MX2022009936A - Anticuerpos que se unen al dominio v-set que contiene el inhibidor de activacion de celulas t 1 (b7h4). - Google Patents
Anticuerpos que se unen al dominio v-set que contiene el inhibidor de activacion de celulas t 1 (b7h4).Info
- Publication number
- MX2022009936A MX2022009936A MX2022009936A MX2022009936A MX2022009936A MX 2022009936 A MX2022009936 A MX 2022009936A MX 2022009936 A MX2022009936 A MX 2022009936A MX 2022009936 A MX2022009936 A MX 2022009936A MX 2022009936 A MX2022009936 A MX 2022009936A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies binding
- antibodies
- binding
- therapeutic
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a anticuerpos que se unen a B7H4, incluyendo anticuerpos biespecíficos que se unen a B7H4 y CD3. La invención proporciona además composiciones farmacéuticas que comprenden los anticuerpos y el uso de los anticuerpos para procedimientos terapéuticos y de diagnóstico, en particular en la terapia contra el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20164059 | 2020-03-18 | ||
PCT/EP2021/056879 WO2021185934A1 (en) | 2020-03-18 | 2021-03-17 | Antibodies binding to b7h4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022009936A true MX2022009936A (es) | 2022-09-12 |
Family
ID=69846241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022009936A MX2022009936A (es) | 2020-03-18 | 2021-03-17 | Anticuerpos que se unen al dominio v-set que contiene el inhibidor de activacion de celulas t 1 (b7h4). |
Country Status (19)
Country | Link |
---|---|
US (3) | US20210292418A1 (es) |
EP (1) | EP4121456A1 (es) |
JP (1) | JP2023517753A (es) |
KR (1) | KR20220154757A (es) |
CN (1) | CN115298221A (es) |
AR (1) | AR121599A1 (es) |
AU (1) | AU2021236906A1 (es) |
BR (1) | BR112022015572A2 (es) |
CA (1) | CA3168613A1 (es) |
CL (1) | CL2022002494A1 (es) |
CO (1) | CO2022014603A2 (es) |
CR (1) | CR20220521A (es) |
DO (1) | DOP2022000181A (es) |
EC (1) | ECSP22080714A (es) |
IL (1) | IL296362A (es) |
MX (1) | MX2022009936A (es) |
PE (1) | PE20230444A1 (es) |
TW (1) | TW202200624A (es) |
WO (1) | WO2021185934A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL296362A (en) | 2020-03-18 | 2022-11-01 | Genmab As | Antibodies that bind to b7h4 |
CA3203721A1 (en) | 2021-01-04 | 2022-07-07 | Timothy B. Lowinger | B7h4-targeted antibody-drug conjugates and methods of use thereof |
CN117321087A (zh) | 2021-03-26 | 2023-12-29 | 先天制药公司 | 包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 |
BR112023021089A2 (pt) * | 2021-05-07 | 2023-12-12 | Genmab As | Composição farmacêutica, método para tratar uma doença, método para tratar câncer em um indivíduo, uso da composição farmacêutica, forma de dosagem unitária, kit de partes, e, método para preparar uma composição farmacêutica |
JP2024521405A (ja) | 2021-06-09 | 2024-05-31 | イナート・ファルマ・ソシエテ・アノニム | Nkp46、サイトカイン受容体、腫瘍抗原およびcd16aに結合する多特異性タンパク質 |
WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
CN116867805A (zh) * | 2021-09-27 | 2023-10-10 | 盛禾(中国)生物制药有限公司 | 一种异源二聚体蛋白质及其应用 |
GB202202171D0 (en) * | 2022-02-17 | 2022-04-06 | Bivictrix Ltd | Novel methods of therapy |
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IL296362A (en) | 2020-03-18 | 2022-11-01 | Genmab As | Antibodies that bind to b7h4 |
-
2021
- 2021-03-17 IL IL296362A patent/IL296362A/en unknown
- 2021-03-17 WO PCT/EP2021/056879 patent/WO2021185934A1/en active Application Filing
- 2021-03-17 EP EP21711911.4A patent/EP4121456A1/en active Pending
- 2021-03-17 JP JP2022555952A patent/JP2023517753A/ja active Pending
- 2021-03-17 BR BR112022015572A patent/BR112022015572A2/pt unknown
- 2021-03-17 KR KR1020227035619A patent/KR20220154757A/ko unknown
- 2021-03-17 AR ARP210100670A patent/AR121599A1/es unknown
- 2021-03-17 CN CN202180022020.7A patent/CN115298221A/zh active Pending
- 2021-03-17 CR CR20220521A patent/CR20220521A/es unknown
- 2021-03-17 US US17/204,604 patent/US20210292418A1/en active Pending
- 2021-03-17 TW TW110109575A patent/TW202200624A/zh unknown
- 2021-03-17 PE PE2022001942A patent/PE20230444A1/es unknown
- 2021-03-17 MX MX2022009936A patent/MX2022009936A/es unknown
- 2021-03-17 CA CA3168613A patent/CA3168613A1/en active Pending
- 2021-03-17 AU AU2021236906A patent/AU2021236906A1/en active Pending
- 2021-10-05 US US17/494,545 patent/US11261254B1/en active Active
-
2022
- 2022-03-15 US US17/695,550 patent/US20220324980A1/en active Pending
- 2022-09-09 DO DO2022000181A patent/DOP2022000181A/es unknown
- 2022-09-13 CL CL2022002494A patent/CL2022002494A1/es unknown
- 2022-10-14 CO CONC2022/0014603A patent/CO2022014603A2/es unknown
- 2022-10-17 EC ECSENADI202280714A patent/ECSP22080714A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023517753A (ja) | 2023-04-26 |
ECSP22080714A (es) | 2022-11-30 |
EP4121456A1 (en) | 2023-01-25 |
TW202200624A (zh) | 2022-01-01 |
CO2022014603A2 (es) | 2023-02-16 |
KR20220154757A (ko) | 2022-11-22 |
CA3168613A1 (en) | 2021-09-23 |
CL2022002494A1 (es) | 2023-03-03 |
PE20230444A1 (es) | 2023-03-08 |
DOP2022000181A (es) | 2022-10-16 |
IL296362A (en) | 2022-11-01 |
US20220048999A1 (en) | 2022-02-17 |
CN115298221A (zh) | 2022-11-04 |
AU2021236906A1 (en) | 2022-08-18 |
BR112022015572A2 (pt) | 2022-09-27 |
US11261254B1 (en) | 2022-03-01 |
AR121599A1 (es) | 2022-06-22 |
WO2021185934A1 (en) | 2021-09-23 |
US20210292418A1 (en) | 2021-09-23 |
US20220324980A1 (en) | 2022-10-13 |
CR20220521A (es) | 2023-01-23 |
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