MX357100B - Tratamiento de neoplasias hematologicas con un anticuerpo anti-cxcr4. - Google Patents
Tratamiento de neoplasias hematologicas con un anticuerpo anti-cxcr4.Info
- Publication number
- MX357100B MX357100B MX2014005267A MX2014005267A MX357100B MX 357100 B MX357100 B MX 357100B MX 2014005267 A MX2014005267 A MX 2014005267A MX 2014005267 A MX2014005267 A MX 2014005267A MX 357100 B MX357100 B MX 357100B
- Authority
- MX
- Mexico
- Prior art keywords
- disclosure
- cxcr4
- cxcr4 antibody
- subject
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a anticuerpos monoclonales humanos que se unen específicamente al CXCR4 con alta afinidad. Esta descripción también proporciona un método para tratar un sujeto afectado con un cáncer que expresa CXCR4 en particular, una neoplasia hematológica tal como mieloma múltiple, leucemia mieloide aguda, o linfoma de no Hodgkin, que comprende administrar al sujeto una cantidad terapéuticamente eficaz de una composición farmacéutica que comprende un anticuerpo anti-CXCR4 de la descripción. La descripción proporciona además un kit para el tratamiento de un cáncer en un sujeto que comprende una dosis de un anticuerpo anti-CXCR4 e instrucciones para usar el anticuerpo anti-CXCR4 en los métodos terapéuticos de la descripción.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161557815P | 2011-11-09 | 2011-11-09 | |
US201161569113P | 2011-12-09 | 2011-12-09 | |
PCT/US2012/064395 WO2013071068A2 (en) | 2011-11-09 | 2012-11-09 | Treatment of hematologic malignancies with an anti-cxcr4 antibody |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014005267A MX2014005267A (es) | 2014-07-28 |
MX357100B true MX357100B (es) | 2018-06-26 |
Family
ID=47179025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014005267A MX357100B (es) | 2011-11-09 | 2012-11-09 | Tratamiento de neoplasias hematologicas con un anticuerpo anti-cxcr4. |
Country Status (23)
Country | Link |
---|---|
US (2) | US10428151B2 (es) |
EP (1) | EP2776032B1 (es) |
JP (1) | JP6541350B2 (es) |
KR (1) | KR102024957B1 (es) |
CN (1) | CN104039320B (es) |
AU (1) | AU2012335553B2 (es) |
BR (1) | BR112014011144A2 (es) |
CA (1) | CA2855155A1 (es) |
CY (1) | CY1121331T1 (es) |
DK (1) | DK2776032T3 (es) |
EA (1) | EA026153B1 (es) |
ES (1) | ES2705001T3 (es) |
HR (1) | HRP20182183T1 (es) |
HU (1) | HUE043001T2 (es) |
IL (1) | IL232517B (es) |
LT (1) | LT2776032T (es) |
MX (1) | MX357100B (es) |
PL (1) | PL2776032T3 (es) |
PT (1) | PT2776032T (es) |
RS (1) | RS58102B1 (es) |
SG (1) | SG11201401386XA (es) |
SI (1) | SI2776032T1 (es) |
WO (1) | WO2013071068A2 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2486941B1 (en) * | 2006-10-02 | 2017-03-15 | E. R. Squibb & Sons, L.L.C. | Human antibodies that bind CXCR4 and uses thereof |
CA2840687C (en) | 2011-07-01 | 2020-04-28 | Dana-Farber Cancer Institute, Inc. | Discovery of a somatic mutation in myd88 gene in lymphoplasmacytic lymphoma |
WO2015019284A2 (en) * | 2013-08-05 | 2015-02-12 | Cambridge Enterprise Limited | Inhibition of cxcr4 signaling in cancer immunotherapy |
AU2014318614B2 (en) * | 2013-09-12 | 2021-01-07 | Dana-Farber Cancer Institute Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
ES2742079T3 (es) * | 2013-11-06 | 2020-02-13 | Bristol Myers Squibb Co | Tratamiento de macroglobulinemia de Waldenström asociada a C1013G/CXCR4 con un anticuerpo anti-CXCR4 |
AU2014360426B2 (en) | 2013-12-06 | 2020-05-07 | Dana-Farber Cancer Institute, Inc. | Methods to distinguish Waldenstrom's Macroglobulinemia from IgM monoclonal gammopathy of undetermined significance |
CA2932351A1 (en) | 2013-12-13 | 2015-06-18 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
WO2015093949A2 (en) | 2013-12-17 | 2015-06-25 | Aimm Therapeutics B.V. | Means and methods for counteracting myeloproliferative or lymphoproliferative disorders |
ES2696348T3 (es) | 2014-02-06 | 2019-01-15 | Yeda Res & Dev | Anticuerpos anti CD84, composiciones que comprenden los mismos y usos de los mismos |
AU2014383868A1 (en) * | 2014-02-19 | 2016-09-08 | MicroConstants China Inc, Disabled Disabled Disabled | Chemokine receptor antagonist and its combinational therapy |
HRP20220860T1 (hr) * | 2015-01-09 | 2022-10-14 | Adalta Limited | Cxcr4 vezujuće molekule |
AU2016249395B2 (en) | 2015-04-17 | 2022-04-07 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-PD-1 antibody and another antibody |
EA201792522A1 (ru) | 2015-06-12 | 2018-05-31 | Бристол-Майерс Сквибб Компани | Лечение злокачественной опухоли с помощью комбинированной блокады сигнальных путей pd-1 и cxcr4 |
EP3744340A3 (en) | 2015-07-16 | 2021-03-03 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
AU2016328279A1 (en) * | 2015-09-24 | 2018-05-10 | The University Of North Carolina At Chapel Hill | Methods and compositions for reducing metastases |
WO2017083440A1 (en) * | 2015-11-09 | 2017-05-18 | The General Hospital Corporation D.B.A Massachusetts General Hospital | Unit dose formulations for use as an anti-fugetactic agent |
KR102033920B1 (ko) * | 2016-02-23 | 2019-10-18 | 바이오라인알엑스 리미티드 | 급성 골수성 백혈병을 치료하는 방법 |
JP2019518006A (ja) | 2016-04-29 | 2019-06-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Myd88変異型疾患における治療標的としてのhck |
EP3458053B1 (en) | 2016-05-20 | 2021-12-08 | Biohaven Pharmaceutical Holding Company Ltd. | Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers |
EP3471715A1 (en) * | 2016-06-16 | 2019-04-24 | Centre National De La Recherche Scientifique | Compounds useful for decreasing interferon level |
AU2017281830B2 (en) | 2016-06-20 | 2023-04-06 | Kymab Limited | Anti-PD-L1 antibodies |
CN110234352A (zh) * | 2017-01-31 | 2019-09-13 | Msm蛋白质技术公司 | 抗cxcr4抗体 |
TWI663974B (zh) * | 2017-02-21 | 2019-07-01 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法 |
JP7458188B2 (ja) | 2017-03-31 | 2024-03-29 | ブリストル-マイヤーズ スクイブ カンパニー | 腫瘍を処置する方法 |
US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2019113456A1 (en) * | 2017-12-08 | 2019-06-13 | The Medical College Of Wisconsin, Inc. | Chemokine variants as immune stimulants |
CN112513079A (zh) * | 2018-03-13 | 2021-03-16 | 拉巴斯大学医院生物医学研究基金会 | 用于癌症免疫疗法的联合激活和扩增的自然杀伤细胞的抗cxcr4抗体 |
CA3093407A1 (en) | 2018-03-23 | 2019-09-26 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
JP2021519298A (ja) | 2018-03-27 | 2021-08-10 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 紫外線シグナルを使用した力価のリアルタイムモニタリング |
CN111971306A (zh) | 2018-03-30 | 2020-11-20 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
EP3973274A1 (en) | 2019-05-23 | 2022-03-30 | Bristol-Myers Squibb Company | Methods of monitoring cell culture media |
EP4225770A1 (en) | 2020-10-05 | 2023-08-16 | Bristol-Myers Squibb Company | Methods for concentrating proteins |
WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
WO2023173011A1 (en) | 2022-03-09 | 2023-09-14 | Bristol-Myers Squibb Company | Transient expression of therapeutic proteins |
WO2024160721A1 (en) * | 2023-01-30 | 2024-08-08 | Kymab Limited | Antibodies |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
CA2117953C (en) | 1993-10-14 | 2001-12-11 | Tasuku Honjo | Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same |
US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
ATE532861T1 (de) | 2003-09-04 | 2011-11-15 | Medarex Inc | Expressionsvektor |
CA2597717C (en) | 2005-02-18 | 2014-10-21 | Dana-Farber Cancer Institute | Antibodies against cxcr4 and methods of use thereof |
US8569280B2 (en) * | 2005-04-25 | 2013-10-29 | Immune Disease Institute | Methods for the treatment of multiple myeloma |
DK2029155T3 (en) * | 2006-02-28 | 2016-08-01 | Pharma Mar Sa | IMPROVED treatment of multiple myeloma |
EP2486941B1 (en) * | 2006-10-02 | 2017-03-15 | E. R. Squibb & Sons, L.L.C. | Human antibodies that bind CXCR4 and uses thereof |
FR2915102B1 (fr) | 2007-04-23 | 2014-05-16 | Pf Medicament | Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer |
CN102027015A (zh) | 2008-05-14 | 2011-04-20 | 伊莱利利公司 | 抗cxcr4抗体 |
WO2010043650A2 (en) | 2008-10-14 | 2010-04-22 | Ablynx Nv | Amino acid sequences directed against cellular receptors for viruses and bacteria |
KR101781654B1 (ko) * | 2009-03-12 | 2017-09-25 | 제넨테크, 인크. | 조혈 악성종양의 치료를 위한 포스포이노시티드 3-키나제 억제제 화합물 및 화학요법제의 조합물 |
US20100298255A1 (en) | 2009-05-19 | 2010-11-25 | Vivia Biotech S.L. | Methods for providing personalized medicine test ex vivo for hematological neoplasms |
JP5655147B2 (ja) | 2010-08-20 | 2015-01-14 | セルリアン・ファーマ・インコーポレイテッド | 治療用ペプチド−ポリマーの複合体、粒子、組成物および関連の方法 |
-
2012
- 2012-11-09 KR KR1020147012396A patent/KR102024957B1/ko active IP Right Grant
- 2012-11-09 CA CA2855155A patent/CA2855155A1/en not_active Abandoned
- 2012-11-09 SI SI201231459T patent/SI2776032T1/sl unknown
- 2012-11-09 RS RS20181552A patent/RS58102B1/sr unknown
- 2012-11-09 EP EP12787343.8A patent/EP2776032B1/en active Active
- 2012-11-09 US US14/356,996 patent/US10428151B2/en active Active
- 2012-11-09 WO PCT/US2012/064395 patent/WO2013071068A2/en active Application Filing
- 2012-11-09 AU AU2012335553A patent/AU2012335553B2/en not_active Ceased
- 2012-11-09 EA EA201490957A patent/EA026153B1/ru not_active IP Right Cessation
- 2012-11-09 PL PL12787343T patent/PL2776032T3/pl unknown
- 2012-11-09 BR BR112014011144A patent/BR112014011144A2/pt not_active Application Discontinuation
- 2012-11-09 ES ES12787343T patent/ES2705001T3/es active Active
- 2012-11-09 LT LTEP12787343.8T patent/LT2776032T/lt unknown
- 2012-11-09 JP JP2014541315A patent/JP6541350B2/ja not_active Expired - Fee Related
- 2012-11-09 DK DK12787343.8T patent/DK2776032T3/en active
- 2012-11-09 CN CN201280066551.7A patent/CN104039320B/zh active Active
- 2012-11-09 PT PT12787343T patent/PT2776032T/pt unknown
- 2012-11-09 MX MX2014005267A patent/MX357100B/es active IP Right Grant
- 2012-11-09 HU HUE12787343A patent/HUE043001T2/hu unknown
- 2012-11-09 SG SG11201401386XA patent/SG11201401386XA/en unknown
-
2014
- 2014-05-08 IL IL232517A patent/IL232517B/en active IP Right Grant
-
2018
- 2018-12-27 HR HRP20182183TT patent/HRP20182183T1/hr unknown
-
2019
- 2019-01-15 CY CY20191100051T patent/CY1121331T1/el unknown
- 2019-10-01 US US16/590,152 patent/US20200231683A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR112014011144A2 (pt) | 2017-05-16 |
CY1121331T1 (el) | 2020-05-29 |
HRP20182183T1 (hr) | 2019-02-22 |
HUE043001T2 (hu) | 2019-07-29 |
CN104039320A (zh) | 2014-09-10 |
EP2776032A2 (en) | 2014-09-17 |
RS58102B1 (sr) | 2019-02-28 |
AU2012335553B2 (en) | 2017-09-21 |
SG11201401386XA (en) | 2014-10-30 |
DK2776032T3 (en) | 2019-02-04 |
PT2776032T (pt) | 2019-01-21 |
EA026153B1 (ru) | 2017-03-31 |
KR20140093945A (ko) | 2014-07-29 |
EA201490957A1 (ru) | 2014-08-29 |
JP6541350B2 (ja) | 2019-07-10 |
US20200231683A1 (en) | 2020-07-23 |
CA2855155A1 (en) | 2013-05-16 |
JP2014533279A (ja) | 2014-12-11 |
US20140322208A1 (en) | 2014-10-30 |
ES2705001T3 (es) | 2019-03-21 |
EP2776032B1 (en) | 2018-10-17 |
KR102024957B1 (ko) | 2019-09-24 |
CN104039320B (zh) | 2019-10-15 |
PL2776032T3 (pl) | 2019-03-29 |
LT2776032T (lt) | 2018-12-10 |
US10428151B2 (en) | 2019-10-01 |
IL232517B (en) | 2018-05-31 |
MX2014005267A (es) | 2014-07-28 |
SI2776032T1 (sl) | 2018-12-31 |
WO2013071068A2 (en) | 2013-05-16 |
WO2013071068A3 (en) | 2013-07-18 |
IL232517A0 (en) | 2014-06-30 |
AU2012335553A1 (en) | 2014-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX357100B (es) | Tratamiento de neoplasias hematologicas con un anticuerpo anti-cxcr4. | |
PH12019502070A1 (en) | Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof | |
PH12020551908A1 (en) | Methods of treating cancers and enhancing efficacy of t cell redirecting therapeutics | |
EA201891428A1 (ru) | Комбинация антител к pd-1 и биспецифических антител к cd20/cd3 для лечения злокачественной опухоли | |
MX2018010331A (es) | Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dll4) y usos de los mismos. | |
PH12016500349B1 (en) | Anti-prlr antibodies and uses thereof | |
SG194701A1 (en) | Anti-cd40 antibodies and methods of use | |
NZ601580A (en) | Therapeutic methods using anti-cd200 antibodies | |
MY191423A (en) | Binding molecules specific for cd73 and uses thereof | |
MX2020009260A (es) | Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenerativos. | |
NZ707086A (en) | Anti-cd40 antibodies and methods of use | |
MX349198B (es) | Agentes que se unen a las proteinas de r-espondinas (rspo) y usos de los mismos. | |
MX341076B (es) | Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados. | |
UA118255C2 (uk) | Композиція, яка містить антитіло до cd38 і леналідомід | |
PH12015500084A1 (en) | Rspo3 binding agents and uses thereof | |
MX2011013424A (es) | Metodo de tratamiento del cancer con antagonista dll4 y agente quimioterapeutico. | |
CR20220521A (es) | Anticuerpos | |
PH12020551447A1 (en) | Antibodies | |
RU2014123781A (ru) | Комбинированная терапия с применением антитела к cd20 и человеческого il-15 | |
MX2009010269A (es) | Metodos de tratamiento del cancer mediante administracion de combinaciones de interleucina-18 humana. | |
MX2022010021A (es) | Anticuerpos de pilra y sus metodos de uso. | |
MX2023014069A (es) | Composiciones y métodos para el tratamiento del cáncer de próstata. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |