CN1182421A - 喹唑啉衍生物 - Google Patents
喹唑啉衍生物 Download PDFInfo
- Publication number
- CN1182421A CN1182421A CN96193526A CN96193526A CN1182421A CN 1182421 A CN1182421 A CN 1182421A CN 96193526 A CN96193526 A CN 96193526A CN 96193526 A CN96193526 A CN 96193526A CN 1182421 A CN1182421 A CN 1182421A
- Authority
- CN
- China
- Prior art keywords
- propoxy
- quinazoline
- group
- formula
- alkoxyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9508538.7 | 1995-04-27 | ||
GBGB9508538.7A GB9508538D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1182421A true CN1182421A (zh) | 1998-05-20 |
CN1100046C CN1100046C (zh) | 2003-01-29 |
Family
ID=10773597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96193526A Expired - Lifetime CN1100046C (zh) | 1995-04-27 | 1996-04-23 | 喹唑啉衍生物 |
Country Status (39)
Country | Link |
---|---|
US (1) | US5770599A (zh) |
EP (1) | EP0823900B1 (zh) |
JP (1) | JP3040486B2 (zh) |
KR (1) | KR100296656B1 (zh) |
CN (1) | CN1100046C (zh) |
AR (1) | AR003944A1 (zh) |
AT (1) | ATE198329T1 (zh) |
AU (1) | AU699163B2 (zh) |
BG (1) | BG62730B1 (zh) |
BR (1) | BRPI9608082B8 (zh) |
CA (1) | CA2215732C (zh) |
CZ (1) | CZ288489B6 (zh) |
DE (2) | DE69611361T2 (zh) |
DK (1) | DK0823900T3 (zh) |
EE (1) | EE03482B1 (zh) |
EG (1) | EG24134A (zh) |
ES (1) | ES2153098T3 (zh) |
FR (1) | FR09C0065I2 (zh) |
GB (1) | GB9508538D0 (zh) |
GR (1) | GR3035211T3 (zh) |
HK (1) | HK1005371A1 (zh) |
HR (1) | HRP960204B1 (zh) |
HU (1) | HU223313B1 (zh) |
IL (1) | IL118045A (zh) |
LU (1) | LU91631I2 (zh) |
MY (1) | MY114425A (zh) |
NL (1) | NL300429I1 (zh) |
NO (2) | NO309472B1 (zh) |
NZ (1) | NZ305444A (zh) |
PL (1) | PL189182B1 (zh) |
PT (1) | PT823900E (zh) |
RO (1) | RO117849B1 (zh) |
RU (1) | RU2153495C2 (zh) |
SI (1) | SI0823900T1 (zh) |
SK (1) | SK282236B6 (zh) |
TW (1) | TW436486B (zh) |
UA (1) | UA52602C2 (zh) |
WO (1) | WO1996033980A1 (zh) |
ZA (1) | ZA963358B (zh) |
Cited By (32)
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CN1300118C (zh) * | 2005-08-25 | 2007-02-14 | 江苏吴中苏药医药开发有限责任公司 | 4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉的制备方法 |
CN100352441C (zh) * | 2002-04-16 | 2007-12-05 | 阿斯特拉曾尼卡有限公司 | 用于治疗肿瘤的zd6126和zd1839的联合药物 |
CN100404032C (zh) * | 2002-02-26 | 2008-07-23 | 阿斯特拉曾尼卡有限公司 | 新型晶形抗癌化合物zd1839 |
CN100429204C (zh) * | 2002-09-13 | 2008-10-29 | 阿斯利康(瑞典)有限公司 | 制备4-(3′-氯-4′-氟苯胺基)-7-甲氧基-6-(3-吗啉代丙氧基)喹唑啉的方法 |
WO2010037339A1 (zh) * | 2008-09-26 | 2010-04-08 | 中国科学院广州生物医药与健康研究院 | 一种具有抗肿瘤活性的氨基喹唑啉衍生物及其盐类 |
CN101177415B (zh) * | 2002-02-26 | 2011-01-05 | 阿斯特拉曾尼卡有限公司 | 抗癌化合物zd1839的新晶形的制备方法 |
CN101103005B (zh) * | 2006-01-20 | 2011-05-04 | 江苏艾力斯生物医药有限公司 | 喹唑啉衍生物、其制备方法及用途 |
CN1972688B (zh) * | 2004-05-06 | 2012-06-27 | 沃尼尔·朗伯有限责任公司 | 4-苯胺基-喹唑啉-6-基-酰胺类化合物 |
CN101072781B (zh) * | 2004-12-08 | 2012-07-18 | 詹森药业有限公司 | 大环喹唑啉衍生物及其作为mtki的用途 |
CN103012290A (zh) * | 2011-09-28 | 2013-04-03 | 齐鲁制药有限公司 | 一种高纯度吉非替尼的制备方法 |
CN103102345A (zh) * | 2011-11-14 | 2013-05-15 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
CN103102342A (zh) * | 2011-11-14 | 2013-05-15 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
CN103130729A (zh) * | 2011-12-05 | 2013-06-05 | 齐鲁制药有限公司 | 一种4-氯代-7-甲氧基喹唑啉-6-醇乙酸酯的制备方法 |
CN103172576A (zh) * | 2011-12-21 | 2013-06-26 | 沈阳药科大学 | 吉非替尼的苹果酸加成盐及其制备和应用 |
US8507010B2 (en) | 2008-05-21 | 2013-08-13 | Shanghai Allist Pharmaceuticals, Inc. | Compositions comprising quinazoline derivatives |
CN103304491A (zh) * | 2013-06-17 | 2013-09-18 | 连云港盛和生物科技有限公司 | 一种吉非替尼的制备方法 |
CN103910690A (zh) * | 2013-01-06 | 2014-07-09 | 上海科胜药物研发有限公司 | 一种吉非替尼新晶型及其制备方法 |
CN104513253A (zh) * | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
US9090588B2 (en) | 2011-03-04 | 2015-07-28 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
US9187459B2 (en) | 2011-05-17 | 2015-11-17 | Newgen Therapeutics, Inc. | Quinazoline-7-ether compounds and methods of use |
CN105250228A (zh) * | 2015-10-12 | 2016-01-20 | 山东罗欣药业集团股份有限公司 | 一种吉非替尼的片剂及其原料的制备方法 |
CN102718775B (zh) * | 2003-05-27 | 2016-02-17 | 詹森药业有限公司 | 作为抗增殖剂的大环喹唑啉衍生物 |
CN105503746A (zh) * | 2014-09-05 | 2016-04-20 | 财团法人交大思源基金会 | 用于促进癌细胞凋亡的化合物、其医药组合物及其用途 |
CN105503748A (zh) * | 2015-12-31 | 2016-04-20 | 哈药集团技术中心 | 一种吉非替尼的制备方法 |
CN106045980A (zh) * | 2016-06-03 | 2016-10-26 | 江苏开放大学 | 一种喹唑啉衍生物及其制备方法 |
CN106432202A (zh) * | 2016-09-22 | 2017-02-22 | 郑州大学第附属医院 | 喹唑啉类衍生物及其应用 |
CN108395410A (zh) * | 2018-05-09 | 2018-08-14 | 日照市普达医药科技有限公司 | 一种苯胺喹唑啉化合物及其在抗肿瘤药物中的应用 |
CN109721552A (zh) * | 2017-10-30 | 2019-05-07 | 上海北卡医药技术有限公司 | 一种吉非替尼的制备方法 |
CN112533602A (zh) * | 2018-04-05 | 2021-03-19 | 大日本住友制药肿瘤公司 | Axl激酶抑制剂及其用途 |
CN113527266A (zh) * | 2021-06-23 | 2021-10-22 | 上海健康医学院 | 一种靶向fap的双氧水响应的前药及其制备方法与应用 |
CN113801068A (zh) * | 2020-06-15 | 2021-12-17 | 鲁南制药集团股份有限公司 | 一种吉非替尼的有机酸盐 |
CN113845485A (zh) * | 2021-10-22 | 2021-12-28 | 湖南中医药大学 | 氨基酸衍生物及其制备方法和应用 |
Families Citing this family (674)
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US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
TW321649B (zh) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
DE69613367T2 (de) * | 1995-04-27 | 2002-04-18 | Astrazeneca Ab | Chinazolin derivate |
GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
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UA61970C2 (en) † | 1997-08-15 | 2003-12-15 | Combined use of tyrosine kinase inhibitor and a chemical castration agent for treating prostate cancer | |
DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
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US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
CN1144786C (zh) | 1998-09-29 | 2004-04-07 | 美国氰胺公司 | 作为蛋白质酪氨酸激酶抑制剂的取代的3-氰基喹啉 |
US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
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