ATE182148T1 - Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden - Google Patents

Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Info

Publication number
ATE182148T1
ATE182148T1 AT96913989T AT96913989T ATE182148T1 AT E182148 T1 ATE182148 T1 AT E182148T1 AT 96913989 T AT96913989 T AT 96913989T AT 96913989 T AT96913989 T AT 96913989T AT E182148 T1 ATE182148 T1 AT E182148T1
Authority
AT
Austria
Prior art keywords
new
crf1
specific ligands
deazapurine derivatives
class
Prior art date
Application number
AT96913989T
Other languages
English (en)
Inventor
Jun Yuan
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/439,874 external-priority patent/US5644057A/en
Priority claimed from US08/476,689 external-priority patent/US5804685A/en
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ATE182148T1 publication Critical patent/ATE182148T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96913989T 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden ATE182148T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/439,874 US5644057A (en) 1995-05-12 1995-05-12 Deazapurine derivatives; a new class of CRF1 specific ligands
US08/476,689 US5804685A (en) 1995-06-07 1995-06-07 Deazapurine derivatives: a new class of CRF1 specific ligands

Publications (1)

Publication Number Publication Date
ATE182148T1 true ATE182148T1 (de) 1999-07-15

Family

ID=27032200

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96913989T ATE182148T1 (de) 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Country Status (9)

Country Link
US (3) US6020492A (de)
EP (1) EP0770080B1 (de)
JP (1) JPH10506126A (de)
KR (1) KR100256707B1 (de)
AT (1) ATE182148T1 (de)
AU (1) AU716993B2 (de)
CA (1) CA2194756A1 (de)
DE (1) DE69603240T2 (de)
WO (1) WO1996035689A1 (de)

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US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
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US6107300A (en) * 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
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US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
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CN1542010A (zh) * 1998-01-28 2004-11-03 �Ű�ҩƷ��˾ 吡咯并三嗪和嘧啶化合物
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
AU3375999A (en) 1998-04-02 1999-10-25 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino(2,3-b)indole and 5,6,7,8-tetrahydro-9h-pyrimidino(4,5-b)indole derivatives: crf1 specific ligands
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US6147085A (en) * 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
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US6221875B1 (en) 1998-04-02 2001-04-24 Neurogen Corporation Substituted 9H-pyridino [2,3-B]indole and 9H-pyrimidino [4,5-B]indole derivatives: selective neuropeptide Y receptor ligands
WO1999064422A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Pyrido[2,3-b]indolizine derivatives and aza analogues thereof; crf1 specific ligands
WO2000027850A2 (en) 1998-11-12 2000-05-18 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
PT1129091E (pt) 1998-11-12 2003-02-28 Neurocrine Biosciences Inc Antagonistas de receptor de crf e metodos relacionados
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CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
EA200200424A1 (ru) 1999-09-30 2002-12-26 Ньюроджен Корпорейшн Некоторые гетероциклы, замещенные алкилендиамином
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
TW200403243A (en) 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
ATE374766T1 (de) 2003-01-14 2007-10-15 Arena Pharm Inc 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
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TW200519116A (en) * 2003-08-26 2005-06-16 Teijin Pharma Ltd Pyrrolopyrimidine derivatives
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
EP1680424A2 (de) * 2003-09-05 2006-07-19 Neurogen Corporation Heteroarylkondensierte pyridine, pyrazine und pyrimidine als crf1-rezeptorliganden
CA2812061A1 (en) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
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KR102061743B1 (ko) 2011-03-04 2020-01-03 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR101420097B1 (ko) * 2011-12-28 2014-07-17 주식회사 두산 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자
EP2913333A1 (de) 2014-02-27 2015-09-02 Laboratoire Biodim 3H-Thieno[3,4]pyrimidin-4-on und Pyrrolopyrimidon-Verbindungen als Gram-Positive Antibakteria
CN107405332A (zh) 2015-01-06 2017-11-28 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
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EP3510029A4 (de) 2016-09-07 2020-03-11 The Regents of The University of California Allosterische corticotropin-freisetzende faktor-1 (crfr1)-antagonisten zur verminderung von p-tau und zur verbesserung der kognition

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Also Published As

Publication number Publication date
DE69603240D1 (de) 1999-08-19
WO1996035689A1 (en) 1996-11-14
US6281220B1 (en) 2001-08-28
AU5679096A (en) 1996-11-29
CA2194756A1 (en) 1996-11-14
US20020065290A1 (en) 2002-05-30
US6495688B2 (en) 2002-12-17
EP0770080A1 (de) 1997-05-02
JPH10506126A (ja) 1998-06-16
DE69603240T2 (de) 2000-01-05
KR100256707B1 (ko) 2000-05-15
AU716993B2 (en) 2000-03-16
US6020492A (en) 2000-02-01
EP0770080B1 (de) 1999-07-14

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