JPH04506458A - Cd3特異的組換え抗体 - Google Patents
Cd3特異的組換え抗体Info
- Publication number
- JPH04506458A JPH04506458A JP3501865A JP50186591A JPH04506458A JP H04506458 A JPH04506458 A JP H04506458A JP 3501865 A JP3501865 A JP 3501865A JP 50186591 A JP50186591 A JP 50186591A JP H04506458 A JPH04506458 A JP H04506458A
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- chain
- antibody
- grafted
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Abstract
Description
Claims (26)
- 1.ドナーの抗CD3抗体のHおよび/またはL鎖可変領域から誘導された抗原 結合領域を含み、抗CD3結合特異性を有する組み換え抗体分子。
- 2.OKT3に類似の抗CD3結合親和性を有する、請求項1に記載の組換え抗 体分子。
- 3.キメラ抗体である、請求項1または2に記載の組換え抗体分子。
- 4.CDRグラフト抗体である請求項1または2に記載の組換え抗体分子。
- 5.人体適応性抗体分子である、任意の先行請求項に記載の組換え抗体分子。
- 6.アクセプターのフレームワークとドナーのCD3結合領域を含み該フレーム ワークが位置6、23および/または24、48および/または49、71およ び/または73、75および/または76および/または78および88および /または91の少なくとも一でドナー残基を含む、可変領域を有する、請求項4 に記載のCDR−グラフト抗体H鎖。
- 7.位置23、24、49、71、73および78、または位置23、24およ び49で、ドナー残基を含む、請求項6に記載のCDRグラフトH鎖。
- 8.位置2、4、6、25、36、37、39、47、48、93、94、10 3、104、106および107でドナー残基を含む、請求項7に記載のCDR グラフトH鎖。
- 9.位置 1および3、 69(48がドナーとアクセプター間で異るなら)38および46(48がドナ ー残基なら)67、 82および18(67がドナー残基なら)91、および 9、11、41、87、108、110および112の任意の一以上 の一つ、いくつかまたはすべてでドナー残基を含む請求項7または8に記載のC DRグラフトH鎖。
- 10.位置26〜35、50〜65および95〜100でドナーCDRを含む、 請求項4または6〜9の任意の−に記載のCDRグラフトH鎖。
- 11.アクセプターのフレームワークとドナーの抗原結合領域を含み、該フレー ムワークが位置1および/または3および46および/または47の任意の−で ドナー残基を含む、可変領域を有する請求項4に記載のCDRグラフト抗体L鎖 。
- 12.位置46および47でドナー残基を含む、請求項11に記載のCDRグラ フトL鎖。
- 13.アクセプターのフレームワークとドナーの抗原結合領域を含み、該フレー ムワークは位置46、48、58および71の少くとも−でドナー残基を含む、 可変領域を有する、請求項4に記載のCDRグラフト抗体L鎖。
- 14.位置46、48、58および71でドナー残基を含む、請求項13に記載 のCDRグラフトL鎖。
- 15.位置2、4、6、35、36、38、44、47、49、62、64〜6 9、85、87、98、99、101および102でドナー残基を含む、請求項 11または13に記載のCDRグラフトL鎖。
- 16.位置 1および3、 63、 60(60および54が塩橋を生成できる可能性あるなら)、 70(70および24が塩橋を生成できる可能性あるなら)、 73および21(47がドナーとアクセプター間で異るなら)、 37および45(47がドナーとアクセプター間で異るなら)、 そして、10、12、40、83、103および105の任意の一以上 の一つ、いくつかまたはすべてでドナー残基を含む、請求項11、13、または 15の任意の一に記載のCDRグラフトL鎖。
- 17.位置24〜34、50〜56および89〜97でドナーCDRを含む、請 求項4または11〜16の任意の一に記載のCDRL鎖。
- 18.請求項6〜10の任意の−に記載の少くとも−のCDRグラフトH鎖、お よび請求項11〜17の任意の−に記載の少くとも−のCDRグラフトL鎖を含 む、CDRグラフト抗体分子。
- 19.ヒトアクセプター残基と非ヒトドナー残基を含む、請求項6〜18の任意 の一に記載のCDRグラフト抗体HまたはL鎖。
- 20.請求項1に記載の組換え抗体、請求項5に記載の人体適応性抗体、請求項 6に記載のCDRグラフトH鎖、または請求項11若しくは請求項13に記載の CDRグラフトL鎖をコードするDNA配列。
- 21.請求項20に記載のDNA配列を含むクローニングまたは発現ベクター。
- 22.請求項20に記載のDNA配列で形質転換した宿主細胞。
- 23.形質転換する宿主細胞中で、請求項20に記載のDNA配列を発現するこ とよりなる、抗CD3CDRグラフト抗体生産物の製造方法。
- 24.(a)請求項6に記載の抗体H鎖をコードするDNA配列を有するオペロ ンを発現ベクター中に作り、そして/または (b)請求項11または請求項13に記載の相補的抗体L鎖をコードするDNA 配列を有するオペロンを発現ベクター中に作り、 (c)その、または各ベクターを宿主細胞にトランスフェクトし、 そして (d)トランスフェクトした細胞系を培養して、CDRグラフト抗体生産物を製 造する、ことよりなる、抗CD3CDRグラフト抗体生産物の製造方法。
- 25.請求項1に記載の組換え抗体分子、請求項5に記載の人体適応性抗体、請 求項6に記載のCDRグラフト抗体H鎖、請求項11または13に記載のCDR グラフトL鎖、または請求項18に記載のCDRグラフト抗体分子を、薬学的に 受容し得るキャリア、希釈剤、または賦形剤と組み合せた、治療用または診断用 組成物。
- 26.有効量の、請求項1に記載の組換え抗体分子、請求項5に記載の人体適応 性分子、請求項6に記載のCDRグラフトH鎖、請求項11または請求項13に 記載のCDRグラフトL鎖、または請求項18に記載のCDRグラフト抗体分子 を、ヒトまたは動物に投与することよりなる治療または診断方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898928874A GB8928874D0 (en) | 1989-12-21 | 1989-12-21 | Humanised antibodies |
GB8928874,0 | 1989-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04506458A true JPH04506458A (ja) | 1992-11-12 |
JP3242913B2 JP3242913B2 (ja) | 2001-12-25 |
Family
ID=10668300
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3501864A Pending JPH04505398A (ja) | 1989-12-21 | 1990-12-21 | 人体化抗体 |
JP50210791A Expired - Lifetime JP3452062B2 (ja) | 1989-12-21 | 1990-12-21 | Cdr―移植された抗体 |
JP50186591A Expired - Lifetime JP3242913B2 (ja) | 1989-12-21 | 1990-12-21 | Cd3特異的組換え抗体 |
JP9353861A Pending JPH11243955A (ja) | 1989-12-21 | 1997-12-22 | 人体化抗体 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3501864A Pending JPH04505398A (ja) | 1989-12-21 | 1990-12-21 | 人体化抗体 |
JP50210791A Expired - Lifetime JP3452062B2 (ja) | 1989-12-21 | 1990-12-21 | Cdr―移植された抗体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9353861A Pending JPH11243955A (ja) | 1989-12-21 | 1997-12-22 | 人体化抗体 |
Country Status (21)
Country | Link |
---|---|
US (10) | US5929212A (ja) |
EP (5) | EP0626390B1 (ja) |
JP (4) | JPH04505398A (ja) |
KR (3) | KR100197956B1 (ja) |
AT (4) | ATE129017T1 (ja) |
AU (4) | AU631481B2 (ja) |
BG (1) | BG60462B1 (ja) |
BR (1) | BR9007197A (ja) |
CA (3) | CA2050479C (ja) |
DE (4) | DE69020544T2 (ja) |
DK (4) | DK0460171T3 (ja) |
ES (4) | ES2074701T3 (ja) |
FI (4) | FI108776B (ja) |
GB (4) | GB8928874D0 (ja) |
GR (2) | GR3017734T3 (ja) |
HU (4) | HU215383B (ja) |
NO (5) | NO316076B1 (ja) |
RO (3) | RO114232B1 (ja) |
RU (1) | RU2112037C1 (ja) |
WO (3) | WO1991009966A1 (ja) |
ZA (1) | ZA9110129B (ja) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002521022A (ja) * | 1998-07-21 | 2002-07-16 | ビーティージー・インターナショナル・リミテッド | CD3に対するヒト/げっ歯動物ハイブリドIgG抗体、およびその構築の方法 |
WO2006121159A1 (ja) * | 2005-05-12 | 2006-11-16 | Kyowa Hakko Kogyo Co., Ltd. | Cd10に特異的に反応するヒト型cdr移植抗体およびその抗体断片 |
WO2007037430A1 (ja) | 2005-09-29 | 2007-04-05 | Eisai R & D Management Co., Ltd. | T細胞接着分子およびそれに対する抗体 |
WO2008059959A1 (fr) | 2006-11-17 | 2008-05-22 | The Research Foundation For Microbial Diseases Of Osaka University | Agent promoteur de l'étirement des nerfs et agent inhibiteur de l'étirement des nerfs |
WO2010016590A1 (ja) | 2008-08-07 | 2010-02-11 | 国立大学法人 長崎大学 | 全身性疼痛症候群の治療または予防薬 |
WO2010110346A1 (ja) | 2009-03-24 | 2010-09-30 | 独立行政法人理化学研究所 | 白血病幹細胞マーカー |
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WO2021145435A1 (ja) | 2020-01-15 | 2021-07-22 | 国立大学法人大阪大学 | 認知症の予防又は治療剤 |
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1991
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1993
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1994
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1995
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1997
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1998
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1999
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2003
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2004
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2005
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JP2002521022A (ja) * | 1998-07-21 | 2002-07-16 | ビーティージー・インターナショナル・リミテッド | CD3に対するヒト/げっ歯動物ハイブリドIgG抗体、およびその構築の方法 |
WO2006121159A1 (ja) * | 2005-05-12 | 2006-11-16 | Kyowa Hakko Kogyo Co., Ltd. | Cd10に特異的に反応するヒト型cdr移植抗体およびその抗体断片 |
WO2007037430A1 (ja) | 2005-09-29 | 2007-04-05 | Eisai R & D Management Co., Ltd. | T細胞接着分子およびそれに対する抗体 |
WO2008059959A1 (fr) | 2006-11-17 | 2008-05-22 | The Research Foundation For Microbial Diseases Of Osaka University | Agent promoteur de l'étirement des nerfs et agent inhibiteur de l'étirement des nerfs |
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