ATE129017T1 - Humanisierte antikörper. - Google Patents

Humanisierte antikörper.

Info

Publication number
ATE129017T1
ATE129017T1 AT91901433T AT91901433T ATE129017T1 AT E129017 T1 ATE129017 T1 AT E129017T1 AT 91901433 T AT91901433 T AT 91901433T AT 91901433 T AT91901433 T AT 91901433T AT E129017 T1 ATE129017 T1 AT E129017T1
Authority
AT
Austria
Prior art keywords
antibody
pref
derived
chain
cdr
Prior art date
Application number
AT91901433T
Other languages
English (en)
Inventor
John Robert Adair
Diljeet Singh Athwal
John Spencer Emtage
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10668300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE129017(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ATE129017T1 publication Critical patent/ATE129017T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT91901433T 1989-12-21 1990-12-21 Humanisierte antikörper. ATE129017T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928874A GB8928874D0 (en) 1989-12-21 1989-12-21 Humanised antibodies

Publications (1)

Publication Number Publication Date
ATE129017T1 true ATE129017T1 (de) 1995-10-15

Family

ID=10668300

Family Applications (4)

Application Number Title Priority Date Filing Date
AT94202090T ATE208794T1 (de) 1989-12-21 1990-12-21 Humanisierte antikörper
AT91901835T ATE159299T1 (de) 1989-12-21 1990-12-21 Cd4-spezifischer rekombinanter antikörper
AT91901559T ATE124459T1 (de) 1989-12-21 1990-12-21 Cd3-spezifischer rekombinanter antikörper.
AT91901433T ATE129017T1 (de) 1989-12-21 1990-12-21 Humanisierte antikörper.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT94202090T ATE208794T1 (de) 1989-12-21 1990-12-21 Humanisierte antikörper
AT91901835T ATE159299T1 (de) 1989-12-21 1990-12-21 Cd4-spezifischer rekombinanter antikörper
AT91901559T ATE124459T1 (de) 1989-12-21 1990-12-21 Cd3-spezifischer rekombinanter antikörper.

Country Status (21)

Country Link
US (11) US5929212A (de)
EP (5) EP0626390B1 (de)
JP (4) JP3242913B2 (de)
KR (3) KR100191152B1 (de)
AT (4) ATE208794T1 (de)
AU (4) AU649645B2 (de)
BG (1) BG60462B1 (de)
BR (1) BR9007197A (de)
CA (3) CA2050479C (de)
DE (4) DE69033857T2 (de)
DK (4) DK0460178T3 (de)
ES (4) ES2165864T3 (de)
FI (4) FI108776B (de)
GB (4) GB8928874D0 (de)
GR (2) GR3017734T3 (de)
HU (4) HU215383B (de)
NO (5) NO913229L (de)
RO (3) RO114298B1 (de)
RU (1) RU2112037C1 (de)
WO (3) WO1991009966A1 (de)
ZA (1) ZA9110129B (de)

Families Citing this family (1402)

* Cited by examiner, † Cited by third party
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US7244615B2 (en) 2007-07-17
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ATE124459T1 (de) 1995-07-15
ZA9110129B (en) 1993-06-23
EP0626390B1 (de) 2001-11-14
KR100197956B1 (ko) 1999-06-15
US7244832B2 (en) 2007-07-17
US20050136054A1 (en) 2005-06-23
GB2246570B (en) 1994-05-11
WO1991009968A1 (en) 1991-07-11
AU631481B2 (en) 1992-11-26
GR3025781T3 (en) 1998-03-31
USRE50178E1 (en) 2024-10-22
EP0460167B1 (de) 1995-10-11
EP0460178B1 (de) 1997-10-15
GB9318911D0 (en) 1993-10-27
BG95018A (bg) 1993-12-24
WO1991009967A1 (en) 1991-07-11
HU912751D0 (en) 1992-01-28
GB2246781B (en) 1994-05-11
FI108917B (fi) 2002-04-30
DE69020544T2 (de) 1996-01-18
AU6461294A (en) 1994-12-22
US20060029593A1 (en) 2006-02-09
JPH04506458A (ja) 1992-11-12
HU912752D0 (en) 1992-01-28
ES2165864T3 (es) 2002-04-01
DK0460178T3 (da) 1997-12-22
US20040076627A1 (en) 2004-04-22
CA2050479A1 (en) 1991-06-22
KR100198478B1 (en) 1999-06-15
EP0460171B1 (de) 1995-06-28
DK0460167T3 (da) 1995-11-20
JPH04505398A (ja) 1992-09-24
NO985468L (no) 1991-10-21
CA2046904A1 (en) 1991-06-22
FI913927A0 (fi) 1991-08-20
CA2037607C (en) 2005-05-24
ES2112270T3 (es) 1998-04-01
BR9007197A (pt) 1992-01-28
JPH11243955A (ja) 1999-09-14
EP0620276A1 (de) 1994-10-19
DE69020544D1 (de) 1995-08-03
HU215383B (hu) 2000-03-28
DE69022982T2 (de) 1996-03-28
AU664801B2 (en) 1995-11-30
FI108777B (fi) 2002-03-28
RO114298B1 (ro) 1999-03-30
FI913932A0 (fi) 1991-08-20
AU7048691A (en) 1991-07-24
GR3017734T3 (en) 1996-01-31
RO114980B1 (ro) 1999-09-30
DE69033857D1 (de) 2001-12-20
DK0626390T3 (da) 2002-03-11
HUT58824A (en) 1992-03-30
AU6974091A (en) 1991-07-24
FI913926A0 (fi) 1991-08-20
GB9117612D0 (en) 1991-11-20
NO310560B1 (no) 2001-07-23
WO1991009966A1 (en) 1991-07-11
US20050123534A1 (en) 2005-06-09
JP3242913B2 (ja) 2001-12-25
FI990875L (fi) 1999-04-19
EP0460171A1 (de) 1991-12-11
FI108776B (fi) 2002-03-28
US20040202662A1 (en) 2004-10-14
EP0626390A1 (de) 1994-11-30
CA2046904C (en) 2003-12-02
NO913229D0 (no) 1991-08-19
NO913229L (no) 1991-10-21
NO913271L (no) 1991-08-20
KR100191152B1 (ko) 1999-06-15
RO114232B1 (ro) 1999-02-26
HUT58372A (en) 1992-02-28
NO985467L (no) 1991-10-21
US7241877B2 (en) 2007-07-10
NO985468D0 (no) 1998-11-23
CA2037607A1 (en) 1992-09-07
GB8928874D0 (en) 1990-02-28
US20060073137A1 (en) 2006-04-06
GB2268744B (en) 1994-05-11
AU646009B2 (en) 1994-02-03
DE69022982D1 (de) 1995-11-16
KR920701465A (ko) 1992-08-11
NO316074B1 (no) 2003-12-08
EP0460178A1 (de) 1991-12-11
FI990875A0 (fi) 1999-04-19
AU7033091A (en) 1991-07-24
GB2246570A (en) 1992-02-05
US7262050B2 (en) 2007-08-28
DK0460171T3 (da) 1995-08-28
HUT60786A (en) 1992-10-28
NO316076B1 (no) 2003-12-08
EP0460167A1 (de) 1991-12-11
GB2246781A (en) 1992-02-12
US20050202529A1 (en) 2005-09-15
GB9117611D0 (en) 1991-10-02
BG60462B1 (bg) 1995-04-28
NO913228L (no) 1991-10-21
CA2050479C (en) 1997-03-25
RU2112037C1 (ru) 1998-05-27
NO913228D0 (no) 1991-08-19

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