JP2000502324A - 異種抗体を産生することができるトランスジェニック非ヒト動物 - Google Patents
異種抗体を産生することができるトランスジェニック非ヒト動物Info
- Publication number
- JP2000502324A JP2000502324A JP9515285A JP51528597A JP2000502324A JP 2000502324 A JP2000502324 A JP 2000502324A JP 9515285 A JP9515285 A JP 9515285A JP 51528597 A JP51528597 A JP 51528597A JP 2000502324 A JP2000502324 A JP 2000502324A
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A01K67/027—New or modified breeds of vertebrates
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- A01K67/0276—Knock-out vertebrates
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
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- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- Medicinal Chemistry (AREA)
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- Cell Biology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/544,404 US5770429A (en) | 1990-08-29 | 1995-10-10 | Transgenic non-human animals capable of producing heterologous antibodies |
| US08/544,404 | 1995-10-10 | ||
| PCT/US1996/016433 WO1997013852A1 (en) | 1995-10-10 | 1996-10-10 | Transgenic non-human animals capable of producing heterologous antibodies |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007198202A Division JP2007332152A (ja) | 1995-10-10 | 2007-07-30 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2008121728A Division JP4897736B2 (ja) | 1995-10-10 | 2008-05-07 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000502324A true JP2000502324A (ja) | 2000-02-29 |
| JP2000502324A5 JP2000502324A5 (https=) | 2008-07-31 |
Family
ID=24172033
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9515285A Withdrawn JP2000502324A (ja) | 1995-10-10 | 1996-10-10 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2007198202A Pending JP2007332152A (ja) | 1995-10-10 | 2007-07-30 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2008113242A Withdrawn JP2008189691A (ja) | 1995-10-10 | 2008-04-23 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2008121728A Expired - Lifetime JP4897736B2 (ja) | 1995-10-10 | 2008-05-07 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2009144731A Withdrawn JP2009201524A (ja) | 1995-10-10 | 2009-06-17 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2011190446A Pending JP2011236257A (ja) | 1995-10-10 | 2011-09-01 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007198202A Pending JP2007332152A (ja) | 1995-10-10 | 2007-07-30 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2008113242A Withdrawn JP2008189691A (ja) | 1995-10-10 | 2008-04-23 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2008121728A Expired - Lifetime JP4897736B2 (ja) | 1995-10-10 | 2008-05-07 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2009144731A Withdrawn JP2009201524A (ja) | 1995-10-10 | 2009-06-17 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2011190446A Pending JP2011236257A (ja) | 1995-10-10 | 2011-09-01 | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
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| US (1) | US5770429A (https=) |
| EP (3) | EP1813672A3 (https=) |
| JP (6) | JP2000502324A (https=) |
| CN (3) | CN1286975C (https=) |
| AT (1) | ATE466936T1 (https=) |
| AU (1) | AU729290B2 (https=) |
| CA (1) | CA2232813C (https=) |
| DE (1) | DE69638184D1 (https=) |
| DK (1) | DK0854917T3 (https=) |
| ES (1) | ES2345580T3 (https=) |
| IL (2) | IL124043A (https=) |
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| JP2008239630A (ja) * | 1995-10-10 | 2008-10-09 | Genpharm Internatl Inc | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2017104125A (ja) * | 2000-10-31 | 2017-06-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 真核生物細胞を改変する方法 |
| JP2017123855A (ja) * | 2000-10-31 | 2017-07-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 真核生物細胞を改変する方法 |
| JP2013090631A (ja) * | 2001-02-16 | 2013-05-16 | Regeneron Pharmaceuticals Inc | 真核生物細胞を改変する方法 |
| JP2016189796A (ja) * | 2001-02-16 | 2016-11-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 真核生物細胞を改変する方法 |
| JP2018108115A (ja) * | 2001-02-16 | 2018-07-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 真核生物細胞を改変する方法 |
| US8182812B2 (en) | 2002-11-15 | 2012-05-22 | Genmab A/S | Human monoclonal antibodies against CD25 |
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| US9598493B2 (en) | 2002-11-15 | 2017-03-21 | Genmab A/S | Human monoclonal antibodies against CD25 |
| JP2006523433A (ja) * | 2002-11-15 | 2006-10-19 | ゲンマブ エー/エス | Cd25に対するヒトモノクローナル抗体 |
| US10703818B2 (en) | 2002-11-15 | 2020-07-07 | Genmab A/S | Human monoclonal antibodies against CD25 |
| JP2019030307A (ja) * | 2008-08-11 | 2019-02-28 | イー・アール・スクイブ・アンド・サンズ・リミテッド・ライアビリティ・カンパニーE.R. Squibb & Sons, L.L.C. | リンパ球活性化遺伝子−3(lag−3)へ結合するヒト抗体およびその使用 |
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| CN102827283A (zh) | 2012-12-19 |
| EP1813672A3 (en) | 2008-05-28 |
| CA2232813A1 (en) | 1997-04-17 |
| JP2009201524A (ja) | 2009-09-10 |
| AU1114997A (en) | 1997-04-30 |
| JP4897736B2 (ja) | 2012-03-14 |
| EP1813672A2 (en) | 2007-08-01 |
| AU729290B2 (en) | 2001-02-01 |
| DK0854917T3 (da) | 2010-08-30 |
| WO1997013852A1 (en) | 1997-04-17 |
| CN1199422A (zh) | 1998-11-18 |
| EP0854917B1 (en) | 2010-05-05 |
| ATE466936T1 (de) | 2010-05-15 |
| JP2011236257A (ja) | 2011-11-24 |
| DE69638184D1 (de) | 2010-06-17 |
| EP0854917A4 (en) | 2002-07-24 |
| IL168028A (en) | 2011-11-30 |
| JP2007332152A (ja) | 2007-12-27 |
| EP0854917A1 (en) | 1998-07-29 |
| JP2008239630A (ja) | 2008-10-09 |
| IL124043A (en) | 2005-08-31 |
| JP2008189691A (ja) | 2008-08-21 |
| EP2186888A1 (en) | 2010-05-19 |
| CA2232813C (en) | 2013-12-17 |
| CN101002549A (zh) | 2007-07-25 |
| CN101002549B (zh) | 2012-05-30 |
| CN102827283B (zh) | 2014-11-12 |
| NZ324076A (en) | 2000-05-26 |
| CN1286975C (zh) | 2006-11-29 |
| US5770429A (en) | 1998-06-23 |
| ES2345580T3 (es) | 2010-09-27 |
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