MX389057B - Sistemas de receptor de antigeno quimerico impulsado por mab para clasificar/reducir celulas inmunes diseñadas. - Google Patents
Sistemas de receptor de antigeno quimerico impulsado por mab para clasificar/reducir celulas inmunes diseñadas.Info
- Publication number
- MX389057B MX389057B MX2017009182A MX2017009182A MX389057B MX 389057 B MX389057 B MX 389057B MX 2017009182 A MX2017009182 A MX 2017009182A MX 2017009182 A MX2017009182 A MX 2017009182A MX 389057 B MX389057 B MX 389057B
- Authority
- MX
- Mexico
- Prior art keywords
- mab
- chimerals
- sorting
- antigen receptor
- driven
- Prior art date
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Abstract
Un polipéptido que codifica un receptor de antígeno quimérico (CAR) que comprende al menos un dominio de unión extracelular que comprende un scFv formado por al menos una cadena de VH y una cadena de VL específicas a un antígeno, en donde el dominio de unión extracelular comprende al menos un epítopo específico de mAb.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201570044 | 2015-01-26 | ||
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| JP2017513818A (ja) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | キメラ抗原受容体を使用する癌の処置 |
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| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
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| ES2688035T3 (es) * | 2014-08-29 | 2018-10-30 | Gemoab Monoclonals Gmbh | Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes |
| CN114085856A (zh) | 2014-12-05 | 2022-02-25 | 希望之城公司 | Cs1靶向性嵌合抗原受体修饰的t细胞 |
| JP6921001B2 (ja) | 2015-04-13 | 2021-08-18 | ファイザー・インク | B細胞成熟抗原を標的にするキメラ抗原受容体 |
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