) | Cross-neutralizing human monoclonal antibodies to sars-cov and methods of use thereof | |
AU2012307816A8 (en) | Anti-alphabeta TCR antibody | |
TN2014000120A1 (en) | Cd27l antigen binding proteins | |
AR094403A1 (es) | Terapia de combinación de anticuerpos anti-her3 | |
PH12015500752A1 (en) | Her3 antigen binding proteins binding to the beta-hairpin of her3 | |
EA201400359A1 (ru) | Серосодержащий палладий/углеродный катализатор, способ его приготовления и способ приготовления пара-фенилендиаминового антиоксиданта | |
PH12015500751A1 (en) | Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and beta-hairpin of her4 | |
NZ629553A (en) | Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof | |
UA113879C2 (xx) | ГУМАНІЗОВАНЕ АНТИТІЛО ПРОТИ ТrkА З АМІНОКИСЛОТНИМИ ЗАМІЩЕННЯМИ | |
MX2016006743A (es) | Ensayo de puente a base de resonancia de plasmon superficial para determinar la actividad biologica de moleculas multiespecificas multivalentes. | |
MX353954B (es) | Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf). | |
MX2016005686A (es) | Ensayo de union competitiva al ligando para detectar anticuerpos neutralizantes. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |