CY1124006T1 - Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινου - Google Patents
Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινουInfo
- Publication number
- CY1124006T1 CY1124006T1 CY20211100272T CY211100272T CY1124006T1 CY 1124006 T1 CY1124006 T1 CY 1124006T1 CY 20211100272 T CY20211100272 T CY 20211100272T CY 211100272 T CY211100272 T CY 211100272T CY 1124006 T1 CY1124006 T1 CY 1124006T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cancer
- antibodies
- treatment
- conjugated antibodies
- lymphoma
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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Abstract
Η εφεύρεση παρέχει αντισώματα που δεσμεύονται με το LY75. Παρέχονται επίσης μόρια νουκλεϊκού οξέος που κωδικοποιούν τα αντισώματα, φορείς έκφρασης, κύτταρα-ξενιστές και μεθόδους έκφρασης των αντισωμάτων. Τα αντισώματα μπορούν να χρησιμοποιηθούν για τη θεραπεία του καρκίνου, συμπεριλαμβανομένου του καρκίνου του παγκρέατος, του καρκίνου των ωοθηκών, του καρκίνου του μαστού, του καρκίνου του παχέος εντέρου, του καρκίνου του οισοφάγου, του καρκίνου του δέρματος, του καρκίνου του θυρεοειδούς, του καρκίνου του πνεύμονα, του καρκίνου της ουροδόχου κύστης, πολλαπλού μυελώματος και λεμφώματος.
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US201361890098P | 2013-10-11 | 2013-10-11 | |
US201361890104P | 2013-10-11 | 2013-10-11 | |
PCT/GB2014/053057 WO2015052537A1 (en) | 2013-10-11 | 2014-10-10 | Conjugated antibodies against ly75 for the treatment of cancer |
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CY1124006T1 true CY1124006T1 (el) | 2022-05-27 |
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CY20211100272T CY1124006T1 (el) | 2013-10-11 | 2021-03-26 | Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινου |
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EP (1) | EP3055331B1 (el) |
JP (1) | JP6657075B2 (el) |
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CR (1) | CR20160156A (el) |
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CY (1) | CY1124006T1 (el) |
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PT3055331T (pt) | 2013-10-11 | 2021-04-05 | Oxford Bio Therapeutics Ltd | Anticorpos conjugados contra ly75 para o tratamento de cancro |
WO2016193117A1 (en) * | 2015-05-29 | 2016-12-08 | Universiteit Maastricht | Method for identifying subjects with aggressive melanoma skin cancer at diagnosis |
GB201703876D0 (en) * | 2017-03-10 | 2017-04-26 | Berlin-Chemie Ag | Pharmaceutical combinations |
US20200347138A1 (en) * | 2017-10-27 | 2020-11-05 | Indian Institute Of Science | Dendritic cells-targeting vaccine |
GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
BR112023023831A2 (pt) | 2021-05-26 | 2024-01-30 | Oxford Biotherapeutics Ltd | Métodos, combinação farmacêutica, anticorpo ou porção de ligação ao antígeno do mesmo |
WO2023089314A1 (en) | 2021-11-18 | 2023-05-25 | Oxford Biotherapeutics Limited | Pharmaceutical combinations |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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