NO20083066L - Antistoffmolekyler med spesifisitet for human-IL-6 - Google Patents

Antistoffmolekyler med spesifisitet for human-IL-6

Info

Publication number
NO20083066L
NO20083066L NO20083066A NO20083066A NO20083066L NO 20083066 L NO20083066 L NO 20083066L NO 20083066 A NO20083066 A NO 20083066A NO 20083066 A NO20083066 A NO 20083066A NO 20083066 L NO20083066 L NO 20083066L
Authority
NO
Norway
Prior art keywords
antibody molecules
specificity
human
preparing
methods
Prior art date
Application number
NO20083066A
Other languages
English (en)
Other versions
NO344847B1 (no
Inventor
Richard Evan Gelinas
Mitra Choudhury Singhal
Yi Zhang
Andrew George Popplewell
Ralph Adams
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37714544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083066(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of NO20083066L publication Critical patent/NO20083066L/no
Publication of NO344847B1 publication Critical patent/NO344847B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Sammendrag Oppfinnelsen vedrører antistoffmolekyler med spesifisitet for antigene determinanter av IL-6, terapeutiske anvendelser av antistoffmolekylene og fremgangsmåter for å fremstille nevnte antistoffmolekyler.
NO20083066A 2005-12-09 2008-07-08 Antistoffmolekyler med spesifisitet for human-IL-6 NO344847B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74892605P 2005-12-09 2005-12-09
PCT/GB2006/004518 WO2007066082A1 (en) 2005-12-09 2006-12-04 Antibody molecules having specificity for human il-6

Publications (2)

Publication Number Publication Date
NO20083066L true NO20083066L (no) 2008-09-08
NO344847B1 NO344847B1 (no) 2020-05-25

Family

ID=37714544

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083066A NO344847B1 (no) 2005-12-09 2008-07-08 Antistoffmolekyler med spesifisitet for human-IL-6

Country Status (28)

Country Link
US (5) US8075889B2 (no)
EP (3) EP2336181A1 (no)
JP (1) JP5183484B2 (no)
KR (2) KR101422523B1 (no)
CN (1) CN101356194B (no)
AR (1) AR057224A1 (no)
AU (1) AU2006323490B2 (no)
BR (1) BRPI0619595B8 (no)
CA (1) CA2632628C (no)
DK (1) DK1960430T3 (no)
EA (1) EA018044B1 (no)
EC (1) ECSP088613A (no)
ES (1) ES2525325T3 (no)
HK (1) HK1125113A1 (no)
HR (1) HRP20141214T1 (no)
IL (2) IL191600A (no)
MY (1) MY147217A (no)
NO (1) NO344847B1 (no)
NZ (1) NZ569234A (no)
PE (1) PE20070998A1 (no)
PL (1) PL1960430T3 (no)
PT (1) PT1960430E (no)
RS (1) RS53708B1 (no)
SI (1) SI1960430T1 (no)
TW (1) TWI390035B (no)
UA (1) UA96141C2 (no)
WO (1) WO2007066082A1 (no)
ZA (1) ZA200804594B (no)

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Also Published As

Publication number Publication date
US20120183996A1 (en) 2012-07-19
US9631015B2 (en) 2017-04-25
PL1960430T3 (pl) 2015-03-31
KR101422523B1 (ko) 2014-07-24
EP2336181A1 (en) 2011-06-22
RS53708B1 (en) 2015-04-30
BRPI0619595B8 (pt) 2022-12-13
JP5183484B2 (ja) 2013-04-17
SI1960430T1 (sl) 2015-01-30
EA200801427A1 (ru) 2008-12-30
HK1125113A1 (en) 2009-07-31
NZ569234A (en) 2011-07-29
US8075889B2 (en) 2011-12-13
AU2006323490A1 (en) 2007-06-14
NO344847B1 (no) 2020-05-25
AR057224A1 (es) 2007-11-21
WO2007066082A1 (en) 2007-06-14
CN101356194A (zh) 2009-01-28
ZA200804594B (en) 2010-08-25
BRPI0619595A2 (pt) 2011-10-04
EP2314626A1 (en) 2011-04-27
US20070154481A1 (en) 2007-07-05
TWI390035B (zh) 2013-03-21
ES2525325T3 (es) 2014-12-22
CA2632628C (en) 2016-01-19
IL191600A0 (en) 2008-12-29
KR101413451B1 (ko) 2014-07-10
CA2632628A1 (en) 2007-06-14
AU2006323490B2 (en) 2012-05-24
EA018044B1 (ru) 2013-05-30
BRPI0619595A8 (pt) 2019-01-15
US20140024077A1 (en) 2014-01-23
UA96141C2 (ru) 2011-10-10
PE20070998A1 (es) 2007-10-09
BRPI0619595B1 (pt) 2020-09-15
KR20080077271A (ko) 2008-08-21
EP1960430B1 (en) 2014-09-24
US20160039929A1 (en) 2016-02-11
MY147217A (en) 2012-11-14
EP1960430A1 (en) 2008-08-27
PT1960430E (pt) 2015-01-05
US20170182159A1 (en) 2017-06-29
US8486662B2 (en) 2013-07-16
IL242434B (en) 2018-04-30
IL191600A (en) 2015-11-30
CN101356194B (zh) 2013-06-12
ECSP088613A (es) 2008-08-29
KR20130100386A (ko) 2013-09-10
TW200728466A (en) 2007-08-01
US9096668B2 (en) 2015-08-04
JP2009518023A (ja) 2009-05-07
DK1960430T3 (da) 2015-01-05
HRP20141214T1 (hr) 2015-02-13

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