ME02485B - Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću - Google Patents

Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću

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Publication number
ME02485B
ME02485B MEP-2016-156A MEP15616A ME02485B ME 02485 B ME02485 B ME 02485B ME P15616 A MEP15616 A ME P15616A ME 02485 B ME02485 B ME 02485B
Authority
ME
Montenegro
Prior art keywords
cdr
seq
chain antibody
bispecific single
antibody molecule
Prior art date
Application number
MEP-2016-156A
Other languages
English (en)
French (fr)
Inventor
Doris Rau
Evelyne Schaller
Susanne Hausmann
Petra Fluhr
Carola Steiger
Peter Kufer
Tobias Raum
Roman Kischel
Ralf LUTTERBÜSE
Patrick Hoffmann
Susanne Mangold
Matthias Klinger
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of ME02485B publication Critical patent/ME02485B/me

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (18)

1. Molekula bispecifičnog jednolančanog protutijela, naznačena time što sadrži prvu vežuću domenu koja se specifično veže na epitop u lancu CD3ε kod čovjeka i Callithrix jacchus, Saguinus oedipus ili Saimiri sciureus, gdje je navedeni epitop dio aminokiselinskogi slijeda iz skupine koju čine SEQ ID NO. 2, 4, 6 ili 8, i u najmanju ruku sadrži aminokiselinski slijed Gln-Asp-Gly-Asn-Glu, te drugu vežuću domenu koja se veže na membranski antigen specifičan za prostatu (PSMA).
2. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što prva vežuća domena sadrži područje VL, koje sadrži CDR-L1, CDR-L2 i CDR-L3, koje se bira između: (a) CDR-L1, kao što je opisan u SEQ ID NO. 27, CDR-L2, kao što je opisan u SEQ ID NO. 28 i CDR-L3, kao što je opisan u SEQ ID NO. 29; (b) CDR-L1, kao što je opisan u SEQ ID NO. 117, CDR-L2, kao što je opisan u SEQ ID NO. 118 i CDR-L3, kao što je opisan u SEQ ID NO. 119; i (c) CDR-L1, kao što je opisan u SEQ ID NO. 153, CDR-L2, kao što je opisan u SEQ ID NO. 154 i CDR-L3, kao što je opisan u SEQ ID NO. 155.
3. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1 ili 2, naznačena time što prva vežuća domena sadrži područje VH, koje sadrži CDR-H1, CDR-H2 i CDR-H3, koje se bira između: (a) CDR-H1, kao što je opisan u SEQ ID NO. 12, CDR-H2, kao što je opisan u SEQ ID NO. 13 i CDR-H3, kao što je opisan u SEQ ID NO. 14; (b) CDR-H1, kao što je opisan u SEQ ID NO. 30, CDR-H2, kao što je opisan u SEQ ID NO. 31 i CDR-H3, kao što je opisan u SEQ ID NO. 32; (c) CDR-H1, kao što je opisan u SEQ ID NO. 48, CDR-H2, kao što je opisan u SEQ ID NO. 49 i CDR-H3, kao što je opisan u SEQ ID NO. 50; (d) CDR-H1, kao što je opisan u SEQ ID NO. 66, CDR-H2, kao što je opisan u SEQ ID NO. 67 i CDR-H3, kao što je opisan u SEQ ID NO. 68; (e) CDR-H1, kao što je opisan u SEQ ID NO. 84, CDR-H2, kao što je opisan u SEQ ID NO. 85 i CDR-H3, kao što je opisan u SEQ ID NO. 86; (f) CDR-H1, kao što je opisan u SEQ ID NO. 102, CDR-H2, kao što je opisan u SEQ ID NO. 103 i CDR-H3, kao što je opisan u SEQ ID NO. 104; (g) CDR-H1, kao što je opisan u SEQ ID NO. 120, CDR-H2 kao što je opisan u SEQ ID NO. 121 i CDR-H3kao što je opisan u SEQ ID NO. 122; (h) CDR-H1, kao što je opisan u SEQ ID NO. 138, CDR-H2, kao što je opisan u SEQ ID NO. 139 i CDR-H3, kao što je opisan u SEQ ID NO. 140; (i) CDR-H1, kao što je opisan u SEQ ID NO. 156, CDR-H2, kao što je opisan u SEQ ID NO. 157 i CDR-H3, kao što je opisan u SEQ ID NO. 158; i (j) CDR-H1, kao što je opisan u SEQ ID NO. 174, CDR-H2, kao što je opisan u SEQ ID NO. 175 i CDR-H3, kao što je opisan u SEQ ID NO. 176.
4. Molekula bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačena time što se druga vežuća domena može vezati na ljudski PSMA i/ili na neljudski primatski PSMA.
5. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 4, naznačena time što molekula bispecifičnog jednolančanog protutijela uključuje skupinu sljedećih sljedova poput CDR H1, CDR H2, CDR H3, CDR L1, CDR L2 i CDR L3 u drugoj vežućoj domeni koju se bira između: a) CDR H1-3 sa SEQ ID NO: 394-396 i CDR L1-3 sa SEQ ID NO: 389-391; b) CDR H1-3 sa SEQ ID NO: 408-410 i CDR L1-3 sa SEQ ID NO: 403-405; c) CDR H1-3 sa SEQ ID NO: 422-424 i CDR L1-3 sa SEQ ID NO: 417-419; d) CDR H1-3 sa SEQ ID NO: 436-438 i CDR L1-3 sa SEQ ID NO: 431-433; e) CDR H1-3 sa SEQ ID NO: 445-447 i CDR L1-3 sa SEQ ID NO: 450-452; f) CDR H1-3 sa SEQ ID NO: 464-466 i CDR L1-3 sa SEQ ID NO: 459-461; g) CDR H1-3 sa SEQ ID NO: 478-480 i CDR L1-3 sa SEQ ID NO: 473-475; h) CDR H1-3 sa SEQ ID NO: 492-494 i CDR L1-3 sa SEQ ID NO: 487-489; i) CDR H1-3 sa SEQ ID NO: 506-508 i CDR L1-3 sa SEQ ID NO: 501-503; j) CDR H1-3 sa SEQ ID NO: 520-522 i CDR L1-3 sa SEQ ID NO: 515-517; k) CDR H1-3 sa SEQ ID NO: 534-536 i CDR L1-3 sa SEQ ID NO: 529-531; l) CDR H1-3 sa SEQ ID NO: 548-550 i CDR L1-3 sa SEQ ID NO: 543-545; m) CDR H1-3 sa SEQ ID NO: 562-564 i CDR L1-3 sa SEQ ID NO: 557-559; n) CDR H1-3 sa SEQ ID NO: 576-578 i CDR L1-3 sa SEQ ID NO: 571-573; o) CDR H1-3 sa SEQ ID NO: 590-592 i CDR L1-3 sa SEQ ID NO: 585-587; p) CDR H1-3 sa SEQ ID NO: 604-606 i CDR L1-3 sa SEQ ID NO: 599-601; q) CDR H1-3 sa SEQ ID NO: 618-620 i CDR L1-3 sa SEQ ID NO: 613-615; r) CDR H1-3 sa SEQ ID NO: 632-634 i CDR L1-3 sa SEQ ID NO: 627-629; s) CDR H1-3 sa SEQ ID NO: 646-648 i CDR L1-3 sa SEQ ID NO: 641-643; t) CDR H1-3 sa SEQ ID NO: 660-662 i CDR L1-3 sa SEQ ID NO: 655-657; u) CDR H1-3 sa SEQ ID NO: 674-676 i CDR L1-3 sa SEQ ID NO: 669-671; v) CDR H1-3 sa SEQ ID NO: 688-690 i CDR L1-3 sa SEQ ID NO: 683-685; w) CDR H1-3 sa SEQ ID NO: 702-704 i CDR L1-3 sa SEQ ID NO: 697-699; x) CDR H1-3 sa SEQ ID NO: 716-718 i CDR L1-3 sa SEQ ID NO: 711-713; y) CDR H1-3 sa SEQ ID NO: 729-731 i CDR L1-3 sa SEQ ID NO: 724-726; z) CDR H1-3 sa SEQ ID NO: 788-790 i CDR L1-3 sa SEQ ID NO: 793-795; aa) CDR H1-3 sa SEQ ID NO: 806-808 i CDR L1-3 sa SEQ ID NO: 811-813; ab) CDR H1-3 sa SEQ ID NO: 852-854 i CDR L1-3 sa SEQ ID NO: 857-859; ac) CDR H1-3 sa SEQ ID NO: 838-840 i CDR L1-3 sa SEQ ID NO: 843-845; ad) CDR H1-3 sa SEQ ID NO: 824-826 i CDR L1-3 sa SEQ ID NO: 829-831; ae) CDR H1-3 sa SEQ ID NO: 774-776 i CDR L1-3 sa SEQ ID NO: 779-781; af) CDR H1-3 sa SEQ ID NO: 688-690 i CDR L1-3 sa SEQ ID NO: 683-685; ag) CDR H1-3 sa SEQ ID NO: 870-872 i CDR L1-3 sa SEQ ID NO: 875-877; ah) CDR H1-3 sa SEQ ID NO: 888-890 i CDR L1-3 sa SEQ ID NO: 893-895; ai) CDR H1-3 sa SEQ ID NO: 924-926 i CDR L1-3 sa SEQ ID NO: 929-931; aj) CDR H1-3 sa SEQ ID NO: 1019-1021 i CDR L1-3 sa SEQ ID NO: 1025-1027; ak) CDR H1-3 sa SEQ ID NO: 1006-1008 i CDR L1-3 sa SEQ ID NO: 1011-1013; al) CDR H1-3 sa SEQ ID NO: 906-908 i CDR L1-3 sa SEQ ID NO: 911-913; am) CDR H1-3 sa SEQ ID NO: 992-994 i CDR L1-3 sa SEQ ID NO: 997-999; an) CDR H1-3 sa SEQ ID NO: 942-944 i CDR L1-3 sa SEQ ID NO: 947-949; ao) CDR H1-3 sa SEQ ID NO: 960-962 i CDR L1-3 sa SEQ ID NO: 965-967; i ap) CDR H1-3 sa SEQ ID NO: 978-980 i CDR L1-3 sa SEQ ID NO: 983-985.
6. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 5, naznačena time što vežuće domene idu redoslijedom VH PSMA-VL PSMA-VH CD3-VL CD3 ili VL PSMA-VH PSMA-VH CD3-VL CD3.
7. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 6, naznačena time što molekula bispecifičnog jednolančanog protutijela ima slijed koji se bira između: (a) aminokiselinskog slijeda kao što je opisan u bilo kojem od SEQ ID NO: 399, 413, 427, 441, 455, 469, 483, 497, 511, 525, 539, 553, 567, 581, 595, 609, 623, 637, 651, 665, 679, 693, 707, 721, 734, 799, 817, 863, 849, 835, 785, 899, 935, 1017, 1031, 917, 1003, 953, 971 ili 989; (b) aminokiselinskog slijeda kojeg kodira nukleinskokiselinski slijed kao što je opisan u bilo kojem od SEQ ID NO: 400, 414, 428, 442, 456, 470, 484,498, 512, 526, 540, 554, 568, 582, 596, 610, 624, 638, 652, 666, 680, 694, 708, 736 735, 800, 818, 864, 850, 836, 786, 882, 900, 936, 1018, 1032, 918, 1004, 954, 972, 990, 804, 822, 868, 886, 904, 940, 922, 958 ili 976; i (c) aminokiselinskog slijeda koji je najmanje 90% identičan, poželjnije najmanje 95% identičan, a najpoželjnije najmanje 96% identičan aminokiselinskom slijedu iz (a) ili (b).
8. Nukleinskokiselinski slijed, naznačen time što kodira molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7.
9. Vektor, naznačen time što sadrži nukleinskokiselinski slijed u skladu s patentnim zahtjevom 8.
10. Stanica domaćin, naznačena time što je transformirana ili transficirana vektorom u skladu s bilo kojim od patentnih zahtjeva 6 do 9.
11. Postupak proizvodnje molekule bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što se navedeni postupak sastoji u uzgoju stanice domaćina u skladu s patentnim zahtjevom 10 u uvjetima koji omogućuju eksprimiranje molekule bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7 i prikupljanju proizvedenog polipeptida iz kulture.
12. Farmaceutski pripravak, naznače time što sadrži molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, ili proizvedenu postupkom u skladu s patentnim zahtjevom 11.
13. Molekula bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, ili proizvedena postupkom u skladu s patentnim zahtjevom 11, naznačena time što je namijenjena upotrebi u sprječavanju, liječenju ili ublažavanju raka.
14. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 13, naznačena time što je navedeni rak čvrsti tumor, po mogućnosti karcinom ili rak prostate.
15. Komplet, naznačen time što sadrži molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, molekula nukleinske kiseline u skladu s patentnim zahtjevom 8, vektor u skladu s patentnim zahtjevom 9, ili stanicu domaćina u skladu s patentnim zahtjevom 10.
16. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što se navedena prva vežuća domena veže na N-terminalni CD3ε polipeptidni fragment in vitro i na nativnu CD3ε podjedinicu CD3 kompleksa na T-stanicama in vivo s istim afinitetom vezanja.
17. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što je navedeni epitop dio aminokiselinskog slijeda koji se sastoji od 26, 25, 24, 23, 22, 21 ,20, 19, 18, 17, 16, 15, 14, 13, 12, 11 , 10, 9, 8, 7, 6 ili 5 aminokiselina.
18. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što je homogenost molekule bispecifičnog jednolančanog protutijela najmanje 90%, 95% ili 98%.
MEP-2016-156A 2008-10-01 2009-10-01 Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću ME02485B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10185708P 2008-10-01 2008-10-01
PCT/EP2009/062793 WO2010037836A2 (en) 2008-10-01 2009-10-01 Cross-species-specific psmaxcd3 bispecific single chain antibody
EP09783664.7A EP2356153B1 (en) 2008-10-01 2009-10-01 Cross-species-specific psmaxcd3 bispecific single chain antibody

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ME02485B true ME02485B (me) 2017-02-20

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US (6) US20110293619A1 (me)
EP (3) EP4180458A1 (me)
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BR (1) BRPI0919841A2 (me)
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MX (1) MX2011003502A (me)
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PL (1) PL2356153T3 (me)
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RS (1) RS54900B1 (me)
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Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2520590T (pt) * 2007-04-03 2018-11-14 Amgen Res Munich Gmbh Domínio de ligação específico de espécies cruzadas
EP2352765B1 (en) * 2008-10-01 2018-01-03 Amgen Research (Munich) GmbH Cross-species-specific single domain bispecific single chain antibody
DK2356153T3 (en) * 2008-10-01 2016-07-04 Amgen Res Munich Gmbh Bispecific single CHAIN ​​PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES
WO2010135313A1 (en) 2009-05-19 2010-11-25 Aic Blab Company Composite current collector and methods therefor
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
CN103052649B (zh) 2010-07-29 2015-12-16 Xencor公司 具有修改的等电点的抗体
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
EP4279513A3 (en) 2010-11-30 2024-02-28 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
EP2699596A4 (en) 2011-04-22 2015-01-14 Emergent Product Dev Seattle PROSTATE-SPECIFIC MEMBRANE-BINDING PROTEINS AND COMPOSITIONS AND METHOD THEREFOR
CN107903325B (zh) * 2011-05-16 2021-10-29 埃泰美德(香港)有限公司 多特异性fab融合蛋白及其使用方法
KR101681818B1 (ko) * 2011-08-23 2016-12-01 로슈 글리카트 아게 T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
EP2820047B1 (en) * 2012-03-01 2018-04-25 Amgen Research (Munich) GmbH Long life polypeptide binding molecules
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
IN2015MN00139A (me) * 2012-09-25 2015-10-16 Glenmark Pharmaceuticals Sa
JP6321667B2 (ja) * 2012-11-06 2018-05-09 バイエル・ファルマ・アクティエンゲゼルシャフト 二重特異性Ｔ細胞エンゲージャー（ＢｉＴＥｓ）のための配合物
CN103087171B (zh) * 2012-12-24 2015-01-14 中国人民解放军第四军医大学 一种用于前列腺癌早期诊断和治疗的抗psma/fitc双特异性抗体及其制备方法
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
CN105051069B (zh) 2013-01-14 2019-12-10 Xencor股份有限公司 新型异二聚体蛋白
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9738722B2 (en) 2013-01-15 2017-08-22 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
US10077315B2 (en) 2013-02-05 2018-09-18 Engmab Sàrl Bispecific antibodies against CD3 and BCMA
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
EP2762497A1 (en) 2013-02-05 2014-08-06 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
JO3529B1 (ar) * 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
WO2014143886A2 (en) * 2013-03-15 2014-09-18 Edimer Pharmaceuticals, Inc. Anti-ectodysplasin antibodies
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
US10544187B2 (en) 2013-03-15 2020-01-28 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
EP2970484B2 (en) * 2013-03-15 2022-09-21 Amgen Inc. Heterodimeric bispecific antibodies
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
BR112016001611B1 (pt) 2013-07-25 2024-01-09 Cytomx Therapeutics, Inc Anticorpo ativável multiespecífico, uso terapêutico do mesmo, molécula de ácido nucleico isolada, vetor e método para produzir um anticorpo ativável multiespecífico
EP3122781B1 (en) 2014-03-28 2020-01-01 Xencor, Inc. Bispecific antibodies that bind to cd38 and cd3
US9212225B1 (en) 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
SG11201609707WA (en) 2014-07-01 2017-01-27 Pfizer Bispecific heterodimeric diabodies and uses thereof
CA2955947A1 (en) * 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
AU2015353416C1 (en) 2014-11-26 2022-01-27 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CD38
EP3223845B1 (en) 2014-11-26 2021-05-19 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cd20
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
CA2974453A1 (en) 2015-01-23 2016-07-28 Sanofi Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123
WO2016130819A2 (en) * 2015-02-11 2016-08-18 Emergent Product Development Seattle Llc Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
US10227411B2 (en) 2015-03-05 2019-03-12 Xencor, Inc. Modulation of T cells with bispecific antibodies and FC fusions
CN107849148B (zh) 2015-05-21 2023-09-19 哈普恩治疗公司 三特异性结合蛋白质及使用方法
KR102537102B1 (ko) 2015-05-29 2023-05-25 엠피베나 테라퓨틱스, 인크. 이중특이적 cd33 및 cd3 결합 단백질을 사용하는 방법
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
JOP20160154B1 (ar) * 2015-07-31 2021-08-17 Regeneron Pharma أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
CA2992797A1 (en) 2015-08-03 2017-02-09 Engmab Sarl Monoclonal antibodies against bcma
IL298041B2 (en) 2015-08-17 2025-10-01 Janssen Pharmaceutica Nv Anti-BCMA antibodies, bispecific antigen-binding molecules that bind BCMA and CD3, and uses thereof
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
BR112018005573A2 (pt) 2015-09-21 2019-01-22 Aptevo Research And Development Llc ?polipeptídeos de ligação a cd3?
CN105198992B (zh) * 2015-10-16 2018-07-13 中国人民解放军海军总医院 一种人源抗创伤弧菌溶血素蛋白(vvh)抗体的制备方法与应用
BR112018008908A2 (pt) 2015-11-02 2018-11-27 Janssen Pharmaceutica Nv anticorpos anti-il1rap, moléculas de ligação ao antígeno biespecíficas que se ligam il1rap e cd3, e seus usos
WO2017100372A1 (en) 2015-12-07 2017-06-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and psma
LT3411404T (lt) * 2016-02-03 2022-12-27 Amgen Research (Munich) Gmbh Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai
CN109476756B (zh) 2016-03-15 2022-05-31 埃泰美德(香港)有限公司 一种多特异性Fab融合蛋白及其用途
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US10100106B2 (en) 2016-05-20 2018-10-16 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
WO2017218707A2 (en) 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
CA3029209A1 (en) 2016-06-21 2017-12-28 Teneobio, Inc. Cd3 binding antibodies
US10316088B2 (en) 2016-06-28 2019-06-11 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
TWI781108B (zh) 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
UA126384C2 (uk) * 2016-09-14 2022-09-28 Тенеобіо, Інк. Антитіло, яке зв'язує cd3
AU2017331256B2 (en) 2016-09-21 2024-11-07 Aptevo Research And Development Llc CD123 binding proteins and related compositions and methods
MA46534A (fr) 2016-10-14 2019-08-21 Xencor Inc Protéines de fusion fc hétérodimères il15/il15r
CN110167964B (zh) 2016-11-02 2023-12-01 百时美施贵宝公司 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物
CA3044729A1 (en) * 2016-11-23 2018-05-31 Harpoon Therapeutics, Inc. Psma targeting trispecific proteins and methods of use
WO2018098354A1 (en) 2016-11-23 2018-05-31 Harpoon Therapeutics, Inc. Prostate specific membrane antigen binding protein
NZ795790A (en) 2016-12-21 2025-11-28 Teneobio Inc Anti-BCMA heavy chain-only antibodies
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN
JP7029822B2 (ja) * 2017-03-29 2022-03-04 タイペイ・メディカル・ユニバーシティ 抗原特異的ｔ細胞及びその使用
CN113896792B (zh) 2017-05-12 2025-08-22 哈普恩治疗公司 间皮素结合蛋白质
US11970540B2 (en) 2017-06-20 2024-04-30 Teneobio, Inc. Anti-BCMA heavy chain-only antibodies
CA3065951A1 (en) 2017-06-20 2018-12-27 Teneoone, Inc. Anti-bcma heavy chain-only antibodies
KR102324568B1 (ko) 2017-06-21 2021-11-10 길리애드 사이언시즈, 인코포레이티드 HIV gp120 및 CD3을 표적화하는 다중특이적 항체
WO2019006472A1 (en) 2017-06-30 2019-01-03 Xencor, Inc. TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
PL3661954T3 (pl) 2017-08-03 2022-05-16 Amgen Inc. Muteiny interleukiny 21 i sposoby leczenia
EP3679040B1 (en) 2017-09-08 2022-08-03 Amgen Inc. Inhibitors of kras g12c and methods of using the same
US12486325B2 (en) 2017-09-21 2025-12-02 WuXi Biologics Ireland Limited Anti-CD3epsilon antibodies
CA3074130A1 (en) 2017-09-21 2019-03-28 WuXi Biologics Ireland Limited Novel anti-cd3epsilon antibodies
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
KR102425983B1 (ko) 2017-10-13 2022-07-29 하푼 테라퓨틱스, 인크. 삼중특이적 단백질 및 사용 방법
CN111247171A (zh) 2017-10-14 2020-06-05 西托姆克斯治疗公司 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
MA51291A (fr) 2017-12-19 2020-10-28 Xencor Inc Protéines de fusion il-2 fc modifiées
MX2020006494A (es) 2017-12-22 2020-11-24 Teneobio Inc Anticuerpos de cadena pesada que se unen a cd22.
TW201940518A (zh) 2017-12-29 2019-10-16 美商安進公司 針對ｍｕｃ１７和ｃｄ３之雙特異性抗體構建體
CN111727197A (zh) 2018-01-12 2020-09-29 美国安进公司 抗pd-1抗体和治疗方法
CA3096052A1 (en) 2018-04-04 2019-10-10 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
EP3773913A1 (en) 2018-04-11 2021-02-17 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses
CA3097741A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
MX2020010910A (es) 2018-04-18 2021-02-09 Xencor Inc Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos.
KR20210020903A (ko) 2018-05-14 2021-02-24 하푼 테라퓨틱스, 인크. 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
CA3100118A1 (en) 2018-05-16 2019-11-21 Janssen Biotech, Inc. Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy
EP3802609A2 (en) * 2018-05-24 2021-04-14 Janssen Biotech, Inc. Psma binding agents and uses thereof
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
CN118459594A (zh) 2018-06-01 2024-08-09 诺华股份有限公司 针对bcma的结合分子及其用途
KR20210029158A (ko) 2018-06-03 2021-03-15 람카프 바이오 베타 엘티디. Ceacam5 및 cd47에 대한 이중특이성 항체
US12195533B2 (en) 2018-07-24 2025-01-14 Inhibrx Biosciences, Inc. Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same
US11976131B2 (en) * 2018-07-31 2024-05-07 Heidelberg Pharma Research Gmbh Humanized antibodies against PSMA
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
IL281683B2 (en) 2018-09-25 2023-04-01 Harpoon Therapeutics Inc dll3 binding proteins and methods of use
CA3115096A1 (en) 2018-10-03 2020-04-09 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
TW202028245A (zh) 2018-10-11 2020-08-01 美商英伊布里克斯公司 Dll3單域抗體及其治療性組合物
BR112021016955A2 (pt) 2019-03-01 2021-11-23 Xencor Inc Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico
KR20210149076A (ko) 2019-04-05 2021-12-08 테네오바이오, 인코포레이티드 Psma에 결합하는 중쇄 항체
CA3136892A1 (en) * 2019-04-19 2020-10-22 Janssen Biotech, Inc. Methods of treating renal cancer with an anti- psma/cd3 antibody
CA3136888A1 (en) 2019-04-19 2020-10-22 Janssen Biotech, Inc. Methods of treating prostate cancer with an anti- psma/cd3 antibody
JP7489407B2 (ja) 2019-05-21 2024-05-23 ノバルティス アーゲー Ｃｄ１９結合分子及びその使用
CR20210622A (es) 2019-06-14 2022-06-27 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
US20220372148A1 (en) 2019-07-05 2022-11-24 Ono Pharmaceutical Co., Ltd. A pharmaceutical composition for treating hematological cancer
US20220251562A1 (en) * 2019-07-26 2022-08-11 Ixaka France Anti-CD3 Aptamers for Use in Cell Targeting and Labeling
WO2021053587A1 (en) 2019-09-18 2021-03-25 Klaus Strein Bispecific antibodies against ceacam5 and cd3
EP3831849A1 (en) 2019-12-02 2021-06-09 LamKap Bio beta AG Bispecific antibodies against ceacam5 and cd47
EP3842461A1 (en) * 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
IL294458A (en) 2020-01-13 2022-09-01 Aptevo Res & Development Llc Formulations for protein therapeutics
IL294461A (en) 2020-01-13 2022-09-01 Aptevo Res & Development Llc Methods and compositions for preventing adsorption of therapeutic proteins to drug delivery system components
CA3170833A1 (en) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Flt3 binding proteins and methods of use
JP7625007B2 (ja) 2020-04-29 2025-01-31 テネオバイオ， インコーポレイテッド 重鎖定常領域が修飾された多重特異性重鎖抗体
AU2021272291A1 (en) 2020-05-11 2023-02-02 Janssen Biotech, Inc. Methods for treating multiple myeloma
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
AU2021329378A1 (en) 2020-08-19 2023-03-23 Xencor, Inc. Anti-CD28 compositions
AU2021345124A1 (en) 2020-09-16 2023-03-30 Amgen Inc. Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer
WO2022060878A1 (en) 2020-09-16 2022-03-24 Amgen Inc. Methods for treating prostate cancer
WO2022081822A1 (en) * 2020-10-15 2022-04-21 Janux Therapeutics, Inc. Antibodies targeting psma and cd3 and uses thereof
KR20230104256A (ko) 2020-11-06 2023-07-07 암젠 인크 증가된 선택성의 다중표적화 이중특이적 항원 결합 분자
CR20230235A (es) * 2020-11-06 2023-10-05 Amgen Res Munich Gmbh Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3
WO2022125576A1 (en) 2020-12-09 2022-06-16 Janux Therapeutics, Inc. Compositions and methods related to tumor activated antibodies targeting psma and effector cell antigens
CR20230398A (es) 2021-02-16 2023-11-15 Janssen Pharmaceutica Nv Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3
CA3212665A1 (en) 2021-03-09 2022-09-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
KR20230154311A (ko) 2021-03-10 2023-11-07 젠코어 인코포레이티드 Cd3 및 gpc3에 결합하는 이종이량체 항체
KR20230160874A (ko) 2021-03-24 2023-11-24 얀센 바이오테크 인코포레이티드 CD79b, CD20 및 CD3을 표적으로 하는 삼중특이적 항체
EP4330281A1 (en) 2021-04-29 2024-03-06 Amgen Inc. Methods for reducing low molecular weight species of recombinantly-produced proteins
WO2022234102A1 (en) 2021-05-06 2022-11-10 Amgen Research (Munich) Gmbh Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
JP2024519964A (ja) 2021-05-21 2024-05-21 アプティーボ リサーチ アンド デベロップメント エルエルシー タンパク質治療薬のための投薬レジメン
CN115536740A (zh) * 2021-06-30 2022-12-30 苏州方德门达新药开发有限公司 介导细胞内有效滞留cd3的空间构象表位及其应用
JP7707834B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707828B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707827B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707823B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707831B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707833B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707822B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707821B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707824B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707835B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707825B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707836B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707820B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707830B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707832B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707829B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
KR20240099376A (ko) 2021-11-03 2024-06-28 얀센 바이오테크 인코포레이티드 암 치료 및 bcmaxcd3 이중특이성 항체의 효능을 향상시키는 방법
AU2023238724A1 (en) 2022-03-21 2024-09-05 Amgen Inc. Combination therapy methods with t-cell engaging molecules for treatment of prostate cancer
EP4522651A1 (en) 2022-05-12 2025-03-19 Amgen Research (Munich) GmbH Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
WO2025134049A1 (en) 2023-12-21 2025-06-26 Janssen Biotech, Inc Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of al amyloidosis
WO2025134050A1 (en) 2023-12-21 2025-06-26 Janssen Biotech, Inc Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of multiple myeloma

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1988009344A1 (en) 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Targeted multifunctional proteins
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
JP3626187B2 (ja) 1993-06-07 2005-03-02 バイカル インコーポレイテッド 遺伝子治療に適するプラスミド
WO1997000957A1 (en) 1995-06-23 1997-01-09 President And Fellows Of Harvard College Transcriptional regulation of genes encoding vascular endothelial growth factor receptors
WO1999054440A1 (en) 1998-04-21 1999-10-28 Micromet Gesellschaft Für Biomedizinische Forschung Mbh CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
SE524615C2 (sv) 1999-06-30 2004-09-07 Volvo Personvagnar Ab Arrangemang för minskning av galvanisk korrosion mellan metallkomponenter
DK1210374T3 (da) * 1999-07-29 2007-02-19 Medarex Inc Humane, monoklonale antistoffer over for prostataspecifikt membranantigen
JP4386776B2 (ja) * 2000-05-18 2009-12-16 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
AU2003224604B2 (en) * 2002-01-28 2007-06-14 Medarex, Inc. Human monoclonal antibodies to prostate specific membrane antigen (PSMA)
WO2004069876A2 (en) 2003-02-06 2004-08-19 Micromet Ag Trimeric polypeptide construct to induce an enduring t cell response
CA2523716C (en) 2003-05-31 2014-11-25 Micromet Ag Human anti-human cd3 binding molecules
RU2005141512A (ru) * 2003-05-31 2007-07-20 Микромет Аг (De) Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками
EP2292664B1 (en) 2003-10-16 2016-11-23 Amgen Research (Munich) GmbH Multispecific deimmunized CD3-binders
US7235641B2 (en) * 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
DE602005022830D1 (de) 2004-02-16 2010-09-23 Micromet Ag Weniger immunogene bindungsmoleküle
WO2005118635A2 (en) 2004-06-03 2005-12-15 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
CA2570990C (en) 2004-07-16 2014-01-21 Micromet Ag Expression-enhanced polypeptides
JP2006040495A (ja) 2004-07-30 2006-02-09 Renesas Technology Corp 半導体集積回路装置
NO20064183L (no) 2005-02-16 2006-11-08 Micromet Ag Mindre immunogene bindingsmolekyler
CA2598522A1 (en) * 2005-02-18 2006-08-24 Medarex, Inc. Human monoclonal antibodies to prostate specific membrane antigen (psma)
EP1726650A1 (en) * 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
WO2007033230A2 (en) 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
EP3770174A1 (en) * 2005-10-11 2021-01-27 Amgen Research (Munich) GmbH Compositions comprising cross-species-specific antibodies and uses thereof
PT2520590T (pt) * 2007-04-03 2018-11-14 Amgen Res Munich Gmbh Domínio de ligação específico de espécies cruzadas
WO2008119566A2 (en) * 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific bispecific binders
RU2561457C2 (ru) 2007-04-03 2015-08-27 Эмджен Рисерч (Мьюник) Гмбх Cd3-эпсилон-связывающий домен с межвидовой специфичностью
JP4970211B2 (ja) * 2007-10-18 2012-07-04 ヘキサゴン・メトロジー株式会社 ３次元形状測定器
CA2738566C (en) 2008-10-01 2024-04-30 Micromet Ag Bispecific single chain antibodies with specificity for high molecular weight target antigens
DK2356153T3 (en) * 2008-10-01 2016-07-04 Amgen Res Munich Gmbh Bispecific single CHAIN ​​PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES
TWI653333B (zh) * 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
LT3411404T (lt) * 2016-02-03 2022-12-27 Amgen Research (Munich) Gmbh Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai

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