JP5622392B2 - 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 - Google Patents

大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 Download PDF

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JP5622392B2
JP5622392B2 JP2009541416A JP2009541416A JP5622392B2 JP 5622392 B2 JP5622392 B2 JP 5622392B2 JP 2009541416 A JP2009541416 A JP 2009541416A JP 2009541416 A JP2009541416 A JP 2009541416A JP 5622392 B2 JP5622392 B2 JP 5622392B2
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array
isfet
pixel
column
sensor
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JP2010513869A5 (enExample
JP2010513869A (ja
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ロスバーグ，ジョナサン，エム．
ヒンズ，ヴォルフガング
ジョンソン，キム，エル．
ビュステイロ，ジェームス
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Life Technologies Corp
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Life Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D30/00—Field-effect transistors [FET]
    • H10D30/60—Insulated-gate field-effect transistors [IGFET]
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D84/00—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers
    • H10D84/80—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs
    • H10D84/82—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs of only field-effect components
    • H10D84/83—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs of only field-effect components of only insulated-gate FETs [IGFET]
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D30/00—Field-effect transistors [FET]
    • H10D30/60—Insulated-gate field-effect transistors [IGFET]
    • H10D30/68—Floating-gate IGFETs
    • H10D30/6891—Floating-gate IGFETs characterised by the shapes, relative sizes or dispositions of the floating gate electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/22—Hydrogen, per se

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2009541416A 2006-12-14 2007-12-14 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 Expired - Fee Related JP5622392B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US87007306P 2006-12-14 2006-12-14
US60/870,073 2006-12-14
US94874807P 2007-07-10 2007-07-10
US60/948,748 2007-07-10
US95632407P 2007-08-16 2007-08-16
US60/956,324 2007-08-16
PCT/US2007/025721 WO2008076406A2 (en) 2006-12-14 2007-12-14 Methods and apparatus for measuring analytes using large scale fet arrays

Related Child Applications (5)

Application Number Title Priority Date Filing Date
JP2012246414A Division JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Division JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Division JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246417A Division JP5643277B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246413A Division JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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JP2010513869A JP2010513869A (ja) 2010-04-30
JP2010513869A5 JP2010513869A5 (enExample) 2011-04-07
JP5622392B2 true JP5622392B2 (ja) 2014-11-12

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JP2009541416A Expired - Fee Related JP5622392B2 (ja) 2006-12-14 2007-12-14 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246417A Expired - Fee Related JP5643277B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246414A Expired - Fee Related JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246413A Active JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Expired - Fee Related JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Expired - Fee Related JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2014245830A Expired - Fee Related JP6125485B2 (ja) 2006-12-14 2014-12-04 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2017030653A Pending JP2017127308A (ja) 2006-12-14 2017-02-22 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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JP2012246417A Expired - Fee Related JP5643277B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246414A Expired - Fee Related JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246413A Active JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Expired - Fee Related JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Expired - Fee Related JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2014245830A Expired - Fee Related JP6125485B2 (ja) 2006-12-14 2014-12-04 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2017030653A Pending JP2017127308A (ja) 2006-12-14 2017-02-22 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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US (37) US7948015B2 (enExample)
EP (10) EP2677309B9 (enExample)
JP (8) JP5622392B2 (enExample)
CN (1) CN101669026B (enExample)
AU (1) AU2007334393A1 (enExample)
CA (1) CA2672315A1 (enExample)
ES (1) ES2923759T3 (enExample)
GB (2) GB2457851B (enExample)
WO (1) WO2008076406A2 (enExample)

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