FI109768B - CD4-specifik rekombinantantikropp - Google Patents
CD4-specifik rekombinantantikropp Download PDFInfo
- Publication number
- FI109768B FI109768B FI990875A FI990875A FI109768B FI 109768 B FI109768 B FI 109768B FI 990875 A FI990875 A FI 990875A FI 990875 A FI990875 A FI 990875A FI 109768 B FI109768 B FI 109768B
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- okt4a
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (24)
1. Diagnostiskt ämne, kännetecknat av att det omfattar en antikroppsmolekyl, som förmär binda 5 sig vid en CD4-antigen, som omfattar en förenad tung ked-ja och en komplementär lätt kedja, varvid stomregionerna i nämnda förenade tunga kedjas variabla region huvudsakligen härstammar frän en human antikropp (receptor) och ätmin-stone resterna 23, 24, 26 - 35, 49 - 65 och 95 - 102 (en-10 ligt Kabats numreringssystem) motsvarar de likvärdiga resterna i den monoklonala musantikroppen OKT4A (donator), säsom figuren 3 i ritningarna visar.
2. Diagnostiskt ämne enligt patentkrav 1, kännetecknat av att den förenade tunga kedjans rester 6 15 och 48 dessutom motsvarar donatorantikroppens likvärdiga rester.
3. Diagnostiskt ämne enligt patentkrav 1 eller 2, kännetecknat av att den förenade tunga kedjans rester 71, 73 och 79 dessutom motsvarar donator-antikroppens . 20 likvärdiga rester.
;;· · 4. Diagnostiskt ämne enligt nägot av patentkraven ·" 1-3, kännetecknat av att vilken som heist av den förenade tunga kedjans rester 57, 58, 60, 88 och 91 eller • · · vilken som heist sammansättning av dessa rester motsvarar >/ i 25 donatorantikroppens likvärdiga rester.
5. Diagnostiskt ämne enligt nägot av patentkraven 1 - 4, kännetecknat av att den förenade tunga ked- : jans receptorrester motsvarar de likvärdiga resterna i en • · · tung human KOL-kedja, säsom figuren 5 i ritningarna visar. 30
6. Diagnostiskt ämne enligt nägot av patentkraven i ί ’· 1-5, kännetecknat av att den komplementära lätta » * I kedjan är en förenad lätt kedja, varvid stomregionerna i ;·. nämnda förenade lätta kedjas variabla region huvudsakligen • · · (ti>. deriverats frän en första antikropp (receptor) och ätmin- 35 stone resterna 24 - 34, 49 - 56 och 89 - 97 (enligt Kabats numreringssystem) motsvarar de likvärdiga resterna i den 109768 monoklonala musantikroppen OKT4A (donator), säsom figuren 4 i ritningarna visar.
7. Diagnostiskt ämne, kännetecknat av att det omfattar en antikroppsmolekyl, som förmär binda 5 sig vid en CD4-antigen och omfattar en förenad lätt kedja och en komplementär tung kedja, varvid stomregionerna i nämnda förenade tunga kedjas variabla region huvudsakligen härstammar frän en human antikropp (receptor) och ätmin-stone resterna 24 - 34, 49 - 56 och 89 - 97 (enligt Ka- 10 bats numreringssystem) motsvarar de likvärdiga resterna i den monoklonala musantikroppen OKT4A (donator) , säsom figuren 4 i ritningarna visar.
8. Diagnostiskt ämne enligt patentkrav 6 eller 7, kännetecknat av att den förenade lätta kedjans rest 15 89 dessutom motsvarar donatorantikroppens likvärdiga rest.
9. Diagnostiskt ämne enligt nägot av patentkraven 6 - 8, kännetecknat av att den förenade lätta kedjans receptorrester motsvarar de likvärdiga resterna i en lätt human REI-kedja, säsom figuren 6 i ritningarna visar.
10. Diagnostiskt ämne enligt nägot av patentkraven .·. 1-9, kännetecknat av att dess affinitet till CD4- !·** antigenen är 105 - 1012 M”1.
. 11. Diagnostiskt ämne enligt patentkrav 10, kän- netecknat av att dess affinitet tili CD4-antigenen är :···: 25 minst 108 M"1.
* « * *.* * 12. Diagnostiskt ämne enligt patentkrav 10 eller i · » ·,·· 11, kännetecknat av att dess affinitet till CD4- antigenen är likadan som affiniteten hos OKT4A.
13. Diagnostiskt ämne enligt nägot av patentkraven 30 1 - 12, kännetecknat av att det är en komplett Ig. i · *
14. Diagnostiskt ämne enligt patentkrav 13, kän- i t • netecknat av att det är av isotyp IgG4. * ·
15. Diagnostiskt ämne enligt patentkrav 13 eller 14, kännetecknat av att en eller flera av resterna i
35 Ig:s konstantregioner har ändrats för ändring av konstant-regionernas efektorfunktioner. 57 109768
16. Diagnostiskt ämne enligt nägot av patentkraven 1 - 15, kännetecknat av att det har producerats genom användning av rekombinant-DNA-teknik.
17. Förfarande för framställning av ett diagnos-5 tiskt ämne enligt nägot av patentkraven 1 - 16, kännetecknat av att en första DNA-sekvens, som kodar den förenade tunga kedjan enligt nägot av patentkraven 1-5 eller den förenade lätta kedjan enligt nägot av patentkraven 6-9, förs under styrning av lämpliga uppströms- ooh 10 nedströmselement; en värdcell transformeras med den första DNA-sekvensen; och den transformerade värdcellen odlas för producering av antikroppen enligt nägot av patentkraven 1 - 16.
18. Förfarande enligt patentkrav 17, känne-15 tecknat av att ytterligare en andra DNA-sekvens, som kodar antikroppens lätta eller tunga kedja, som är komple-mentär med den första kedjan, förs under styrning av lämpliga uppströms- och nedströmselement; och värdcellen transf ormeras med bade den första och den andra DNA-20 sekvensen.
.·. 19. Förfarande enligt patentkrav 18, känne- • · • tecknat av att den andra DNA-sekvensen kodar den för-• · . enade antikroppskedjan. • ·
20. Förfarande enligt patentkrav 18 eller 19, 25 kännetecknat av att den första och andra DNA: n är i i » V * närvarande i samma vektor. Ill
’ 21. Förfarande enligt patentkrav 20, känne tecknat av att sekvenserna är under styrning av samma uppströms- och/eller nedströmselement. • · 30
22. Förfarande enligt patentkrav 20, känne- Ml ,,· tecknat av att sekvenserna är under styrning av olika • ” uppströms- och/eller nedströmselement. • « · • » I I · » · I 58 109768
23. Förfarande enligt patentkrav 18 eller 19, kännetecknat av att den första och andra DNA:n är närvarande i olika vektorer.
24. Förfarande enligt nägot av patentkraven 17 - 5 23, kännetecknat av att värdcellen är en CHO-cell. * • · • · t I • | t f a a • · » · · • a Il I • a « »aa • · 4 · · » • « a »aa i a · i » < · · » ta • · I I I I ft a i a · I » t a s ft · 4 1· t a t a » i « i » i aa a s i a * i » »
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898928874A GB8928874D0 (en) | 1989-12-21 | 1989-12-21 | Humanised antibodies |
GB8928874 | 1989-12-21 | ||
PCT/GB1990/002015 WO1991009966A1 (en) | 1989-12-21 | 1990-12-21 | Cd4 specific recombinant antibody |
GB9002015 | 1990-12-21 | ||
FI913932 | 1991-08-20 | ||
FI913932A FI108917B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för framställning av en terapeutiskt användbar CD4-specifik rekombinantantikropp |
Publications (3)
Publication Number | Publication Date |
---|---|
FI990875A0 FI990875A0 (sv) | 1999-04-19 |
FI990875A FI990875A (sv) | 1999-04-19 |
FI109768B true FI109768B (sv) | 2002-10-15 |
Family
ID=10668300
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913926A FI108777B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för att producera en antikroppsmolekyl bearbetad med CDR-graft |
FI913927A FI108776B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för att producera en antantikroppsmolekyl bearbetad med anti-CD3-CDR-graft |
FI913932A FI108917B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för framställning av en terapeutiskt användbar CD4-specifik rekombinantantikropp |
FI990875A FI109768B (sv) | 1989-12-21 | 1999-04-19 | CD4-specifik rekombinantantikropp |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913926A FI108777B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för att producera en antikroppsmolekyl bearbetad med CDR-graft |
FI913927A FI108776B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för att producera en antantikroppsmolekyl bearbetad med anti-CD3-CDR-graft |
FI913932A FI108917B (sv) | 1989-12-21 | 1991-08-20 | Förfarande för framställning av en terapeutiskt användbar CD4-specifik rekombinantantikropp |
Country Status (21)
Country | Link |
---|---|
US (10) | US5929212A (sv) |
EP (5) | EP0626390B1 (sv) |
JP (4) | JPH04505398A (sv) |
KR (3) | KR100197956B1 (sv) |
AT (4) | ATE124459T1 (sv) |
AU (4) | AU649645B2 (sv) |
BG (1) | BG60462B1 (sv) |
BR (1) | BR9007197A (sv) |
CA (3) | CA2050479C (sv) |
DE (4) | DE69020544T2 (sv) |
DK (4) | DK0626390T3 (sv) |
ES (4) | ES2074701T3 (sv) |
FI (4) | FI108777B (sv) |
GB (4) | GB8928874D0 (sv) |
GR (2) | GR3017734T3 (sv) |
HU (4) | HU215383B (sv) |
NO (5) | NO316076B1 (sv) |
RO (3) | RO114298B1 (sv) |
RU (1) | RU2112037C1 (sv) |
WO (3) | WO1991009966A1 (sv) |
ZA (1) | ZA9110129B (sv) |
Families Citing this family (1309)
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US5062934A (en) * | 1989-12-18 | 1991-11-05 | Oronzio Denora S.A. | Method and apparatus for cathodic protection |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
GB9019812D0 (en) * | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
GB9021679D0 (en) * | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
US5558864A (en) * | 1991-03-06 | 1996-09-24 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies |
DE69231828T3 (de) * | 1991-03-18 | 2008-06-19 | New York University | Spezifisch gegen menschlichen Tumornekrosefaktor gerichtete monoklonale und chimäre Antikörper |
JPH06202412A (ja) * | 1992-12-26 | 1994-07-22 | Canon Inc | 画像形成装置 |
US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US5535089A (en) * | 1994-10-17 | 1996-07-09 | Jing Mei Industrial Holdings, Ltd. | Ionizer |
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1989
- 1989-12-21 GB GB898928874A patent/GB8928874D0/en active Pending
-
1990
- 1990-12-21 DK DK94202090T patent/DK0626390T3/da active
- 1990-12-21 ES ES91901559T patent/ES2074701T3/es not_active Expired - Lifetime
- 1990-12-21 EP EP94202090A patent/EP0626390B1/en not_active Revoked
- 1990-12-21 DE DE69020544T patent/DE69020544T2/de not_active Expired - Lifetime
- 1990-12-21 ES ES91901433T patent/ES2079638T3/es not_active Expired - Lifetime
- 1990-12-21 DE DE69033857T patent/DE69033857T2/de not_active Revoked
- 1990-12-21 AT AT91901559T patent/ATE124459T1/de not_active IP Right Cessation
- 1990-12-21 ES ES94202090T patent/ES2165864T3/es not_active Expired - Lifetime
- 1990-12-21 HU HU734/91A patent/HU215383B/hu unknown
- 1990-12-21 AT AT91901835T patent/ATE159299T1/de not_active IP Right Cessation
- 1990-12-21 KR KR1019910700949A patent/KR100197956B1/ko not_active IP Right Cessation
- 1990-12-21 HU HU752/91A patent/HU217693B/hu unknown
- 1990-12-21 HU HU912734A patent/HUT58372A/hu unknown
- 1990-12-21 WO PCT/GB1990/002015 patent/WO1991009966A1/en active IP Right Grant
- 1990-12-21 HU HU912751A patent/HUT60786A/hu unknown
- 1990-12-21 RO RO148282A patent/RO114298B1/ro unknown
- 1990-12-21 EP EP91901835A patent/EP0460178B1/en not_active Expired - Lifetime
- 1990-12-21 WO PCT/GB1990/002017 patent/WO1991009967A1/en not_active Application Discontinuation
- 1990-12-21 RO RO148281A patent/RO114232B1/ro unknown
- 1990-12-21 RU SU5001870A patent/RU2112037C1/ru active
- 1990-12-21 CA CA002050479A patent/CA2050479C/en not_active Expired - Lifetime
- 1990-12-21 KR KR1019910700944A patent/KR100191152B1/ko not_active IP Right Cessation
- 1990-12-21 DK DK91901433.2T patent/DK0460167T3/da active
- 1990-12-21 DE DE69031591T patent/DE69031591T2/de not_active Expired - Lifetime
- 1990-12-21 EP EP91901433A patent/EP0460167B1/en not_active Revoked
- 1990-12-21 CA CA002046904A patent/CA2046904C/en not_active Expired - Lifetime
- 1990-12-21 ES ES91901835T patent/ES2112270T3/es not_active Expired - Lifetime
- 1990-12-21 EP EP94104042A patent/EP0620276A1/en not_active Withdrawn
- 1990-12-21 RO RO148283A patent/RO114980B1/ro unknown
- 1990-12-21 AU AU70330/91A patent/AU649645B2/en not_active Expired
- 1990-12-21 WO PCT/GB1990/002018 patent/WO1991009968A1/en active IP Right Grant
- 1990-12-21 AT AT94202090T patent/ATE208794T1/de not_active IP Right Cessation
- 1990-12-21 AU AU70486/91A patent/AU631481B2/en not_active Expired
- 1990-12-21 JP JP3501864A patent/JPH04505398A/ja active Pending
- 1990-12-21 JP JP50186591A patent/JP3242913B2/ja not_active Expired - Lifetime
- 1990-12-21 DE DE69022982T patent/DE69022982T2/de not_active Revoked
- 1990-12-21 EP EP91901559A patent/EP0460171B1/en not_active Expired - Lifetime
- 1990-12-21 DK DK91901835.8T patent/DK0460178T3/da active
- 1990-12-21 AT AT91901433T patent/ATE129017T1/de not_active IP Right Cessation
- 1990-12-21 DK DK91901559.4T patent/DK0460171T3/da active
- 1990-12-21 AU AU69740/91A patent/AU646009B2/en not_active Expired
- 1990-12-21 BR BR909007197A patent/BR9007197A/pt unknown
- 1990-12-21 JP JP50210791A patent/JP3452062B2/ja not_active Expired - Lifetime
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1991
- 1991-03-06 CA CA002037607A patent/CA2037607C/en not_active Expired - Lifetime
- 1991-08-15 GB GB9117611A patent/GB2246781B/en not_active Revoked
- 1991-08-15 GB GB9117612A patent/GB2246570B/en not_active Expired - Lifetime
- 1991-08-19 NO NO19913228A patent/NO316076B1/no not_active IP Right Cessation
- 1991-08-19 NO NO91913229A patent/NO913229L/no not_active Application Discontinuation
- 1991-08-20 FI FI913926A patent/FI108777B/sv active
- 1991-08-20 FI FI913927A patent/FI108776B/sv active
- 1991-08-20 FI FI913932A patent/FI108917B/sv active
- 1991-08-20 KR KR1019910700950A patent/KR100198478B1/ko not_active IP Right Cessation
- 1991-08-20 NO NO19913271A patent/NO310560B1/no not_active IP Right Cessation
- 1991-08-20 BG BG95018A patent/BG60462B1/bg unknown
- 1991-12-23 ZA ZA9110129A patent/ZA9110129B/xx unknown
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1993
- 1993-09-03 US US08/116,247 patent/US5929212A/en not_active Expired - Lifetime
- 1993-09-13 GB GB9318911A patent/GB2268744B/en not_active Expired - Lifetime
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1994
- 1994-06-08 AU AU64612/94A patent/AU664801B2/en not_active Expired
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1995
- 1995-10-12 GR GR950402787T patent/GR3017734T3/el unknown
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1997
- 1997-12-22 JP JP9353861A patent/JPH11243955A/ja active Pending
- 1997-12-24 GR GR970403432T patent/GR3025781T3/el unknown
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1998
- 1998-11-23 NO NO19985468A patent/NO316074B1/no not_active IP Right Cessation
- 1998-11-23 NO NO985467A patent/NO985467D0/no not_active Application Discontinuation
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1999
- 1999-04-19 FI FI990875A patent/FI109768B/sv active
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2003
- 2003-11-07 US US10/703,963 patent/US7244832B2/en not_active Expired - Fee Related
- 2003-11-07 US US10/704,352 patent/US7241877B2/en not_active Expired - Fee Related
- 2003-11-07 US US10/704,071 patent/US7244615B2/en not_active Expired - Fee Related
- 2003-11-07 US US10/703,344 patent/US7262050B2/en not_active Expired - Fee Related
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2004
- 2004-09-10 US US10/937,971 patent/US20050123534A1/en not_active Abandoned
- 2004-09-10 US US10/937,949 patent/US20050136054A1/en not_active Abandoned
- 2004-09-10 US US10/938,117 patent/US20060029593A1/en not_active Abandoned
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2005
- 2005-11-21 US US11/284,260 patent/US20060073136A1/en not_active Abandoned
- 2005-11-21 US US11/284,261 patent/US20060073137A1/en not_active Abandoned
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