BR112022026508A2 - Anticorpos que reconhecem sortilina - Google Patents
Anticorpos que reconhecem sortilinaInfo
- Publication number
- BR112022026508A2 BR112022026508A2 BR112022026508A BR112022026508A BR112022026508A2 BR 112022026508 A2 BR112022026508 A2 BR 112022026508A2 BR 112022026508 A BR112022026508 A BR 112022026508A BR 112022026508 A BR112022026508 A BR 112022026508A BR 112022026508 A2 BR112022026508 A2 BR 112022026508A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- sortilin
- recognize
- delay
- changes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
ANTICORPOS QUE RECONHECEM SORTILINA. A invenção fornece anticorpos que se ligam especificamente à sortilina. Os anticorpos inibem ou retardam as patologias associadas a alterações nos níveis de progranulina e deterioração sintomática associada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063043481P | 2020-06-24 | 2020-06-24 | |
PCT/US2021/070764 WO2021263279A1 (en) | 2020-06-24 | 2021-06-23 | Antibodies recognizing sortilin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022026508A2 true BR112022026508A2 (pt) | 2023-03-07 |
Family
ID=79281994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022026508A BR112022026508A2 (pt) | 2020-06-24 | 2021-06-23 | Anticorpos que reconhecem sortilina |
Country Status (12)
Country | Link |
---|---|
US (3) | US20230235048A1 (pt) |
EP (1) | EP4171743A1 (pt) |
JP (1) | JP2023533458A (pt) |
KR (1) | KR20230026489A (pt) |
CN (1) | CN116249717A (pt) |
AR (1) | AR122736A1 (pt) |
AU (1) | AU2021297540A1 (pt) |
BR (1) | BR112022026508A2 (pt) |
CA (1) | CA3183994A1 (pt) |
IL (1) | IL299329A (pt) |
TW (1) | TW202216773A (pt) |
WO (1) | WO2021263279A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202342516A (zh) * | 2021-12-23 | 2023-11-01 | 愛爾蘭商普羅希那生物科學有限公司 | 識別分選蛋白的抗體 |
WO2023247754A1 (en) | 2022-06-23 | 2023-12-28 | Draupnir Bio Aps | Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007098184A2 (en) * | 2006-02-21 | 2007-08-30 | Nanogen, Inc. | Methods and compositions for analyte detection |
RU2603102C2 (ru) * | 2009-12-10 | 2016-11-20 | Ридженерон Фармасьютикалз, Инк. | Мыши, которые производят антитела, имеющие только тяжелые цепи |
PH12018501083A1 (en) * | 2010-03-04 | 2019-02-18 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
US9527913B2 (en) * | 2012-05-02 | 2016-12-27 | Symphogen A/S | Humanized pan-HER antibody compositions |
JP6999421B2 (ja) * | 2015-04-07 | 2022-02-04 | アレクトル エルエルシー | 抗ソルチリン抗体及びその使用方法 |
-
2021
- 2021-06-23 CA CA3183994A patent/CA3183994A1/en active Pending
- 2021-06-23 BR BR112022026508A patent/BR112022026508A2/pt unknown
- 2021-06-23 IL IL299329A patent/IL299329A/en unknown
- 2021-06-23 CN CN202180051773.0A patent/CN116249717A/zh active Pending
- 2021-06-23 JP JP2022579951A patent/JP2023533458A/ja active Pending
- 2021-06-23 AU AU2021297540A patent/AU2021297540A1/en active Pending
- 2021-06-23 WO PCT/US2021/070764 patent/WO2021263279A1/en unknown
- 2021-06-23 US US18/011,764 patent/US20230235048A1/en active Pending
- 2021-06-23 KR KR1020237002522A patent/KR20230026489A/ko unknown
- 2021-06-23 EP EP21829181.3A patent/EP4171743A1/en active Pending
- 2021-06-24 AR ARP210101748A patent/AR122736A1/es unknown
- 2021-06-24 TW TW110123220A patent/TW202216773A/zh unknown
-
2023
- 2023-10-26 US US18/384,230 patent/US20240117040A1/en active Pending
- 2023-10-26 US US18/384,223 patent/US20240117039A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2023533458A (ja) | 2023-08-03 |
AU2021297540A1 (en) | 2023-02-02 |
US20240117040A1 (en) | 2024-04-11 |
US20230235048A1 (en) | 2023-07-27 |
IL299329A (en) | 2023-02-01 |
EP4171743A1 (en) | 2023-05-03 |
TW202216773A (zh) | 2022-05-01 |
KR20230026489A (ko) | 2023-02-24 |
WO2021263279A1 (en) | 2021-12-30 |
AR122736A1 (es) | 2022-10-05 |
US20240117039A1 (en) | 2024-04-11 |
CA3183994A1 (en) | 2021-12-30 |
CN116249717A (zh) | 2023-06-09 |
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