CR20160156A - Anticuerpos conjugados contra ly75 para el tratamiento del cáncer - Google Patents
Anticuerpos conjugados contra ly75 para el tratamiento del cáncerInfo
- Publication number
- CR20160156A CR20160156A CR20160156A CR20160156A CR20160156A CR 20160156 A CR20160156 A CR 20160156A CR 20160156 A CR20160156 A CR 20160156A CR 20160156 A CR20160156 A CR 20160156A CR 20160156 A CR20160156 A CR 20160156A
- Authority
- CR
- Costa Rica
- Prior art keywords
- cancer
- antibodies
- cancer treatment
- antibodies against
- conjugated antibodies
- Prior art date
Links
- 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 title abstract 2
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6861—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
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- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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Abstract
La invención proporciona anticuerpos que se unen a LY75. También se proporcionan moléculas de ácido nucleico que codifican los anticuerpos, vectores de expresión, células hospedadoras y procedimientos para expresar los anticuerpos. Los anticuerpos se pueden usar para el tratamiento del cáncer, incluyendo cáncer de páncreas, cáncer de ovario, cáncer de mama, cáncer colorrectal, cáncer de esófago, cáncer de piel, cáncer de tiroides, cáncer de pulmón, cáncer de vejiga, mieloma múltiple y linfoma
Applications Claiming Priority (3)
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US201361890098P | 2013-10-11 | 2013-10-11 | |
US201361890104P | 2013-10-11 | 2013-10-11 | |
PCT/GB2014/053057 WO2015052537A1 (en) | 2013-10-11 | 2014-10-10 | Conjugated antibodies against ly75 for the treatment of cancer |
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CR20160156A true CR20160156A (es) | 2016-11-01 |
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CR20160156A CR20160156A (es) | 2013-10-11 | 2014-10-10 | Anticuerpos conjugados contra ly75 para el tratamiento del cáncer |
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JP (1) | JP6657075B2 (es) |
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CN (1) | CN105745224B (es) |
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CL (1) | CL2016000770A1 (es) |
CR (1) | CR20160156A (es) |
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DO (1) | DOP2016000072A (es) |
EA (1) | EA036927B1 (es) |
ES (1) | ES2859604T3 (es) |
HK (1) | HK1222869A1 (es) |
HR (1) | HRP20210410T1 (es) |
HU (1) | HUE055190T2 (es) |
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PE (1) | PE20160561A1 (es) |
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RS61620B1 (sr) | 2013-10-11 | 2021-04-29 | Oxford Bio Therapeutics Ltd | Konjugovana antitela prema ly75 za lečenje kancera |
EP3303625B1 (en) * | 2015-05-29 | 2019-03-27 | Universiteit Maastricht | Method for identifying subjects with aggressive melanoma skin cancer at diagnosis |
GB201703876D0 (en) * | 2017-03-10 | 2017-04-26 | Berlin-Chemie Ag | Pharmaceutical combinations |
US20200347138A1 (en) * | 2017-10-27 | 2020-11-05 | Indian Institute Of Science | Dendritic cells-targeting vaccine |
GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
BR112023023831A2 (pt) | 2021-05-26 | 2024-01-30 | Oxford Biotherapeutics Ltd | Métodos, combinação farmacêutica, anticorpo ou porção de ligação ao antígeno do mesmo |
WO2023089314A1 (en) | 2021-11-18 | 2023-05-25 | Oxford Biotherapeutics Limited | Pharmaceutical combinations |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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