AU2004316290C1 - Monomethylvaline compounds capable of conjugation to ligands - Google Patents

Monomethylvaline compounds capable of conjugation to ligands Download PDF

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Publication number
AU2004316290C1
AU2004316290C1 AU2004316290A AU2004316290A AU2004316290C1 AU 2004316290 C1 AU2004316290 C1 AU 2004316290C1 AU 2004316290 A AU2004316290 A AU 2004316290A AU 2004316290 A AU2004316290 A AU 2004316290A AU 2004316290 C1 AU2004316290 C1 AU 2004316290C1
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Australia
Prior art keywords
antibody
alkyl
drug conjugate
pharmaceutically acceptable
solvate
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AU2004316290A
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AU2004316290A2 (en
AU2004316290B2 (en
AU2004316290A1 (en
Inventor
Svetlana O. Doronina
Allen J. Ebens
Toni Beth Kline
Paul Polakis
Peter D. Senter
Mark X. Sliwkowski
Susan D. Spencer
Brian E. Toki
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Seagen Inc
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Seagen Inc
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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    • Y10T428/00—Stock material or miscellaneous articles
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2004316290A 2003-11-06 2004-11-05 Monomethylvaline compounds capable of conjugation to ligands Active 2029-11-05 AU2004316290C1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US51853403P 2003-11-06 2003-11-06
US60/518,534 2003-11-06
US55711604P 2004-03-26 2004-03-26
US60/557,116 2004-03-26
US59889904P 2004-08-04 2004-08-04
US60/598,899 2004-08-04
US62245504P 2004-10-27 2004-10-27
US60/622,455 2004-10-27
PCT/US2004/038392 WO2005081711A2 (en) 2003-11-06 2004-11-05 Monomethylvaline compounds capable of conjugation to ligands

Publications (4)

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AU2004316290A2 AU2004316290A2 (en) 2005-09-09
AU2004316290A1 AU2004316290A1 (en) 2005-09-09
AU2004316290B2 AU2004316290B2 (en) 2011-08-18
AU2004316290C1 true AU2004316290C1 (en) 2012-02-02

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EP (8) EP2260858B1 (cg-RX-API-DMAC7.html)
JP (4) JP5020636B2 (cg-RX-API-DMAC7.html)
KR (3) KR101520209B1 (cg-RX-API-DMAC7.html)
CN (4) CN103394083B (cg-RX-API-DMAC7.html)
AU (1) AU2004316290C1 (cg-RX-API-DMAC7.html)
BR (3) BR122018071968B8 (cg-RX-API-DMAC7.html)
CA (3) CA2841741C (cg-RX-API-DMAC7.html)
DK (2) DK1725249T3 (cg-RX-API-DMAC7.html)
ES (6) ES2456325T3 (cg-RX-API-DMAC7.html)
IL (5) IL175247A (cg-RX-API-DMAC7.html)
IN (1) IN2012DN00520A (cg-RX-API-DMAC7.html)
NZ (2) NZ547633A (cg-RX-API-DMAC7.html)
PL (2) PL2489364T3 (cg-RX-API-DMAC7.html)
PT (2) PT1725249E (cg-RX-API-DMAC7.html)
SG (3) SG10201701737XA (cg-RX-API-DMAC7.html)
SI (2) SI1725249T1 (cg-RX-API-DMAC7.html)
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