EA200970418A1 - Применение мультитаргетного ингибитора киназ для лечения или предупреждения рака головного мозга - Google Patents

Применение мультитаргетного ингибитора киназ для лечения или предупреждения рака головного мозга

Info

Publication number
EA200970418A1
EA200970418A1 EA200970418A EA200970418A EA200970418A1 EA 200970418 A1 EA200970418 A1 EA 200970418A1 EA 200970418 A EA200970418 A EA 200970418A EA 200970418 A EA200970418 A EA 200970418A EA 200970418 A1 EA200970418 A1 EA 200970418A1
Authority
EA
Eurasian Patent Office
Prior art keywords
brain cancer
prevention
treatment
multitargetic
kinaz
Prior art date
Application number
EA200970418A
Other languages
English (en)
Inventor
Тимоти Пьетро Сурен Перера
Мартин Джон Пэйдж
Мишель Мари Франсуа Жанико
Эдди Жан Эдгар Фрейн
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA200970418A1 publication Critical patent/EA200970418A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение предлагает использовать макроциклическое производное хиназолина, 4,6-этандиилиденпиримидо[4,5-b][6,1,12]бензоксадиазациклопентадецин, 17-бром-8,9,10,11,12,13,14,19-октагидро-20-метокси-13-метил-, описанное как соединение 22 в РСТ публикации WO2004/105765, для изготовления лекарственного препарата для лечения или предупреждения первичного рака головного мозга или метастазирования в головной мозг. Соответственно, изобретение связано со способами лечения, предупреждения, задержки или подавления рака головного мозга или предупреждения или замедления пролиферации клеток головного мозга.
EA200970418A 2006-10-27 2007-10-25 Применение мультитаргетного ингибитора киназ для лечения или предупреждения рака головного мозга EA200970418A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86316206P 2006-10-27 2006-10-27
EP06123058 2006-10-27
US97616807P 2007-09-28 2007-09-28
PCT/EP2007/061498 WO2008049901A1 (en) 2006-10-27 2007-10-25 Use of a mt kinase inhibitor for treating or preventing brain cancer

Publications (1)

Publication Number Publication Date
EA200970418A1 true EA200970418A1 (ru) 2009-10-30

Family

ID=38925659

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970418A EA200970418A1 (ru) 2006-10-27 2007-10-25 Применение мультитаргетного ингибитора киназ для лечения или предупреждения рака головного мозга

Country Status (10)

Country Link
EP (1) EP2077843A1 (ru)
JP (1) JP2010507625A (ru)
KR (1) KR20090091119A (ru)
AU (1) AU2007310842A1 (ru)
CA (1) CA2664145A1 (ru)
EA (1) EA200970418A1 (ru)
IL (1) IL198347A0 (ru)
MX (1) MX2009004437A (ru)
NO (1) NO20092046L (ru)
WO (1) WO2008049901A1 (ru)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives

Also Published As

Publication number Publication date
EP2077843A1 (en) 2009-07-15
KR20090091119A (ko) 2009-08-26
AU2007310842A1 (en) 2008-05-02
MX2009004437A (es) 2009-05-11
WO2008049901A1 (en) 2008-05-02
IL198347A0 (en) 2010-02-17
JP2010507625A (ja) 2010-03-11
CA2664145A1 (en) 2008-05-02
NO20092046L (no) 2009-07-01

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