ME02485B - Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću - Google Patents

Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću

Info

Publication number
ME02485B
ME02485B MEP-2016-156A MEP15616A ME02485B ME 02485 B ME02485 B ME 02485B ME P15616 A MEP15616 A ME P15616A ME 02485 B ME02485 B ME 02485B
Authority
ME
Montenegro
Prior art keywords
cdr
seq
chain antibody
bispecific single
antibody molecule
Prior art date
Application number
MEP-2016-156A
Other languages
English (en)
French (fr)
Inventor
Doris Rau
Evelyne Schaller
Susanne Hausmann
Petra Fluhr
Carola Steiger
Peter Kufer
Tobias Raum
Roman Kischel
Ralf LUTTERBÜSE
Patrick Hoffmann
Susanne Mangold
Matthias Klinger
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42073956&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02485(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of ME02485B publication Critical patent/ME02485B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (18)

1. Molekula bispecifičnog jednolančanog protutijela, naznačena time što sadrži prvu vežuću domenu koja se specifično veže na epitop u lancu CD3ε kod čovjeka i Callithrix jacchus, Saguinus oedipus ili Saimiri sciureus, gdje je navedeni epitop dio aminokiselinskogi slijeda iz skupine koju čine SEQ ID NO. 2, 4, 6 ili 8, i u najmanju ruku sadrži aminokiselinski slijed Gln-Asp-Gly-Asn-Glu, te drugu vežuću domenu koja se veže na membranski antigen specifičan za prostatu (PSMA).
2. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što prva vežuća domena sadrži područje VL, koje sadrži CDR-L1, CDR-L2 i CDR-L3, koje se bira između: (a) CDR-L1, kao što je opisan u SEQ ID NO. 27, CDR-L2, kao što je opisan u SEQ ID NO. 28 i CDR-L3, kao što je opisan u SEQ ID NO. 29; (b) CDR-L1, kao što je opisan u SEQ ID NO. 117, CDR-L2, kao što je opisan u SEQ ID NO. 118 i CDR-L3, kao što je opisan u SEQ ID NO. 119; i (c) CDR-L1, kao što je opisan u SEQ ID NO. 153, CDR-L2, kao što je opisan u SEQ ID NO. 154 i CDR-L3, kao što je opisan u SEQ ID NO. 155.
3. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1 ili 2, naznačena time što prva vežuća domena sadrži područje VH, koje sadrži CDR-H1, CDR-H2 i CDR-H3, koje se bira između: (a) CDR-H1, kao što je opisan u SEQ ID NO. 12, CDR-H2, kao što je opisan u SEQ ID NO. 13 i CDR-H3, kao što je opisan u SEQ ID NO. 14; (b) CDR-H1, kao što je opisan u SEQ ID NO. 30, CDR-H2, kao što je opisan u SEQ ID NO. 31 i CDR-H3, kao što je opisan u SEQ ID NO. 32; (c) CDR-H1, kao što je opisan u SEQ ID NO. 48, CDR-H2, kao što je opisan u SEQ ID NO. 49 i CDR-H3, kao što je opisan u SEQ ID NO. 50; (d) CDR-H1, kao što je opisan u SEQ ID NO. 66, CDR-H2, kao što je opisan u SEQ ID NO. 67 i CDR-H3, kao što je opisan u SEQ ID NO. 68; (e) CDR-H1, kao što je opisan u SEQ ID NO. 84, CDR-H2, kao što je opisan u SEQ ID NO. 85 i CDR-H3, kao što je opisan u SEQ ID NO. 86; (f) CDR-H1, kao što je opisan u SEQ ID NO. 102, CDR-H2, kao što je opisan u SEQ ID NO. 103 i CDR-H3, kao što je opisan u SEQ ID NO. 104; (g) CDR-H1, kao što je opisan u SEQ ID NO. 120, CDR-H2 kao što je opisan u SEQ ID NO. 121 i CDR-H3kao što je opisan u SEQ ID NO. 122; (h) CDR-H1, kao što je opisan u SEQ ID NO. 138, CDR-H2, kao što je opisan u SEQ ID NO. 139 i CDR-H3, kao što je opisan u SEQ ID NO. 140; (i) CDR-H1, kao što je opisan u SEQ ID NO. 156, CDR-H2, kao što je opisan u SEQ ID NO. 157 i CDR-H3, kao što je opisan u SEQ ID NO. 158; i (j) CDR-H1, kao što je opisan u SEQ ID NO. 174, CDR-H2, kao što je opisan u SEQ ID NO. 175 i CDR-H3, kao što je opisan u SEQ ID NO. 176.
4. Molekula bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačena time što se druga vežuća domena može vezati na ljudski PSMA i/ili na neljudski primatski PSMA.
5. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 4, naznačena time što molekula bispecifičnog jednolančanog protutijela uključuje skupinu sljedećih sljedova poput CDR H1, CDR H2, CDR H3, CDR L1, CDR L2 i CDR L3 u drugoj vežućoj domeni koju se bira između: a) CDR H1-3 sa SEQ ID NO: 394-396 i CDR L1-3 sa SEQ ID NO: 389-391; b) CDR H1-3 sa SEQ ID NO: 408-410 i CDR L1-3 sa SEQ ID NO: 403-405; c) CDR H1-3 sa SEQ ID NO: 422-424 i CDR L1-3 sa SEQ ID NO: 417-419; d) CDR H1-3 sa SEQ ID NO: 436-438 i CDR L1-3 sa SEQ ID NO: 431-433; e) CDR H1-3 sa SEQ ID NO: 445-447 i CDR L1-3 sa SEQ ID NO: 450-452; f) CDR H1-3 sa SEQ ID NO: 464-466 i CDR L1-3 sa SEQ ID NO: 459-461; g) CDR H1-3 sa SEQ ID NO: 478-480 i CDR L1-3 sa SEQ ID NO: 473-475; h) CDR H1-3 sa SEQ ID NO: 492-494 i CDR L1-3 sa SEQ ID NO: 487-489; i) CDR H1-3 sa SEQ ID NO: 506-508 i CDR L1-3 sa SEQ ID NO: 501-503; j) CDR H1-3 sa SEQ ID NO: 520-522 i CDR L1-3 sa SEQ ID NO: 515-517; k) CDR H1-3 sa SEQ ID NO: 534-536 i CDR L1-3 sa SEQ ID NO: 529-531; l) CDR H1-3 sa SEQ ID NO: 548-550 i CDR L1-3 sa SEQ ID NO: 543-545; m) CDR H1-3 sa SEQ ID NO: 562-564 i CDR L1-3 sa SEQ ID NO: 557-559; n) CDR H1-3 sa SEQ ID NO: 576-578 i CDR L1-3 sa SEQ ID NO: 571-573; o) CDR H1-3 sa SEQ ID NO: 590-592 i CDR L1-3 sa SEQ ID NO: 585-587; p) CDR H1-3 sa SEQ ID NO: 604-606 i CDR L1-3 sa SEQ ID NO: 599-601; q) CDR H1-3 sa SEQ ID NO: 618-620 i CDR L1-3 sa SEQ ID NO: 613-615; r) CDR H1-3 sa SEQ ID NO: 632-634 i CDR L1-3 sa SEQ ID NO: 627-629; s) CDR H1-3 sa SEQ ID NO: 646-648 i CDR L1-3 sa SEQ ID NO: 641-643; t) CDR H1-3 sa SEQ ID NO: 660-662 i CDR L1-3 sa SEQ ID NO: 655-657; u) CDR H1-3 sa SEQ ID NO: 674-676 i CDR L1-3 sa SEQ ID NO: 669-671; v) CDR H1-3 sa SEQ ID NO: 688-690 i CDR L1-3 sa SEQ ID NO: 683-685; w) CDR H1-3 sa SEQ ID NO: 702-704 i CDR L1-3 sa SEQ ID NO: 697-699; x) CDR H1-3 sa SEQ ID NO: 716-718 i CDR L1-3 sa SEQ ID NO: 711-713; y) CDR H1-3 sa SEQ ID NO: 729-731 i CDR L1-3 sa SEQ ID NO: 724-726; z) CDR H1-3 sa SEQ ID NO: 788-790 i CDR L1-3 sa SEQ ID NO: 793-795; aa) CDR H1-3 sa SEQ ID NO: 806-808 i CDR L1-3 sa SEQ ID NO: 811-813; ab) CDR H1-3 sa SEQ ID NO: 852-854 i CDR L1-3 sa SEQ ID NO: 857-859; ac) CDR H1-3 sa SEQ ID NO: 838-840 i CDR L1-3 sa SEQ ID NO: 843-845; ad) CDR H1-3 sa SEQ ID NO: 824-826 i CDR L1-3 sa SEQ ID NO: 829-831; ae) CDR H1-3 sa SEQ ID NO: 774-776 i CDR L1-3 sa SEQ ID NO: 779-781; af) CDR H1-3 sa SEQ ID NO: 688-690 i CDR L1-3 sa SEQ ID NO: 683-685; ag) CDR H1-3 sa SEQ ID NO: 870-872 i CDR L1-3 sa SEQ ID NO: 875-877; ah) CDR H1-3 sa SEQ ID NO: 888-890 i CDR L1-3 sa SEQ ID NO: 893-895; ai) CDR H1-3 sa SEQ ID NO: 924-926 i CDR L1-3 sa SEQ ID NO: 929-931; aj) CDR H1-3 sa SEQ ID NO: 1019-1021 i CDR L1-3 sa SEQ ID NO: 1025-1027; ak) CDR H1-3 sa SEQ ID NO: 1006-1008 i CDR L1-3 sa SEQ ID NO: 1011-1013; al) CDR H1-3 sa SEQ ID NO: 906-908 i CDR L1-3 sa SEQ ID NO: 911-913; am) CDR H1-3 sa SEQ ID NO: 992-994 i CDR L1-3 sa SEQ ID NO: 997-999; an) CDR H1-3 sa SEQ ID NO: 942-944 i CDR L1-3 sa SEQ ID NO: 947-949; ao) CDR H1-3 sa SEQ ID NO: 960-962 i CDR L1-3 sa SEQ ID NO: 965-967; i ap) CDR H1-3 sa SEQ ID NO: 978-980 i CDR L1-3 sa SEQ ID NO: 983-985.
6. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 5, naznačena time što vežuće domene idu redoslijedom VH PSMA-VL PSMA-VH CD3-VL CD3 ili VL PSMA-VH PSMA-VH CD3-VL CD3.
7. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 6, naznačena time što molekula bispecifičnog jednolančanog protutijela ima slijed koji se bira između: (a) aminokiselinskog slijeda kao što je opisan u bilo kojem od SEQ ID NO: 399, 413, 427, 441, 455, 469, 483, 497, 511, 525, 539, 553, 567, 581, 595, 609, 623, 637, 651, 665, 679, 693, 707, 721, 734, 799, 817, 863, 849, 835, 785, 899, 935, 1017, 1031, 917, 1003, 953, 971 ili 989; (b) aminokiselinskog slijeda kojeg kodira nukleinskokiselinski slijed kao što je opisan u bilo kojem od SEQ ID NO: 400, 414, 428, 442, 456, 470, 484,498, 512, 526, 540, 554, 568, 582, 596, 610, 624, 638, 652, 666, 680, 694, 708, 736 735, 800, 818, 864, 850, 836, 786, 882, 900, 936, 1018, 1032, 918, 1004, 954, 972, 990, 804, 822, 868, 886, 904, 940, 922, 958 ili 976; i (c) aminokiselinskog slijeda koji je najmanje 90% identičan, poželjnije najmanje 95% identičan, a najpoželjnije najmanje 96% identičan aminokiselinskom slijedu iz (a) ili (b).
8. Nukleinskokiselinski slijed, naznačen time što kodira molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7.
9. Vektor, naznačen time što sadrži nukleinskokiselinski slijed u skladu s patentnim zahtjevom 8.
10. Stanica domaćin, naznačena time što je transformirana ili transficirana vektorom u skladu s bilo kojim od patentnih zahtjeva 6 do 9.
11. Postupak proizvodnje molekule bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što se navedeni postupak sastoji u uzgoju stanice domaćina u skladu s patentnim zahtjevom 10 u uvjetima koji omogućuju eksprimiranje molekule bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7 i prikupljanju proizvedenog polipeptida iz kulture.
12. Farmaceutski pripravak, naznače time što sadrži molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, ili proizvedenu postupkom u skladu s patentnim zahtjevom 11.
13. Molekula bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, ili proizvedena postupkom u skladu s patentnim zahtjevom 11, naznačena time što je namijenjena upotrebi u sprječavanju, liječenju ili ublažavanju raka.
14. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 13, naznačena time što je navedeni rak čvrsti tumor, po mogućnosti karcinom ili rak prostate.
15. Komplet, naznačen time što sadrži molekulu bispecifičnog jednolančanog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 7, molekula nukleinske kiseline u skladu s patentnim zahtjevom 8, vektor u skladu s patentnim zahtjevom 9, ili stanicu domaćina u skladu s patentnim zahtjevom 10.
16. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što se navedena prva vežuća domena veže na N-terminalni CD3ε polipeptidni fragment in vitro i na nativnu CD3ε podjedinicu CD3 kompleksa na T-stanicama in vivo s istim afinitetom vezanja.
17. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što je navedeni epitop dio aminokiselinskog slijeda koji se sastoji od 26, 25, 24, 23, 22, 21 ,20, 19, 18, 17, 16, 15, 14, 13, 12, 11 , 10, 9, 8, 7, 6 ili 5 aminokiselina.
18. Molekula bispecifičnog jednolančanog protutijela u skladu s patentnim zahtjevom 1, naznačena time što je homogenost molekule bispecifičnog jednolančanog protutijela najmanje 90%, 95% ili 98%.
MEP-2016-156A 2008-10-01 2009-10-01 Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću ME02485B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10185708P 2008-10-01 2008-10-01
PCT/EP2009/062793 WO2010037836A2 (en) 2008-10-01 2009-10-01 Cross-species-specific psmaxcd3 bispecific single chain antibody
EP09783664.7A EP2356153B1 (en) 2008-10-01 2009-10-01 Cross-species-specific psmaxcd3 bispecific single chain antibody

Publications (1)

Publication Number Publication Date
ME02485B true ME02485B (me) 2017-02-20

Family

ID=42073956

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2016-156A ME02485B (me) 2008-10-01 2009-10-01 Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću

Country Status (26)

Country Link
US (6) US20110293619A1 (me)
EP (3) EP4180458A1 (me)
JP (4) JP6126782B2 (me)
KR (1) KR101820535B1 (me)
CN (1) CN102171248B (me)
AU (1) AU2009299792B2 (me)
BR (1) BRPI0919841A2 (me)
CA (1) CA2738565C (me)
CY (1) CY1118303T1 (me)
DK (1) DK2356153T3 (me)
ES (1) ES2588155T3 (me)
HR (1) HRP20160684T1 (me)
HU (1) HUE030090T2 (me)
IL (1) IL212099A (me)
ME (1) ME02485B (me)
MX (1) MX2011003502A (me)
NZ (1) NZ591134A (me)
PL (1) PL2356153T3 (me)
PT (1) PT2356153T (me)
RS (1) RS54900B1 (me)
RU (1) RU2559531C2 (me)
SG (1) SG194398A1 (me)
SI (1) SI2356153T1 (me)
SM (1) SMT201600256B (me)
WO (1) WO2010037836A2 (me)
ZA (1) ZA201101067B (me)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE040467T2 (hu) * 2007-04-03 2019-03-28 Amgen Res Munich Gmbh Keresztfaj-specifikus kötõdomén
US10981998B2 (en) * 2008-10-01 2021-04-20 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
JP6126782B2 (ja) * 2008-10-01 2017-05-10 アムゲン リサーチ （ミュンヘン） ゲーエムベーハー 異種間特異的ｐｓｍａ×ｃｄ３二重特異性単鎖抗体
EA201290020A1 (ru) 2009-05-19 2013-10-30 ЭйАйСи БЛЭБ КОМПАНИ Композитный токоприемник и способы его изготовления
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
AU2011283694B2 (en) 2010-07-29 2017-04-13 Xencor, Inc. Antibodies with modified isoelectric points
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
KR102447595B1 (ko) 2010-11-30 2022-09-26 추가이 세이야쿠 가부시키가이샤 세포상해 유도 치료제
CN103687872A (zh) 2011-04-22 2014-03-26 新兴产品开发西雅图有限公司 前列腺特异性膜抗原结合蛋白和相关组合物以及方法
EP2710042A2 (en) * 2011-05-16 2014-03-26 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
KR101870555B1 (ko) 2011-08-23 2018-06-22 로슈 글리카트 아게 T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
CA2864177C (en) 2012-03-01 2019-11-26 Amgen Research (Munich) Gmbh Prolonged half-life albumin-binding protein fused bispecific antibodies
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
HK1215950A1 (zh) * 2012-09-25 2016-09-30 艾科诺斯科技股份有限公司 异源二聚免疫球蛋白的纯化
CN104780940B (zh) 2012-11-06 2017-11-07 拜耳制药股份公司 用于双特异性t细胞衔接体(bites)的制剂
CN103087171B (zh) * 2012-12-24 2015-01-14 中国人民解放军第四军医大学 一种用于前列腺癌早期诊断和治疗的抗psma/fitc双特异性抗体及其制备方法
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
CA2898100C (en) 2013-01-14 2023-10-10 Xencor, Inc. Novel heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
CA2897987A1 (en) 2013-01-15 2014-07-24 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
EP2762497A1 (en) 2013-02-05 2014-08-06 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
CN104968682A (zh) 2013-02-05 2015-10-07 英格玛布股份公司 针对CD3ε和BCMA的双特异性抗体
JO3529B1 (ar) * 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
US9695245B2 (en) 2013-03-15 2017-07-04 Edimer Pharmaceuticals, Inc Anti-ectodysplasin antibodies
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
EP2970486B1 (en) 2013-03-15 2018-05-16 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
EP3424952A1 (en) * 2013-03-15 2019-01-09 Amgen, Inc Heterodimeric bispecific antibodies
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
PT3406633T (pt) 2013-07-25 2022-05-04 Cytomx Therapeutics Inc Anticorpos multi-específicos, anticorpos ativáveis multi-específicos e métodos de utilização dos mesmos
EA201691925A1 (ru) 2014-03-28 2017-06-30 Ксенкор, Инк. Биспецифические антитела, которые связываются с cd38 и cd3
CA2895659A1 (en) 2014-07-01 2016-01-01 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
US9212225B1 (en) 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
CN107108738A (zh) 2014-07-25 2017-08-29 西托姆克斯治疗公司 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法
SG11201704274QA (en) 2014-11-26 2017-06-29 Xencor Inc Heterodimeric antibodies that bind cd3 and cd38
KR20240116967A (ko) 2014-11-26 2024-07-30 젠코어 인코포레이티드 Ｃｄ3 및 종양 항원과 결합하는 이종이량체 항체
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
KR20240104220A (ko) 2015-01-23 2024-07-04 사노피 항-ｃｄ3 항체, 항-ｃｄ123 항체, 및 ｃｄ3 및/또는 ｃｄ123에 특이적으로 결합하는 이중특이적 항체
CA2976360A1 (en) * 2015-02-11 2016-08-18 Aptevo Research And Development Llc Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
US10227411B2 (en) 2015-03-05 2019-03-12 Xencor, Inc. Modulation of T cells with bispecific antibodies and FC fusions
MX383614B (es) 2015-05-21 2025-03-14 Harpoon Therapeutics Inc Proteinas de union triespecificas y metodos de uso.
EA201792581A1 (ru) * 2015-05-29 2018-07-31 Амфивена Терапьютикс, Инк. Способы применения биспецифических cd33- и cd3- связывающих белков
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
JOP20160154B1 (ar) 2015-07-31 2021-08-17 Regeneron Pharma أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
PL3331910T3 (pl) 2015-08-03 2020-05-18 Engmab Sàrl Przeciwciała monoklonalne przeciwko ludzkiemu antygenowi dojrzewania limfocytów B (BCMA)
RS60755B1 (sr) 2015-08-17 2020-10-30 Janssen Pharmaceutica Nv Anti-bcma antitela, bispecifični antigen vezujući molekuli koji se vezuju za bcma i cd3, i njihove upotrebe
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
UA126278C2 (uk) 2015-09-21 2022-09-14 Аптево Рісьорч Енд Девелопмент Ллс Поліпептиди, які зв'язують cd3
CN105198992B (zh) * 2015-10-16 2018-07-13 中国人民解放军海军总医院 一种人源抗创伤弧菌溶血素蛋白(vvh)抗体的制备方法与应用
CR20180250A (es) 2015-11-02 2018-10-01 Janssen Pharmaceutica Nv Anticuerpos anti-il1rap, moléculas de unión a antígenos biespecíficas que se unen a il1rap y cd3, y uso de estas
AU2016365742A1 (en) * 2015-12-07 2018-06-21 Xencor, Inc. Heterodimeric antibodies that bind CD3 and PSMA
IL260920B (en) 2016-02-03 2022-09-01 Amgen Res Munich Gmbh Constructs of psma and cd3 bispecific antigens that bind to t-cells, preparations containing them and uses thereof
CA3017776A1 (en) 2016-03-15 2017-09-21 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
WO2017201488A1 (en) 2016-05-20 2017-11-23 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
HUE068801T2 (hu) 2016-06-14 2025-01-28 Xencor Inc Bispecifikus kontrollpont-gátló antitestek
KR20230129583A (ko) 2016-06-21 2023-09-08 테네오바이오, 인코포레이티드 Cd3 결합 항체
WO2018005706A1 (en) 2016-06-28 2018-01-04 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
TWI781108B (zh) 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
HRP20240767T1 (hr) * 2016-09-14 2024-09-13 Teneoone, Inc. Cd3 vezujuća antitijela
KR102559732B1 (ko) * 2016-09-21 2023-07-26 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd123 결합 단백질 그리고 관련된 조성물 및 방법
KR102562519B1 (ko) 2016-10-14 2023-08-02 젠코어 인코포레이티드 IL-15/IL-15Rα FC-융합 단백질 및 PD-1 항체 단편을 포함하는 이중특이성 이종이량체 융합 단백질
EA201990787A1 (ru) 2016-11-02 2019-12-30 Энгмаб Сарл Биспецифичное антитело к всма и cd3 и иммунологическое лекарственное средство для комбинированного применения в лечении множественной миеломы
JP7215997B2 (ja) 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
JP6812551B2 (ja) 2016-11-23 2021-01-13 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原結合タンパク質
KR102633423B1 (ko) 2016-12-21 2024-02-06 테네오바이오, 인코포레이티드 항-bcma 중쇄-단독 항체
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
WO2018177371A1 (en) * 2017-03-29 2018-10-04 Taipei Medical University Antigen-specific t cells and uses thereof
CN110891974B (zh) 2017-05-12 2021-08-06 哈普恩治疗公司 间皮素结合蛋白质
CA3067584A1 (en) 2017-06-20 2018-12-27 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
JP7240335B2 (ja) 2017-06-20 2023-03-15 テネオワン， インコーポレイテッド 抗ｂｃｍａ重鎖のみ抗体
CA3065328C (en) 2017-06-21 2023-08-15 Gilead Sciences, Inc. Multispecific antibodies that target hiv gp120 and cd3
EP3645122A1 (en) 2017-06-30 2020-05-06 Xencor, Inc. Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains
KR102414120B1 (ko) 2017-08-03 2022-06-28 암젠 인크 인터류킨-21 뮤테인 및 치료 방법
EP4403175A3 (en) 2017-09-08 2024-10-02 Amgen Inc. Inhibitors of kras g12c and methods of using the same
SG11202001358RA (en) 2017-09-21 2020-03-30 Wuxi Biologics Ireland Ltd Novel anti-cd3epsilon antibodies
US12486325B2 (en) 2017-09-21 2025-12-02 WuXi Biologics Ireland Limited Anti-CD3epsilon antibodies
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
PE20201183A1 (es) 2017-10-13 2020-11-03 Harpoon Therapeutics Inc Proteinas trispecificas y metodos de uso
CN111247171A (zh) 2017-10-14 2020-06-05 西托姆克斯治疗公司 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法
CN112272563A (zh) 2017-11-08 2021-01-26 Xencor股份有限公司 使用新颖抗pd-1序列的双特异性和单特异性抗体
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
SG11202005732XA (en) 2017-12-19 2020-07-29 Xencor Inc Engineered il-2 fc fusion proteins
PE20201171A1 (es) 2017-12-22 2020-10-28 Teneobio Inc Anticuerpos de cadena pesada que se unen a cd22
UY38041A (es) 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
CR20200330A (es) 2018-01-12 2020-12-23 Amgen Inc Anticuerpos anti-pd-1 y métodos de tratamiento
CA3096052A1 (en) 2018-04-04 2019-10-10 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
IL277863B1 (en) 2018-04-11 2025-10-01 Inhibrx Inc Multispecific polypeptide constructs with forced CD3 binding and related methods and uses
KR20210010862A (ko) 2018-04-18 2021-01-28 젠코어 인코포레이티드 IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도
JP2021520829A (ja) 2018-04-18 2021-08-26 ゼンコア インコーポレイテッド ＩＬ−１５／ＩＬ−１５ＲＡ Ｆｃ融合タンパク質およびＴＩＭ−３抗原結合ドメインを含む、ＴＩＭ−３標的化ヘテロ二量体融合タンパク質
CN119192397A (zh) 2018-05-14 2024-12-27 哈普恩治疗公司 用于条件性激活免疫球蛋白分子的结合部分
MY205856A (en) 2018-05-16 2024-11-15 Stichting Vumc Methods of treating cancers and enhancing efficacy of t cell redirecting therapeutics
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
CN112513085B (zh) 2018-05-24 2024-06-18 詹森生物科技公司 Psma结合剂及其用途
MX2020012495A (es) 2018-06-01 2021-02-15 Novartis Ag Moleculas de union contra bcma y usos de las mismas.
US20210221908A1 (en) 2018-06-03 2021-07-22 Lamkap Bio Beta Ltd. Bispecific antibodies against ceacam5 and cd47
JP7651450B2 (ja) 2018-07-24 2025-03-26 インヒブルクス バイオサイエンシズ インコーポレイテッド 制約されたｃｄ３結合ドメインおよび受容体結合領域を含有する多重特異性ポリペプチド構築物ならびにそれを使用する方法
FI3830132T3 (fi) 2018-07-31 2023-01-13 Humanisoituja vasta-aineita psma:ta vastaan
JP7548587B2 (ja) 2018-09-07 2024-09-10 アイタブメッド （エイチケイ） リミテッド 二重特異性抗原結合タンパク質及びその使用
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
JP7612571B2 (ja) 2018-10-03 2025-01-14 ゼンコア インコーポレイテッド Ｉｌ－１２ヘテロ二量体ｆｃ－融合タンパク質
CA3115089A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
MX2021010390A (es) 2019-03-01 2021-11-17 Xencor Inc Anticuerpos heterodimericos que se unen a enpp3 y cd3.
JOP20210253A1 (ar) 2019-04-05 2023-01-30 Teneobio Inc أجسام مضادة ذات سلسلة ثقيلة ترتبط بـ psma
AR118721A1 (es) * 2019-04-19 2021-10-27 Janssen Biotech Inc Métodos para tratar el cáncer renal con un anticuerpo anti-psma / cd3
MA55717A (fr) * 2019-04-19 2022-02-23 Janssen Biotech Inc Méthodes de traitement du cancer de la prostate avec un anticorps anti-psma/cd3
MX2021014007A (es) 2019-05-14 2022-01-24 Harpoon Therapeutics Inc Proteinas de union a epcam y metodos de uso.
CU20210096A7 (es) 2019-05-21 2022-06-06 Novartis Ag Moléculas de unión a cd19
AR119746A1 (es) 2019-06-14 2022-01-05 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
WO2021006199A1 (ja) 2019-07-05 2021-01-14 小野薬品工業株式会社 Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療
KR20220083667A (ko) * 2019-07-26 2022-06-20 익사카 프랑스 압타머 기반의 다중특이 치료제
US12441807B2 (en) 2019-09-18 2025-10-14 Lamkap Bio Alpha AG Bispecific antibodies against CEACAM5 and CD3
EP3831849A1 (en) 2019-12-02 2021-06-09 LamKap Bio beta AG Bispecific antibodies against ceacam5 and cd47
EP3842461A1 (en) 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
US20230151102A1 (en) 2020-01-13 2023-05-18 Aptevo Research And Development Llc Methods and compositions for preventing adsorption of therapeutic proteins to drug delivery system components
BR112022013725A2 (pt) 2020-01-13 2022-10-11 Aptevo Res & Development Llc Formulações para agentes terapêuticos proteicos
IL295448A (en) 2020-02-21 2022-10-01 Harpoon Therapeutics Inc flt3 binding proteins and methods of use
AU2021263448A1 (en) 2020-04-29 2022-11-24 Teneobio, Inc. Multispecific heavy chain antibodies with modified heavy chain constant regions
BR112022022800A2 (pt) 2020-05-11 2022-12-13 Janssen Biotech Inc Métodos para tratamento de mieloma múltiplo
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
AU2021329378A1 (en) 2020-08-19 2023-03-23 Xencor, Inc. Anti-CD28 compositions
WO2022060878A1 (en) 2020-09-16 2022-03-24 Amgen Inc. Methods for treating prostate cancer
JP2023542257A (ja) 2020-09-16 2023-10-05 アムジェン インコーポレイテッド 癌の治療のために二重特異性ｔ細胞誘導分子の治療用量を投与する方法
EP4228694A4 (en) * 2020-10-15 2024-12-18 Janux Therapeutics, Inc. ANTIBODIES DIRECTED AGAINST PSMA AND CD3 AND USES THEREOF
EP4240770A1 (en) * 2020-11-06 2023-09-13 Amgen Research (Munich) GmbH Polypeptide constructs selectively binding to cldn6 and cd3
US20240209078A1 (en) 2020-11-06 2024-06-27 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
MX2023006817A (es) 2020-12-09 2023-08-14 Janux Therapeutics Inc Composiciones y metodos relacionados con anticuerpos activados por tumores dirigidos a psma y antigenos de celulas efectoras.
IL305144A (en) 2021-02-16 2023-10-01 Janssen Pharmaceutica Nv Trispecific antibodies targeting BCMA, GPRC5D and CD3
IL305736A (en) 2021-03-09 2023-11-01 Xencor Inc Heterodimeric antibodies that bind cd3 and cldn6
KR20230154311A (ko) 2021-03-10 2023-11-07 젠코어 인코포레이티드 Cd3 및 gpc3에 결합하는 이종이량체 항체
EP4314070A1 (en) 2021-03-24 2024-02-07 Janssen Biotech, Inc. Trispecific antibody targeting cd79b, cd20, and cd3
EP4330281A1 (en) 2021-04-29 2024-03-06 Amgen Inc. Methods for reducing low molecular weight species of recombinantly-produced proteins
WO2022234102A1 (en) 2021-05-06 2022-11-10 Amgen Research (Munich) Gmbh Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
EP4341291A1 (en) 2021-05-21 2024-03-27 Aptevo Research and Development LLC Dosing regimens for protein therapeutics
CN115536740A (zh) * 2021-06-30 2022-12-30 苏州方德门达新药开发有限公司 介导细胞内有效滞留cd3的空间构象表位及其应用
JP7707822B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707835B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707836B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707823B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707830B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707828B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707824B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707829B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707821B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707827B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707820B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707834B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707833B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707831B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707832B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
JP7707825B2 (ja) * 2021-10-06 2025-07-15 株式会社三洋物産 遊技機
AU2022380722A1 (en) 2021-11-03 2024-06-20 Janssen Biotech, Inc. Methods of treating cancers and enhancing efficacy of bcmaxcd3 bispecific antibodies
EP4496814A1 (en) 2022-03-21 2025-01-29 Amgen Inc. Combination therapy methods with t-cell engaging molecules for treatment of prostate cancer
KR20250011917A (ko) 2022-05-12 2025-01-22 암젠 리서치 (뮌헨) 게엠베하 증가된 선택성의 다중쇄 다중표적화 이중특이적 항원 결합 분자
WO2025134050A1 (en) 2023-12-21 2025-06-26 Janssen Biotech, Inc Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of multiple myeloma
WO2025134049A1 (en) 2023-12-21 2025-06-26 Janssen Biotech, Inc Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of al amyloidosis

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1988009344A1 (en) 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Targeted multifunctional proteins
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
JP3626187B2 (ja) 1993-06-07 2005-03-02 バイカル インコーポレイテッド 遺伝子治療に適するプラスミド
EP0833907A1 (en) 1995-06-23 1998-04-08 President And Fellows Of Harvard College Transcriptional regulation of genes encoding vascular endothelial growth factor receptors
SI1071752T1 (en) 1998-04-21 2003-12-31 Micromet Ag CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
SE524615C2 (sv) 1999-06-30 2004-09-07 Volvo Personvagnar Ab Arrangemang för minskning av galvanisk korrosion mellan metallkomponenter
ES2277846T3 (es) * 1999-07-29 2007-08-01 Medarex, Inc. Anticuerpos monoclonales humanos para antigeno prostatico especifico.
JP4386776B2 (ja) * 2000-05-18 2009-12-16 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
AU2003224604B2 (en) * 2002-01-28 2007-06-14 Medarex, Inc. Human monoclonal antibodies to prostate specific membrane antigen (PSMA)
WO2004069876A2 (en) 2003-02-06 2004-08-19 Micromet Ag Trimeric polypeptide construct to induce an enduring t cell response
CN100509850C (zh) * 2003-05-31 2009-07-08 麦克罗梅特股份公司 用于治疗b细胞相关疾病的包含双特异性抗cd3、抗cd19抗体构建体的药物组合物
EP1629011B1 (en) 2003-05-31 2010-01-13 Micromet AG Human anti-human cd3 binding molecules
BRPI0415457A (pt) 2003-10-16 2006-12-05 Micromet Ag constructo de ligação especìfico de cd3 citotoxicamente ativo, seu processo de produção, composição compreendendo o mesmo, seqüência de ácido nucléico, vetor, hospedeiro, seus usos na preparação de uma composição farmacêutica e kit compreendendo os mesmo
US7235641B2 (en) * 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
CA2555503C (en) 2004-02-16 2018-03-27 Micromet Ag Humanized anti-cd3 bispecific binding molecules having reduced immunogenicity, uses and compositions relating thereto
SG155883A1 (en) 2004-06-03 2009-10-29 Novimmune Sa Anti-cd3 antibodies and methods of use thereof
MX2007000387A (es) * 2004-07-16 2007-03-28 Micromet Ag Polipeptidos de expresion mejorada.
JP2006040495A (ja) 2004-07-30 2006-02-09 Renesas Technology Corp 半導体集積回路装置
NO20064183L (no) 2005-02-16 2006-11-08 Micromet Ag Mindre immunogene bindingsmolekyler
KR20070115967A (ko) * 2005-02-18 2007-12-06 메다렉스, 인코포레이티드 전립선 특이 막 항원(ｐｓｍａ)에 대한 인간 모노클로날항체
EP1726650A1 (en) * 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
BRPI0615745A2 (pt) 2005-09-12 2011-05-24 Novimmune Sa formulação de anticorpo anti-cd3
EP1940881B1 (en) * 2005-10-11 2016-11-30 Amgen Research (Munich) GmbH Compositions comprising cross-species-specific antibodies and uses thereof
HUE040467T2 (hu) * 2007-04-03 2019-03-28 Amgen Res Munich Gmbh Keresztfaj-specifikus kötõdomén
PL2155788T3 (pl) * 2007-04-03 2013-02-28 Amgen Res Munich Gmbh Swoiste międzygatunkowe bispecyficzne czynniki wiążące
EP2155783B2 (en) * 2007-04-03 2022-10-19 Amgen Research (Munich) GmbH Cross-species-specific cd3-epsilon binding domain
JP4970211B2 (ja) * 2007-10-18 2012-07-04 ヘキサゴン・メトロジー株式会社 ３次元形状測定器
CA2738566C (en) 2008-10-01 2024-04-30 Micromet Ag Bispecific single chain antibodies with specificity for high molecular weight target antigens
JP6126782B2 (ja) * 2008-10-01 2017-05-10 アムゲン リサーチ （ミュンヘン） ゲーエムベーハー 異種間特異的ｐｓｍａ×ｃｄ３二重特異性単鎖抗体
TWI653333B (zh) * 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
IL260920B (en) 2016-02-03 2022-09-01 Amgen Res Munich Gmbh Constructs of psma and cd3 bispecific antigens that bind to t-cells, preparations containing them and uses thereof

Also Published As

Publication number Publication date
CY1118303T1 (el) 2017-06-28
RU2559531C2 (ru) 2015-08-10
CN102171248B (zh) 2015-07-15
US20110293619A1 (en) 2011-12-01
MX2011003502A (es) 2011-09-01
JP2012504403A (ja) 2012-02-23
PT2356153T (pt) 2016-07-15
US20190169310A1 (en) 2019-06-06
HUE030090T2 (en) 2017-04-28
CN102171248A (zh) 2011-08-31
IL212099A (en) 2016-02-29
SMT201600256B (it) 2016-08-31
ES2588155T3 (es) 2016-10-31
RS54900B1 (sr) 2016-10-31
HRP20160684T1 (hr) 2016-07-15
JP2021164459A (ja) 2021-10-14
WO2010037836A9 (en) 2011-05-05
AU2009299792A1 (en) 2010-04-08
WO2010037836A3 (en) 2010-07-22
IL212099A0 (en) 2011-06-30
JP6643822B2 (ja) 2020-02-12
CA2738565C (en) 2023-10-10
US12281172B2 (en) 2025-04-22
EP3106468A1 (en) 2016-12-21
PL2356153T3 (pl) 2016-11-30
EP4180458A1 (en) 2023-05-17
AU2009299792B2 (en) 2015-07-16
CA2738565A1 (en) 2010-04-08
ZA201101067B (en) 2013-03-27
EP2356153A2 (en) 2011-08-17
HK1158669A1 (zh) 2012-07-20
US11472886B2 (en) 2022-10-18
BRPI0919841A2 (pt) 2014-11-18
SI2356153T1 (sl) 2016-07-29
SG194398A1 (en) 2013-11-29
DK2356153T3 (en) 2016-07-04
KR20110066195A (ko) 2011-06-16
US20230037742A1 (en) 2023-02-09
RU2011108687A (ru) 2012-11-10
NZ591134A (en) 2012-08-31
EP2356153B1 (en) 2016-05-04
JP2016000736A (ja) 2016-01-07
WO2010037836A2 (en) 2010-04-08
JP2018198595A (ja) 2018-12-20
US20250163179A1 (en) 2025-05-22
US20210269550A1 (en) 2021-09-02
JP6126782B2 (ja) 2017-05-10
US20210277143A1 (en) 2021-09-09
JP7273106B2 (ja) 2023-05-12
KR101820535B1 (ko) 2018-01-19

Similar Documents

Publication Publication Date Title
ME02485B (me) Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću
JP2012504403A5 (me)
HRP20120759T1 (hr) Bispecifična veziva specifična između vrsta
HRP20130883T4 (hr) Međuvrsno specifična cd3-epsilon-vežuća domena
FI2155783T4 (fi) Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni
JP6409034B2 (ja) 多重特異性多価抗体の生成方法
JP2010535012A5 (me)
HRP20160857T1 (hr) Bispecifična jednolančana protutijela, specifična za visokomolekulske ciljne antigene
SI9720020B (en) Human antibodies that bind human TNF alpha
JP2005518336A5 (me)
CA2420231A1 (en) Antibodies to human il-1.beta.
JP2010524435A5 (me)
RU2011116927A (ru) Антитела против интерлейкина 17 (ил-17) человека и их применение
JP2007526880A5 (me)
CA2401342A1 (en) Human antibodies against eotaxin and their use
HRP20231410T1 (hr) Konstrukti bispecifičnih antitijela koji vežu mezotelin i cd3
SI2753646T1 (en) Anti-CD40 antibodies, uses and methods
HRP20191983T1 (hr) Konstrukti protutijela za cdh19 i cd3
KR20130010123A (ko) ＴＮＦ-α 결합 단백질
NZ591087A (en) Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody
RU2009124591A (ru) Соединения
HRP20110187T1 (hr) Multispecifične deimunizirane tvari koje vežu cd3
CN108164600B (zh) 一种抗gpc3抗体及其制备方法和用途
MY137078A (en) Recombinant antibodies associated to gangliosides. their use indiagnosis and treatment of tumors.
JP2021509012A5 (me)