BR112019002035A2 - tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2 - Google Patents

tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2

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Publication number
BR112019002035A2
BR112019002035A2 BR112019002035-7A BR112019002035A BR112019002035A2 BR 112019002035 A2 BR112019002035 A2 BR 112019002035A2 BR 112019002035 A BR112019002035 A BR 112019002035A BR 112019002035 A2 BR112019002035 A2 BR 112019002035A2
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BR
Brazil
Prior art keywords
pro
inhibitor
combination
cancer treatment
antigen receptor
Prior art date
Application number
BR112019002035-7A
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English (en)
Inventor
Gill Saar
Ruella Marco
Klichinsky Michael
Original Assignee
Novartis Ag
The Trustees Of The University Of Pennsylvania
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Publication date
Application filed by Novartis Ag, The Trustees Of The University Of Pennsylvania filed Critical Novartis Ag
Publication of BR112019002035A2 publication Critical patent/BR112019002035A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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Abstract

a presente invenção refere-se a composições e métodos para o tratamento de doenças associadas a expressão de um antígeno, por exemplo, um antígeno de tumor sólido ou antígeno expresso em um tumor associado a tams e/ou mdscs, por administração de uma célula t recombinante compreendendo um car se ligando ao referido antígeno, como descrito aqui, em combinação com um inibidor de uma molécula pró-macrófago m2, por exemplo, descrito aqui. a invenção também proporciona kits e composições descritos aqui.
BR112019002035-7A 2016-08-01 2017-08-01 tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2 BR112019002035A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369589P 2016-08-01 2016-08-01
US62/369,589 2016-08-01
PCT/US2017/044909 WO2018026819A2 (en) 2016-08-01 2017-08-01 Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule

Publications (1)

Publication Number Publication Date
BR112019002035A2 true BR112019002035A2 (pt) 2019-05-14

Family

ID=59684040

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002035-7A BR112019002035A2 (pt) 2016-08-01 2017-08-01 tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2

Country Status (13)

Country Link
US (1) US20190161542A1 (pt)
EP (1) EP3490590A2 (pt)
JP (2) JP2019527696A (pt)
KR (1) KR20190036551A (pt)
CN (1) CN110267677A (pt)
AU (1) AU2017306267A1 (pt)
BR (1) BR112019002035A2 (pt)
CA (1) CA3032581A1 (pt)
IL (1) IL264588A (pt)
MX (1) MX2019001469A (pt)
RU (1) RU2019105693A (pt)
SG (1) SG11201900885VA (pt)
WO (1) WO2018026819A2 (pt)

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