DE69603240T2 - Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden - Google Patents

Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Info

Publication number
DE69603240T2
DE69603240T2 DE69603240T DE69603240T DE69603240T2 DE 69603240 T2 DE69603240 T2 DE 69603240T2 DE 69603240 T DE69603240 T DE 69603240T DE 69603240 T DE69603240 T DE 69603240T DE 69603240 T2 DE69603240 T2 DE 69603240T2
Authority
DE
Germany
Prior art keywords
new
deazapore
crf1
derivatives
specific ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69603240T
Other languages
English (en)
Other versions
DE69603240D1 (de
Inventor
Jun Yuan
Alan Hutchison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/439,874 external-priority patent/US5644057A/en
Priority claimed from US08/476,689 external-priority patent/US5804685A/en
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of DE69603240D1 publication Critical patent/DE69603240D1/de
Publication of DE69603240T2 publication Critical patent/DE69603240T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DE69603240T 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden Expired - Fee Related DE69603240T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/439,874 US5644057A (en) 1995-05-12 1995-05-12 Deazapurine derivatives; a new class of CRF1 specific ligands
US08/476,689 US5804685A (en) 1995-06-07 1995-06-07 Deazapurine derivatives: a new class of CRF1 specific ligands
PCT/US1996/006708 WO1996035689A1 (en) 1995-05-12 1996-05-09 Novel deazapurine derivatives; a new class of crf1 specific ligands

Publications (2)

Publication Number Publication Date
DE69603240D1 DE69603240D1 (de) 1999-08-19
DE69603240T2 true DE69603240T2 (de) 2000-01-05

Family

ID=27032200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69603240T Expired - Fee Related DE69603240T2 (de) 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Country Status (9)

Country Link
US (3) US6020492A (de)
EP (1) EP0770080B1 (de)
JP (1) JPH10506126A (de)
KR (1) KR100256707B1 (de)
AT (1) ATE182148T1 (de)
AU (1) AU716993B2 (de)
CA (1) CA2194756A1 (de)
DE (1) DE69603240T2 (de)
WO (1) WO1996035689A1 (de)

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US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
AU719434B2 (en) 1996-02-13 2000-05-11 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
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GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
CA2244897C (en) 1996-03-05 2006-04-11 Zeneca Limited 4-anilinoquinazoline derivatives
US6107300A (en) * 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
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US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
EP1908764A1 (de) * 1996-07-24 2008-04-09 Bristol-Myers Squibb Pharma Company Azolotriazine und Pyrimidine
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
DE69719193T2 (de) * 1996-08-06 2003-09-25 Pfizer Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate
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US20010007867A1 (en) 1999-12-13 2001-07-12 Yuhpyng L. Chen Substituted 6,5-hetero-bicyclic derivatives
SK23399A3 (en) * 1996-08-28 2000-08-14 Pfizer 6,5-hetero-bicyclic derivatives, use thereof and pharmaceutical composition on their base
US5760225A (en) 1996-11-15 1998-06-02 Neurogen Corporation Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
AU6279598A (en) * 1997-02-18 1998-09-08 Neurocrine Biosciences, Inc. Biazacyclic CRF antagonists
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US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
EP1068205A1 (de) 1998-04-02 2001-01-17 Neurogen Corporation Aminoalkylsubstituierte 5,6,7,8-tetrahydro-9h-pyrido[2,3-b]indol- und 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indolderivate: crf1-spezifische liganden
US6147085A (en) * 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
US6472402B1 (en) 1998-04-02 2002-10-29 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
EP1068207A1 (de) * 1998-04-02 2001-01-17 Neurogen Corporation Aminoalkyl substituierte 9h-pyridino[2,3-b]indol- und 9h-pyrimidino[4,5-b]indol-derivate
AU3220299A (en) 1998-04-02 1999-10-25 Neurogen Corporation Substituted 9h-pyridino(2,3-b)indole and 9h-pyrimidino(4,5-b)indole derivatives:selective neuropeptide y receptor ligands
ATE239019T1 (de) 1998-06-09 2003-05-15 Neurogen Corp Pyrido(2,3-b)indolizinderivate und aza analoge: crf1 spezifische liganden
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
IL143105A0 (en) 1998-11-12 2002-04-21 Neurocrine Biosciences Inc Fused polycyclic heterocyclic compounds and pharmaceutical compositions containing the same
WO2000027846A2 (en) 1998-11-12 2000-05-18 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
NZ517575A (en) 1999-09-30 2004-04-30 Neurogen Corp Certain alkylene diamine-substituted heterocycles
SI1676845T1 (sl) 1999-11-05 2008-10-31 Astrazeneca Ab Novi kinazolinski derivati
TW200403243A (en) * 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
RS20050532A (en) 2003-01-14 2007-12-31 Arena Pharmaceuticals Inc., 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
MXPA06000554A (es) 2003-07-14 2006-07-03 Arena Pharm Inc Derivados arilo y heteroarilo fusionados como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos.
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
TW200519116A (en) * 2003-08-26 2005-06-16 Teijin Pharma Ltd Pyrrolopyrimidine derivatives
CN1878773A (zh) * 2003-09-05 2006-12-13 神经能质公司 作为crf1受体配位体的杂芳基稠合的吡啶,吡嗪及嘧啶
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
KR20120079015A (ko) * 2011-01-03 2012-07-11 한미약품 주식회사 Ｇ 단백질-커플링된 수용체의 조절을 위한 신규한 비사이클릭 화합물
CA2828713C (en) 2011-03-04 2022-08-16 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compounds and methods of use
KR101420097B1 (ko) * 2011-12-28 2014-07-17 주식회사 두산 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자
EP2913333A1 (de) 2014-02-27 2015-09-02 Laboratoire Biodim 3H-Thieno[3,4]pyrimidin-4-on und Pyrrolopyrimidon-Verbindungen als Gram-Positive Antibakteria
NZ734220A (en) 2015-01-06 2022-01-28 Arena Pharm Inc Methods of treating conditions related to the s1p1 receptor
CN108349891B (zh) 2015-06-22 2022-04-05 艾尼纳制药公司 用于s1p1受体相关病症的化合物的结晶l-精氨酸盐
KR102571296B1 (ko) 2016-09-07 2023-08-28 더 리전트 오브 더 유니버시티 오브 캘리포니아 P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제

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Also Published As

Publication number Publication date
AU716993B2 (en) 2000-03-16
JPH10506126A (ja) 1998-06-16
EP0770080B1 (de) 1999-07-14
WO1996035689A1 (en) 1996-11-14
CA2194756A1 (en) 1996-11-14
ATE182148T1 (de) 1999-07-15
US6495688B2 (en) 2002-12-17
US20020065290A1 (en) 2002-05-30
AU5679096A (en) 1996-11-29
KR100256707B1 (ko) 2000-05-15
US6020492A (en) 2000-02-01
DE69603240D1 (de) 1999-08-19
US6281220B1 (en) 2001-08-28
EP0770080A1 (de) 1997-05-02

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8339 Ceased/non-payment of the annual fee