MX2020004196A - Trifab-contorsbody. - Google Patents

Trifab-contorsbody.

Info

Publication number
MX2020004196A
MX2020004196A MX2020004196A MX2020004196A MX2020004196A MX 2020004196 A MX2020004196 A MX 2020004196A MX 2020004196 A MX2020004196 A MX 2020004196A MX 2020004196 A MX2020004196 A MX 2020004196A MX 2020004196 A MX2020004196 A MX 2020004196A
Authority
MX
Mexico
Prior art keywords
contorsbody
trifab
pair
binding site
fusion polypeptides
Prior art date
Application number
MX2020004196A
Other languages
English (en)
Inventor
Guy Georges
Ulrich Brinkmann
Steffen Dickopf
Irmgard Thorey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2020004196A publication Critical patent/MX2020004196A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Calculators And Similar Devices (AREA)

Abstract

Se reporta en la presente un anticuerpo multiespecífico que comprende dos polipéptidos de fusión circulares cada uno de ellos que comprende un par VH/VL y de esta manera un primer y un segundo sitios de unión, mediante los cuales un tercer par VH/VL y de esta manera un tercer sitio de unión se forma por el asociado de los dos polipéptidos de fusión circulares.
MX2020004196A 2017-11-01 2018-10-30 Trifab-contorsbody. MX2020004196A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17199608 2017-11-01
PCT/EP2018/079612 WO2019086395A1 (en) 2017-11-01 2018-10-30 Trifab-contorsbody

Publications (1)

Publication Number Publication Date
MX2020004196A true MX2020004196A (es) 2020-11-09

Family

ID=60421554

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004196A MX2020004196A (es) 2017-11-01 2018-10-30 Trifab-contorsbody.

Country Status (14)

Country Link
US (2) US20210122832A1 (es)
EP (1) EP3704146B1 (es)
JP (1) JP7092881B2 (es)
KR (1) KR102559706B1 (es)
CN (1) CN111278856A (es)
AU (2) AU2018358904A1 (es)
BR (1) BR112020008031A2 (es)
CA (1) CA3079129C (es)
ES (1) ES2907054T3 (es)
IL (1) IL274118A (es)
MX (1) MX2020004196A (es)
PL (1) PL3704146T3 (es)
TW (1) TWI814749B (es)
WO (1) WO2019086395A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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CA2757931C (en) 2009-04-07 2019-03-26 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
CN107001482B (zh) * 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
WO2019136405A1 (en) 2018-01-05 2019-07-11 City Of Hope Multi-specific ligand binders
JP2022543669A (ja) * 2019-08-08 2022-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 新規抗原結合分子フォーマット
WO2023230209A1 (en) 2022-05-25 2023-11-30 Genentech, Inc. Methods for preparing mammalian cells for perfusion cell culture
CN115160440A (zh) * 2022-06-15 2022-10-11 复旦大学 新型双特异性抗体
EP4296280A1 (en) 2022-06-21 2023-12-27 F. Hoffmann-La Roche AG Cd123 and cd200 as markers for the diagnosis and immune-eradication of leukemic stem cells (lscs)

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Also Published As

Publication number Publication date
KR102559706B1 (ko) 2023-07-25
PL3704146T3 (pl) 2022-03-07
CA3079129C (en) 2023-02-28
ES2907054T3 (es) 2022-04-21
JP2021500931A (ja) 2021-01-14
AU2022201960A1 (en) 2022-04-14
US20240158533A1 (en) 2024-05-16
US20210122832A1 (en) 2021-04-29
TW201927818A (zh) 2019-07-16
EP3704146B1 (en) 2021-12-15
JP7092881B2 (ja) 2022-06-28
AU2018358904A1 (en) 2020-04-16
IL274118A (en) 2020-06-30
WO2019086395A1 (en) 2019-05-09
CA3079129A1 (en) 2019-05-09
BR112020008031A2 (pt) 2020-10-27
TWI814749B (zh) 2023-09-11
EP3704146A1 (en) 2020-09-09
KR20200069367A (ko) 2020-06-16
CN111278856A (zh) 2020-06-12

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