PE13396A1 - Compuesto biciclico - Google Patents

Compuesto biciclico

Info

Publication number
PE13396A1
PE13396A1 PE1995270715A PE27071595A PE13396A1 PE 13396 A1 PE13396 A1 PE 13396A1 PE 1995270715 A PE1995270715 A PE 1995270715A PE 27071595 A PE27071595 A PE 27071595A PE 13396 A1 PE13396 A1 PE 13396A1
Authority
PE
Peru
Prior art keywords
bicycle compound
bicycle
compound
formulawherein
stress
Prior art date
Application number
PE1995270715A
Other languages
English (en)
Inventor
Yuhpyng L Chen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE13396A1 publication Critical patent/PE13396A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Controls And Circuits For Display Device (AREA)
  • Projection Apparatus (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: A ES N o -CR6; B ES -NR1R2, -CR1R2R11, -NHCHR1R2, TETRAHIDROFURANILO ENTRE OTROS, DE PREFERENCIA LOS MENCIONADOS; R1 ES ALQUILO DE C1-C6 OPCIONALMENTE SUSTITUIDO POR OH, F, Cl ENTRE OTROS, DE PREFERENCIA ES ALQUILO DE C1-C4, SUSTITUIDOS CON OH y F; R2 ES ALQUILO DE C1-C12, ARILO,-(ALQUILENO C1-C4)ARILO, DONDE ARILO ES FENILO, NAFTILO ENTRE OTROS; DE PREFERENCIA BENCILO o ALQUILO DE C1-C6; R3 ES ALQUILO DE C1-C4, F, Br, I ENTRE OTROS, DE PREFERENCIA METILO Y CLORO; R4 ES HIDROGENO, ALQUILO C1-C6, F, Cl, Br; DE PREFERENCIA HIDROGENO, METILO Y ETILO; R5 ES FENILO, NAFTILO, TIENILO ENTRE OTROS Y PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS CON 2 o 3 SUSTITUYENTES TAL COMO F,Cl, FENILO ENTRE OTROS; R6 ES HIDROGENO, ALQUILO C1-C4, F, Cl, DE PREFRENCIA HIDROGENO, METILO, ETILO; R7 ES H, ALQUILO C1-C4, F; R11 ES H, F, OH, DE PREFERENCIA LAS DOS PRIMERAS; R12 ES H o ALQUILO C1-C4. SE CARACTERIZA POR ANTAGONIZAR EL CRF, EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y GASTROINTESTINALES
PE1995270715A 1994-06-16 1995-06-08 Compuesto biciclico PE13396A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26005594A 1994-06-16 1994-06-16

Publications (1)

Publication Number Publication Date
PE13396A1 true PE13396A1 (es) 1996-04-27

Family

ID=22987613

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995270715A PE13396A1 (es) 1994-06-16 1995-06-08 Compuesto biciclico

Country Status (27)

Country Link
US (1) US6248753B1 (es)
EP (1) EP0765327B1 (es)
JP (1) JP2891544B2 (es)
KR (1) KR100235277B1 (es)
CN (1) CN1056611C (es)
AT (1) ATE182332T1 (es)
AU (1) AU687196B2 (es)
BR (1) BR9502707A (es)
CA (1) CA2192820C (es)
CO (1) CO4290424A1 (es)
CZ (1) CZ287613B6 (es)
DE (1) DE69510940T2 (es)
DK (1) DK0765327T3 (es)
ES (1) ES2135062T3 (es)
FI (1) FI112659B (es)
GR (1) GR3031166T3 (es)
HU (1) HU219911B (es)
IL (1) IL114003A (es)
MX (1) MX9606504A (es)
NO (1) NO307968B1 (es)
NZ (1) NZ284846A (es)
PE (1) PE13396A1 (es)
PL (1) PL181895B1 (es)
RU (1) RU2135498C1 (es)
TW (1) TW432064B (es)
WO (1) WO1995034563A1 (es)
ZA (1) ZA954679B (es)

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ATE182332T1 (de) 1999-08-15
HUT75776A (en) 1997-05-28
AU2350595A (en) 1996-01-05
HU9603469D0 (en) 1997-02-28
EP0765327A1 (en) 1997-04-02
ES2135062T3 (es) 1999-10-16
CZ287613B6 (en) 2001-01-17
HU219911B (hu) 2001-09-28
WO1995034563A1 (en) 1995-12-21
FI965022A0 (fi) 1996-12-13
EP0765327B1 (en) 1999-07-21
NO965378D0 (no) 1996-12-13
CZ367096A3 (en) 1997-10-15
ZA954679B (en) 1996-12-09
RU2135498C1 (ru) 1999-08-27
NO965378L (no) 1996-12-13
CN1056611C (zh) 2000-09-20
CO4290424A1 (es) 1996-04-17
FI112659B (fi) 2003-12-31
CN1150803A (zh) 1997-05-28
CA2192820C (en) 2000-11-28
PL317705A1 (en) 1997-04-28
IL114003A (en) 1999-12-31
FI965022A (fi) 1996-12-13
JP2891544B2 (ja) 1999-05-17
AU687196B2 (en) 1998-02-19
US6248753B1 (en) 2001-06-19
DK0765327T3 (da) 1999-11-29
PL181895B1 (pl) 2001-10-31
MX9606504A (es) 1997-03-29
GR3031166T3 (en) 1999-12-31
IL114003A0 (en) 1995-10-31
DE69510940T2 (de) 1999-11-11
DE69510940D1 (de) 1999-08-26
CA2192820A1 (en) 1995-12-21
NZ284846A (en) 1998-12-23
TW432064B (en) 2001-05-01
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NO307968B1 (no) 2000-06-26
KR100235277B1 (ko) 1999-12-15

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