ATE520979T1 - Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors - Google Patents
Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptorsInfo
- Publication number
- ATE520979T1 ATE520979T1 AT06813702T AT06813702T ATE520979T1 AT E520979 T1 ATE520979 T1 AT E520979T1 AT 06813702 T AT06813702 T AT 06813702T AT 06813702 T AT06813702 T AT 06813702T AT E520979 T1 ATE520979 T1 AT E520979T1
- Authority
- AT
- Austria
- Prior art keywords
- biomarrkers
- egf
- modulators
- receptor
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71105405P | 2005-08-24 | 2005-08-24 | |
PCT/US2006/033073 WO2007025044A2 (en) | 2005-08-24 | 2006-08-24 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE520979T1 true ATE520979T1 (de) | 2011-09-15 |
Family
ID=37772388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06813702T ATE520979T1 (de) | 2005-08-24 | 2006-08-24 | Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors |
Country Status (7)
Country | Link |
---|---|
US (2) | US8129114B2 (de) |
EP (1) | EP1917528B1 (de) |
JP (1) | JP2009505658A (de) |
AT (1) | ATE520979T1 (de) |
CA (1) | CA2620195A1 (de) |
ES (1) | ES2370054T3 (de) |
WO (1) | WO2007025044A2 (de) |
Families Citing this family (29)
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JP4606879B2 (ja) | 2002-11-15 | 2011-01-05 | ジェノミック ヘルス, インコーポレイテッド | Egfr陽性癌の遺伝子発現プロファイリング |
WO2005070020A2 (en) | 2004-01-23 | 2005-08-04 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
EP2527460B1 (de) | 2004-05-27 | 2014-12-24 | The Regents of The University of Colorado | Verfahren zur Vorhersage der klinischen Resultate in Bezug auf epidermale Wachstumsfaktor-Rezeptorhemmer von Krebspatienten |
AU2016250348A1 (en) * | 2007-03-13 | 2016-11-10 | Amgen Inc. | K-ras mutations and anti-EGFr antibody therapy field |
AR065687A1 (es) * | 2007-03-13 | 2009-06-24 | Amgen Inc | Metodo para determinar la presencia o no de una mutacion k-ras y terapia con anticuerpos anti-egfr |
FI20070795A0 (fi) * | 2007-10-24 | 2007-10-24 | Faron Pharmaceuticals Oy | Uusi biomarkkeri sairauksien kehittämisen tarkkailuun ja terapioiden tehon arviointiin |
US8975081B2 (en) | 2007-10-24 | 2015-03-10 | Faron Pharmaceuticals Oy | Biomarker for monitoring development of diseases and assessing the efficacy of therapies |
EP2227558A1 (de) * | 2007-11-30 | 2010-09-15 | GlaxoSmithKline Biologicals SA | Verfahren zur klassifizierung von krebspatienten als auf eine immuntherapie ansprechend bzw. nicht ansprechend |
WO2009140409A1 (en) * | 2008-05-14 | 2009-11-19 | Genomic Health Inc. | Predictors of patient response to treatment with egf receptor inhibitors |
WO2010065626A1 (en) * | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
WO2010080804A1 (en) * | 2009-01-06 | 2010-07-15 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
US8765383B2 (en) | 2009-04-07 | 2014-07-01 | Genomic Health, Inc. | Methods of predicting cancer risk using gene expression in premalignant tissue |
MX2011013578A (es) * | 2009-06-19 | 2012-01-20 | Merck Patent Gmbh | Biomarcadores y metodos para determinar la eficacia de anticuerpos anti-receptor del factor de crecimiento epidermal (anti-egfr) en terapia de cancer. |
CA2771369A1 (en) * | 2009-08-24 | 2011-03-10 | Genentech, Inc. | Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels |
EP2507628A4 (de) * | 2009-12-01 | 2013-04-24 | Medimmune Llc | Verbesserte verfahren und zusammensetzungen für den nachweis und die behandlung von cea-exprimierenden tumoren |
EP2558595A2 (de) * | 2010-04-12 | 2013-02-20 | Response Genetics, Inc | Kras-primer und -sonden |
CN104427984A (zh) | 2012-01-20 | 2015-03-18 | D·布朗 | 包括二脱水半乳糖醇和类似物的经取代的己糖醇类于治疗包括多形性胶质母细胞瘤和成神经管细胞瘤的肿瘤疾病和癌症干细胞的用途 |
EP2823307A4 (de) * | 2012-03-08 | 2015-07-29 | Bioscale Inc | Verfahren und kits zur analyse von biomarkern in einem signaltransduktionsweg |
WO2014063206A1 (en) * | 2012-10-26 | 2014-05-01 | The University Of Queensland | Methods for classifying tumors and uses therefor |
WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
EP2891884B1 (de) | 2014-01-07 | 2017-10-25 | Samsung Electronics Co., Ltd | IL-8 zur Prognose oder Überwachung der Effizienz von c-Met-Hemmern |
US20150254433A1 (en) * | 2014-03-05 | 2015-09-10 | Bruce MACHER | Methods and Models for Determining Likelihood of Cancer Drug Treatment Success Utilizing Predictor Biomarkers, and Methods of Diagnosing and Treating Cancer Using the Biomarkers |
US9753036B2 (en) | 2014-04-29 | 2017-09-05 | Edp Biotech Corporation | Methods and compositions for screening and detecting biomarkers |
US20160024585A1 (en) * | 2014-05-02 | 2016-01-28 | Duke University | Methods of predicting responsiveness of a cancer to an agent and methods of determining a prognosis for a cancer patient |
KR20160037666A (ko) | 2014-09-29 | 2016-04-06 | 삼성전자주식회사 | KRAS 또는 BRAF의 변이를 이용한 c-Met 저해제의 효능 예측 |
EP3073268A1 (de) * | 2015-03-27 | 2016-09-28 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Biomarker-tafel zur diagnose von krebs |
WO2017062867A1 (en) * | 2015-10-09 | 2017-04-13 | Helmy Eltoukhy | Population based treatment recommender using cell free dna |
WO2018078143A1 (en) | 2016-10-28 | 2018-05-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy |
CN109457052A (zh) * | 2018-12-18 | 2019-03-12 | 苏州德思普生物科技有限公司 | 检测人类免疫缺陷病毒核酸的引物、探针、试剂盒及检测方法 |
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EP1766068A4 (de) * | 2004-06-04 | 2010-03-03 | Genentech Inc | Egfr-mutationen |
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JP2008546421A (ja) * | 2005-06-28 | 2008-12-25 | ジェネンテック・インコーポレーテッド | Egfrおよびkras変異 |
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ES2426814T3 (es) | 2007-03-13 | 2013-10-25 | Amgen Inc. | Mutaciones de K-ras y B-raf y terapia con anticuerpos anti-EGFr |
AR065687A1 (es) | 2007-03-13 | 2009-06-24 | Amgen Inc | Metodo para determinar la presencia o no de una mutacion k-ras y terapia con anticuerpos anti-egfr |
-
2006
- 2006-08-24 US US11/990,713 patent/US8129114B2/en active Active
- 2006-08-24 JP JP2008528150A patent/JP2009505658A/ja not_active Withdrawn
- 2006-08-24 AT AT06813702T patent/ATE520979T1/de not_active IP Right Cessation
- 2006-08-24 EP EP06813702A patent/EP1917528B1/de active Active
- 2006-08-24 ES ES06813702T patent/ES2370054T3/es active Active
- 2006-08-24 CA CA002620195A patent/CA2620195A1/en not_active Abandoned
- 2006-08-24 WO PCT/US2006/033073 patent/WO2007025044A2/en active Application Filing
-
2012
- 2012-02-14 US US13/372,824 patent/US20120195889A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8129114B2 (en) | 2012-03-06 |
WO2007025044A2 (en) | 2007-03-01 |
EP1917528B1 (de) | 2011-08-17 |
WO2007025044A3 (en) | 2007-09-20 |
EP1917528A2 (de) | 2008-05-07 |
US20100221754A1 (en) | 2010-09-02 |
EP1917528A4 (de) | 2009-03-11 |
ES2370054T3 (es) | 2011-12-12 |
CA2620195A1 (en) | 2007-03-01 |
JP2009505658A (ja) | 2009-02-12 |
US20120195889A1 (en) | 2012-08-02 |
WO2007025044A8 (en) | 2007-07-05 |
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