UA96141C2 - Нейтрализующее антитело, которое имеет специфичность к человеческому il-6 - Google Patents

Нейтрализующее антитело, которое имеет специфичность к человеческому il-6

Info

Publication number
UA96141C2
UA96141C2 UAA200808897A UAA200808897A UA96141C2 UA 96141 C2 UA96141 C2 UA 96141C2 UA A200808897 A UAA200808897 A UA A200808897A UA A200808897 A UAA200808897 A UA A200808897A UA 96141 C2 UA96141 C2 UA 96141C2
Authority
UA
Ukraine
Prior art keywords
specificity
human
antibody
neutralising antibody
relates
Prior art date
Application number
UAA200808897A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ричард Эван Желинас
Митра Чудхури Сингхал
Йи Жанг
Эндрю Джордж Попплвэлл
Ральф Адамс
Original Assignee
Юсиби Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37714544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96141(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юсиби Фарма, С.А. filed Critical Юсиби Фарма, С.А.
Publication of UA96141C2 publication Critical patent/UA96141C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Изобретение относится к гуманизированному нейтрализующему антителу, которое специфически связывается с человеческим IL-6, последовательности ДНК, которая его кодирует, вектору, клетке-хозяину, процессу изготовления антитела. Изобретение также относится к фармацевтической композиции, содержащей данное антитело, для применения в лечении или профилактике патологического расстройства, опосредованного IL-6 или связанного с ростом уровня IL-6.
UAA200808897A 2005-12-09 2006-12-04 Нейтрализующее антитело, которое имеет специфичность к человеческому il-6 UA96141C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74892605P 2005-12-09 2005-12-09

Publications (1)

Publication Number Publication Date
UA96141C2 true UA96141C2 (ru) 2011-10-10

Family

ID=37714544

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200808897A UA96141C2 (ru) 2005-12-09 2006-12-04 Нейтрализующее антитело, которое имеет специфичность к человеческому il-6

Country Status (28)

Country Link
US (5) US8075889B2 (ru)
EP (3) EP1960430B1 (ru)
JP (1) JP5183484B2 (ru)
KR (2) KR101422523B1 (ru)
CN (1) CN101356194B (ru)
AR (1) AR057224A1 (ru)
AU (1) AU2006323490B2 (ru)
BR (1) BRPI0619595B8 (ru)
CA (1) CA2632628C (ru)
DK (1) DK1960430T3 (ru)
EA (1) EA018044B1 (ru)
EC (1) ECSP088613A (ru)
ES (1) ES2525325T3 (ru)
HK (1) HK1125113A1 (ru)
HR (1) HRP20141214T1 (ru)
IL (2) IL191600A (ru)
MY (1) MY147217A (ru)
NO (1) NO344847B1 (ru)
NZ (1) NZ569234A (ru)
PE (1) PE20070998A1 (ru)
PL (1) PL1960430T3 (ru)
PT (1) PT1960430E (ru)
RS (1) RS53708B1 (ru)
SI (1) SI1960430T1 (ru)
TW (1) TWI390035B (ru)
UA (1) UA96141C2 (ru)
WO (1) WO2007066082A1 (ru)
ZA (1) ZA200804594B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
UA96141C2 (ru) * 2005-12-09 2011-10-10 Юсиби Фарма, С.А. Нейтрализующее антитело, которое имеет специфичность к человеческому il-6
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US8679485B2 (en) 2007-08-02 2014-03-25 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
CN102089326B (zh) 2008-05-13 2014-12-31 诺维莫尼公司 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法
JP5789192B2 (ja) * 2008-11-13 2015-10-07 フェムタ ファーマシューティカルズ インコーポレイテッドＦｅｍｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒト化抗ｉｌ−６抗体
NZ602166A (en) 2008-11-25 2014-02-28 Alder Biopharmaceuticals Inc Antibodies to il-6 and use thereof
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
CN102712683B (zh) 2009-08-21 2014-09-10 吉联亚生物科技有限公司 赖氨酰氧化酶和loxl2的催化结构域
KR20120089274A (ko) * 2009-08-21 2012-08-09 길리아드 바이오로직스, 인크. 생체내 스크리닝 검정
SG183174A1 (en) * 2010-02-04 2012-09-27 Gilead Biologics Inc Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
US8992908B2 (en) 2010-11-23 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of oral mucositis
US8465413B2 (en) 2010-11-25 2013-06-18 Coloplast A/S Method of treating Peyronie's disease
US9289467B2 (en) * 2011-08-10 2016-03-22 Case Western Reserve University Compositions and methods for treating bone conditions
US20130149351A1 (en) * 2011-12-09 2013-06-13 University Of Southern California Polymer scaffolds and their use in the treatment of vision loss
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
JP6469012B2 (ja) 2012-10-22 2019-02-13 ファウンテン バイオファーマ インコーポレーテッドＦｏｕｎｔａｉｎ Ｂｉｏｐｈａｒｍａ Ｉｎｃ． インターロイキン−６に対する抗体およびその使用
BR112015008186A2 (pt) * 2012-10-25 2017-09-19 Medimmune Llc formulação de um anticorpo estável e de baixa viscosidade
JP7311113B2 (ja) * 2016-05-05 2023-07-19 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｉｌ－６及びｃｄ１２６を標的とするｄｎａモノクローナル抗体
CN106413047A (zh) * 2016-10-31 2017-02-15 北京小米移动软件有限公司 智能设备接入无线网络的方法和装置
WO2018144773A1 (en) 2017-02-01 2018-08-09 Yale University Treatment of diuretic resistance
JP6950242B2 (ja) * 2017-03-31 2021-10-13 ブラザー工業株式会社 通信装置
US20190241650A1 (en) 2018-01-05 2019-08-08 Corvidia Therapeutics, Inc. Methods for treating il-6 mediated inflammation without immunosuppression
CN116178544A (zh) 2018-09-28 2023-05-30 礼进生物医药科技（上海）有限公司 具有经过工程化的Fc结构域的抗CD40结合分子及其治疗用途
JP2022553108A (ja) * 2019-10-23 2022-12-21 リビジェン バイオファーマ ホールディングス リミテッド 抗ｃｄ４０結合分子およびそのようなものを含む二重特異性抗体

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
CA1341588C (en) * 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
IL88375A (en) * 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL91501A (en) 1988-09-02 1998-03-10 Dyax Corp Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JP3614183B2 (ja) * 1993-05-31 2005-01-26 中外製薬株式会社 ヒトインターロイキン−６に対する再構成ヒト抗体
TW458985B (en) * 1993-05-31 2001-10-11 Chugai Pharmaceutical Co Ltd Reconstructed human antibody against human interleukin-6
FR2707882B1 (fr) * 1993-07-23 1997-08-01 Immunotech Sa Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant.
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
ATE300610T1 (de) 1994-01-31 2005-08-15 Univ Boston Bibliotheken aus polyklonalen antikörpern
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
EP2322216A1 (en) * 1997-03-21 2011-05-18 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
EP2308888B1 (en) * 2001-11-14 2017-03-01 Janssen Biotech, Inc. Anti-IL-6 antibodies, compositions, methods and uses
US7482436B2 (en) * 2002-08-30 2009-01-27 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Human antihuman interleukin-6 antibody and fragment of antibody
ES2374068T3 (es) 2002-12-03 2012-02-13 Ucb Pharma, S.A. Ensayo para identificar células productoras de anticuerpos.
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
ES2551439T5 (es) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
UA96141C2 (ru) 2005-12-09 2011-10-10 Юсиби Фарма, С.А. Нейтрализующее антитело, которое имеет специфичность к человеческому il-6

Also Published As

Publication number Publication date
ZA200804594B (en) 2010-08-25
CA2632628C (en) 2016-01-19
SI1960430T1 (sl) 2015-01-30
HRP20141214T1 (hr) 2015-02-13
IL242434B (en) 2018-04-30
JP5183484B2 (ja) 2013-04-17
TW200728466A (en) 2007-08-01
US20070154481A1 (en) 2007-07-05
EP2336181A1 (en) 2011-06-22
RS53708B1 (en) 2015-04-30
ES2525325T3 (es) 2014-12-22
US20170182159A1 (en) 2017-06-29
PE20070998A1 (es) 2007-10-09
US8486662B2 (en) 2013-07-16
EP1960430A1 (en) 2008-08-27
EP1960430B1 (en) 2014-09-24
US9631015B2 (en) 2017-04-25
CN101356194B (zh) 2013-06-12
CN101356194A (zh) 2009-01-28
CA2632628A1 (en) 2007-06-14
PT1960430E (pt) 2015-01-05
NO20083066L (no) 2008-09-08
AR057224A1 (es) 2007-11-21
KR101422523B1 (ko) 2014-07-24
EP2314626A1 (en) 2011-04-27
TWI390035B (zh) 2013-03-21
JP2009518023A (ja) 2009-05-07
AU2006323490B2 (en) 2012-05-24
KR20080077271A (ko) 2008-08-21
PL1960430T3 (pl) 2015-03-31
US9096668B2 (en) 2015-08-04
US20120183996A1 (en) 2012-07-19
NZ569234A (en) 2011-07-29
NO344847B1 (no) 2020-05-25
IL191600A (en) 2015-11-30
KR101413451B1 (ko) 2014-07-10
ECSP088613A (es) 2008-08-29
US20160039929A1 (en) 2016-02-11
DK1960430T3 (da) 2015-01-05
WO2007066082A1 (en) 2007-06-14
BRPI0619595A8 (pt) 2019-01-15
EA200801427A1 (ru) 2008-12-30
US8075889B2 (en) 2011-12-13
KR20130100386A (ko) 2013-09-10
HK1125113A1 (en) 2009-07-31
AU2006323490A1 (en) 2007-06-14
BRPI0619595B1 (pt) 2020-09-15
BRPI0619595B8 (pt) 2022-12-13
IL191600A0 (en) 2008-12-29
EA018044B1 (ru) 2013-05-30
BRPI0619595A2 (pt) 2011-10-04
US20140024077A1 (en) 2014-01-23
MY147217A (en) 2012-11-14

Similar Documents

Publication Publication Date Title
UA96141C2 (ru) Нейтрализующее антитело, которое имеет специфичность к человеческому il-6
MX2014001916A (es) Moleculas biespecificas de union a antigeno.
MX2009012950A (es) ANTICUERPOS HUMANIZADOS CONTRA EL GLOBULOMERO Aß (20-42) Y SUS USOS.
CA2813849C (en) Secukinumab for use in the treatment of ankylosing spondylitis
MX2009006471A (es) Anticuerpo anti especifico de linfopoyetina estromal timica de diseño.
UA90048C2 (ru) Кондиционированная композиция и способ ее получения
WO2010017103A3 (en) Fully human anti-human nkg2d monoclonal antibodies
EA201492149A8 (ru) St2-антигенсвязывающие белки
MX2009003973A (es) Moleculas de anticuerpo que unen il-17 e il-17f.
MX2012004084A (es) Anticuerpos siglec-15 para tratar enfermedad relacionada con perdida osea.
TW200730624A (en) Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38
MX2014006158A (es) Metodos para el tratamiento de artritis psoriasica (psa) utilizando antagonistas de il-17 y alelos con respuesta o sin respuesta a la psa.
PH12013502205A1 (en) Antibodies to il-6 and their uses
JO3097B1 (ar) الأجسام المضادة c-Met
MY157173A (en) Modified humanised anti-interleukin-18
WO2006125640A3 (en) Generation and profiling of fully human hucal gold®-derived therapeutic antibodies specific for human cd38
TN2011000528A1 (en) Compositions and methods for antibodies targeting complement protein c3b
EA200700175A1 (ru) Композиции и способы лечения воспалительных заболеваний
MX2010000537A (es) Anticuerpos monoclonales contra glipicano-3.
MX2010010387A (es) Anticuerpos especificos para el complejo de bcr y metodos para el uso de los mismos.
MX2010009190A (es) Anticuerpos anti-c5ar humanizados.
MX361929B (es) Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes.
WO2007025977A8 (en) Anti-tnf alpha producing lactic acid bacteria for the treatment of chronic enterocolitis
MX2009013410A (es) Biomarcadores para predecir capacidad de respuesta anti-tnf o sin capacidad de respuesta.
MX2011012039A (es) Anticuerpos bloqueadores anti-dkk-1 y sus usos.