BR112022024930A2 - Fármaco de camptotecina possuindo unidade de conexão hidrofílica de alta estabilidade e conjugado do mesmo - Google Patents
Fármaco de camptotecina possuindo unidade de conexão hidrofílica de alta estabilidade e conjugado do mesmoInfo
- Publication number
- BR112022024930A2 BR112022024930A2 BR112022024930A BR112022024930A BR112022024930A2 BR 112022024930 A2 BR112022024930 A2 BR 112022024930A2 BR 112022024930 A BR112022024930 A BR 112022024930A BR 112022024930 A BR112022024930 A BR 112022024930A BR 112022024930 A2 BR112022024930 A2 BR 112022024930A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugate
- connection unit
- high stability
- camptothecin
- drug
- Prior art date
Links
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 title abstract 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
- 229940127093 camptothecin Drugs 0.000 title abstract 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
FÁRMACO DE CAMPTOTECINA POSSUINDO UNIDADE DE CONEXÃO HIDROFÍLICA DE ALTA ESTABILIDADE E CONJUGADO DO MESMO. A presente invenção refere-se a fármaco camptotecina com uma unidade de conexão hidrofílica altamente estável e conjugado do mesmo, ou sal farmaceuticamente aceitável do mesmo, incluindo métodos para sua preparação e suas aplicações na prevenção e/ou tratamento do câncer. O conjugado pode se ligar especificamente a receptores altamente expressos em células tumorais. Os conjugados possuem excelente solubilidade, estabilidade e homogeneidade em água, e podem ser usados para prevenir e/ou tratar tumores e/ou outras doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN202010510363 | 2020-06-08 | ||
PCT/CN2021/097302 WO2021249228A1 (zh) | 2020-06-08 | 2021-05-31 | 一种带有高稳定性亲水连接单元的喜树碱类药物及其偶联物 |
Publications (1)
Publication Number | Publication Date |
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BR112022024930A2 true BR112022024930A2 (pt) | 2022-12-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112022024930A BR112022024930A2 (pt) | 2020-06-08 | 2021-05-31 | Fármaco de camptotecina possuindo unidade de conexão hidrofílica de alta estabilidade e conjugado do mesmo |
Country Status (11)
Country | Link |
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US (1) | US20230226207A1 (pt) |
EP (1) | EP4162954A1 (pt) |
JP (1) | JP2023529415A (pt) |
KR (1) | KR20230022211A (pt) |
CN (1) | CN113827736A (pt) |
AU (1) | AU2021289927A1 (pt) |
BR (1) | BR112022024930A2 (pt) |
CA (1) | CA3186295A1 (pt) |
IL (1) | IL298787A (pt) |
MX (1) | MX2022015695A (pt) |
WO (1) | WO2021249228A1 (pt) |
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AU2020442003C1 (en) * | 2020-09-15 | 2024-05-23 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | A camptothecin drug and its antibody conjugate thereof |
IL302053A (en) * | 2020-10-12 | 2023-06-01 | Sichuan Baili Pharm Co Ltd | Camptothecin derivative is canceled and their conjugation to anti-body drugs |
JP2024506819A (ja) * | 2021-02-05 | 2024-02-15 | シチュアン ケルン-バイオテック バイオファーマシューティカル カンパニー リミテッド | カンプトテシン化合物、その調製方法、及びその適用 |
AU2022386505A1 (en) * | 2021-11-15 | 2024-05-23 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
WO2023098889A1 (zh) * | 2021-12-03 | 2023-06-08 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
WO2023208168A1 (zh) * | 2022-04-29 | 2023-11-02 | 成都百利多特生物药业有限责任公司 | 一种包含亲水性糖结构的配体-药物偶联物 |
WO2023217064A1 (zh) * | 2022-05-09 | 2023-11-16 | 同宜医药(苏州)有限公司 | 一种喜树碱衍生物,基于其的抗体-药物偶联物和药物组合物,及其应用 |
CN116789733A (zh) * | 2022-07-05 | 2023-09-22 | 上海药明合联生物技术有限公司 | 偶联连接子 |
WO2024067811A1 (en) * | 2022-09-30 | 2024-04-04 | Beigene, Ltd. | Ligand-drug conjugate of exatecan analogue, and medical use thereof |
WO2024067754A1 (zh) * | 2022-09-30 | 2024-04-04 | 成都百利多特生物药业有限责任公司 | 一种带有高稳定性亲水连接单元的奥瑞他汀类药物及其偶联物 |
WO2024091437A1 (en) * | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof |
WO2024109840A1 (zh) * | 2022-11-22 | 2024-05-30 | 康诺亚生物医药科技(成都)有限公司 | 稠环类化合物及其偶联物和用途 |
WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
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EP1482972A4 (en) * | 2001-11-20 | 2005-11-23 | Seattle Genetics Inc | TREATMENT OF IMMUNOLOGICAL DISORDERS USING ANTI-CD30 ANTIBODIES |
SI1725249T1 (sl) | 2003-11-06 | 2014-04-30 | Seattle Genetics, Inc. | Spojine monometilvalina, sposobne konjugacije na ligande |
AU2005316844A1 (en) * | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
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WO2009011285A1 (ja) | 2007-07-13 | 2009-01-22 | Taisho Pharmaceutical Co., Ltd. | ヘテロアリールベンゼン化合物 |
ES2690315T3 (es) | 2012-06-15 | 2018-11-20 | Mitsubishi Tanabe Pharma Corporation | Compuestos de imidazol y triazol como inhibidores de DGAT-1 |
KR102087017B1 (ko) * | 2012-10-11 | 2020-03-10 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 |
US11185594B2 (en) * | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
WO2018233571A1 (zh) | 2017-06-19 | 2018-12-27 | 四川百利药业有限责任公司 | 一种带酸性自稳定接头的抗体-药物偶联物 |
EP3677589A4 (en) | 2017-08-31 | 2021-04-21 | Daiichi Sankyo Company, Limited | IMPROVED PROCESS FOR PREPARING ANTIBODY-ACTIVE CONJUGATE |
MX2021003382A (es) | 2018-09-26 | 2021-05-27 | Jiangsu Hengrui Medicine Co | Conjugado de ligando y farmaco analogo de exatecan, metodo de preparacion del mismo y aplicacion del mismo. |
AU2019351427A1 (en) | 2018-09-30 | 2021-04-15 | Changzhou Hansoh Pharmaceutical Co., Ltd. | Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof |
US20230072897A1 (en) | 2019-06-06 | 2023-03-09 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-b7-h4 antibody-drug conjugate and medicinal use thereof |
-
2021
- 2021-05-31 MX MX2022015695A patent/MX2022015695A/es unknown
- 2021-05-31 KR KR1020237000429A patent/KR20230022211A/ko unknown
- 2021-05-31 JP JP2022575365A patent/JP2023529415A/ja active Pending
- 2021-05-31 CA CA3186295A patent/CA3186295A1/en active Pending
- 2021-05-31 BR BR112022024930A patent/BR112022024930A2/pt unknown
- 2021-05-31 AU AU2021289927A patent/AU2021289927A1/en active Pending
- 2021-05-31 WO PCT/CN2021/097302 patent/WO2021249228A1/zh active Application Filing
- 2021-05-31 IL IL298787A patent/IL298787A/en unknown
- 2021-05-31 EP EP21821872.5A patent/EP4162954A1/en active Pending
- 2021-05-31 US US18/008,798 patent/US20230226207A1/en active Pending
- 2021-06-01 CN CN202110610405.7A patent/CN113827736A/zh active Pending
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WO2021249228A1 (zh) | 2021-12-16 |
AU2021289927A1 (en) | 2023-01-19 |
MX2022015695A (es) | 2023-03-21 |
CA3186295A1 (en) | 2021-12-16 |
US20230226207A1 (en) | 2023-07-20 |
EP4162954A1 (en) | 2023-04-12 |
IL298787A (en) | 2023-02-01 |
CN113827736A (zh) | 2021-12-24 |
KR20230022211A (ko) | 2023-02-14 |
JP2023529415A (ja) | 2023-07-10 |
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