CN1100046C - 喹唑啉衍生物 - Google Patents

喹唑啉衍生物 Download PDF

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Publication number
CN1100046C
CN1100046C CN96193526A CN96193526A CN1100046C CN 1100046 C CN1100046 C CN 1100046C CN 96193526 A CN96193526 A CN 96193526A CN 96193526 A CN96193526 A CN 96193526A CN 1100046 C CN1100046 C CN 1100046C
Authority
CN
China
Prior art keywords
formula
chloro
quinazoline
fluoroanilino
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96193526A
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English (en)
Chinese (zh)
Other versions
CN1182421A (zh
Inventor
K·H·吉布森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10773597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1100046(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of CN1182421A publication Critical patent/CN1182421A/zh
Application granted granted Critical
Publication of CN1100046C publication Critical patent/CN1100046C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96193526A 1995-04-27 1996-04-23 喹唑啉衍生物 Expired - Lifetime CN1100046C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9508538.7A GB9508538D0 (en) 1995-04-27 1995-04-27 Quinazoline derivatives
GB9508538.7 1995-04-27

Publications (2)

Publication Number Publication Date
CN1182421A CN1182421A (zh) 1998-05-20
CN1100046C true CN1100046C (zh) 2003-01-29

Family

ID=10773597

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96193526A Expired - Lifetime CN1100046C (zh) 1995-04-27 1996-04-23 喹唑啉衍生物

Country Status (38)

Country Link
US (1) US5770599A (enExample)
EP (1) EP0823900B1 (enExample)
JP (1) JP3040486B2 (enExample)
KR (1) KR100296656B1 (enExample)
CN (1) CN1100046C (enExample)
AR (1) AR003944A1 (enExample)
AT (1) ATE198329T1 (enExample)
AU (1) AU699163B2 (enExample)
BG (1) BG62730B1 (enExample)
BR (1) BRPI9608082B8 (enExample)
CA (1) CA2215732C (enExample)
CZ (1) CZ288489B6 (enExample)
DE (2) DE122009000076I1 (enExample)
DK (1) DK0823900T3 (enExample)
EE (1) EE03482B1 (enExample)
EG (1) EG24134A (enExample)
ES (1) ES2153098T3 (enExample)
FR (1) FR09C0065I2 (enExample)
GB (1) GB9508538D0 (enExample)
GR (1) GR3035211T3 (enExample)
HR (1) HRP960204B1 (enExample)
HU (1) HU223313B1 (enExample)
IL (1) IL118045A (enExample)
LU (1) LU91631I2 (enExample)
MY (1) MY114425A (enExample)
NL (1) NL300429I1 (enExample)
NO (2) NO309472B1 (enExample)
NZ (1) NZ305444A (enExample)
PL (1) PL189182B1 (enExample)
PT (1) PT823900E (enExample)
RO (1) RO117849B1 (enExample)
RU (1) RU2153495C2 (enExample)
SI (1) SI0823900T1 (enExample)
SK (1) SK282236B6 (enExample)
TW (1) TW436486B (enExample)
UA (1) UA52602C2 (enExample)
WO (1) WO1996033980A1 (enExample)
ZA (1) ZA963358B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007082434A1 (en) * 2006-01-20 2007-07-26 Shanghai Allist Pharmaceutical., Inc. Quinazoline derivatives,preparation methods and uses thereof
CN112321814A (zh) * 2020-12-30 2021-02-05 广州初曲科技有限公司 一种吉非替尼艾地苯醌轭合物的制备及用途

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