JP5148028B2 - 二本鎖ｒｎａによる遺伝子阻害 - Google Patents

二本鎖ｒｎａによる遺伝子阻害 Download PDF

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JP5148028B2
JP5148028B2 JP2000525538A JP2000525538A JP5148028B2 JP 5148028 B2 JP5148028 B2 JP 5148028B2 JP 2000525538 A JP2000525538 A JP 2000525538A JP 2000525538 A JP2000525538 A JP 2000525538A JP 5148028 B2 JP5148028 B2 JP 5148028B2
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rna
target gene
cell
gene
organism
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JP2002516062A (ja
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ファイア、アンドリュー
スー、シクン
モントゴメリー、メアリー、ケイ
コスタス、スチーブン、エイ
ティモンズ、ライザ
タバラ、ヒロアキ
ドライバー、サミュエル、イー
メルロ、クレイグ、シー
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ザ カーネギー インスチチューション オブ ワシントン
ザ ユニバーシティー オブ マサチューセッツ
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Wood Science & Technology (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
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  • Microbiology (AREA)
  • Plant Pathology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
JP2000525538A 1997-12-23 1998-12-21 二本鎖ｒｎａによる遺伝子阻害 Expired - Lifetime JP5148028B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6856297P 1997-12-23 1997-12-23
US60/068,562 1997-12-23
US09/215,257 1998-12-18
US09/215,257 US6506559B1 (en) 1997-12-23 1998-12-18 Genetic inhibition by double-stranded RNA
PCT/US1998/027233 WO1999032619A1 (en) 1997-12-23 1998-12-21 Genetic inhibition by double-stranded rna

Related Child Applications (1)

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JP2009205958A Division JP2009291209A (ja) 1997-12-23 2009-09-07 二本鎖ｒｎａによる遺伝子阻害

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JP2002516062A JP2002516062A (ja) 2002-06-04
JP5148028B2 true JP5148028B2 (ja) 2013-02-20

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JP2000525538A Expired - Lifetime JP5148028B2 (ja) 1997-12-23 1998-12-21 二本鎖ｒｎａによる遺伝子阻害
JP2009205958A Pending JP2009291209A (ja) 1997-12-23 2009-09-07 二本鎖ｒｎａによる遺伝子阻害
JP2012229547A Expired - Lifetime JP5969889B2 (ja) 1997-12-23 2012-10-17 二本鎖ｒｎａによる遺伝子阻害
JP2015095160A Pending JP2015133993A (ja) 1997-12-23 2015-05-07 二本鎖ｒｎａによる遺伝子阻害

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JP2009205958A Pending JP2009291209A (ja) 1997-12-23 2009-09-07 二本鎖ｒｎａによる遺伝子阻害
JP2012229547A Expired - Lifetime JP5969889B2 (ja) 1997-12-23 2012-10-17 二本鎖ｒｎａによる遺伝子阻害
JP2015095160A Pending JP2015133993A (ja) 1997-12-23 2015-05-07 二本鎖ｒｎａによる遺伝子阻害

Country Status (6)

Country Link
US (11) US6506559B1 (https=)
EP (2) EP1042462A1 (https=)
JP (4) JP5148028B2 (https=)
AU (1) AU743798C (https=)
CA (1) CA2311999C (https=)
WO (1) WO1999032619A1 (https=)

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US20030051263A1 (en) 2003-03-13
US20160208280A1 (en) 2016-07-21
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US7560438B2 (en) 2009-07-14
US7538095B2 (en) 2009-05-26
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US8283329B2 (en) 2012-10-09
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