ATE182148T1 - Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden - Google Patents
Neue deazapurinderivate; eine neue klasse von crf1-spezifischen ligandenInfo
- Publication number
- ATE182148T1 ATE182148T1 AT96913989T AT96913989T ATE182148T1 AT E182148 T1 ATE182148 T1 AT E182148T1 AT 96913989 T AT96913989 T AT 96913989T AT 96913989 T AT96913989 T AT 96913989T AT E182148 T1 ATE182148 T1 AT E182148T1
- Authority
- AT
- Austria
- Prior art keywords
- new
- crf1
- specific ligands
- deazapurine derivatives
- class
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/439,874 US5644057A (en) | 1995-05-12 | 1995-05-12 | Deazapurine derivatives; a new class of CRF1 specific ligands |
US08/476,689 US5804685A (en) | 1995-06-07 | 1995-06-07 | Deazapurine derivatives: a new class of CRF1 specific ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE182148T1 true ATE182148T1 (de) | 1999-07-15 |
Family
ID=27032200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96913989T ATE182148T1 (de) | 1995-05-12 | 1996-05-09 | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
Country Status (9)
Country | Link |
---|---|
US (3) | US6020492A (de) |
EP (1) | EP0770080B1 (de) |
JP (1) | JPH10506126A (de) |
KR (1) | KR100256707B1 (de) |
AT (1) | ATE182148T1 (de) |
AU (1) | AU716993B2 (de) |
CA (1) | CA2194756A1 (de) |
DE (1) | DE69603240T2 (de) |
WO (1) | WO1996035689A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW321649B (de) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
WO1996033977A1 (en) * | 1995-04-27 | 1996-10-31 | Zeneca Limited | Quinazoline derivatives |
GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
JPH10506126A (ja) * | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体;crf1特異性リガンドの新規なクラス |
AU738304B2 (en) | 1995-10-13 | 2001-09-13 | Neurogen Corporation | Certain pyrrolopyridine derivatives; novel CRF 1 specific ligands |
US5955613A (en) * | 1995-10-13 | 1999-09-21 | Neurogen Corporation | Certain pyrrolopyridine derivatives; novel CRF1 specific ligands |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
ATE208395T1 (de) * | 1996-02-07 | 2001-11-15 | Janssen Pharmaceutica Nv | Thiophenopyrimidine |
US6664261B2 (en) | 1996-02-07 | 2003-12-16 | Neurocrine Biosciences, Inc. | Pyrazolopyrimidines as CRF receptor antagonists |
CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
ATE375344T1 (de) * | 1996-07-24 | 2007-10-15 | Bristol Myers Squibb Pharma Co | Azolotriazine und pyrimidine |
DK0920429T3 (da) * | 1996-08-06 | 2003-05-12 | Pfizer | Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater |
TW477787B (en) * | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
US20010007867A1 (en) | 1999-12-13 | 2001-07-12 | Yuhpyng L. Chen | Substituted 6,5-hetero-bicyclic derivatives |
SK23399A3 (en) * | 1996-08-28 | 2000-08-14 | Pfizer | 6,5-hetero-bicyclic derivatives, use thereof and pharmaceutical composition on their base |
US5760225A (en) * | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
JP2001511813A (ja) * | 1997-02-18 | 2001-08-14 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | Crfレセプターアンタゴニストおよびそれらに関連する方法 |
WO1998047874A1 (en) * | 1997-04-22 | 1998-10-29 | Janssen Pharmaceutica N.V. | Crf antagonistic quino- and quinazolines |
NZ335823A (en) | 1997-04-22 | 2001-06-29 | Neurocrine Biosciences Inc | Thiophenopyridines, preparation as CRF receptor antagonists |
NZ524842A (en) * | 1998-01-28 | 2003-10-31 | Bristol Myers Squibb Pharma Co | Azolo triazines and pyrimidines |
US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
AU3220299A (en) | 1998-04-02 | 1999-10-25 | Neurogen Corporation | Substituted 9h-pyridino(2,3-b)indole and 9h-pyrimidino(4,5-b)indole derivatives:selective neuropeptide y receptor ligands |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
JP2002510686A (ja) | 1998-04-02 | 2002-04-09 | ニューロゲン コーポレイション | アミノアルキルで置換された5,6,7,8−テトラヒドロ−9H−ピリジノ[2,3−b]インドール及び5,6,7,8−テトラヒドロ−9Hピリミジノ[4,5−B]インドール誘導体:CRF1特異的配位子 |
WO1999051600A1 (en) * | 1998-04-02 | 1999-10-14 | Neurogen Corporation | AMINOALKYL SUBSTITUTED 9H-PYRIDINO[2,3-b]INDOLE AND 9H-PYRIMIDINO[4,5-b]INDOLE DERIVATIVES |
ATE239019T1 (de) | 1998-06-09 | 2003-05-15 | Neurogen Corp | Pyrido(2,3-b)indolizinderivate und aza analoge: crf1 spezifische liganden |
AU755997B2 (en) | 1998-11-12 | 2003-01-02 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
DK1129091T3 (da) | 1998-11-12 | 2002-11-04 | Neurocrine Biosciences Inc | Antagonister for CRF-receptorer og fremgangsmåder med relation dertil |
CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
ATE318267T1 (de) | 1999-09-30 | 2006-03-15 | Neurogen Corp | Einige alkylendiamin-substituierte heterocyclen |
BR0015203A (pt) | 1999-11-05 | 2002-07-16 | Astrazeneca Ab | Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente |
TW200403243A (en) * | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
NZ544200A (en) | 2003-07-14 | 2009-07-31 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US7557113B2 (en) | 2003-08-26 | 2009-07-07 | Teijin Pharma Limited | Substituted pyrrolo[3,2-d]pyrimidine derivatives |
TW200509938A (en) * | 2003-08-26 | 2005-03-16 | Teijin Pharma Ltd | Pyrrolopyrimidine thion derivatives |
CA2537829A1 (en) * | 2003-09-05 | 2005-03-17 | Neurogen Corporation | Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012093809A2 (en) * | 2011-01-03 | 2012-07-12 | Hanmi Pharm Co., Ltd. | New bicyclic compound for modulating g protein-coupled receptors |
CA2828713C (en) | 2011-03-04 | 2022-08-16 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compounds and methods of use |
KR101420097B1 (ko) * | 2011-12-28 | 2014-07-17 | 주식회사 두산 | 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자 |
EP2913333A1 (de) | 2014-02-27 | 2015-09-02 | Laboratoire Biodim | 3H-Thieno[3,4]pyrimidin-4-on und Pyrrolopyrimidon-Verbindungen als Gram-Positive Antibakteria |
MX2021011472A (es) | 2015-01-06 | 2022-08-17 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
CA3039026A1 (en) | 2016-09-07 | 2018-03-15 | The Regents Of The University Of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932431A (en) | 1970-06-24 | 1976-01-13 | Schering Corporation | Certain 2-[α(2-pyridyl)-benzyl] imidazolines and derivatives thereof |
US3988338A (en) | 1974-04-24 | 1976-10-26 | Wisconsin Alumni Research Foundation | 4-Substituted amino-2-substituted thio-pyrrolo-[2,3-d]pyrimidine derivatives |
DE3145287A1 (de) * | 1981-11-14 | 1983-05-19 | Troponwerke GmbH & Co KG, 5000 Köln | Pyrrolo (2.3-d)pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
EP0239191A3 (de) * | 1986-01-30 | 1988-07-20 | Beecham Group Plc | Pyrazolo[4,3-b]pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
KR0155955B1 (ko) | 1989-10-11 | 1998-11-16 | 이따가끼 히로시 | 2 환성 피리미딘 유도체, 그의 제조방법 및 그를 유효성분으로 하는 의약제제 |
US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
US5244896A (en) | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
KR0173172B1 (ko) * | 1992-12-17 | 1999-02-01 | 알렌 제이. 스피겔 | Crf 길항제로서의 피롤로피리미딘 |
CN1142817A (zh) * | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
JPH10506126A (ja) * | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体;crf1特異性リガンドの新規なクラス |
US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
US5804685A (en) * | 1995-06-07 | 1998-09-08 | Neurogen Corporation | Deazapurine derivatives: a new class of CRF1 specific ligands |
JPH10114744A (ja) | 1996-08-22 | 1998-05-06 | Takeda Chem Ind Ltd | アミノグアニジンヒドラゾン誘導体、その製法及び剤 |
SK23399A3 (en) | 1996-08-28 | 2000-08-14 | Pfizer | 6,5-hetero-bicyclic derivatives, use thereof and pharmaceutical composition on their base |
-
1996
- 1996-05-09 JP JP8534296A patent/JPH10506126A/ja not_active Ceased
- 1996-05-09 US US08/776,147 patent/US6020492A/en not_active Expired - Fee Related
- 1996-05-09 EP EP96913989A patent/EP0770080B1/de not_active Expired - Lifetime
- 1996-05-09 AU AU56790/96A patent/AU716993B2/en not_active Ceased
- 1996-05-09 AT AT96913989T patent/ATE182148T1/de not_active IP Right Cessation
- 1996-05-09 WO PCT/US1996/006708 patent/WO1996035689A1/en active IP Right Grant
- 1996-05-09 CA CA002194756A patent/CA2194756A1/en not_active Abandoned
- 1996-05-09 KR KR1019970700196A patent/KR100256707B1/ko not_active IP Right Cessation
- 1996-05-09 DE DE69603240T patent/DE69603240T2/de not_active Expired - Fee Related
-
1999
- 1999-08-05 US US09/368,543 patent/US6281220B1/en not_active Expired - Fee Related
-
2001
- 2001-06-21 US US09/887,206 patent/US6495688B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20020065290A1 (en) | 2002-05-30 |
CA2194756A1 (en) | 1996-11-14 |
AU5679096A (en) | 1996-11-29 |
WO1996035689A1 (en) | 1996-11-14 |
JPH10506126A (ja) | 1998-06-16 |
US6020492A (en) | 2000-02-01 |
EP0770080A1 (de) | 1997-05-02 |
EP0770080B1 (de) | 1999-07-14 |
AU716993B2 (en) | 2000-03-16 |
US6281220B1 (en) | 2001-08-28 |
KR100256707B1 (ko) | 2000-05-15 |
US6495688B2 (en) | 2002-12-17 |
DE69603240T2 (de) | 2000-01-05 |
DE69603240D1 (de) | 1999-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |