BR112017013981A2 - receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer - Google Patents

receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer

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Publication number
BR112017013981A2
BR112017013981A2 BR112017013981-2A BR112017013981A BR112017013981A2 BR 112017013981 A2 BR112017013981 A2 BR 112017013981A2 BR 112017013981 A BR112017013981 A BR 112017013981A BR 112017013981 A2 BR112017013981 A2 BR 112017013981A2
Authority
BR
Brazil
Prior art keywords
sccars
cll1
cancer immunotherapy
antigen receptors
chain antigen
Prior art date
Application number
BR112017013981-2A
Other languages
English (en)
Inventor
Smith Julianne
Valton Julien
Duchateau Philippe
Juillerat Alexandre
Rajpal Arvind
Johnson Sasu Barbra
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of BR112017013981A2 publication Critical patent/BR112017013981A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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Abstract

a presente invenção refere-se a receptores antigênicos quiméricos (cars), os quais são proteínas quiméricas recombinantes capazes de redirecionar a especificidade e a reatividade de célula imune em relação a células positivas para cll1. as células imunes modificadas dotadas de tais cars são particularmente adequadas para imunoterapia em tratamento de câncer, particularmente leucemia.
BR112017013981-2A 2015-01-26 2016-01-25 receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer BR112017013981A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570044 2015-01-26
DKPA201570044 2015-01-26
PCT/EP2016/051469 WO2016120218A1 (en) 2015-01-26 2016-01-25 ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (scCARS) FOR CANCER IMMUNOTHERAPY

Publications (1)

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BR112017013981A2 true BR112017013981A2 (pt) 2018-01-02

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