ES2135062T3 - Pirazolo y pirrolopiridinas. - Google Patents

Pirazolo y pirrolopiridinas.

Info

Publication number
ES2135062T3
ES2135062T3 ES95917436T ES95917436T ES2135062T3 ES 2135062 T3 ES2135062 T3 ES 2135062T3 ES 95917436 T ES95917436 T ES 95917436T ES 95917436 T ES95917436 T ES 95917436T ES 2135062 T3 ES2135062 T3 ES 2135062T3
Authority
ES
Spain
Prior art keywords
pyrrolopyridins
pirazolo
formulawherein
stress
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95917436T
Other languages
English (en)
Inventor
Yuhpyng L Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2135062T3 publication Critical patent/ES2135062T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Controls And Circuits For Display Device (AREA)
  • Projection Apparatus (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE A ES N O -CT{SUB,6}; B ES -NR{SUB,1}R{SUB,2}, -CR{SUB,1}R{SUB,2}R{SUB,11}, -C(=CR{SUB,2}R{SUB,12})R{SUB,1}, -NHCHR{SUB,1}R{SUB,2}, -OCHR{SUB,1}R{SUB,2}, -SCHR{SUB,1}R{SUB,2}, -CHR{SUB,2}OR{SUB,12}, -C(S)R{SUB,1} O -C(O)R{SUB,1}. LOS COMPUESTOS MUESTRAN ACTIVIDAD ANTAGONISTA DEL FACTOR DE LIBERACION DE CORTICOTROPINA (CRF). LOS ANTAGONISTAS DE CRF, SE CREE QUE SON EFECTIVOS EN EL TRATAMIENTO DE UNA AMPLIA GAMA DE ENFERMEDADES RELACIONADAS CON EL ESTRES, COMO LA DEPRESION, ANSIEDAD, DOLOR DE CABEZA, SINDROME DEL COLON IRRITABLE, ENFERMEDADES INFLAMATORIAS, INMUNOSUPRESION, ENFERMEDAD DE ALZHEIMER, ENFERMEDADES GASTROINTESTINALES, ANOREXIA NERVIOSA, ESTRES HEMORRAGICO, SINDROMES DE ABSTINENCIA DE ALCOHOL Y DROGAS, ADICCION A DROGAS E INFERTILIDAD.
ES95917436T 1994-06-16 1995-05-18 Pirazolo y pirrolopiridinas. Expired - Lifetime ES2135062T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26005594A 1994-06-16 1994-06-16

Publications (1)

Publication Number Publication Date
ES2135062T3 true ES2135062T3 (es) 1999-10-16

Family

ID=22987613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95917436T Expired - Lifetime ES2135062T3 (es) 1994-06-16 1995-05-18 Pirazolo y pirrolopiridinas.

Country Status (27)

Country Link
US (1) US6248753B1 (es)
EP (1) EP0765327B1 (es)
JP (1) JP2891544B2 (es)
KR (1) KR100235277B1 (es)
CN (1) CN1056611C (es)
AT (1) ATE182332T1 (es)
AU (1) AU687196B2 (es)
BR (1) BR9502707A (es)
CA (1) CA2192820C (es)
CO (1) CO4290424A1 (es)
CZ (1) CZ287613B6 (es)
DE (1) DE69510940T2 (es)
DK (1) DK0765327T3 (es)
ES (1) ES2135062T3 (es)
FI (1) FI112659B (es)
GR (1) GR3031166T3 (es)
HU (1) HU219911B (es)
IL (1) IL114003A (es)
MX (1) MX9606504A (es)
NO (1) NO307968B1 (es)
NZ (1) NZ284846A (es)
PE (1) PE13396A1 (es)
PL (1) PL181895B1 (es)
RU (1) RU2135498C1 (es)
TW (1) TW432064B (es)
WO (1) WO1995034563A1 (es)
ZA (1) ZA954679B (es)

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FI965022A0 (fi) 1996-12-13
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FI112659B (fi) 2003-12-31
CZ287613B6 (en) 2001-01-17
IL114003A (en) 1999-12-31
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GR3031166T3 (en) 1999-12-31
CN1056611C (zh) 2000-09-20
JPH09507855A (ja) 1997-08-12
CA2192820C (en) 2000-11-28
DK0765327T3 (da) 1999-11-29
US6248753B1 (en) 2001-06-19
DE69510940T2 (de) 1999-11-11
PE13396A1 (es) 1996-04-27
NO965378L (no) 1996-12-13
CA2192820A1 (en) 1995-12-21
FI965022A (fi) 1996-12-13
KR100235277B1 (ko) 1999-12-15
RU2135498C1 (ru) 1999-08-27
TW432064B (en) 2001-05-01
IL114003A0 (en) 1995-10-31
MX9606504A (es) 1997-03-29
ATE182332T1 (de) 1999-08-15
CO4290424A1 (es) 1996-04-17
NO965378D0 (no) 1996-12-13
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PL317705A1 (en) 1997-04-28
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AU2350595A (en) 1996-01-05
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CN1150803A (zh) 1997-05-28
JP2891544B2 (ja) 1999-05-17
ZA954679B (en) 1996-12-09
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HUT75776A (en) 1997-05-28
AU687196B2 (en) 1998-02-19
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DE69510940D1 (de) 1999-08-26
PL181895B1 (pl) 2001-10-31

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