JP5662407B2 - 大規模fetアレイを用いた分析物測定のための方法および装置 - Google Patents
大規模fetアレイを用いた分析物測定のための方法および装置 Download PDFInfo
- Publication number
- JP5662407B2 JP5662407B2 JP2012246414A JP2012246414A JP5662407B2 JP 5662407 B2 JP5662407 B2 JP 5662407B2 JP 2012246414 A JP2012246414 A JP 2012246414A JP 2012246414 A JP2012246414 A JP 2012246414A JP 5662407 B2 JP5662407 B2 JP 5662407B2
- Authority
- JP
- Japan
- Prior art keywords
- array
- isfet
- pixel
- field effect
- effect transistor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 229
- 238000003491 array Methods 0.000 title description 78
- 239000012491 analyte Substances 0.000 title description 63
- 238000005259 measurement Methods 0.000 title description 41
- 150000007523 nucleic acids Chemical class 0.000 claims description 156
- 108020004707 nucleic acids Proteins 0.000 claims description 151
- 102000039446 nucleic acids Human genes 0.000 claims description 151
- 238000006243 chemical reaction Methods 0.000 claims description 98
- 238000002161 passivation Methods 0.000 claims description 82
- 238000012163 sequencing technique Methods 0.000 claims description 72
- 230000005669 field effect Effects 0.000 claims description 56
- 239000002773 nucleotide Substances 0.000 claims description 51
- 229910052751 metal Inorganic materials 0.000 claims description 50
- 239000002184 metal Substances 0.000 claims description 50
- 125000003729 nucleotide group Chemical group 0.000 claims description 43
- 230000008859 change Effects 0.000 claims description 40
- -1 hydrogen ions Chemical class 0.000 claims description 40
- 229920003023 plastic Polymers 0.000 claims description 32
- 239000004033 plastic Substances 0.000 claims description 32
- 238000007667 floating Methods 0.000 claims description 28
- 229910052710 silicon Inorganic materials 0.000 claims description 27
- 239000010703 silicon Substances 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 238000010348 incorporation Methods 0.000 claims description 23
- 239000011521 glass Substances 0.000 claims description 22
- 239000007787 solid Substances 0.000 claims description 18
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 claims description 13
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 claims description 12
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 claims description 12
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 claims description 12
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 claims description 12
- 239000011534 wash buffer Substances 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000004793 Polystyrene Substances 0.000 claims description 6
- 108010090804 Streptavidin Proteins 0.000 claims description 6
- 229920002223 polystyrene Polymers 0.000 claims description 6
- 229920002307 Dextran Polymers 0.000 claims description 5
- 229920006316 polyvinylpyrrolidine Polymers 0.000 claims description 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 239000000020 Nitrocellulose Substances 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 229920001220 nitrocellulos Polymers 0.000 claims description 3
- 229920000178 Acrylic resin Polymers 0.000 claims description 2
- 239000004925 Acrylic resin Substances 0.000 claims description 2
- 239000011543 agarose gel Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 229920001971 elastomer Polymers 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 239000005060 rubber Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 7
- 238000010168 coupling process Methods 0.000 claims 7
- 238000005859 coupling reaction Methods 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 239000010410 layer Substances 0.000 description 191
- 239000011324 bead Substances 0.000 description 143
- 210000004027 cell Anatomy 0.000 description 99
- 238000013461 design Methods 0.000 description 91
- 230000008569 process Effects 0.000 description 78
- 239000000872 buffer Substances 0.000 description 69
- 239000012530 fluid Substances 0.000 description 69
- 238000010586 diagram Methods 0.000 description 66
- 238000004519 manufacturing process Methods 0.000 description 64
- 239000000243 solution Substances 0.000 description 60
- 239000000463 material Substances 0.000 description 57
- 230000000875 corresponding effect Effects 0.000 description 55
- 239000000126 substance Substances 0.000 description 52
- 150000002500 ions Chemical class 0.000 description 43
- 238000009739 binding Methods 0.000 description 41
- 230000027455 binding Effects 0.000 description 40
- 238000001514 detection method Methods 0.000 description 38
- 108090000623 proteins and genes Proteins 0.000 description 36
- 238000005070 sampling Methods 0.000 description 32
- 239000004065 semiconductor Substances 0.000 description 32
- 150000001875 compounds Chemical class 0.000 description 31
- 239000000758 substrate Substances 0.000 description 28
- 239000003153 chemical reaction reagent Substances 0.000 description 27
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 26
- 108020004414 DNA Proteins 0.000 description 24
- 229910052581 Si3N4 Inorganic materials 0.000 description 24
- 239000004020 conductor Substances 0.000 description 24
- 235000018102 proteins Nutrition 0.000 description 24
- 102000004169 proteins and genes Human genes 0.000 description 24
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 24
- 239000011295 pitch Substances 0.000 description 23
- 239000004205 dimethyl polysiloxane Substances 0.000 description 22
- 125000005647 linker group Chemical group 0.000 description 22
- 238000012856 packing Methods 0.000 description 22
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 22
- 230000002829 reductive effect Effects 0.000 description 22
- 238000011068 loading method Methods 0.000 description 21
- 238000004458 analytical method Methods 0.000 description 20
- 230000005540 biological transmission Effects 0.000 description 20
- 235000012431 wafers Nutrition 0.000 description 20
- 239000003990 capacitor Substances 0.000 description 19
- 229920002120 photoresistant polymer Polymers 0.000 description 19
- 102000004190 Enzymes Human genes 0.000 description 18
- 108090000790 Enzymes Proteins 0.000 description 18
- 238000005516 engineering process Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- 230000015572 biosynthetic process Effects 0.000 description 15
- 230000000295 complement effect Effects 0.000 description 15
- 238000012545 processing Methods 0.000 description 15
- 239000006227 byproduct Substances 0.000 description 14
- 239000007788 liquid Substances 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 12
- 238000002493 microarray Methods 0.000 description 12
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 12
- 229920005591 polysilicon Polymers 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
- 230000003321 amplification Effects 0.000 description 11
- 238000000151 deposition Methods 0.000 description 11
- 238000005530 etching Methods 0.000 description 11
- 238000003199 nucleic acid amplification method Methods 0.000 description 11
- 238000003498 protein array Methods 0.000 description 11
- 241000894007 species Species 0.000 description 11
- 238000007792 addition Methods 0.000 description 10
- 238000009792 diffusion process Methods 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 239000007789 gas Substances 0.000 description 10
- 238000009396 hybridization Methods 0.000 description 10
- 230000036961 partial effect Effects 0.000 description 10
- 102000007347 Apyrase Human genes 0.000 description 9
- 108010007730 Apyrase Proteins 0.000 description 9
- 238000001712 DNA sequencing Methods 0.000 description 9
- 238000013459 approach Methods 0.000 description 9
- 230000008021 deposition Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 9
- 238000003499 nucleic acid array Methods 0.000 description 9
- 230000006641 stabilisation Effects 0.000 description 9
- 238000011105 stabilization Methods 0.000 description 9
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 9
- 238000000137 annealing Methods 0.000 description 8
- 230000001588 bifunctional effect Effects 0.000 description 8
- 238000001459 lithography Methods 0.000 description 8
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 8
- 238000000059 patterning Methods 0.000 description 8
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 239000001226 triphosphate Substances 0.000 description 8
- 235000011178 triphosphate Nutrition 0.000 description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 229910052782 aluminium Inorganic materials 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 230000014509 gene expression Effects 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 230000003993 interaction Effects 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 238000004806 packaging method and process Methods 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 229920001296 polysiloxane Polymers 0.000 description 7
- 239000011550 stock solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
- SEQKRHFRPICQDD-UHFFFAOYSA-N N-tris(hydroxymethyl)methylglycine Chemical compound OCC(CO)(CO)[NH2+]CC([O-])=O SEQKRHFRPICQDD-UHFFFAOYSA-N 0.000 description 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
- 230000035508 accumulation Effects 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 229960002685 biotin Drugs 0.000 description 6
- 235000020958 biotin Nutrition 0.000 description 6
- 239000011616 biotin Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 239000002131 composite material Substances 0.000 description 6
- 239000002555 ionophore Substances 0.000 description 6
- 230000000236 ionophoric effect Effects 0.000 description 6
- 229910044991 metal oxide Inorganic materials 0.000 description 6
- 150000004706 metal oxides Chemical class 0.000 description 6
- 238000000206 photolithography Methods 0.000 description 6
- 238000001020 plasma etching Methods 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- 239000007997 Tricine buffer Substances 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000005380 borophosphosilicate glass Substances 0.000 description 5
- 238000002508 contact lithography Methods 0.000 description 5
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 5
- 235000011180 diphosphates Nutrition 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 238000001139 pH measurement Methods 0.000 description 5
- 239000005360 phosphosilicate glass Substances 0.000 description 5
- 239000011591 potassium Substances 0.000 description 5
- 229910052700 potassium Inorganic materials 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 125000003396 thiol group Chemical group [H]S* 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 4
- 239000004593 Epoxy Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 229940125773 compound 10 Drugs 0.000 description 4
- 238000013480 data collection Methods 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000011229 interlayer Substances 0.000 description 4
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 4
- 238000001465 metallisation Methods 0.000 description 4
- 239000011368 organic material Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 230000002194 synthesizing effect Effects 0.000 description 4
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
- 229920002732 Polyanhydride Polymers 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 3
- 102000009609 Pyrophosphatases Human genes 0.000 description 3
- 108010009413 Pyrophosphatases Proteins 0.000 description 3
- 229920001486 SU-8 photoresist Polymers 0.000 description 3
- 229910004298 SiO 2 Inorganic materials 0.000 description 3
- 229910021607 Silver chloride Inorganic materials 0.000 description 3
- UZMAPBJVXOGOFT-UHFFFAOYSA-N Syringetin Natural products COC1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UZMAPBJVXOGOFT-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 230000031018 biological processes and functions Effects 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000002800 charge carrier Substances 0.000 description 3
- 238000001311 chemical methods and process Methods 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 238000004518 low pressure chemical vapour deposition Methods 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 238000004377 microelectronic Methods 0.000 description 3
- 230000000116 mitigating effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002581 neurotoxin Substances 0.000 description 3
- 231100000618 neurotoxin Toxicity 0.000 description 3
- 229910017604 nitric acid Inorganic materials 0.000 description 3
- 238000003203 nucleic acid sequencing method Methods 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920001721 polyimide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000000992 sputter etching Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 230000000153 supplemental effect Effects 0.000 description 3
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 102000004594 DNA Polymerase I Human genes 0.000 description 2
- 108010017826 DNA Polymerase I Proteins 0.000 description 2
- 230000006820 DNA synthesis Effects 0.000 description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920001305 Poly(isodecyl(meth)acrylate) Polymers 0.000 description 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 2
- 229920002319 Poly(methyl acrylate) Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 108010067973 Valinomycin Proteins 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000001273 butane Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229940125904 compound 1 Drugs 0.000 description 2
- 229940125782 compound 2 Drugs 0.000 description 2
- 229940126214 compound 3 Drugs 0.000 description 2
- 229940125898 compound 5 Drugs 0.000 description 2
- FCFNRCROJUBPLU-UHFFFAOYSA-N compound M126 Natural products CC(C)C1NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O FCFNRCROJUBPLU-UHFFFAOYSA-N 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000013481 data capture Methods 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 230000004941 influx Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 2
- 235000011285 magnesium acetate Nutrition 0.000 description 2
- 239000011654 magnesium acetate Substances 0.000 description 2
- 229940069446 magnesium acetate Drugs 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 108091070501 miRNA Proteins 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000002966 oligonucleotide array Methods 0.000 description 2
- 238000013021 overheating Methods 0.000 description 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 2
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 2
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 description 2
- 229920000212 poly(isobutyl acrylate) Polymers 0.000 description 2
- 229920000196 poly(lauryl methacrylate) Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920000184 poly(octadecyl acrylate) Polymers 0.000 description 2
- 229920000129 polyhexylmethacrylate Polymers 0.000 description 2
- 229920000197 polyisopropyl acrylate Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920000182 polyphenyl methacrylate Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229940080818 propionamide Drugs 0.000 description 2
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 2
- 229910052814 silicon oxide Inorganic materials 0.000 description 2
- 238000005549 size reduction Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 229910001936 tantalum oxide Inorganic materials 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- 229910001887 tin oxide Inorganic materials 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000007704 wet chemistry method Methods 0.000 description 2
- XUDGDVPXDYGCTG-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-[2-(2,5-dioxopyrrolidin-1-yl)oxycarbonyloxyethylsulfonyl]ethyl carbonate Chemical compound O=C1CCC(=O)N1OC(=O)OCCS(=O)(=O)CCOC(=O)ON1C(=O)CCC1=O XUDGDVPXDYGCTG-UHFFFAOYSA-N 0.000 description 1
- LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 1
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 1
- HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- AASYSXRGODIQGY-UHFFFAOYSA-N 1-[1-(2,5-dioxopyrrol-1-yl)hexyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(CCCCC)N1C(=O)C=CC1=O AASYSXRGODIQGY-UHFFFAOYSA-N 0.000 description 1
- FPKVOQKZMBDBKP-UHFFFAOYSA-N 1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 FPKVOQKZMBDBKP-UHFFFAOYSA-N 0.000 description 1
- KXZQYLBVMZGIKC-UHFFFAOYSA-N 1-pyridin-2-yl-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=CC=NC=1CNCC1=CC=CC=N1 KXZQYLBVMZGIKC-UHFFFAOYSA-N 0.000 description 1
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
- VGFIFGDQCGDVTI-UHFFFAOYSA-N 2,3-bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-naphthalen-1-ylphenol Chemical compound C=1C=CC=NC=1CN(CC=1N=CC=CC=1)CC=1C(O)=CC=C(C=2C3=CC=CC=C3C=CC=2)C=1CN(CC=1N=CC=CC=1)CC1=CC=CC=N1 VGFIFGDQCGDVTI-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- NITXODYAMWZEJY-UHFFFAOYSA-N 3-(pyridin-2-yldisulfanyl)propanehydrazide Chemical compound NNC(=O)CCSSC1=CC=CC=N1 NITXODYAMWZEJY-UHFFFAOYSA-N 0.000 description 1
- ZMRMMAOBSFSXLN-UHFFFAOYSA-N 4-[4-(2,5-dioxopyrrol-1-yl)phenyl]butanehydrazide Chemical compound C1=CC(CCCC(=O)NN)=CC=C1N1C(=O)C=CC1=O ZMRMMAOBSFSXLN-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- HIYAVKIYRIFSCZ-CYEMHPAKSA-N 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid Chemical compound O=C([C@@H](C)[C@H]1O[C@@]2([C@@H](C[C@H]1C)C)O[C@@H]([C@@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C1=CC=CN1 HIYAVKIYRIFSCZ-CYEMHPAKSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 101100328892 Arabidopsis thaliana COL4 gene Proteins 0.000 description 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 241001598984 Bromius obscurus Species 0.000 description 1
- 101100328886 Caenorhabditis elegans col-2 gene Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 230000004568 DNA-binding Effects 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- UDSFAEKRVUSQDD-UHFFFAOYSA-N Dimethyl adipate Chemical compound COC(=O)CCCCC(=O)OC UDSFAEKRVUSQDD-UHFFFAOYSA-N 0.000 description 1
- 101100310856 Drosophila melanogaster spri gene Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004533 Endonucleases Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010026389 Gramicidin Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- VHJLVAABSRFDPM-IMJSIDKUSA-N L-1,4-dithiothreitol Chemical compound SC[C@H](O)[C@@H](O)CS VHJLVAABSRFDPM-IMJSIDKUSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 229930191564 Monensin Natural products 0.000 description 1
- GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
- 101710138657 Neurotoxin Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 108010010677 Phosphodiesterase I Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001283 Polyalkylene terephthalate Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 101150044917 Prl3b1 gene Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 229910006404 SnO 2 Inorganic materials 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000007984 Tris EDTA buffer Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 101100237842 Xenopus laevis mmp18 gene Proteins 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- NYEWVWNUXGFPNY-UHFFFAOYSA-N [amino(benzoyl)amino]-diazonioazanide Chemical compound [N-]=[N+]=NN(N)C(=O)C1=CC=CC=C1 NYEWVWNUXGFPNY-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- XYWMWLADMNOAAA-UHFFFAOYSA-N acetic acid;buta-1,3-diene Chemical compound CC(O)=O.C=CC=C XYWMWLADMNOAAA-UHFFFAOYSA-N 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229920013820 alkyl cellulose Polymers 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 238000000637 aluminium metallisation Methods 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229940064734 aminobenzoate Drugs 0.000 description 1
- 239000006117 anti-reflective coating Substances 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910001422 barium ion Inorganic materials 0.000 description 1
- GYSCAQFHASJXRS-FFCOJMSVSA-N beauvericin Chemical compound C([C@H]1C(=O)O[C@@H](C(N(C)[C@@H](CC=2C=CC=CC=2)C(=O)O[C@@H](C(=O)N(C)[C@@H](CC=2C=CC=CC=2)C(=O)O[C@@H](C(=O)N1C)C(C)C)C(C)C)=O)C(C)C)C1=CC=CC=C1 GYSCAQFHASJXRS-FFCOJMSVSA-N 0.000 description 1
- 108010079684 beauvericin Proteins 0.000 description 1
- GYSCAQFHASJXRS-UHFFFAOYSA-N beauvericin Natural products CN1C(=O)C(C(C)C)OC(=O)C(CC=2C=CC=CC=2)N(C)C(=O)C(C(C)C)OC(=O)C(CC=2C=CC=CC=2)N(C)C(=O)C(C(C)C)OC(=O)C1CC1=CC=CC=C1 GYSCAQFHASJXRS-UHFFFAOYSA-N 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- NXVYSVARUKNFNF-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) 2,3-dihydroxybutanedioate Chemical compound O=C1CCC(=O)N1OC(=O)C(O)C(O)C(=O)ON1C(=O)CCC1=O NXVYSVARUKNFNF-UHFFFAOYSA-N 0.000 description 1
- VYLDEYYOISNGST-UHFFFAOYSA-N bissulfosuccinimidyl suberate Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)C(S(O)(=O)=O)CC1=O VYLDEYYOISNGST-UHFFFAOYSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000006388 chemical passivation reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000005137 deposition process Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- FRTGEIHSCHXMTI-UHFFFAOYSA-N dimethyl octanediimidate Chemical compound COC(=N)CCCCCCC(=N)OC FRTGEIHSCHXMTI-UHFFFAOYSA-N 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000000313 electron-beam-induced deposition Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- DANUORFCFTYTSZ-UHFFFAOYSA-N epinigericin Natural products O1C2(C(CC(C)(O2)C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)C)C(C)C(OC)CC1CC1CCC(C)C(C(C)C(O)=O)O1 DANUORFCFTYTSZ-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- SYUXAJSOZXEFPP-UHFFFAOYSA-N glutin Natural products COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3OC4OC(CO)C(O)C(O)C4O SYUXAJSOZXEFPP-UHFFFAOYSA-N 0.000 description 1
- 229960004905 gramicidin Drugs 0.000 description 1
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 238000005468 ion implantation Methods 0.000 description 1
- 238000000869 ion-assisted deposition Methods 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 1
- PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011901 isothermal amplification Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000005272 metallurgy Methods 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960005358 monensin Drugs 0.000 description 1
- GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 1
- 150000004712 monophosphates Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- RQUGVTLRYOAFLV-UHFFFAOYSA-N n-(4-aminobutyl)-4-azido-2-hydroxybenzamide Chemical group NCCCCNC(=O)C1=CC=C(N=[N+]=[N-])C=C1O RQUGVTLRYOAFLV-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 230000004751 neurological system process Effects 0.000 description 1
- DANUORFCFTYTSZ-BIBFWWMMSA-N nigericin Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)C2O[C@@](C)(CC2)C2[C@H](CC(O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-BIBFWWMMSA-N 0.000 description 1
- 229920003986 novolac Polymers 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000007517 polishing process Methods 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920000111 poly(butyric acid) Polymers 0.000 description 1
- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000128 polypyrrole Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920001290 polyvinyl ester Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 150000003139 primary aliphatic amines Chemical class 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108060006613 prolamin Proteins 0.000 description 1
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000001552 radio frequency sputter deposition Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 238000011451 sequencing strategy Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000003373 small molecule array Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- YPZYGIQXBGHDBH-WKWCOTLASA-M sodium;(2r)-2-[(2r,5s,6r)-6-[(2s,3s,4s,6r)-6-[(3s,5s,9s,10s,12r,15r)-3-[(2r,5r,6s)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan- Chemical compound [Na+].O1[C@@H]([C@@H](CC)C([O-])=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)C2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 YPZYGIQXBGHDBH-WKWCOTLASA-M 0.000 description 1
- ZAPNXDUFCQIHFS-UHFFFAOYSA-M sodium;2,5-dioxo-1-[6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoyloxy]pyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCNC(=O)CCSSC1=CC=CC=N1 ZAPNXDUFCQIHFS-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 1
- 238000001847 surface plasmon resonance imaging Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- PBCFLUZVCVVTBY-UHFFFAOYSA-N tantalum pentoxide Inorganic materials O=[Ta](=O)O[Ta](=O)=O PBCFLUZVCVVTBY-UHFFFAOYSA-N 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000002207 thermal evaporation Methods 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 229920006163 vinyl copolymer Polymers 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
- H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers
- H01L27/04—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body
- H01L27/08—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body including only semiconductor components of a single kind
- H01L27/085—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only
- H01L27/088—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L29/00—Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having potential barriers; Capacitors or resistors having potential barriers, e.g. a PN-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
- H01L29/66—Types of semiconductor device ; Multistep manufacturing processes therefor
- H01L29/68—Types of semiconductor device ; Multistep manufacturing processes therefor controllable by only the electric current supplied, or only the electric potential applied, to an electrode which does not carry the current to be rectified, amplified or switched
- H01L29/76—Unipolar devices, e.g. field effect transistors
- H01L29/772—Field effect transistors
- H01L29/78—Field effect transistors with field effect produced by an insulated gate
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L29/00—Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having potential barriers; Capacitors or resistors having potential barriers, e.g. a PN-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
- H01L29/40—Electrodes ; Multistep manufacturing processes therefor
- H01L29/41—Electrodes ; Multistep manufacturing processes therefor characterised by their shape, relative sizes or dispositions
- H01L29/423—Electrodes ; Multistep manufacturing processes therefor characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
- H01L29/42312—Gate electrodes for field effect devices
- H01L29/42316—Gate electrodes for field effect devices for field-effect transistors
- H01L29/4232—Gate electrodes for field effect devices for field-effect transistors with insulated gate
- H01L29/42324—Gate electrodes for transistors with a floating gate
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01006—Carbon [C]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01013—Aluminum [Al]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01015—Phosphorus [P]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01073—Tantalum [Ta]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/10—Details of semiconductor or other solid state devices to be connected
- H01L2924/11—Device type
- H01L2924/14—Integrated circuits
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/10—Details of semiconductor or other solid state devices to be connected
- H01L2924/11—Device type
- H01L2924/14—Integrated circuits
- H01L2924/143—Digital devices
- H01L2924/1433—Application-specific integrated circuit [ASIC]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/22—Hydrogen, per se
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Power Engineering (AREA)
- Computer Hardware Design (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ceramic Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Description
1つの化学感応性電界効果トランジスタを含む複数の電界効果トランジスタ(FET)および複数のFETに電気的に接続した複数の電気伝導体を含み、ここで複数のFETは、複数の電気伝導体が、各センサによって占有されたエリアを横断し、アレイの多数のセンサと相互接続する4つ以下の導体を含むように配置される装置に関する。
多くの使用に対して、上で説明した高密度電子アレイを用いて化学反応または化学剤を感知するシステムを完成させるために、アレイ素子(「ピクセル」と呼ばれる)に、感知のための化学的または生化学的要素を含有する流体を送達するための、技法および装置が必要である。この節では、例示の技法および方法が説明され、これらは所望の特徴を有しており、かかる目的に有用である。
他の場所で検討したように、例えばDNAシークエンシングなどの多くの使用について、半導体センサアレイの上に、対応するマイクロウェルのアレイを提供するのが望ましく、ここで各マイクロウェルは、好ましくは1つのみのDNA負荷ビーズ(DNA-loaded bead)を受け取るのに十分小さく、これに関連して、アレイの下にあるピクセルは、対応する出力信号を提供する。
マイクロウェルの製造は、多くの方法により行ってよい。製造の実際の詳細にはいくつかの実験が必要となることもあり、利用可能な加工能力により変化する。
接触リソグラフィには制限があり、最高密度のウェルを製造するために選択される製造方法ではない可能性があり、すなわち、横方向に、望ましい最小ピッチ限界よりも大きい値をもたらす可能性がある。
チップ上のセンサのアレイのアセンブリをマイクロウェルのアレイと組み合わせて用いて、試料中のDNAのシークエンシングを行うプロセスを、「実験」と呼ぶ。実験の実施には、ウェルにDNA結合ビーズを装填し、ウェル全体に数種類の異なる溶液(すなわち、試薬および洗浄液)を流すことが必要である。流体インターフェイスと結合した液体送達システムが必要であり、これは、種々の溶液をウェル全体に、制御された層流で許容し得る程度の小さい死容積および、順次の溶液間での少ない二次汚染を有して流す。流体インターフェイスは「フローセル」と呼ばれることもある。
・ 流体送達システムとの好適な相互接続−例えば、適当な寸法の配管を介して。
・ ウェルの上の適当なヘッドスペース(dnaシークエンシング用には、約300μm)。
・ フローチャンバ内に入る前に、流体が遭遇する死容積(すなわち、マイクロウェルアレイの上に包含されるスペース)の最小化。
・ 液体と接触する小さなスペースの除去、しかし、フローセルを通って除去するのではない(二次汚染を最小化するため)。
・ 層流特性が、これが入り口側から出口側までチップ全体を横切る間、広い/平らなフロントのプロファイルを維持するようなものであること。
・ 取り外し可能な参照電極の、フローチャンバ内部またはこれにできるだけ近くへの配置に対して、適合性があること。
・ ビーズの装填の容易さ。
・ 許容できるコストで製造可能であること。
・ フローセルの組み立てとチップパッケージへの取り付けの容易さ。
記載を容易にするため、図38から開始される製造についての検討において、これからはグラススライド3422を、図34〜37における配置と比較して上下を逆にして考える。
第2の層は好ましくは約150μmの深さであり、これは流体輸送チャネルを覆っているが、ただし、スリット形成領域4014と4016の下にある、センサアレイチップのそれぞれの端における約150μmの長さのスリットは除く。
図34〜36には図示されていないが、参照電極は、図37に示すように、フローチャンバの天井におけるメタライゼーション3710であることが理解される。
中央ボア5550は、参照電極5560を受けるように、ガラス層を通してエッチングすることができる。電極は、シリコーンカラー5570または同様の構造により、位置に固定および密封することができる。または、電極は好適なワッシャーと一体的に構成して、同様の目的を有効にすることができる。
市販のフロー型流体電極、例えば塩化銀プロトン透過性電極を、直列で流体系に挿入することができ、これらの電極は一般に、種々の電気化学的目的のために、流体系に沿って安定な電位を提供するよう設計されている。しかし上記のシステムおいては、かかる電位はマイクロウェルISFETチップと接触している流体容積において維持されなければならない。従来の塩化銀電極では、チップ表面と電極との間の(フローセル内の小さなチャネルを通る)電気的に長い流体路のために、安定な電位の実現は困難であることが見出された。これは、チップの電子機器においてノイズの受信をもたらす。さらに、電極の流れの空洞(flow cavity)内の大きな容積は、流体との電気的接続を劣化させる気泡を閉じ込めて蓄積しがちである。
センサアレイを用いるための完全なシステムは、好適な流体源、バルブ操作および、用途に依存して、マイクロアレイまたはセンサアレイ上の低い試薬および洗浄液のためのバルブ操作用のコントローラを含むであろう。これらの素子は既製の要素から容易に組み立てることができ、コントローラは容易にプログラムして、所望の実験を実施することができる。
以下は、一本鎖オリゴヌクレオチドの、ISFETアレイを用いた迅速シークエンシングのための原理の証明例である。
5’デュアルビオチンタグ(HPLC精製)付き一本鎖DNAオリゴヌクレオチドテンプレートおよび20塩基汎用プライマーは、IDT(Integrated DNA Technologies, Coralville, IN)から注文した。
5’末端において5.91μmの磁気ビーズに結合した不動化テンプレートを、次にテンプレートの3’末端に相補的な20塩基プライマーにアニーリングした(表1)。400μMのプライマー原液の、不動化テンプレートに対してプライマーの20倍過剰量である1.0μlのアリコートを加え、次にビーズとテンプレートとを、プライマーを用いて15分間95℃でインキュベーションし、次に温度をゆっくりと室温に下げた。次にビーズを、上述のようにMPC−sを用いて、120μlの25mMトリシン緩衝液(25mMトリシン、0.4mg/mlのPVP、0.1%のTween 20、8.8mMの酢酸マグネシウム、pH7.8)で3回洗浄した。ビーズを25mMのトリシン緩衝液中に再懸濁させた。
テンプレートとプライマーのハイブリッドを、基本的にMargulies et al. Nature 2005 437(15):376-380および添付の補足資料に記載のようにしてポリメラーゼと共にインキュベーションした。
ISFETアレイおよびその上のマイクロ流体の寸法および密度は、用途に応じて変えてよい。非限定的な例は、512×512アレイである。かかるアレイの各グリッド(262144個となる)は、単一のISFETを有する。各グリッドはまた、その上に位置するウェル(またはこれは本明細書では「マイクロウェル」と同義で用いられる)を有する。
テンプレート1〜4を有するビーズを、チップ上に負荷した(各テンプレートを10μl)。簡略に述べると、各テンプレートのアリコートを、エッペンドルフピペットを用いてチップ上に加えた。次に磁石を用いてビーズをウェル内に引き入れた。
捕捉ビーズとパッキングビーズの両方を、流れを用いて負荷する。ビーズ溶液の容積に対するマイクロリットル単位の精度、およびビーズ溶液の流体接続を通した配置は、図62に示すように、ビーズ負荷取付け部品(bead loading fitting)を用いて実現する。該ビーズ負荷取付け部品は、大リザーバ(容積約1ml)、小リザーバ(容積約10μl)、および小容積のビーズ溶液を操作するためのマイクロ流体チャネルを含む。この方法はまた、精密なピペットにより可能となる、流体適用のマイクロリットル単位の精度も利用する。
3.1 「オープン」システムでのDNAシークエンシング
提示する結果は、「オープン」システムにおいて行われた実験の代表的なものである(すなわち、この実験は、ISFETチップをISFET装置のプラットフォーム上に配置し、次に各ヌクレオチド(5μl、その結果それぞれ6.5μM)を手動で次の順序:dATP、dCTP、dGTPおよびdTTP(100mM原液、Pierce, Milwaukee, WI)により、与えられたヌクレオチドをチップ表面上に既にある液体中にピペットで加えて、チップから2.5mHzの速度でデータを収集した)。これにより、データ収集は、7.5秒間で約18フレーム/秒となった。次にデータをLab Viewを用いて解析した。
流動様式におけるシークエンシングは、ヌクレオチド試薬のDNAへの取り込みへの、開かれた適用の拡張である。試薬をISFETチップのバルクの溶液中に加えるのでなく、試薬を連続的な様式でチップ表面全体に流し、1回に単一DNA塩基(単数または複数)を伸長させる。dNTPを、dTTPから初めて、次にdATP、dCTPおよびdGTPと連続して流す。チップ上の流体の動きの層流の性質による、ヌクレオチドのマイクロウェルへの、および最終的には核酸負荷ビーズの周りへの拡散が、送達の主要な機構である。
ISFETチップは、ヌクレオチド流の最中に、DNA伸長の化学的生成物を感知するために活性化される。
Claims (25)
- 核酸シークエンシングのための方法であって、
複数のテンプレート核酸を、少なくとも105個のセンサに対し少なくとも105個の反応体積内に配置すること、ここで、フローティングゲートを有する電界効果トランジスタを含む前記センサは、前記反応体積に結合され、複数のテンプレート核酸のうちの少なくとも1つとハイブリダイズされる1または2以上のプライマーにヌクレオチドを取り込むことにより放出された水素イオンを検出する、
既知のヌクレオチドを反応体積に導入すること、
pH7とpH9との間に亘る、予め指定されたpH範囲内で、反応体積内のpH変化を測定するため、回路をセンサの電界効果トランジスタに結合すること、ここで、測定されたpH変化は、導入された既知のヌクレオチドを1または2以上のプライマーに取り込むことから生じ、電界効果トランジスタで検出される水素イオンの放出に基づき、前記回路が、測定されたpH変化を示す出力信号をさらに生成する、および、
テンプレート核酸の部分に対応する配列の少なくとも部分を決定するために、回路によって生成された出力信号を分析すること、
を含む、前記方法。 - センサが、それぞれ100μm2以下の面積を占め、10μm以下のピッチを有し、かつ、反応体積が、1μm3〜1500μm3範囲内にある各体積を有する、請求項1に記載の方法。
- 反応体積が、それぞれ少なくとも前記テンプレート核酸の105のコピーを含有する、請求項1に記載の方法。
- 核酸テンプレートが、少なくとも一つの固体支持体により保持される、請求項1に記載の方法。
- 反応体積およびセンサが、それぞれ256,000個より多い、請求項1に記載の方法。
- 少なくとも1つの固体支持体が少なくとも1つの粒子を含む、請求項4に記載の方法。
- 少なくとも1つの粒子が、セルロース、セルロース誘導体、ゼラチン、アクリル樹脂、ガラス、シリカゲル、ポリビニルピロリジン(PVP)、ビニルとアクリルアミドとのコポリマー、ポリスチレン、ジビニルベンゼンと架橋されたポリスチレン、ポリアクリルアミド、ラテックスゲル、デキストラン、架橋デキストラン、ゴム、ケイ素、プラスチック、ニトロセルロース、天然スポンジ、金属、アガロースゲル、またはストレプトアビジン被覆を含む、請求項6に記載の方法。
- 少なくとも1つの粒子が、直径1〜10μmである、請求項6に記載の方法。
- 既知のヌクレオチドが、dATP、dCTP、dGTPおよびdTTPからなる群から選択されるヌクレオチドである、請求項1に記載の方法。
- 既知のヌクレオチドの導入が、ATPを含む洗浄緩衝液を反応体積に送達することを含む、請求項1に記載の方法。
- 反応体積から、非取り込みで、導入された既知のヌクレオチドを洗浄すること、
既知の第2のヌクレオチドを反応体積に導入すること、
導入された既知の第2のヌクレオチドを1または2以上のプライマーに取り込むことから生じ、電界効果トランジスタによって検出された水素イオンの放出に基づく、反応体積内の第2のpH変化を測定するため、回路を電界効果トランジスタに結合すること、ここで、前記回路は、測定された第2のpH変化を示す第2の出力信号をさらに生成する、および、
テンプレート核酸の第2の部分に対応する配列の少なくとも第2の部分を決定するために、第2の出力信号を分析すること、
をさらに含む、請求項1に記載の方法。 - 測定されたpH変化が、放出された水素イオンによる電界効果トランジスタの閾値電圧に基づく、請求項1に記載の方法。
- 回路をセンサにおける所与のセンサの所与の電界効果トランジスタに結合することが、
所与の電界効果トランジスタの第1端子および第2端子をバイアス回路に結合すること、ここで、前記バイアス回路は、読取り電圧を第1端子に印加し、かつ、第1端子と第2端子間の電圧差を構築する、
所与の電界効果トランジスタを、所与の電界効果トランジスタによってバイアス電流を提供する電源に結合すること、それによって、対応するpH変化から生じる所与の電界効果トランジスタの閾値電圧に基づき、第2端子における電圧レベルを構築する、および、
対応する出力信号を生成するため、第2端子を、第2端子における電圧レベルを読み取るための読取り回路に結合すること、
を含む、請求項1に記載の方法。 - 所与のセンサが、さらに、
所与の電界効果トランジスタおよびバイアス回路の第2端子と読取り回路との間に結合された第1スイッチ、および、
所与の電界効果トランジスタの第2端子と電源との間に結合された第2スイッチ、
を含む、請求項13に記載の方法。 - 第1スイッチおよび第2スイッチが、所与の電界効果トランジスタの第2端子をバイアス回路および電源に結合するため、共通の選択信号に応答する、請求項14に記載の方法。
- 第1スイッチおよび第2スイッチが、それぞれ、所与の電界効果トランジスタのチャンネル型と同じチャンネル型を有する単一トランジスタスイッチである、請求項14に記載の方法。
- 所与の電界効果トランジスタの第1端子が、バイアス回路に直接に接続される、請求項14に記載の方法。
- バイアス回路および読取り回路が、複数のセンサの間で共有される、請求項14に記載の方法。
- センサが複数の行および複数の列に並べられ、バイアス回路および読取り回路が複数の列のセンサの列の間で共有される、請求項18に記載の方法。
- センサにおける所与のセンサが、
pH変化に基づいて、所与の電界効果トランジスタの第1端子の電圧レベルを構築するための、所与の電界効果トランジスタによるバイアス電流を提供するため、所与のセンサの所与の電界効果トランジスタと電源との間を結合する第1の単一トランジスタスイッチ、および、
所与の出力信号を生成するための、第1端子の電圧レベルを読み取るため、所与の電界効果トランジスタの第1端子と回路との間を結合する第2の単一トランジスタスイッチ、
をさらに含む、請求項1に記載の方法。 - 第1の単一トランジスタスイッチおよび第2の単一トランジスタスイッチが、所与の電界効果トランジスタのチャンネル型と同じチャンネル型を有する、請求項20に記載の方法。
- 第1の単一トランジスタスイッチ、第2の単一トランジスタスイッチおよび所与の電界効果トランジスタのボディ接続が、それぞれ共通のラインに接続される、請求項20に記載の方法。
- 電界効果トランジスタのフローティングゲートが、水素イオンに感応するパシベーション層を介して反応体積に結合される、請求項1に記載の方法。
- 配置することが、テンプレート核酸を反応体積に配置すること、および反応体積においてテンプレート核酸を増幅することを含む、請求項1に記載の方法。
- 増幅することが、反応体積において等温的にテンプレート核酸を増幅することを含む、請求項24に記載の方法。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87007306P | 2006-12-14 | 2006-12-14 | |
US60/870,073 | 2006-12-14 | ||
US94874807P | 2007-07-10 | 2007-07-10 | |
US60/948,748 | 2007-07-10 | ||
US95632407P | 2007-08-16 | 2007-08-16 | |
US60/956,324 | 2007-08-16 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009541416A Division JP5622392B2 (ja) | 2006-12-14 | 2007-12-14 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014245830A Division JP6125485B2 (ja) | 2006-12-14 | 2014-12-04 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013081464A JP2013081464A (ja) | 2013-05-09 |
JP5662407B2 true JP5662407B2 (ja) | 2015-01-28 |
Family
ID=39536915
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009541416A Active JP5622392B2 (ja) | 2006-12-14 | 2007-12-14 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246413A Active JP5563044B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246417A Active JP5643277B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246414A Active JP5662407B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246415A Active JP5622825B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246416A Active JP5643276B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2014245830A Active JP6125485B2 (ja) | 2006-12-14 | 2014-12-04 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2017030653A Pending JP2017127308A (ja) | 2006-12-14 | 2017-02-22 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009541416A Active JP5622392B2 (ja) | 2006-12-14 | 2007-12-14 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246413A Active JP5563044B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246417A Active JP5643277B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012246415A Active JP5622825B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2012246416A Active JP5643276B2 (ja) | 2006-12-14 | 2012-11-08 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2014245830A Active JP6125485B2 (ja) | 2006-12-14 | 2014-12-04 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
JP2017030653A Pending JP2017127308A (ja) | 2006-12-14 | 2017-02-22 | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Country Status (9)
Country | Link |
---|---|
US (36) | US7948015B2 (ja) |
EP (10) | EP2092322B1 (ja) |
JP (8) | JP5622392B2 (ja) |
CN (1) | CN101669026B (ja) |
AU (1) | AU2007334393A1 (ja) |
CA (1) | CA2672315A1 (ja) |
ES (1) | ES2923759T3 (ja) |
GB (2) | GB2457851B (ja) |
WO (1) | WO2008076406A2 (ja) |
Families Citing this family (926)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US7833709B2 (en) | 2004-05-28 | 2010-11-16 | Wafergen, Inc. | Thermo-controllable chips for multiplex analyses |
US20070248958A1 (en) | 2004-09-15 | 2007-10-25 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US20100137163A1 (en) | 2006-01-11 | 2010-06-03 | Link Darren R | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors |
CA2641271A1 (en) | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
US8889348B2 (en) * | 2006-06-07 | 2014-11-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by nanopore using modified nucleotides |
US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
EP2092322B1 (en) | 2006-12-14 | 2016-02-17 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale fet arrays |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8349167B2 (en) * | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US7932034B2 (en) | 2006-12-20 | 2011-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Heat and pH measurement for sequencing of DNA |
KR20100028526A (ko) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 및 나노유체 장치, 시스템 및 응용 |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8487231B2 (en) * | 2007-03-05 | 2013-07-16 | Arokia Nathan | Sensor pixels, arrays and array systems and methods therefor |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
GB2445036B (en) * | 2007-05-18 | 2008-12-17 | Vernacare Ltd | Device for reducing fibrous products |
WO2009017882A2 (en) * | 2007-06-08 | 2009-02-05 | Takulapalli Bharath R | Nano structured field effect sensor and methods of forming and using same |
KR101375547B1 (ko) * | 2007-06-19 | 2014-03-25 | 삼성전자주식회사 | 표준 전극이 포함된 전계 효과 트랜지스터 어레이를 이용한생체 분자의 검출 장치 및 방법 |
KR101478540B1 (ko) * | 2007-09-17 | 2015-01-02 | 삼성전자 주식회사 | 트랜지스터의 채널로 나노 물질을 이용하는 바이오 센서 및그 제조 방법 |
WO2009108260A2 (en) | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
JP5412048B2 (ja) * | 2008-04-02 | 2014-02-12 | ルネサスエレクトロニクス株式会社 | 半導体記憶装置及びその製造方法 |
GB2461127B (en) * | 2008-06-25 | 2010-07-14 | Ion Torrent Systems Inc | Methods and apparatus for measuring analytes using large scale FET arrays |
GB2461128B (en) * | 2008-06-25 | 2010-12-15 | Ion Torrent Systems Inc | ChemFET Arrays for Nucleic Acid Sequencing |
WO2010008480A2 (en) | 2008-06-25 | 2010-01-21 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes using large scale fet arrays |
EP2304420A4 (en) * | 2008-06-26 | 2013-10-30 | Life Technologies Corp | METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS |
WO2010004115A1 (fr) * | 2008-06-27 | 2010-01-14 | Stmicroelectronics (Research & Development) Limited | Dispositif d'analyse biologique de type pixel, biocapteur cmos et procedes de fabrication correspondants |
EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
TWI474305B (zh) * | 2008-07-31 | 2015-02-21 | Sitronix Technology Corp | The polarity switching structure of point conversion system |
US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
US8278614B2 (en) * | 2008-10-09 | 2012-10-02 | Dongbu Hitek Co., Ltd. | Image sensor and method for manufacturing the same |
WO2013154750A1 (en) | 2012-04-10 | 2013-10-17 | The Trustees Of Columbia Unversity In The City Of New York | Systems and methods for biological ion channel interfaces |
US11951474B2 (en) | 2008-10-22 | 2024-04-09 | Life Technologies Corporation | Fluidics systems for sequential delivery of reagents |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100301398A1 (en) * | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
CN102301228A (zh) * | 2008-10-22 | 2011-12-28 | 生命技术公司 | 用于生物和化学分析的集成式传感器阵列 |
US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
KR20110042188A (ko) * | 2008-10-24 | 2011-04-25 | 가부시키가이샤 어드밴티스트 | 전자 디바이스 및 제조 방법 |
EP2384429A1 (en) | 2008-12-31 | 2011-11-09 | Integenx Inc. | Instrument with microfluidic chip |
US8853832B2 (en) * | 2009-01-22 | 2014-10-07 | Stmicroelectronics Inc. | Methods and apparatus for reducing coupling in a MOS device |
TWI394948B (zh) * | 2009-03-17 | 2013-05-01 | Univ Nat Chiao Tung | 無須標定之感測器 |
EP2411148B1 (en) | 2009-03-23 | 2018-02-21 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
EP2425240A4 (en) | 2009-04-30 | 2012-12-12 | Good Start Genetics Inc | METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS |
US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
TWI414787B (zh) * | 2009-05-26 | 2013-11-11 | Univ Chang Gung | 感測場效電晶體裝置 |
US8574835B2 (en) * | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
US20120261274A1 (en) | 2009-05-29 | 2012-10-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
EP3301104B1 (en) | 2009-05-29 | 2019-10-30 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
CN102459565A (zh) | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | 具有隔膜阀的流控设备 |
RU2559541C2 (ru) | 2009-06-05 | 2015-08-10 | Интедженкс Инк. | Универсальная система подготовки образцов и применение в интегрированной системе анализа |
US9029132B2 (en) | 2009-08-06 | 2015-05-12 | International Business Machines Corporation | Sensor for biomolecules |
JP5083287B2 (ja) * | 2009-09-11 | 2012-11-28 | セイコーエプソン株式会社 | 検出装置、物理量測定装置及び電子機器 |
DE102009043527B4 (de) * | 2009-09-30 | 2021-06-10 | Boehringer Ingelheim Vetmedica Gmbh | Anordnung und Verfahren unter Verwendung von Mikrosensoren zum Messen von Zell-Vitalitäten |
EP2486409A1 (en) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
CN103954656A (zh) * | 2009-11-25 | 2014-07-30 | 出光兴产株式会社 | 润滑油的劣化度测定装置、以及机械、装置的润滑油监视系统 |
US8584703B2 (en) * | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
EP2507387B1 (en) | 2009-12-01 | 2017-01-25 | Oxford Nanopore Technologies Limited | Biochemical analysis instrument and method |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US8052931B2 (en) * | 2010-01-04 | 2011-11-08 | International Business Machines Corporation | Ultra low-power CMOS based bio-sensor circuit |
US8398418B2 (en) * | 2010-01-07 | 2013-03-19 | Life Technologies Corporation | Electronic connector having a clamping member urging a flow cell toward an electrical circuitry with an electrically conductive membrane disposed in between |
EP2357468B1 (en) * | 2010-01-21 | 2017-09-20 | Nxp B.V. | Sensor and measurement method |
US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
JP2011163993A (ja) * | 2010-02-12 | 2011-08-25 | Hitachi Ltd | 試料分析チップ及び試料分析システム |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US8535889B2 (en) | 2010-02-12 | 2013-09-17 | Raindance Technologies, Inc. | Digital analyte analysis |
CA3116307C (en) | 2010-02-23 | 2023-10-17 | University Of Washington | Artificial mycolic acid membranes |
US20120202276A1 (en) | 2010-02-26 | 2012-08-09 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
US20110262903A1 (en) * | 2010-02-26 | 2011-10-27 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
GB201004147D0 (en) * | 2010-03-12 | 2010-04-28 | Dna Electronics Ltd | Method and apparatus for sensing methylation |
PL2556171T3 (pl) | 2010-04-05 | 2016-04-29 | Prognosys Biosciences Inc | Oznaczenia biologiczne kodowane przestrzennie |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US9068935B2 (en) | 2010-04-08 | 2015-06-30 | International Business Machines Corporation | Dual FET sensor for sensing biomolecules and charged ions in an electrolyte |
EP2558854B1 (en) | 2010-04-16 | 2018-10-10 | Chronix Biomedical | Breast cancer associated circulating nucleic acid biomarkers |
US10378064B1 (en) | 2010-04-16 | 2019-08-13 | Chronix Biomedical | Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population |
WO2011128096A1 (en) | 2010-04-16 | 2011-10-20 | Roche Diagnostics Gmbh | Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
ES2647612T3 (es) | 2010-06-04 | 2017-12-22 | Chronix Biomedical | Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de próstata |
US20120035062A1 (en) * | 2010-06-11 | 2012-02-09 | Life Technologies Corporation | Alternative nucleotide flows in sequencing-by-synthesis methods |
US20110318820A1 (en) * | 2010-06-29 | 2011-12-29 | Life Technologies Corporation | Immobilized Buffer Particles and Uses Thereof |
EP2588850B1 (en) * | 2010-06-30 | 2016-12-28 | Life Technologies Corporation | Method for dry testing isfet arrays |
US9164070B2 (en) | 2010-06-30 | 2015-10-20 | Life Technologies Corporation | Column adc |
AU2011226767B1 (en) * | 2010-06-30 | 2011-11-10 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
TWI527245B (zh) | 2010-07-03 | 2016-03-21 | 生命技術公司 | 具有微摻雜汲極之化學感測器 |
WO2012006546A2 (en) * | 2010-07-08 | 2012-01-12 | The Johns Hopkins University | Circuits, devices and sensors for fluid detection |
PT2591125T (pt) * | 2010-07-09 | 2018-05-09 | Cergentis B V | Estratégias 3-d de sequenciação de regiões genómicas de interesse |
EP2601609B1 (en) | 2010-08-02 | 2017-05-17 | Population Bio, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
EP2601517B8 (en) | 2010-08-06 | 2016-02-17 | Dnae Group Holdings Limited | Fluid sensor on a wirelessly connected chip |
JP5959516B2 (ja) * | 2010-08-18 | 2016-08-02 | ライフ テクノロジーズ コーポレーション | 電気化学的検出装置のためのマイクロウェルの化学コーティング法 |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
EP2606154B1 (en) | 2010-08-20 | 2019-09-25 | Integenx Inc. | Integrated analysis system |
CN103201696B (zh) * | 2010-08-23 | 2015-09-23 | 生命科技股份有限公司 | 化学检测系统的温度控制 |
WO2012036679A1 (en) | 2010-09-15 | 2012-03-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
JP5920687B2 (ja) * | 2010-09-17 | 2016-05-18 | 国立大学法人 東京大学 | Dna塩基配列解析装置およびdna塩基配列解析方法 |
EP2619329B1 (en) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
CN105911126B (zh) | 2010-09-24 | 2018-12-18 | 生命科技公司 | 匹配的晶体管对电路 |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
GB2499340B (en) | 2010-10-04 | 2015-10-28 | Genapsys Inc | Methods for sequencing nucleic acids |
GB2540904B (en) | 2010-10-08 | 2017-05-24 | Dnae Group Holdings Ltd | Electrostatic discharge protection |
GB201017023D0 (en) * | 2010-10-08 | 2010-11-24 | Dna Electronics Ltd | ISFET switch |
US10273540B2 (en) | 2010-10-27 | 2019-04-30 | Life Technologies Corporation | Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis |
EP3141614B1 (en) | 2010-10-27 | 2018-11-28 | Life Technologies Corporation | Predictive model for use in sequencing-by-synthesis |
EP2632593B1 (en) | 2010-10-27 | 2021-09-29 | Illumina, Inc. | Flow cells for biological or chemical analysis |
US9074251B2 (en) | 2011-02-10 | 2015-07-07 | Illumina, Inc. | Linking sequence reads using paired code tags |
EP3709303A1 (en) | 2010-12-14 | 2020-09-16 | Life Technologies Corporation | Systems and methods for run-time sequencing run quality monitoring |
WO2013082164A1 (en) | 2011-11-28 | 2013-06-06 | Life Technologies Corporation | Enhanced ligation reactions |
GB2500360B (en) | 2010-12-22 | 2019-10-23 | Genia Tech Inc | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
WO2012118555A1 (en) | 2010-12-29 | 2012-09-07 | Life Technologies Corporation | Time-warped background signal for sequencing-by-synthesis operations |
US20130060482A1 (en) | 2010-12-30 | 2013-03-07 | Life Technologies Corporation | Methods, systems, and computer readable media for making base calls in nucleic acid sequencing |
WO2012092455A2 (en) | 2010-12-30 | 2012-07-05 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
WO2012092515A2 (en) | 2010-12-30 | 2012-07-05 | Life Technologies Corporation | Methods, systems, and computer readable media for nucleic acid sequencing |
CN102175740A (zh) * | 2011-01-07 | 2011-09-07 | 浙江工业大学 | 基于标准CMOS工艺的多层浮栅全固态pH值传感器 |
CN103620403B (zh) | 2011-01-11 | 2016-08-10 | 纽约市哥伦比亚大学理事会 | 使用纳米管监测单分子的系统和方法 |
US9581563B2 (en) | 2011-01-24 | 2017-02-28 | Genia Technologies, Inc. | System for communicating information from an array of sensors |
US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
CN102621188B (zh) * | 2011-01-30 | 2015-09-30 | 东莞博识生物科技有限公司 | 电磁生物传感器装置及其制作方法 |
US8594951B2 (en) | 2011-02-01 | 2013-11-26 | Life Technologies Corporation | Methods and systems for nucleic acid sequence analysis |
US10457936B2 (en) | 2011-02-02 | 2019-10-29 | University Of Washington Through Its Center For Commercialization | Massively parallel contiguity mapping |
EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
WO2012116161A1 (en) | 2011-02-23 | 2012-08-30 | The Trustees Of Columbia University In The City Of New York | Systems and methods for single-molecule detection using nanopores |
WO2012138921A1 (en) | 2011-04-08 | 2012-10-11 | Life Technologies Corporation | Phase-protecting reagent flow orderings for use in sequencing-by-synthesis |
US20120258546A1 (en) | 2011-04-08 | 2012-10-11 | Life Technologies Corporation | Automated On-Instrument pH Adjustment |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
CN110016499B (zh) | 2011-04-15 | 2023-11-14 | 约翰·霍普金斯大学 | 安全测序系统 |
EP2699903B1 (en) * | 2011-04-20 | 2018-07-18 | Life Technologies Corporation | Methods, compositions and systems for sample deposition |
WO2012166742A2 (en) | 2011-05-27 | 2012-12-06 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
WO2012166647A1 (en) | 2011-05-27 | 2012-12-06 | Life Technologies Corporation | Methods for manipulating biomolecules |
EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
CN102324002B (zh) * | 2011-06-03 | 2013-10-30 | 哈尔滨工程大学 | 基于数字图像处理的dna序列的二维图像表示方法 |
WO2012168932A1 (en) * | 2011-06-06 | 2012-12-13 | Yeda Research And Development Co. Ltd | Protein detector based on molecular controlled semiconductor resistor |
EP2718465B1 (en) | 2011-06-09 | 2022-04-13 | Illumina, Inc. | Method of making an analyte array |
US9139874B2 (en) | 2011-07-07 | 2015-09-22 | Life Technologies Corporation | Bi-directional sequencing compositions and methods |
JP6028025B2 (ja) | 2011-07-08 | 2016-11-16 | キージーン・エン・フェー | オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定 |
WO2013010062A2 (en) | 2011-07-14 | 2013-01-17 | Life Technologies Corporation | Nucleic acid complexity reduction |
CN102890101B (zh) * | 2011-07-18 | 2014-09-10 | 东莞博识生物科技有限公司 | 具有自校准区域的生物传感器芯片及其测试方法 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US9670538B2 (en) | 2011-08-05 | 2017-06-06 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
LT2742151T (lt) * | 2011-08-10 | 2018-02-12 | Life Technologies Corporation | Polimerazės kompozicija |
US11208636B2 (en) | 2011-08-10 | 2021-12-28 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
EP2745108B1 (en) | 2011-08-18 | 2019-06-26 | Life Technologies Corporation | Methods, systems, and computer readable media for making base calls in nucleic acid sequencing |
US10704164B2 (en) | 2011-08-31 | 2020-07-07 | Life Technologies Corporation | Methods, systems, computer readable media, and kits for sample identification |
US20130073214A1 (en) | 2011-09-20 | 2013-03-21 | Life Technologies Corporation | Systems and methods for identifying sequence variation |
US10378051B2 (en) | 2011-09-29 | 2019-08-13 | Illumina Cambridge Limited | Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing |
WO2013049504A1 (en) | 2011-09-30 | 2013-04-04 | Stc.Unm | Dna sample preparation and sequencing |
WO2013055553A1 (en) | 2011-10-03 | 2013-04-18 | Life Technologies Corporation | Electric field directed loading of microwell array |
CA2850930A1 (en) | 2011-10-03 | 2013-04-11 | Celmatix, Inc. | Methods and devices for assessing risk to a putative offspring of developing a condition |
WO2013052837A1 (en) | 2011-10-05 | 2013-04-11 | Life Technologies Corporation | Signal correction for multiplexer cross-talk in chemical sensor arrays |
WO2013052825A1 (en) | 2011-10-05 | 2013-04-11 | Life Technologies Corporation | Bypass for r-c filter in chemical sensor arrays |
US10221454B2 (en) | 2011-10-10 | 2019-03-05 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
US20130091126A1 (en) | 2011-10-11 | 2013-04-11 | Life Technologies Corporation | Systems and methods for analysis and interpretation of nucleic acid sequence data |
CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
PL2768985T3 (pl) | 2011-10-21 | 2019-10-31 | Chronix Biomedical | Biomarkery będące krążącymi kwasami nukleinowymi związane z rakiem jelita grubego |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
DE102011085473A1 (de) | 2011-10-28 | 2013-05-02 | Albert-Ludwigs-Universität Freiburg | Verfahren zur Identifikation von Aptameren |
WO2013063382A2 (en) | 2011-10-28 | 2013-05-02 | Illumina, Inc. | Microarray fabrication system and method |
US11180807B2 (en) | 2011-11-04 | 2021-11-23 | Population Bio, Inc. | Methods for detecting a genetic variation in attractin-like 1 (ATRNL1) gene in subject with Parkinson's disease |
EP2776165A2 (en) | 2011-11-07 | 2014-09-17 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
TWI427760B (zh) * | 2011-11-17 | 2014-02-21 | Helio Optoelectronics Corp | 高壓交流發光二極體結構 |
JP6193252B2 (ja) * | 2011-12-01 | 2017-09-06 | ジナプシス インコーポレイテッド | 高効率電子配列決定及び検出のためのシステム並びに方法 |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US10167520B2 (en) | 2011-12-06 | 2019-01-01 | Scot E. Dowd | Universal or broad range assays and multi-tag sample specific diagnostic process using non-optical sequencing |
DK2788499T3 (en) | 2011-12-09 | 2016-03-21 | Illumina Inc | Enhanced root for polymer tags |
CN104487834B (zh) | 2011-12-22 | 2018-07-17 | Bd公司 | 用于快速检测传染性微生物的方法和设备 |
US10150993B2 (en) | 2011-12-22 | 2018-12-11 | Ibis Biosciences, Inc. | Macromolecule positioning by electrical potential |
US9803188B2 (en) | 2011-12-22 | 2017-10-31 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
WO2013096799A1 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
WO2013096777A2 (en) * | 2011-12-23 | 2013-06-27 | Wake Forest University Health Sciences | Integrated compound discovery systems and methods |
US9823246B2 (en) | 2011-12-28 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon |
US9506113B2 (en) | 2011-12-28 | 2016-11-29 | Ibis Biosciences, Inc. | Nucleic acid ligation systems and methods |
US9803231B2 (en) | 2011-12-29 | 2017-10-31 | Ibis Biosciences, Inc. | Macromolecule delivery to nanowells |
JP2015503923A (ja) | 2012-01-09 | 2015-02-05 | オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf | 結腸直腸癌の解析のための方法およびバイオマーカー |
US20130184165A1 (en) | 2012-01-13 | 2013-07-18 | Data2Bio | Genotyping by next-generation sequencing |
US8747748B2 (en) | 2012-01-19 | 2014-06-10 | Life Technologies Corporation | Chemical sensor with conductive cup-shaped sensor surface |
US8821798B2 (en) | 2012-01-19 | 2014-09-02 | Life Technologies Corporation | Titanium nitride as sensing layer for microwell structure |
US9194840B2 (en) * | 2012-01-19 | 2015-11-24 | Life Technologies Corporation | Sensor arrays and methods for making same |
US9728652B2 (en) * | 2012-01-25 | 2017-08-08 | Infineon Technologies Ag | Sensor device and method |
CN105861487B (zh) | 2012-01-26 | 2020-05-05 | 纽亘技术公司 | 用于靶向核酸序列富集和高效文库产生的组合物和方法 |
US9515676B2 (en) | 2012-01-31 | 2016-12-06 | Life Technologies Corporation | Methods and computer program products for compression of sequencing data |
US9864846B2 (en) | 2012-01-31 | 2018-01-09 | Life Technologies Corporation | Methods and computer program products for compression of sequencing data |
WO2013116523A1 (en) | 2012-01-31 | 2013-08-08 | The Regents Of The University Of Michigan | Circulating tumor cell capturing techniques and devices |
JP6170074B2 (ja) * | 2012-02-09 | 2017-07-26 | ライフ テクノロジーズ コーポレーション | 親水性ポリマー粒子およびその製造方法 |
DK2812452T3 (da) | 2012-02-09 | 2020-06-29 | Population Bio Inc | Fremgangsmåder og sammensætninger til screening og behandling af udviklingsforstyrrelser |
WO2013120089A1 (en) | 2012-02-10 | 2013-08-15 | Raindance Technologies, Inc. | Molecular diagnostic screening assay |
PT3363901T (pt) | 2012-02-17 | 2021-01-22 | Hutchinson Fred Cancer Res | Composições e métodos para identificar mutações com precisão |
CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
FI124531B (en) | 2012-03-19 | 2014-09-30 | Marja Tiirola | Method for measuring radioactivity |
US9541386B2 (en) * | 2012-03-21 | 2017-01-10 | Semiconductor Energy Laboratory Co., Ltd. | Distance measurement device and distance measurement system |
ES2716995T3 (es) | 2012-04-03 | 2019-06-18 | Univ Michigan Regents | Biomarcadores asociados con el síndrome del intestino irritable y la enfermedad de Crohn |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
WO2013155116A1 (en) | 2012-04-09 | 2013-10-17 | Takulapalli Bharath | Field effect transistor, device including the transistor, and methods of forming and using same |
US20130268207A1 (en) | 2012-04-09 | 2013-10-10 | Life Technologies Corporation | Systems and methods for identifying somatic mutations |
US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
US20130274148A1 (en) | 2012-04-11 | 2013-10-17 | Illumina, Inc. | Portable genetic detection and analysis system and method |
US9444880B2 (en) | 2012-04-11 | 2016-09-13 | Illumina, Inc. | Cloud computing environment for biological data |
US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
KR20150011359A (ko) * | 2012-04-19 | 2015-01-30 | 라이프 테크놀로지스 코포레이션 | 디지털 pcr을 수행하는 방법 |
EP3461910B1 (en) | 2012-04-19 | 2020-08-26 | Life Technologies Corporation | Nucleic acid amplification |
CN114854832A (zh) | 2012-04-19 | 2022-08-05 | 生命技术公司 | 核酸扩增 |
WO2013158280A1 (en) | 2012-04-20 | 2013-10-24 | The Trustees Of Columbia University In The City Of New York | Systems and methods for single-molecule nucleic-acid assay platforms |
CN104245042B (zh) * | 2012-04-23 | 2018-03-06 | 西门子医疗保健诊断公司 | 传感器阵列 |
US20130288902A1 (en) | 2012-04-30 | 2013-10-31 | Life Technologies Corporation | Systems and methods for paired end sequencing |
EP2844772B1 (en) | 2012-05-02 | 2018-07-11 | Ibis Biosciences, Inc. | Dna sequencing |
WO2013166302A1 (en) | 2012-05-02 | 2013-11-07 | Ibis Biosciences, Inc. | Nucleic acid sequencing systems and methods |
WO2013166444A2 (en) | 2012-05-04 | 2013-11-07 | Boreal Genomics Corp. | Biomarker analysis using scodaphoresis |
US9646132B2 (en) | 2012-05-11 | 2017-05-09 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
US8786331B2 (en) | 2012-05-29 | 2014-07-22 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
US9494554B2 (en) | 2012-06-15 | 2016-11-15 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
US8895249B2 (en) | 2012-06-15 | 2014-11-25 | Illumina, Inc. | Kinetic exclusion amplification of nucleic acid libraries |
DE102012210183B4 (de) * | 2012-06-18 | 2017-03-23 | Siemens Healthcare Gmbh | Anordnung und Verfahren zur Analyse von Nukleinsäuresequenzen |
CN104619894B (zh) | 2012-06-18 | 2017-06-06 | 纽亘技术公司 | 用于非期望核酸序列的阴性选择的组合物和方法 |
US9341589B2 (en) | 2012-06-20 | 2016-05-17 | Board Of Regents, The University Of Texas System | Active-electrode integrated biosensor array and methods for use thereof |
WO2014005076A2 (en) | 2012-06-29 | 2014-01-03 | The Regents Of The University Of Michigan | Methods and biomarkers for detection of kidney disorders |
US9075041B2 (en) | 2012-07-06 | 2015-07-07 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
GB201212775D0 (en) * | 2012-07-18 | 2012-08-29 | Dna Electronics Ltd | Sensing apparatus and method |
US9388465B2 (en) | 2013-02-08 | 2016-07-12 | 10X Genomics, Inc. | Polynucleotide barcode generation |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US20150376609A1 (en) | 2014-06-26 | 2015-12-31 | 10X Genomics, Inc. | Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
JP2015526092A (ja) | 2012-08-24 | 2015-09-10 | ライフ テクノロジーズ コーポレーション | 核酸ペアエンド配列決定のための方法、組成物、システム、装置、およびキット |
US20140073511A1 (en) * | 2012-09-07 | 2014-03-13 | 454 Life Sciences Corporation | System and Method for Operation of Isfet Arrays Using pH Inert Reference Sensors |
WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
WO2014043298A1 (en) | 2012-09-14 | 2014-03-20 | Life Technologies Corporation | Systems and methods for identifying sequence variation associated with genetic diseases |
EP2895621B1 (en) | 2012-09-14 | 2020-10-21 | Population Bio, Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
US10233495B2 (en) | 2012-09-27 | 2019-03-19 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
US10329608B2 (en) | 2012-10-10 | 2019-06-25 | Life Technologies Corporation | Methods, systems, and computer readable media for repeat sequencing |
JP6383358B2 (ja) * | 2012-10-16 | 2018-08-29 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 遮蔽層を有するナノワイヤセンサを備えた集積回路、センシング装置、測定方法、及び製造方法 |
ES2701750T3 (es) | 2012-10-16 | 2019-02-25 | Abbott Molecular Inc | Procedimientos para secuenciar un ácido nucleico |
US9177098B2 (en) | 2012-10-17 | 2015-11-03 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
US10162800B2 (en) | 2012-10-17 | 2018-12-25 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
US9181583B2 (en) | 2012-10-23 | 2015-11-10 | Illumina, Inc. | HLA typing using selective amplification and sequencing |
CN104956225B (zh) | 2012-10-29 | 2018-10-02 | 约翰·霍普金斯大学 | 卵巢和子宫内膜癌的帕帕尼科拉乌测试 |
US9116139B2 (en) | 2012-11-05 | 2015-08-25 | Illumina, Inc. | Sequence scheduling and sample distribution techniques |
WO2014074611A1 (en) | 2012-11-07 | 2014-05-15 | Good Start Genetics, Inc. | Methods and systems for identifying contamination in samples |
US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
EP4012716A1 (en) | 2012-11-19 | 2022-06-15 | Apton Biosystems, Inc. | Digital analysis of molecular analytes using single molecule detection |
US10829816B2 (en) | 2012-11-19 | 2020-11-10 | Apton Biosystems, Inc. | Methods of analyte detection |
JP6014480B2 (ja) * | 2012-12-07 | 2016-10-25 | 株式会社日立ハイテクノロジーズ | 生体分子計測装置および生体分子の計測方法 |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9836577B2 (en) | 2012-12-14 | 2017-12-05 | Celmatix, Inc. | Methods and devices for assessing risk of female infertility |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US9683230B2 (en) | 2013-01-09 | 2017-06-20 | Illumina Cambridge Limited | Sample preparation on a solid support |
US10691775B2 (en) | 2013-01-17 | 2020-06-23 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
WO2014112199A1 (ja) | 2013-01-17 | 2014-07-24 | 株式会社日立ハイテクノロジーズ | 生体分子計測装置 |
US9679104B2 (en) | 2013-01-17 | 2017-06-13 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
US10847251B2 (en) | 2013-01-17 | 2020-11-24 | Illumina, Inc. | Genomic infrastructure for on-site or cloud-based DNA and RNA processing and analysis |
US9128861B2 (en) | 2013-01-17 | 2015-09-08 | Personalis, Inc. | Methods and systems for genetic analysis |
US10068054B2 (en) | 2013-01-17 | 2018-09-04 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
US9792405B2 (en) | 2013-01-17 | 2017-10-17 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
US9805407B2 (en) | 2013-01-25 | 2017-10-31 | Illumina, Inc. | Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data |
US8962366B2 (en) | 2013-01-28 | 2015-02-24 | Life Technologies Corporation | Self-aligned well structures for low-noise chemical sensors |
US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
US8871549B2 (en) | 2013-02-14 | 2014-10-28 | International Business Machines Corporation | Biological and chemical sensors |
US9512422B2 (en) | 2013-02-26 | 2016-12-06 | Illumina, Inc. | Gel patterned surfaces |
WO2014138119A2 (en) | 2013-03-04 | 2014-09-12 | Fry Laboratories, LLC | Method and kit for characterizing microorganisms |
US20140256571A1 (en) | 2013-03-06 | 2014-09-11 | Life Technologies Corporation | Systems and Methods for Determining Copy Number Variation |
US20140274733A1 (en) * | 2013-03-12 | 2014-09-18 | Life Technologies Corporation | Methods and Systems for Local Sequence Alignment |
WO2014142850A1 (en) | 2013-03-13 | 2014-09-18 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
CA2898453C (en) | 2013-03-13 | 2021-07-27 | Illumina, Inc. | Multilayer fluidic devices and methods for their fabrication |
US20140296080A1 (en) | 2013-03-14 | 2014-10-02 | Life Technologies Corporation | Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood |
EP2971154A4 (en) | 2013-03-14 | 2017-03-01 | Ibis Biosciences, Inc. | Nucleic acid control panels |
CN110066853B (zh) * | 2013-03-14 | 2023-03-28 | 生命技术公司 | 基质阵列和其制备方法 |
US10421996B2 (en) | 2013-03-14 | 2019-09-24 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
EP2971159B1 (en) | 2013-03-14 | 2019-05-08 | Molecular Loop Biosolutions, LLC | Methods for analyzing nucleic acids |
US9701999B2 (en) | 2013-03-14 | 2017-07-11 | Abbott Molecular, Inc. | Multiplex methylation-specific amplification systems and methods |
EP2971139A4 (en) | 2013-03-15 | 2016-12-07 | Abbott Molecular Inc | SYSTEMS AND METHOD FOR PROVIDING THE CHANGE OF A GENOMIC COPY NUMBER |
US9116117B2 (en) | 2013-03-15 | 2015-08-25 | Life Technologies Corporation | Chemical sensor with sidewall sensor surface |
EP2971051A4 (en) | 2013-03-15 | 2017-03-01 | The Trustees of Columbia University in the City of New York | Method for detecting multiple predetermined compounds in a sample |
WO2014144092A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
JP6581074B2 (ja) | 2013-03-15 | 2019-09-25 | ライフ テクノロジーズ コーポレーション | 一貫性のあるセンサ表面積を有する化学センサ |
BR112015022448B1 (pt) | 2013-03-15 | 2020-12-08 | Illumina Cambridge Limited | molécula de nucleotídeo ou nucleosídeo modificado, métodos para preparar o crescimento de polinucleotídeo complementar a polinucleotídeo alvo de fita simples em reação de sequenciação e para determinar a sequência de polinucleotídeo alvo de fita simples e kit |
EP2972281B1 (en) | 2013-03-15 | 2023-07-26 | Life Technologies Corporation | Chemical device with thin conductive element |
US9340835B2 (en) | 2013-03-15 | 2016-05-17 | Boreal Genomics Corp. | Method for separating homoduplexed and heteroduplexed nucleic acids |
ES2716094T3 (es) | 2013-03-15 | 2019-06-10 | Ibis Biosciences Inc | Métodos para analizar la contaminación en la secuenciación del ADN |
US8951716B2 (en) * | 2013-03-15 | 2015-02-10 | Taiwan Semiconductor Manufacturing Company, Ltd. | Surface modification, functionalization and integration of microfluidics and biosensor to form a biochip |
CN105051214B (zh) | 2013-03-15 | 2018-12-28 | 吉纳普赛斯股份有限公司 | 用于生物分析的系统和方法 |
WO2014144391A1 (en) * | 2013-03-15 | 2014-09-18 | Rambus Inc. | Threshold-monitoring, conditional-reset image sensor |
US9835585B2 (en) | 2013-03-15 | 2017-12-05 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
JP2016510895A (ja) | 2013-03-15 | 2016-04-11 | ライフ テクノロジーズ コーポレーション | 一貫性のあるセンサ表面積を有する化学センサ |
JP6450366B2 (ja) * | 2013-03-29 | 2019-01-09 | ライフ テクノロジーズ コーポレーション | 半導体装置を処理するための方法 |
WO2014165554A1 (en) * | 2013-04-03 | 2014-10-09 | Life Technologies Corporation | Systems and methods for genetic sequencing |
EP2986741B1 (en) | 2013-04-17 | 2019-07-24 | Agency For Science, Technology And Research | Method for generating extended sequence reads |
DE112014002066T5 (de) * | 2013-04-21 | 2015-12-31 | Kerstan Hoobler Eric | lonensensitive Vorrichtung und Herstellungsverfahren |
CN105378113B (zh) | 2013-05-06 | 2020-02-21 | 加利福尼亚太平洋生物科学股份有限公司 | 实时电子测序 |
US20140336063A1 (en) | 2013-05-09 | 2014-11-13 | Life Technologies Corporation | Windowed Sequencing |
US9719867B2 (en) | 2013-05-30 | 2017-08-01 | Kla-Tencor Corporation | Method and system for measuring heat flux |
EP3005200A2 (en) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
US20140367748A1 (en) | 2013-06-14 | 2014-12-18 | International Business Machines Corporation | EXTENDED GATE SENSOR FOR pH SENSING |
US9868979B2 (en) | 2013-06-25 | 2018-01-16 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
ES2899618T3 (es) | 2013-07-01 | 2022-03-14 | Illumina Inc | Funcionalización de superficie exenta de catalizador e injerto de polímero |
EP3241913B1 (en) | 2013-07-03 | 2019-02-20 | Illumina, Inc. | System for sequencing by orthogonal synthesis |
US9926597B2 (en) | 2013-07-26 | 2018-03-27 | Life Technologies Corporation | Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same |
US10036013B2 (en) | 2013-08-19 | 2018-07-31 | Abbott Molecular Inc. | Next-generation sequencing libraries |
US9898575B2 (en) | 2013-08-21 | 2018-02-20 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences |
US9116866B2 (en) | 2013-08-21 | 2015-08-25 | Seven Bridges Genomics Inc. | Methods and systems for detecting sequence variants |
CN105637126B (zh) | 2013-08-22 | 2022-09-23 | 雅普顿生物系统公司 | 使用电方法的分子分析物的数字分析 |
SG10201806890VA (en) | 2013-08-28 | 2018-09-27 | Cellular Res Inc | Massively parallel single cell analysis |
WO2015031689A1 (en) | 2013-08-30 | 2015-03-05 | Personalis, Inc. | Methods and systems for genomic analysis |
EP3038834B1 (en) | 2013-08-30 | 2018-12-12 | Illumina, Inc. | Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces |
US9797011B2 (en) | 2013-09-13 | 2017-10-24 | Life Technologies Corporation | Device preparation using condensed nucleic acid particles |
JP2016540275A (ja) | 2013-09-30 | 2016-12-22 | セブン ブリッジズ ジェノミクス インコーポレイテッド | 配列変異体を検出するための方法およびシステム |
EP3052652B1 (en) | 2013-09-30 | 2022-11-23 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
WO2015050919A1 (en) | 2013-10-01 | 2015-04-09 | Life Technologies Corporation | Systems and methods for detecting structural variants |
WO2015051275A1 (en) | 2013-10-03 | 2015-04-09 | Personalis, Inc. | Methods for analyzing genotypes |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
JP6532456B2 (ja) | 2013-10-04 | 2019-06-19 | ライフ テクノロジーズ コーポレーション | 終止化学を用いる配列決定における整相効果(phasing effects)をモデル化するための方法及びシステム |
JP6309734B2 (ja) * | 2013-10-04 | 2018-04-11 | 株式会社日立ハイテクノロジーズ | 生体分子計測装置 |
EP3055676A1 (en) | 2013-10-07 | 2016-08-17 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
EP3875601A1 (en) | 2013-10-17 | 2021-09-08 | Illumina, Inc. | Methods and compositions for preparing nucleic acid libraries |
US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
EP3058096A1 (en) | 2013-10-18 | 2016-08-24 | Good Start Genetics, Inc. | Methods for assessing a genomic region of a subject |
SG11201603039PA (en) | 2013-10-18 | 2016-05-30 | Seven Bridges Genomics Inc | Methods and systems for identifying disease-induced mutations |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
WO2015058120A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences in the presence of repeating elements |
SG11201602903XA (en) | 2013-10-18 | 2016-05-30 | Seven Bridges Genomics Inc | Methods and systems for genotyping genetic samples |
WO2015058095A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for quantifying sequence alignment |
US9092402B2 (en) | 2013-10-21 | 2015-07-28 | Seven Bridges Genomics Inc. | Systems and methods for using paired-end data in directed acyclic structure |
US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
EP3640349A3 (en) | 2013-10-23 | 2020-07-29 | Roche Sequencing Solutions, Inc. | High speed molecular sensing with nanopores |
CN106132555B (zh) | 2013-11-11 | 2019-07-26 | 生命科技股份有限公司 | 转子组合件及其使用方法 |
CN105849264B (zh) | 2013-11-13 | 2019-09-27 | 纽亘技术公司 | 用于鉴别重复测序读数的组合物和方法 |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
WO2015077632A1 (en) | 2013-11-21 | 2015-05-28 | Avails Medical, Inc. | Electrical biosensor for detecting a substance in a bodily fluid, and method and system for same |
CN103604854B (zh) * | 2013-11-28 | 2016-08-17 | 胡文闯 | 基于离子敏感场效应晶体管的生物传感器阵列 |
EP3080268A1 (en) | 2013-12-09 | 2016-10-19 | Illumina, Inc. | Methods and compositions for targeted nucleic acid sequencing |
US9476853B2 (en) | 2013-12-10 | 2016-10-25 | Life Technologies Corporation | System and method for forming microwells |
CN110411998B (zh) | 2013-12-10 | 2022-06-07 | 伊鲁米那股份有限公司 | 用于生物或化学分析的生物传感器及其制造方法 |
EP3792921A1 (en) * | 2013-12-11 | 2021-03-17 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
EP3080267B1 (en) | 2013-12-12 | 2020-02-19 | Altratech Limited | A sample preparation method and apparatus |
EP3080294B1 (en) * | 2013-12-12 | 2018-06-13 | Altratech Limited | A capacitive sensor and method of use |
EP3249055B1 (en) * | 2013-12-12 | 2019-06-26 | Altratech Limited | A nucleic acid analysis method and apparatus |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
EP3083700B1 (en) | 2013-12-17 | 2023-10-11 | The Brigham and Women's Hospital, Inc. | Detection of an antibody against a pathogen |
EP3957750A1 (en) | 2013-12-20 | 2022-02-23 | Illumina, Inc. | Preserving genomic connectivity information in fragmented genomic dna samples |
JP6076243B2 (ja) * | 2013-12-26 | 2017-02-08 | 京セラドキュメントソリューションズ株式会社 | 画像読取装置及び画像形成装置 |
WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
JP2017510871A (ja) | 2014-01-10 | 2017-04-13 | セブン ブリッジズ ジェノミクス インコーポレイテッド | リードマッピングにおける公知の対立遺伝子の使用のためのシステム及び方法 |
WO2015108663A1 (en) | 2014-01-16 | 2015-07-23 | Illumina, Inc. | Amplicon preparation and sequencing on solid supports |
US9677132B2 (en) | 2014-01-16 | 2017-06-13 | Illumina, Inc. | Polynucleotide modification on solid support |
WO2015107430A2 (en) | 2014-01-16 | 2015-07-23 | Oslo Universitetssykehus Hf | Methods and biomarkers for detection and prognosis of cervical cancer |
EP3102691B1 (en) | 2014-02-03 | 2019-09-11 | Thermo Fisher Scientific Baltics UAB | Method for controlled dna fragmentation |
US9817944B2 (en) | 2014-02-11 | 2017-11-14 | Seven Bridges Genomics Inc. | Systems and methods for analyzing sequence data |
EP3105695B1 (en) | 2014-02-13 | 2022-06-01 | Illumina, Inc. | Integrated consumer genomic services |
CN106062547B (zh) * | 2014-02-14 | 2018-11-02 | 艾乐蒙茨有限责任公司 | 高灵敏度多通道检测设备 |
RS61976B1 (sr) | 2014-02-18 | 2021-07-30 | Illumina Inc | Postupci i kompozicije za određivanje dnk profila |
US9697327B2 (en) | 2014-02-24 | 2017-07-04 | Edico Genome Corporation | Dynamic genome reference generation for improved NGS accuracy and reproducibility |
WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
WO2015138648A1 (en) | 2014-03-11 | 2015-09-17 | Illumina, Inc. | Disposable, integrated microfluidic cartridge and methods of making and using same |
US10006899B2 (en) * | 2014-03-25 | 2018-06-26 | Genia Technologies, Inc. | Nanopore-based sequencing chips using stacked wafer technology |
US9765326B2 (en) | 2014-04-03 | 2017-09-19 | Stmicroelectronics S.R.L. | Apparatus and method for nucleic acid sequencing based on nanochannels |
US10190161B2 (en) * | 2014-04-03 | 2019-01-29 | Stmicroelectronics S.R.L. | Apparatus and method for nucleic acid sequencing based on nanowire detectors |
WO2015161054A2 (en) | 2014-04-18 | 2015-10-22 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
US9404884B2 (en) * | 2014-04-25 | 2016-08-02 | Taiwan Semiconductor Manufacturing Company Limited | Biosensor device and related method |
US9765395B2 (en) * | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
US11215580B2 (en) | 2014-04-28 | 2022-01-04 | Cardea Bio, Inc. | System and method for DNA sequencing and blood chemistry analysis |
US20160054312A1 (en) | 2014-04-28 | 2016-02-25 | Nanomedical Diagnostics, Inc. | Chemically differentiated sensor array |
US9618476B2 (en) * | 2014-04-28 | 2017-04-11 | Nanomedical Diagnostics, Inc. | System and method for electronic biological sample analysis |
CN103969314B (zh) * | 2014-05-06 | 2017-02-15 | 中国农业科学院农业信息研究所 | 多参数离子传感器及其制备方法、多参数离子传感器芯片和监测系统 |
US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
WO2015175691A1 (en) | 2014-05-13 | 2015-11-19 | Life Technologies Corporation | Systems and methods for validation of sequencing results |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
US9710592B2 (en) | 2014-05-23 | 2017-07-18 | International Business Machines Corporation | Multiple-depth trench interconnect technology at advanced semiconductor nodes |
US9454631B2 (en) | 2014-05-23 | 2016-09-27 | International Business Machines Corporation | Stitch-derived via structures and methods of generating the same |
US10427155B2 (en) | 2014-05-27 | 2019-10-01 | Illumina, Inc. | Systems and methods for biochemical analysis including a base instrument and a removable cartridge |
US10254242B2 (en) | 2014-06-04 | 2019-04-09 | Life Technologies Corporation | Methods, systems, and computer-readable media for compression of sequencing data |
US20150355129A1 (en) * | 2014-06-05 | 2015-12-10 | Avails Medical, Inc. | Systems and methods for detecting substances in bodily fluids |
EP3151733B1 (en) | 2014-06-06 | 2020-04-15 | The Regents Of The University Of Michigan | Compositions and methods for characterizing and diagnosing periodontal disease |
US20150353989A1 (en) | 2014-06-09 | 2015-12-10 | Illumina Cambridge Limited | Sample preparation for nucleic acid amplification |
CN117867071A (zh) | 2014-06-13 | 2024-04-12 | 伊卢米纳剑桥有限公司 | 用于制备序列文库的方法和组合物 |
US20150361481A1 (en) | 2014-06-13 | 2015-12-17 | Life Technologies Corporation | Multiplex nucleic acid amplification |
CN114214314A (zh) | 2014-06-24 | 2022-03-22 | 生物辐射实验室股份有限公司 | 数字式pcr条码化 |
US10017759B2 (en) | 2014-06-26 | 2018-07-10 | Illumina, Inc. | Library preparation of tagged nucleic acid |
ES2753573T3 (es) | 2014-06-27 | 2020-04-13 | Abbott Lab | Composiciones y métodos para detectar pegivirus humano 2 (HPGV-2) |
CN106536728A (zh) | 2014-06-27 | 2017-03-22 | 伊鲁米那股份有限公司 | 用于核苷酸类似物的改进的掺入的修饰的聚合酶 |
CA2953791A1 (en) | 2014-06-30 | 2016-01-07 | Illumina, Inc. | Methods and compositions using one-sided transposition |
JP6794350B2 (ja) * | 2014-07-02 | 2020-12-02 | ライフ テクノロジーズ コーポレーション | 半導体センサの表面処理 |
CN106794439B (zh) * | 2014-07-02 | 2019-03-26 | 生命技术公司 | 用于装载传感器衬底的方法 |
DK3169805T5 (en) | 2014-07-15 | 2018-12-03 | Illumina Inc | Biochemically activated electronic device |
AU2015289464A1 (en) | 2014-07-17 | 2017-02-02 | Celmatix Inc. | Methods and systems for assessing infertility and related pathologies |
US20160019340A1 (en) | 2014-07-18 | 2016-01-21 | Life Technologies Corporation | Systems and methods for detecting structural variants |
US10457969B2 (en) | 2014-07-21 | 2019-10-29 | Illumina, Inc. | Polynucleotide enrichment using CRISPR-Cas systems |
CA2955771C (en) | 2014-07-24 | 2022-08-30 | Abbott Molecular Inc. | Compositions and methods for the detection and analysis of mycobacterium tuberculosis |
GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
AU2015302059B2 (en) | 2014-08-12 | 2020-02-06 | Nextgen Jane, Inc. | System and method for monitoring health based on collected bodily fluid |
US9140662B1 (en) * | 2014-08-19 | 2015-09-22 | Honeywell International Inc. | Preventing stray currents in sensors in conductive media |
US9982250B2 (en) | 2014-08-21 | 2018-05-29 | Illumina Cambridge Limited | Reversible surface functionalization |
WO2016035752A1 (ja) * | 2014-09-02 | 2016-03-10 | 国立大学法人京都大学 | 参照電極用素子及びイオンセンサ装置 |
GB2558326B (en) | 2014-09-05 | 2021-01-20 | Population Bio Inc | Methods and compositions for inhibiting and treating neurological conditions |
WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
WO2016040602A1 (en) | 2014-09-11 | 2016-03-17 | Epicentre Technologies Corporation | Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv |
EP3194945B1 (en) | 2014-09-15 | 2023-07-26 | Life Technologies Corporation | Apparatus and method for fluid potential artifact correction in reagent delivery systems comprising a sensor array |
CN114410830A (zh) | 2014-09-17 | 2022-04-29 | 豪洛捷公司 | 部分裂解和测定的方法 |
EP3224595A4 (en) | 2014-09-24 | 2018-06-13 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
WO2016054096A1 (en) | 2014-09-30 | 2016-04-07 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
WO2016153999A1 (en) | 2015-03-25 | 2016-09-29 | Life Technologies Corporation | Modified nucleotides and uses thereof |
US10487357B2 (en) | 2014-10-03 | 2019-11-26 | Life Technologies Corporation | Methods of nucleic acid analysis using terminator nucleotides |
US10544455B2 (en) | 2014-10-03 | 2020-01-28 | Life Technologies Corporation | Sequencing methods, compositions and systems using terminator nucleotides |
JP6493955B2 (ja) * | 2014-10-09 | 2019-04-03 | ラピスセミコンダクタ株式会社 | 半導体装置及び半導体装置の製造方法 |
US11094398B2 (en) | 2014-10-10 | 2021-08-17 | Life Technologies Corporation | Methods for calculating corrected amplicon coverages |
WO2016060974A1 (en) | 2014-10-13 | 2016-04-21 | Life Technologies Corporation | Methods, systems, and computer-readable media for accelerated base calling |
CN107408043A (zh) | 2014-10-14 | 2017-11-28 | 七桥基因公司 | 用于序列流水线中的智能工具的系统和方法 |
US9897791B2 (en) | 2014-10-16 | 2018-02-20 | Illumina, Inc. | Optical scanning systems for in situ genetic analysis |
IL299976A (en) | 2014-10-17 | 2023-03-01 | Illumina Cambridge Ltd | Continuity-preserving transposition |
EP3835429A1 (en) | 2014-10-17 | 2021-06-16 | Good Start Genetics, Inc. | Pre-implantation genetic screening and aneuploidy detection |
CN113092563B (zh) | 2014-10-22 | 2024-06-07 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
EP3212808B1 (en) | 2014-10-30 | 2022-03-02 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
PL3212684T3 (pl) | 2014-10-31 | 2020-10-19 | Illumina Cambridge Limited | Polimery i powłoki z kopolimeru DNA |
US10000799B2 (en) | 2014-11-04 | 2018-06-19 | Boreal Genomics, Inc. | Methods of sequencing with linked fragments |
US9828627B2 (en) | 2014-11-05 | 2017-11-28 | Illumina Cambridge Limited | Reducing DNA damage during sample preparation and sequencing using siderophore chelators |
US20160146799A1 (en) | 2014-11-05 | 2016-05-26 | Nirmidas Biotech, Inc. | Metal composites for enhanced imaging |
GB201419731D0 (en) | 2014-11-05 | 2014-12-17 | Illumina Cambridge Ltd | Sequencing from multiple primers to increase data rate and density |
AU2015346514B2 (en) | 2014-11-11 | 2021-04-08 | Illumina, Inc. | Polynucleotide amplification using CRISPR-Cas systems |
SG11201703693UA (en) | 2014-11-11 | 2017-06-29 | Illumina Cambridge Ltd | Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid |
WO2016077324A1 (en) | 2014-11-11 | 2016-05-19 | Life Technologies Corporation | Thiolated nucleotide analogues for nucleic acid synthesis |
US11789906B2 (en) | 2014-11-19 | 2023-10-17 | Arc Bio, Llc | Systems and methods for genomic manipulations and analysis |
US10233490B2 (en) | 2014-11-21 | 2019-03-19 | Metabiotech Corporation | Methods for assembling and reading nucleic acid sequences from mixed populations |
DE112015004899B4 (de) | 2014-11-27 | 2022-10-20 | Hitachi High-Tech Corporation | Spot-array-substrat, verfahren zum herstellen eines solchen und nukleinsäurepolymer-analyseverfahren und -vorrichtung |
EP3227461A1 (en) | 2014-12-05 | 2017-10-11 | Amyris, Inc. | High-throughput sequencing of polynucleotides |
PL3234187T3 (pl) | 2014-12-15 | 2021-10-25 | Illumina, Inc. | Sposób pojedynczego umieszczenia cząsteczki na podłożu |
EP3234115B1 (en) | 2014-12-16 | 2020-07-22 | Life Technologies Corporation | Polymerase compositions and methods of making and using same |
US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US9373561B1 (en) | 2014-12-18 | 2016-06-21 | International Business Machines Corporation | Integrated circuit barrierless microfluidic channel |
TWI684004B (zh) | 2014-12-18 | 2020-02-01 | 美商生命技術公司 | 用於使用大規模fet陣列量測分析物之方法及設備 |
US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
US11782057B2 (en) | 2014-12-18 | 2023-10-10 | Cardea Bio, Inc. | Ic with graphene fet sensor array patterned in layers above circuitry formed in a silicon based cmos wafer |
US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
EP3235010A4 (en) | 2014-12-18 | 2018-08-29 | Agilome, Inc. | Chemically-sensitive field effect transistor |
TWI832669B (zh) | 2014-12-18 | 2024-02-11 | 美商生命技術公司 | 具有傳輸器組態的高資料速率積體電路 |
WO2016100895A1 (en) | 2014-12-18 | 2016-06-23 | Life Technologies Corporation | Calibration panels and methods for designing the same |
US11921112B2 (en) | 2014-12-18 | 2024-03-05 | Paragraf Usa Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
US9702847B2 (en) | 2014-12-30 | 2017-07-11 | Avails Medical, Inc. | Systems and methods for detecting a substance in bodily fluid |
CA3010579A1 (en) | 2015-01-06 | 2016-07-14 | Good Start Genetics, Inc. | Screening for structural variants |
CN104502427A (zh) * | 2015-01-07 | 2015-04-08 | 融智生物科技(青岛)有限公司 | 微生物检测装置和方法 |
JP6425546B2 (ja) | 2015-01-09 | 2018-11-21 | 日立オートモティブシステムズ株式会社 | 水素センサシステム |
US20160289669A1 (en) * | 2015-01-22 | 2016-10-06 | Becton, Dickinson And Company | Devices and systems for molecular barcoding of nucleic acid targets in single cells |
US9810661B2 (en) * | 2015-02-18 | 2017-11-07 | Sensor Kinesis Corporation | Carbon nanotube biofet with a local amplifier in a system array for analysis of biomarkers and method of analysis of same |
US10208339B2 (en) | 2015-02-19 | 2019-02-19 | Takara Bio Usa, Inc. | Systems and methods for whole genome amplification |
CN107250379B (zh) | 2015-02-19 | 2021-12-28 | 贝克顿迪金森公司 | 结合蛋白质组信息和基因组信息的高通量单细胞分析 |
WO2016134342A1 (en) | 2015-02-20 | 2016-08-25 | Wafergen, Inc. | Method for rapid accurate dispensing, visualization and analysis of single cells |
EP3262192B1 (en) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Spatially addressable molecular barcoding |
EP3489367B1 (en) | 2015-03-05 | 2020-09-09 | Life Technologies Corporation | Surface stabilization of biosensors |
US10192026B2 (en) | 2015-03-05 | 2019-01-29 | Seven Bridges Genomics Inc. | Systems and methods for genomic pattern analysis |
WO2016143705A1 (ja) * | 2015-03-07 | 2016-09-15 | 国立大学法人名古屋大学 | 参照電極保持部材及び物質検出装置 |
US20160273049A1 (en) | 2015-03-16 | 2016-09-22 | Personal Genome Diagnostics, Inc. | Systems and methods for analyzing nucleic acid |
WO2016154038A1 (en) | 2015-03-20 | 2016-09-29 | Illumina, Inc. | Fluidics cartridge for use in the vertical or substantially vertical position |
US9708647B2 (en) | 2015-03-23 | 2017-07-18 | Insilixa, Inc. | Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays |
US9940266B2 (en) | 2015-03-23 | 2018-04-10 | Edico Genome Corporation | Method and system for genomic visualization |
CN113172036A (zh) | 2015-03-26 | 2021-07-27 | 生命技术公司 | 用于处理半导体传感器阵列装置的方法 |
ES2934982T3 (es) | 2015-03-30 | 2023-02-28 | Becton Dickinson Co | Métodos para la codificación con códigos de barras combinatorios |
EP3783109B1 (en) | 2015-03-31 | 2024-05-29 | Illumina Cambridge Limited | Surface concatamerization of templates |
ES2955916T3 (es) | 2015-04-10 | 2023-12-11 | Spatial Transcriptomics Ab | Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
US11180522B2 (en) | 2015-05-08 | 2021-11-23 | Centrillion Technology Holdings Corporation | Disulfide-linked reversible terminators |
DK3760737T3 (en) | 2015-05-11 | 2023-04-11 | Illumina Inc | Platform for discovery and analysis of therapeutic agents |
US10978174B2 (en) | 2015-05-14 | 2021-04-13 | Life Technologies Corporation | Barcode sequences, and related systems and methods |
US10275567B2 (en) | 2015-05-22 | 2019-04-30 | Seven Bridges Genomics Inc. | Systems and methods for haplotyping |
DK3303614T3 (da) | 2015-05-29 | 2020-05-18 | Illumina Cambridge Ltd | Forbedret anvendelse af overfladeprimere i klynger |
WO2016196358A1 (en) | 2015-05-29 | 2016-12-08 | Epicentre Technologies Corporation | Methods of analyzing nucleic acids |
US11124823B2 (en) | 2015-06-01 | 2021-09-21 | Becton, Dickinson And Company | Methods for RNA quantification |
EP3307908B1 (en) | 2015-06-09 | 2019-09-11 | Life Technologies Corporation | Methods for molecular tagging |
EP3310933B1 (en) | 2015-06-17 | 2020-11-18 | The Translational Genomics Research Institute | Methods for obtaining biological molecules from a sample |
US9702689B2 (en) * | 2015-06-18 | 2017-07-11 | Xerox Corporation | Use of a full width array imaging sensor to measure real time film thicknesses on film manufacturing equipment |
WO2017004556A1 (en) | 2015-07-02 | 2017-01-05 | Life Technologies Corporation | Polymer substrates formed from carboxy functional acrylamide |
US10379080B2 (en) | 2015-07-06 | 2019-08-13 | Robert Bosch Gmbh | Electronic control of the pH of a solution close to an electrode surfaces |
EP3320340A1 (en) | 2015-07-06 | 2018-05-16 | Robert Bosch GmbH | METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS |
ES2877205T3 (es) | 2015-07-06 | 2021-11-16 | Illumina Cambridge Ltd | Preparación de muestras para la amplificación de ácido nucleico |
US10011549B2 (en) | 2015-07-06 | 2018-07-03 | Robert Bosch Gmbh | Electrochemically active agents for pH modulation in biological buffers |
CN107924121B (zh) | 2015-07-07 | 2021-06-08 | 亿明达股份有限公司 | 经由纳米压印的选择性表面图案化 |
EP3322483A4 (en) | 2015-07-14 | 2019-01-02 | Abbott Molecular Inc. | Compositions and methods for identifying drug resistant tuberculosis |
EP3322805B1 (en) | 2015-07-14 | 2021-10-20 | Abbott Molecular Inc. | Purification of nucleic acids using copper-titanium oxides or magnesium-titanium oxides |
TWI571626B (zh) * | 2015-07-15 | 2017-02-21 | 力晶科技股份有限公司 | 具有奈米腔的集成生物感測器及其製作方法 |
US20180207920A1 (en) | 2015-07-17 | 2018-07-26 | Illumina, Inc. | Polymer sheets for sequencing applications |
US11214829B2 (en) | 2015-07-23 | 2022-01-04 | Asuragen, Inc. | Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments |
CN108138225B (zh) | 2015-07-27 | 2022-10-14 | 亿明达股份有限公司 | 核酸序列信息的空间定位 |
DK3329007T3 (da) | 2015-07-30 | 2021-04-26 | Illumina Inc | Ortogonal afblokering af nukleotider |
JP6544571B2 (ja) * | 2015-08-04 | 2019-07-17 | 国立大学法人山形大学 | エタノールアミンリン酸センサ及びその製造方法 |
EP3332033B1 (en) | 2015-08-06 | 2021-04-21 | Pacific Biosciences of California, Inc. | Single-molecule nanofet sequencing systems and methods |
CA2994406A1 (en) | 2015-08-06 | 2017-02-09 | Arc Bio, Llc | Systems and methods for genomic analysis |
US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
PL3334839T3 (pl) | 2015-08-14 | 2021-08-02 | Illumina, Inc. | Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej |
US10793895B2 (en) | 2015-08-24 | 2020-10-06 | Seven Bridges Genomics Inc. | Systems and methods for epigenetic analysis |
CN108350408B (zh) | 2015-08-25 | 2022-12-16 | 阿威尔斯医疗公司 | 用于检测流体样品中有活力的微生物的设备、系统和方法 |
EP3341718B1 (en) | 2015-08-25 | 2022-06-08 | Life Technologies Corporation | Deep microwell design and method of making the same |
US10724110B2 (en) | 2015-09-01 | 2020-07-28 | Seven Bridges Genomics Inc. | Systems and methods for analyzing viral nucleic acids |
US10584380B2 (en) | 2015-09-01 | 2020-03-10 | Seven Bridges Genomics Inc. | Systems and methods for mitochondrial analysis |
WO2017037078A1 (en) | 2015-09-02 | 2017-03-09 | Illumina Cambridge Limited | Systems and methods of improving droplet operations in fluidic systems |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CA3005985A1 (en) | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics of infectious disease and other health conditions associated with antibiotic usage |
US9499861B1 (en) | 2015-09-10 | 2016-11-22 | Insilixa, Inc. | Methods and systems for multiplex quantitative nucleic acid amplification |
US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
US10450598B2 (en) | 2015-09-11 | 2019-10-22 | Illumina, Inc. | Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest |
CN109416312B (zh) * | 2015-09-18 | 2022-11-11 | 紫荆实验室股份有限公司 | 利用表面附着结构的流动池,以及相关的系统和方法 |
US20170081712A1 (en) | 2015-09-22 | 2017-03-23 | Life Technologies Corporation | Systems and methods for analysis of nucleic acids |
US10344268B2 (en) | 2015-10-01 | 2019-07-09 | Life Technologies Corporation | Polymerase compositions and kits, and methods of using and making the same |
US10577643B2 (en) | 2015-10-07 | 2020-03-03 | Illumina, Inc. | Off-target capture reduction in sequencing techniques |
US11347704B2 (en) | 2015-10-16 | 2022-05-31 | Seven Bridges Genomics Inc. | Biological graph or sequence serialization |
US10843192B2 (en) | 2015-11-04 | 2020-11-24 | Robert Bosch Gmbh | Integration of electrochemical pH modulation with lab on a chip technologies |
KR20180081561A (ko) | 2015-11-06 | 2018-07-16 | 벤타나 메디컬 시스템즈, 인코포레이티드 | 대표 진단법 |
CA3168463A1 (en) | 2015-12-17 | 2017-06-22 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
US20170199960A1 (en) | 2016-01-07 | 2017-07-13 | Seven Bridges Genomics Inc. | Systems and methods for adaptive local alignment for graph genomes |
CN108431223A (zh) | 2016-01-08 | 2018-08-21 | 生物辐射实验室股份有限公司 | 每液滴分辨率下的多个珠 |
US20170270245A1 (en) | 2016-01-11 | 2017-09-21 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing |
US10068183B1 (en) | 2017-02-23 | 2018-09-04 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on a quantum processing platform |
US10364468B2 (en) | 2016-01-13 | 2019-07-30 | Seven Bridges Genomics Inc. | Systems and methods for analyzing circulating tumor DNA |
US10254245B2 (en) | 2016-01-25 | 2019-04-09 | Avails Medical, Inc. | Devices, systems and methods for detecting viable infectious agents in a fluid sample using an electrolyte-insulator-semiconductor sensor |
US10460829B2 (en) | 2016-01-26 | 2019-10-29 | Seven Bridges Genomics Inc. | Systems and methods for encoding genetic variation for a population |
WO2017132567A1 (en) | 2016-01-28 | 2017-08-03 | Roswell Biotechnologies, Inc. | Massively parallel dna sequencing apparatus |
CN109071212A (zh) * | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
CN108779442B (zh) | 2016-02-08 | 2022-07-12 | 瑞尔基因公司 | 多种连接酶的组合物、系统以及方法 |
EP3414784B1 (en) | 2016-02-09 | 2021-04-14 | Roswell Biotechnologies, Inc | Electronic label-free dna and genome sequencing |
US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
US10262102B2 (en) | 2016-02-24 | 2019-04-16 | Seven Bridges Genomics Inc. | Systems and methods for genotyping with graph reference |
WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
JP2017168812A (ja) * | 2016-03-10 | 2017-09-21 | パナソニックIpマネジメント株式会社 | 撮像装置 |
US20190062827A1 (en) | 2016-03-14 | 2019-02-28 | RGENE, Inc. | HYPER-THERMOSTABLE LYSINE-MUTANT ssDNA/RNA LIGASES |
US11021742B2 (en) | 2016-03-28 | 2021-06-01 | Boreal Genomics, Inc. | Linked-fragment sequencing |
US10961573B2 (en) | 2016-03-28 | 2021-03-30 | Boreal Genomics, Inc. | Linked duplex target capture |
WO2017177017A1 (en) | 2016-04-07 | 2017-10-12 | Omniome, Inc. | Methods of quantifying target nucleic acids and identifying sequence variants |
EP3442706A4 (en) | 2016-04-13 | 2020-02-19 | NextGen Jane, Inc. | SAMPLE COLLECTION AND PRESERVATION DEVICES, SYSTEMS AND METHODS |
EP3446113A4 (en) | 2016-04-19 | 2020-01-08 | Takulapalli, Bharath | NANOPORE SENSOR, STRUCTURE AND DEVICE WITH THE SENSOR AND METHOD FOR SHAPING AND USE THEREOF |
EP4269616A3 (en) | 2016-05-02 | 2024-02-14 | Becton, Dickinson and Company | Accurate molecular barcoding |
US10619205B2 (en) | 2016-05-06 | 2020-04-14 | Life Technologies Corporation | Combinatorial barcode sequences, and related systems and methods |
WO2017196676A1 (en) | 2016-05-10 | 2017-11-16 | Life Technologies Corporation | Metal chelation post incorporation detection methods |
US11542544B2 (en) | 2016-05-11 | 2023-01-03 | Illumina, Inc. | Polynucleotide enrichment and amplification using CRISPR-Cas or Argonaute systems |
WO2017201081A1 (en) | 2016-05-16 | 2017-11-23 | Agilome, Inc. | Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids |
WO2017201315A1 (en) | 2016-05-18 | 2017-11-23 | Roche Sequencing Solutions, Inc. | Quantitative real time pcr amplification using an electrowetting-based device |
EP3467121A4 (en) * | 2016-05-25 | 2020-02-12 | Nikon Corporation | METHOD FOR IDENTIFYING TARGET BIOLOGICAL, BALLS FOR USE IN IDENTIFYING TARGET BIOLOGICAL, BALL SET, AND DEVICE FOR IDENTIFYING TARGET BIOLOGICAL |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
EP3465502B1 (en) | 2016-05-26 | 2024-04-10 | Becton, Dickinson and Company | Molecular label counting adjustment methods |
US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
US10174356B2 (en) | 2016-05-31 | 2019-01-08 | Avails Medical, Inc. | Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
KR101960963B1 (ko) * | 2016-06-03 | 2019-03-22 | 서울대학교 산학협력단 | 수평형 플로팅 게이트를 갖는 fet형 센서의 펄스 구동 방법 |
CN107460233A (zh) * | 2016-06-06 | 2017-12-12 | 张家港万众芯生物科技有限公司 | 一种通过检测焦磷酸电荷的基因测序方法 |
US11268117B2 (en) | 2016-06-10 | 2022-03-08 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
CN109415727A (zh) | 2016-06-13 | 2019-03-01 | 格里尔公司 | 富集突变的无细胞核酸以供癌症检测的方法 |
US10082481B2 (en) | 2016-07-07 | 2018-09-25 | Sharp Life Science (Eu) Limited | Bio-sensor pixel circuit with amplification |
WO2018013509A1 (en) | 2016-07-11 | 2018-01-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
CN116397014A (zh) | 2016-07-20 | 2023-07-07 | 测序健康公司 | 用于核酸测序的系统和方法 |
WO2018017892A1 (en) | 2016-07-21 | 2018-01-25 | Takara Bio Usa, Inc. | Multi-z imaging and dispensing with multi-well devices |
AU2017299803B2 (en) | 2016-07-22 | 2023-06-29 | Illumina, Inc. | Single cell whole genome libraries and combinatorial indexing methods of making thereof |
US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
CN109791039B (zh) * | 2016-08-10 | 2021-03-23 | 科磊股份有限公司 | 使用光学显微镜产生样本的三维信息的方法 |
TWI586171B (zh) * | 2016-08-16 | 2017-06-01 | 恆景科技股份有限公司 | 共用行讀取電路的影像感測器 |
EP3500082A1 (en) | 2016-08-22 | 2019-06-26 | Biolumic Limited | System, device and methods of seed treatment |
WO2018042251A1 (en) | 2016-08-29 | 2018-03-08 | Oslo Universitetssykehus Hf | Chip-seq assays |
US10611994B2 (en) | 2016-08-30 | 2020-04-07 | International Business Machines Corporation | Electrochemical sensors for cell culture monitoring |
US11250931B2 (en) | 2016-09-01 | 2022-02-15 | Seven Bridges Genomics Inc. | Systems and methods for detecting recombination |
EP3510388A1 (en) | 2016-09-09 | 2019-07-17 | Life Technologies Corporation | Chemically-sensitive field-effect transistor with microwell structure and method for producing the same |
CA3213915A1 (en) | 2016-09-22 | 2018-03-29 | Illumina, Inc. | Somatic copy number variation detection |
WO2018057928A1 (en) | 2016-09-23 | 2018-03-29 | Grail, Inc. | Methods of preparing and analyzing cell-free nucleic acid sequencing libraries |
EP3516400B1 (en) | 2016-09-26 | 2023-08-16 | Becton, Dickinson and Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
WO2018064311A2 (en) | 2016-09-28 | 2018-04-05 | Life Technologies Corporation | Methods and systems for reducing phasing errors when sequencing nucleic acids using termination chemistry |
US10389519B2 (en) * | 2016-09-30 | 2019-08-20 | International Business Machines Corporation | Hardware based cryptographic side-channel attack prevention |
FI3522713T3 (fi) | 2016-10-03 | 2023-01-13 | Amiinien ja hydratsiinien fluoresoiva tunnistus ja niiden määritysmenetelmiä | |
US9698803B1 (en) * | 2016-10-03 | 2017-07-04 | Frank R. Dropps | Analog system and associated methods thereof |
US10876986B2 (en) * | 2016-10-05 | 2020-12-29 | Hewlett-Packard Development Company, L.P. | Insulated sensors |
WO2018071522A1 (en) | 2016-10-11 | 2018-04-19 | Life Technologies Corporation | Rapid amplification of nucleic acids |
CN109906276A (zh) | 2016-11-07 | 2019-06-18 | 格里尔公司 | 用于检测早期癌症中体细胞突变特征的识别方法 |
JP7228510B2 (ja) | 2016-11-08 | 2023-02-24 | ベクトン・ディキンソン・アンド・カンパニー | 細胞標識分類の方法 |
EP3539035B1 (en) | 2016-11-08 | 2024-04-17 | Becton, Dickinson and Company | Methods for expression profile classification |
US20180181707A1 (en) | 2016-11-10 | 2018-06-28 | Life Technologies Corporation | Methods, systems and computer readable media to correct base calls in repeat regions of nucleic acid sequence reads |
GB201619458D0 (en) | 2016-11-17 | 2017-01-04 | Spatial Transcriptomics Ab | Method for spatial tagging and analysing nucleic acids in a biological specimen |
CN110383385B (zh) | 2016-12-08 | 2023-07-25 | 生命科技股份有限公司 | 从肿瘤样品中检测突变负荷的方法 |
CA3048420A1 (en) | 2016-12-09 | 2018-06-14 | Boreal Genomics, Inc. | Linked ligation |
WO2018111872A1 (en) | 2016-12-12 | 2018-06-21 | Grail, Inc. | Methods for tagging and amplifying rna template molecules for preparing sequencing libraries |
EP3555290B1 (en) | 2016-12-19 | 2022-11-02 | Bio-Rad Laboratories, Inc. | Droplet tagging contiguity preserved tagmented dna |
WO2018119399A1 (en) | 2016-12-23 | 2018-06-28 | Grail, Inc. | Methods for high efficiency library preparation using double-stranded adapters |
EP3565905B1 (en) | 2017-01-04 | 2022-05-25 | MGI Tech Co., Ltd. | Nucleic acid sequencing using affinity reagents |
GB201704754D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Kinetic exclusion amplification of nucleic acid libraries |
DK3566158T3 (da) | 2017-01-06 | 2022-07-18 | Illumina Inc | Faseinddelingskorrektion |
KR102622275B1 (ko) | 2017-01-10 | 2024-01-05 | 로스웰 바이오테크놀로지스 인코포레이티드 | Dna 데이터 저장을 위한 방법들 및 시스템들 |
US10722880B2 (en) | 2017-01-13 | 2020-07-28 | Cellular Research, Inc. | Hydrophilic coating of fluidic channels |
AU2018210316A1 (en) | 2017-01-17 | 2019-06-27 | Illumina, Inc. | Oncogenic splice variant determination |
KR20230158636A (ko) | 2017-01-19 | 2023-11-20 | 로스웰 바이오테크놀로지스 인코포레이티드 | 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들 |
WO2018136117A1 (en) | 2017-01-20 | 2018-07-26 | Omniome, Inc. | Allele-specific capture of nucleic acids |
AU2017394645B2 (en) | 2017-01-20 | 2020-01-23 | Pacific Biosciences Of California, Inc. | Genotyping by polymerase binding |
WO2018144240A1 (en) | 2017-02-01 | 2018-08-09 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
US11492666B2 (en) | 2017-02-15 | 2022-11-08 | Pacific Biosciences Of California, Inc. | Distinguishing sequences by detecting polymerase dissociation |
FI3452621T3 (fi) | 2017-02-21 | 2022-12-15 | Tagmentaatio käyttäen immobilisoituja transposomeja linkkereillä | |
US11054386B2 (en) * | 2017-03-03 | 2021-07-06 | The Charles Stark Draper Laboratory, Inc. | VeSFET chemical sensor and methods of use thereof |
CN114921537A (zh) | 2017-03-17 | 2022-08-19 | 雅普顿生物系统公司 | 测序和高分辨率成像 |
US11092567B2 (en) | 2017-03-21 | 2021-08-17 | International Business Machines Corporation | Biosensor electrode having three-dimensional structured sensing surfaces |
EP3601593B1 (en) | 2017-03-24 | 2021-12-22 | Bio-Rad Laboratories, Inc. | Universal hairpin primers |
WO2018183918A1 (en) | 2017-03-30 | 2018-10-04 | Grail, Inc. | Enhanced ligation in sequencing library preparation |
US11118222B2 (en) | 2017-03-31 | 2021-09-14 | Grail, Inc. | Higher target capture efficiency using probe extension |
WO2018183942A1 (en) | 2017-03-31 | 2018-10-04 | Grail, Inc. | Improved library preparation and use thereof for sequencing-based error correction and/or variant identification |
EP3607087A4 (en) | 2017-04-04 | 2020-12-30 | Omniome, Inc. | FLUIDIC APPARATUS AND USEFUL METHODS FOR CHEMICAL AND BIOLOGICAL REACTIONS |
EP3615671B1 (en) | 2017-04-23 | 2021-07-21 | Illumina Cambridge Limited | Compositions and methods for improving sample identification in indexed nucleic acid libraries |
NL2019043B1 (en) * | 2017-04-25 | 2018-11-05 | Illumina Inc | Sensors having integrated protection circuitry |
US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
CA3057151A1 (en) | 2017-04-25 | 2018-11-01 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
CA3057155A1 (en) | 2017-05-09 | 2018-11-15 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
CN110914911B (zh) | 2017-05-16 | 2023-09-22 | 生命科技股份有限公司 | 压缩分子标记的核酸序列数据的方法 |
GB201708338D0 (en) * | 2017-05-24 | 2017-07-05 | Univ Court Univ Of Glasgow | Metabolite detection apparatus and method of detecting metabolites |
CN110997944A (zh) | 2017-05-26 | 2020-04-10 | 生命科技股份有限公司 | 用于检测brca1/2中的大片段重排方法和系统 |
JP2020522262A (ja) | 2017-06-05 | 2020-07-30 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 単一細胞用のサンプルインデックス付加 |
EP4293122A3 (en) | 2017-06-07 | 2024-01-24 | Oregon Health & Science University | Single cell whole genome libraries for methylation sequencing |
EP3634992B1 (en) | 2017-06-08 | 2024-03-27 | The Brigham And Women's Hospital, Inc. | Methods and compositions for identifying epitopes |
GB2578038B (en) | 2017-06-16 | 2022-11-23 | Life Technologies Corp | Control nucleic acids, and compositions, kits, and uses thereof |
US11702654B2 (en) | 2017-06-20 | 2023-07-18 | Illumina, Inc. | Methods and compositions for addressing inefficiencies in amplification reactions |
WO2018236918A1 (en) | 2017-06-20 | 2018-12-27 | Bio-Rad Laboratories, Inc. | MDA USING A BALL OLIGONUCLEOTIDE |
WO2019005296A1 (en) | 2017-06-27 | 2019-01-03 | Avails Medical, Inc. | APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS |
US10578577B2 (en) | 2017-06-28 | 2020-03-03 | International Business Machines Corporation | Methods of fabricating and operating a solid-state zinc sensor |
CN110785813A (zh) | 2017-07-31 | 2020-02-11 | 伊鲁米那股份有限公司 | 具有多路生物样本聚合的测序系统 |
EP3662083A4 (en) | 2017-08-01 | 2021-03-03 | Illumina, Inc. | SPATIAL INDEXING OF GENETIC MATERIAL AND LIBRARY MANUFACTURING USING HYDROGEL BEADS AND FLOW CELLS |
AU2018312560B2 (en) | 2017-08-01 | 2022-03-10 | Illumina, Inc. | Hydrogel beads for nucleotide sequencing |
US11905552B2 (en) | 2017-08-04 | 2024-02-20 | Keck Graduate Institute Of Applied Life Sciences | Immobilized RNPs for sequence-specific nucleic acid capture and digital detection |
JP2021500531A (ja) | 2017-08-15 | 2021-01-07 | オムニオム インコーポレイテッドOmniome, Inc. | 化学的および生物学的検体の検出に有用なスキャン装置および方法 |
WO2019038594A2 (en) | 2017-08-21 | 2019-02-28 | Biolumic Limited | TRANSGENIC PLANTS WITH HIGH GROWTH AND HIGH RUSTICITY |
CN111373049A (zh) | 2017-08-30 | 2020-07-03 | 罗斯威尔生命技术公司 | 用于dna数据存储的进行性酶分子电子传感器 |
US20200263170A1 (en) | 2017-09-14 | 2020-08-20 | Grail, Inc. | Methods for preparing a sequencing library from single-stranded dna |
WO2019060494A1 (en) | 2017-09-20 | 2019-03-28 | Life Technologies Corporation | METHODS OF DETECTING FUSIONS USING COMPRESSED MOLECULAR LABEL NUCLEIC ACID SEQUENCE DATA |
US11459601B2 (en) | 2017-09-20 | 2022-10-04 | Altratech Limited | Diagnostic device and system |
JP2021500858A (ja) * | 2017-09-21 | 2021-01-14 | ジナプシス インコーポレイテッド | 核酸シーケンシングのためのシステム及び方法 |
EP4269583A3 (en) | 2017-09-28 | 2024-01-17 | Grail, LLC | Enrichment of short nucleic acid fragments in sequencing library preparation |
JP7209701B2 (ja) | 2017-10-03 | 2023-01-20 | アベイルズ メディカル,インコーポレイテッド | レドックス反応に基づいて微生物の濃度及び抗感染剤に対する微生物の感受性を決定する装置、システム、及び方法 |
CA3077085A1 (en) | 2017-10-06 | 2019-04-11 | Oncotherapy Science, Inc. | Screening of t lymphocytes for cancer-specific antigens |
WO2019075100A1 (en) | 2017-10-10 | 2019-04-18 | Roswell Biotechnologies, Inc. | METHODS, APPARATUS AND SYSTEMS FOR STORING DNA DATA WITHOUT AMPLIFICATION |
US10014390B1 (en) | 2017-10-10 | 2018-07-03 | Globalfoundries Inc. | Inner spacer formation for nanosheet field-effect transistors with tall suspensions |
JP6752768B2 (ja) * | 2017-10-17 | 2020-09-09 | 矢崎総業株式会社 | フィルムアンテナ |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
CN118186055A (zh) | 2017-11-02 | 2024-06-14 | 生物辐射实验室股份有限公司 | 基于转座酶的基因组分析 |
CA3202587A1 (en) | 2017-11-06 | 2019-05-09 | Illumina, Inc | Nucleic acid indexing techniques |
JP7038209B2 (ja) | 2017-11-13 | 2022-03-17 | エフ.ホフマン-ラ ロシュ アーゲー | エピタコ電気泳動を使用する試料分析のための装置 |
US20190156922A1 (en) | 2017-11-16 | 2019-05-23 | Illumina, Inc. | Systems and methods for determining microsatellite instability |
KR102058626B1 (ko) | 2017-11-29 | 2019-12-23 | (주)엔젤스윙 | 지형변화량 가시화 방법 및 장치 |
US11657437B2 (en) | 2017-11-29 | 2023-05-23 | Angelswing Inc | Method and apparatus for providing drone data by matching user with provider |
CN110870016A (zh) | 2017-11-30 | 2020-03-06 | 伊鲁米那股份有限公司 | 用于序列变体呼出的验证方法和系统 |
EP4273267A3 (en) | 2017-12-01 | 2023-12-27 | Life Technologies Corporation | Methods, systems, and computer-readable media for detection of internal tandem duplication in the flt3 gene |
WO2019118925A1 (en) | 2017-12-15 | 2019-06-20 | Grail, Inc. | Methods for enriching for duplex reads in sequencing and error correction |
CN111492068A (zh) | 2017-12-19 | 2020-08-04 | 贝克顿迪金森公司 | 与寡核苷酸相关联的颗粒 |
WO2019126803A1 (en) | 2017-12-22 | 2019-06-27 | Grail, Inc. | Error removal using improved library preparation methods |
US10793963B2 (en) * | 2017-12-22 | 2020-10-06 | Illumina, Inc. | Passivating fissures in substrates |
US11561196B2 (en) | 2018-01-08 | 2023-01-24 | Illumina, Inc. | Systems and devices for high-throughput sequencing with semiconductor-based detection |
SG11201911784PA (en) | 2018-01-08 | 2020-01-30 | Illumina Inc | Systems and devices for high-throughput sequencing with semiconductor-based detection |
US20190237163A1 (en) | 2018-01-12 | 2019-08-01 | Life Technologies Corporation | Methods for flow space quality score prediction by neural networks |
CN108192802A (zh) * | 2018-01-24 | 2018-06-22 | 中国科学院半导体研究所 | Isfet阵列的放大和读出电路 |
WO2019152395A1 (en) | 2018-01-31 | 2019-08-08 | Bio-Rad Laboratories, Inc. | Methods and compositions for deconvoluting partition barcodes |
CA3186025A1 (en) | 2018-02-13 | 2019-08-22 | Illumina, Inc. | Dna sequencing using hydrogel beads |
CN110184325A (zh) * | 2018-02-22 | 2019-08-30 | 张家港万众一芯生物科技有限公司 | 基于微孔阵列芯片的单分子文库pcr扩增的基因测序方法 |
CN111094592A (zh) | 2018-03-09 | 2020-05-01 | 伊鲁米纳剑桥有限公司 | 广义随机超分辨率测序 |
US20190367909A1 (en) | 2018-04-02 | 2019-12-05 | Illumina, Inc. | Compositions and methods for making controls for sequence-based genetic testing |
EP3553182A1 (en) | 2018-04-11 | 2019-10-16 | Université de Bourgogne | Detection method of somatic genetic anomalies, combination of capture probes and kit of detection |
US11512002B2 (en) | 2018-04-18 | 2022-11-29 | University Of Virginia Patent Foundation | Silica materials and methods of making thereof |
US20190338352A1 (en) | 2018-04-19 | 2019-11-07 | Omniome, Inc. | Accuracy of base calls in nucleic acid sequencing methods |
MX2019014802A (es) | 2018-04-20 | 2021-03-02 | Illumina Inc | Métodos para encapsular células individuales, las células encapsuladas y usos de las mismas. |
EP3788170A1 (en) | 2018-05-03 | 2021-03-10 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
US11773441B2 (en) | 2018-05-03 | 2023-10-03 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
US20210239700A1 (en) | 2018-05-04 | 2021-08-05 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
GB2573562B (en) * | 2018-05-10 | 2022-08-24 | Advanced Risc Mach Ltd | Fluid control delivery device and method |
RU2744175C1 (ru) | 2018-05-17 | 2021-03-03 | Иллумина, Инк. | Высокопроизводительное секвенирование одиночной клетки со сниженной ошибкой амплификации |
US10801064B2 (en) | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
US11814750B2 (en) | 2018-05-31 | 2023-11-14 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
ES2966028T3 (es) | 2018-06-04 | 2024-04-18 | Illumina Inc | Bibliotecas de transcriptomas unicelulares de alto rendimiento y métodos de preparación y de uso |
CN108827747A (zh) * | 2018-06-04 | 2018-11-16 | 华中科技大学苏州脑空间信息研究院 | 一种多色荧光标记样本的塑性包埋方法 |
US11221966B2 (en) | 2018-06-05 | 2022-01-11 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Method and system for biological information pattern storage and readout |
WO2020001783A1 (en) | 2018-06-29 | 2020-01-02 | Thermo Fisher Scientific Geneart Gmbh | High throughput assembly of nucleic acid molecules |
US11561197B2 (en) | 2018-06-29 | 2023-01-24 | AMMR Joint Venture | Electronic detection of a target based on enzymatic cleavage of a reporter moiety |
CN110763736B (zh) * | 2018-07-25 | 2022-06-03 | 中国石油化工股份有限公司 | 一种非导电泥浆随钻电阻率成像测量装置 |
HRP20221504T1 (hr) | 2018-08-08 | 2023-03-31 | Pml Screening, Llc | Postupci procjene rizika od razvoja progresivne multifokalne leukoencefalopatije uzrokovane john cunningham virusom pomoću genetskog testiranja |
US20210164932A1 (en) * | 2018-08-17 | 2021-06-03 | Life Technologies Corporation | Method of forming ion sensors |
CN113166807B (zh) | 2018-08-20 | 2024-06-04 | 生物辐射实验室股份有限公司 | 通过分区中条码珠共定位生成核苷酸序列 |
CN113366117A (zh) | 2018-08-28 | 2021-09-07 | 10X基因组学股份有限公司 | 用于生物样品中转座酶介导的空间标记和分析基因组dna的方法 |
US20210317524A1 (en) | 2018-08-28 | 2021-10-14 | 10X Genomics, Inc. | Resolving spatial arrays |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
WO2020046784A1 (en) | 2018-08-28 | 2020-03-05 | Life Technologies Corporation | Methods for detecting mutation load from a tumor sample |
EP3850350A1 (en) * | 2018-09-13 | 2021-07-21 | Life Technologies Corporation | Cell analysis using chemfet sensor array-based systems |
US10731141B2 (en) | 2018-09-17 | 2020-08-04 | Omniome, Inc. | Engineered polymerases for improved sequencing |
EP3853382A4 (en) | 2018-09-19 | 2022-06-22 | Apton Biosystems, Inc. | DENSELY PACKED ANALYTE LAYERS AND DETECTION METHODS |
US11035794B2 (en) | 2018-09-28 | 2021-06-15 | Uchicago Argonne, Llc | Scalable, large-area optical sensing platform with compact light delivery and imaging system |
WO2020069424A1 (en) | 2018-09-28 | 2020-04-02 | Centrillion Technologies, Inc. | Disulfide-linked reversible terminators |
US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
US10971765B2 (en) * | 2018-10-05 | 2021-04-06 | Palo Alto Research Center Incorporated | Current control systems and methods |
US11572586B2 (en) | 2018-10-12 | 2023-02-07 | Life Technologies Corporation | Methods and systems for evaluating microsatellite instability status |
WO2020074742A1 (en) | 2018-10-12 | 2020-04-16 | F. Hoffmann-La Roche Ag | Detection methods for epitachophoresis workflow automation |
US11327045B2 (en) * | 2018-10-18 | 2022-05-10 | Globalfoundries Singapore Pte. Ltd. | Sensor device for detecting a pH change in a solution and a method for forming the sensor device |
SG11202102703VA (en) | 2018-10-26 | 2021-04-29 | Illumina Inc | Modulating polymer beads for dna processing |
WO2020092830A1 (en) | 2018-10-31 | 2020-05-07 | Illumina, Inc. | Polymerases, compositions, and methods of use |
JP2022506546A (ja) | 2018-11-08 | 2022-01-17 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
US11680261B2 (en) | 2018-11-15 | 2023-06-20 | Grail, Inc. | Needle-based devices and methods for in vivo diagnostics of disease conditions |
BR112021006183A2 (pt) | 2018-11-30 | 2021-06-29 | Illumina, Inc. | análise de múltiplos analitos com o uso de um único ensaio |
CN211311477U (zh) | 2018-12-04 | 2020-08-21 | 欧姆尼欧美公司 | 测序系统 |
MX2020013357A (es) | 2018-12-05 | 2021-04-28 | Illumina Inc | Polimerasas, composiciones y metodos de uso. |
WO2020114918A1 (en) | 2018-12-05 | 2020-06-11 | Illumina Cambridge Limited | Methods and compositions for cluster generation by bridge amplification |
EP3894592A2 (en) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Generating spatial arrays with gradients |
GB201820300D0 (en) | 2018-12-13 | 2019-01-30 | 10X Genomics Inc | Method for spatial tagging and analysing genomic DNA in a biological specimen |
CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
CN112739830A (zh) | 2018-12-18 | 2021-04-30 | 伊卢米纳剑桥有限公司 | 使用单一表面引物进行配对末端测序的方法和组合物 |
CN113286883A (zh) | 2018-12-18 | 2021-08-20 | 格里尔公司 | 使用rna分析以检测疾病的方法 |
AU2019402925A1 (en) | 2018-12-19 | 2021-01-14 | Illumina, Inc. | Methods for improving polynucleotide cluster clonality priority |
WO2020132350A2 (en) | 2018-12-20 | 2020-06-25 | Omniome, Inc. | Temperature control for analysis of nucleic acids and other analytes |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
US11473136B2 (en) | 2019-01-03 | 2022-10-18 | Ncan Genomics, Inc. | Linked target capture |
US20220081714A1 (en) | 2019-01-04 | 2022-03-17 | Northwestern University | Storing temporal data into dna |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
EP4242322A3 (en) | 2019-01-23 | 2023-09-20 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
EP3691253B1 (en) * | 2019-01-31 | 2023-11-15 | Fundació Institut de Ciències Fotòniques | Charge sensing device with readout of signal by detecting a change of capacitance of combined gate and quantum capacitance compared to a reference capacitancea |
US11499189B2 (en) | 2019-02-14 | 2022-11-15 | Pacific Biosciences Of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
CN113613787B (zh) | 2019-02-20 | 2023-06-13 | 加利福尼亚太平洋生物科学股份有限公司 | 用于检测化学和生物分析物的扫描装置和方法 |
WO2020176788A1 (en) | 2019-02-28 | 2020-09-03 | 10X Genomics, Inc. | Profiling of biological analytes with spatially barcoded oligonucleotide arrays |
CA3113841A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | High-throughput single-nuclei and single-cell libraries and methods of making and of using |
CN113924041A (zh) | 2019-03-14 | 2022-01-11 | 因斯利克萨公司 | 基于时间门控的荧光检测的方法和系统 |
WO2020190509A1 (en) | 2019-03-15 | 2020-09-24 | 10X Genomics, Inc. | Methods for using spatial arrays for single cell sequencing |
JP2020153695A (ja) * | 2019-03-18 | 2020-09-24 | 株式会社東芝 | イオンセンサ、イオンセンサキット及びイオン検出方法 |
WO2020198071A1 (en) | 2019-03-22 | 2020-10-01 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
CN113614832A (zh) | 2019-03-22 | 2021-11-05 | 生命科技股份有限公司 | 用于检测伴侣未知的基因融合的方法 |
GB201905303D0 (en) | 2019-04-15 | 2019-05-29 | Thermo Fisher Scient Geneart Gmbh | Multiplex assembly of nucleic acid molecules |
US11610648B2 (en) | 2019-04-18 | 2023-03-21 | Life Technologies Corporation | Methods for context based compression of genomic data for immuno-oncology biomarkers |
WO2020214642A1 (en) | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
US20220325268A1 (en) | 2019-05-14 | 2022-10-13 | Roche Sequencing Solutions, Inc | Devices and methods for sample analysis |
US11423306B2 (en) | 2019-05-16 | 2022-08-23 | Illumina, Inc. | Systems and devices for characterization and performance analysis of pixel-based sequencing |
EP3969884B1 (en) | 2019-05-16 | 2024-04-17 | Illumina, Inc. | Systems and methods for characterization and performance analysis of pixel-based sequencing |
EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
US11644406B2 (en) | 2019-06-11 | 2023-05-09 | Pacific Biosciences Of California, Inc. | Calibrated focus sensing |
CN118226175A (zh) * | 2019-06-19 | 2024-06-21 | 泰克元有限公司 | 测试腔室 |
CN113226519A (zh) | 2019-07-12 | 2021-08-06 | Illumina剑桥有限公司 | 使用电泳制备核酸文库 |
CN113260711A (zh) | 2019-07-12 | 2021-08-13 | Illumina剑桥有限公司 | 使用固定在固体载体上的crispr/cas9制备核酸测序文库的组合物和方法 |
US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
US10656368B1 (en) | 2019-07-24 | 2020-05-19 | Omniome, Inc. | Method and system for biological imaging using a wide field objective lens |
US11054387B2 (en) * | 2019-08-22 | 2021-07-06 | Globalfoundries Singapore Pte. Ltd. | Semiconductor devices with ion-sensitive field effect transistor |
JP2022546117A (ja) | 2019-08-28 | 2022-11-02 | アッセンブリー バイオサイエンシズ,インコーポレイテッド | 細菌種を含む組成物及びそれに関連する方法 |
RU2724507C1 (ru) * | 2019-08-30 | 2020-06-23 | Ооо "Гамма-Днк" | Способ регистрации результата реакции полимеризации днк и устройство для его реализации |
CN114728996B (zh) | 2019-09-10 | 2022-11-29 | 加利福尼亚太平洋生物科学股份有限公司 | 核苷酸的可逆修饰 |
US11514575B2 (en) | 2019-10-01 | 2022-11-29 | 10X Genomics, Inc. | Systems and methods for identifying morphological patterns in tissue samples |
WO2021072439A1 (en) | 2019-10-11 | 2021-04-15 | Life Technologies Corporation | Compositions and methods for assessing microbial populations |
EP4045683A1 (en) | 2019-10-18 | 2022-08-24 | Omniome, Inc. | Methods and compositions for capping nucleic acids |
WO2021078947A1 (en) | 2019-10-25 | 2021-04-29 | Illumina Cambridge Limited | Methods for generating, and sequencing from, asymmetric adaptors on the ends of polynucleotide templates comprising hairpin loops |
EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
US20210139867A1 (en) | 2019-11-08 | 2021-05-13 | Omniome, Inc. | Engineered polymerases for improved sequencing by binding |
JP2023500679A (ja) | 2019-11-08 | 2023-01-10 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
WO2021102003A1 (en) | 2019-11-18 | 2021-05-27 | 10X Genomics, Inc. | Systems and methods for tissue classification |
US20210155982A1 (en) | 2019-11-21 | 2021-05-27 | 10X Genomics, Inc. | Pipeline for spatial analysis of analytes |
US11501440B2 (en) | 2019-11-22 | 2022-11-15 | 10X Genomics, Inc. | Systems and methods for spatial analysis of analytes using fiducial alignment |
DE202019106694U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
CN113631721A (zh) | 2019-12-04 | 2021-11-09 | 因美纳有限公司 | 用于检测血浆中dna病原体的dna测序文库的制备 |
CN114008199A (zh) | 2019-12-19 | 2022-02-01 | 伊路敏纳公司 | 高通量单细胞文库及其制备和使用方法 |
WO2021123387A1 (en) | 2019-12-20 | 2021-06-24 | Da Volterra | Prediction of clinical manifestations of gut microbiota dysbiosis |
EP3891300B1 (en) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
JP7451198B2 (ja) | 2020-02-03 | 2024-03-18 | キヤノンメディカルシステムズ株式会社 | 検体検査装置及び検体検査方法 |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
WO2021158511A1 (en) | 2020-02-04 | 2021-08-12 | Omniome, Inc. | Flow cells and methods for their manufacture and use |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
EP4103580A4 (en) | 2020-02-13 | 2024-03-06 | Zymergen Inc. | METAGENOMIC LIBRARY AND NATURAL PRODUCT DISCOVERY PLATFORM |
JP2023514749A (ja) | 2020-02-21 | 2023-04-07 | 10エックス ジェノミクス インコーポレイテッド | 統合型インサイチュ空間的アッセイのための方法および組成物 |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
WO2021178467A1 (en) | 2020-03-03 | 2021-09-10 | Omniome, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
WO2021183095A1 (en) * | 2020-03-09 | 2021-09-16 | Hewlett-Packard Development Company, L.P. | Clamps for power transistors |
WO2021185320A1 (en) | 2020-03-18 | 2021-09-23 | Mgi Tech Co., Ltd. | Restoring phase in massively parallel sequencing |
WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
US20230203592A1 (en) | 2020-05-05 | 2023-06-29 | Akershus Universitetssykehus Hf | Compositions and methods for characterizing bowel cancer |
BR112022020101A2 (pt) | 2020-05-08 | 2022-11-29 | Illumina Inc | Técnicas de sequenciamento e detecção de genoma |
WO2021231477A2 (en) | 2020-05-12 | 2021-11-18 | Illumina, Inc. | Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase |
EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
EP4158054A1 (en) | 2020-06-02 | 2023-04-05 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
WO2021252617A1 (en) | 2020-06-09 | 2021-12-16 | Illumina, Inc. | Methods for increasing yield of sequencing libraries |
EP4165207A1 (en) | 2020-06-10 | 2023-04-19 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
EP4165549A1 (en) | 2020-06-11 | 2023-04-19 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
BR112022026056A2 (pt) | 2020-06-22 | 2023-03-07 | Illumina Cambridge Ltd | Nucleosídeos e nucleotídeos com grupo bloqueador 3? acetal |
CN116034166A (zh) | 2020-06-25 | 2023-04-28 | 10X基因组学有限公司 | Dna甲基化的空间分析 |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
IL299042A (en) | 2020-07-08 | 2023-02-01 | Illumina Inc | Beads as transpososome carriers |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
EP4192951A1 (en) | 2020-08-06 | 2023-06-14 | Illumina, Inc. | Preparation of rna and dna sequencing libraries using bead-linked transposomes |
KR20230051508A (ko) | 2020-08-18 | 2023-04-18 | 일루미나, 인코포레이티드 | 핵산의 서열-특이적 표적화된 전위 및 선택과 분류 |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
MX2023001400A (es) | 2020-09-11 | 2023-04-25 | Illumina Cambridge Ltd | Metodos para enriquecer una secuencia diana a partir de una genoteca de secuenciación usando adaptadores de horquilla. |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US20220113305A1 (en) * | 2020-10-14 | 2022-04-14 | Morton M. Mower | System, apparatus, and method for viral monitoring in effluent |
AU2021378290A1 (en) | 2020-11-11 | 2023-06-29 | Nautilus Subsidiary, Inc. | Affinity reagents having enhanced binding and detection characteristics |
CN112630288B (zh) * | 2020-11-17 | 2021-10-12 | 燕山大学 | 一种基于放电的二次电子发射系数测量装置及方法 |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
CN116635533A (zh) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | 高表达的蛋白和低表达的蛋白的谱分析 |
CA3179883A1 (en) | 2020-12-02 | 2022-06-09 | Illumina Software, Inc. | System and method for detection of genetic alterations |
AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
AU2022209365A1 (en) | 2021-01-21 | 2023-07-20 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
CA3208854A1 (en) | 2021-02-04 | 2022-08-11 | Illumina, Inc. | Long indexed-linked read generation on transposome bound beads |
WO2022174054A1 (en) | 2021-02-13 | 2022-08-18 | The General Hospital Corporation | Methods and compositions for in situ macromolecule detection and uses thereof |
IL305336A (en) | 2021-03-11 | 2023-10-01 | Nautilus Subsidiary Inc | Systems and methods for the preservation of biomolecules |
WO2022194764A1 (en) | 2021-03-15 | 2022-09-22 | F. Hoffmann-La Roche Ag | Targeted next-generation sequencing via anchored primer extension |
EP4301870A1 (en) | 2021-03-18 | 2024-01-10 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
AU2022245985A1 (en) | 2021-03-22 | 2023-09-21 | Illumina Cambridge Limited | Methods for improving nucleic acid cluster clonality |
JP2024513187A (ja) | 2021-03-29 | 2024-03-22 | イルミナ インコーポレイテッド | ライブラリー中のdna損傷を評価し、アンプリコンサイズバイアスを正規化するための組成物及び方法 |
BR112023019898A2 (pt) | 2021-03-29 | 2023-11-07 | Illumina Inc | Métodos aprimorados de preparação de biblioteca |
BR112023019945A2 (pt) | 2021-03-31 | 2023-11-14 | Illumina Cambridge Ltd | Métodos para a preparação de bibliotecas de sequenciamento por tagmentação direcional com o uso de tecnologia baseada em transposon com identificadores moleculares exclusivos para correção de erros |
KR20230165273A (ko) | 2021-03-31 | 2023-12-05 | 일루미나 케임브리지 리미티드 | 어댑터 이량체 검출을 갖는 핵산 라이브러리 서열분석 기술 |
KR20230167028A (ko) | 2021-04-02 | 2023-12-07 | 일루미나, 인코포레이티드 | 시퀀싱을 위한 뉴클레오티드 샘플 슬라이드 내 거품을 검출하기 위한 기계-학습 모델 |
WO2022232425A2 (en) | 2021-04-29 | 2022-11-03 | Illumina, Inc. | Amplification techniques for nucleic acid characterization |
US11965663B2 (en) | 2021-05-03 | 2024-04-23 | Copeland Lp | Refrigerant leak sensor with extended life |
CA3216735A1 (en) | 2021-05-20 | 2022-11-24 | Patrizia IAVICOLI | Compositions and methods for sequencing by synthesis |
EP4347872A2 (en) | 2021-05-28 | 2024-04-10 | Illumina, Inc. | Oligo-modified nucleotide analogues for nucleic acid preparation |
WO2022265982A1 (en) * | 2021-06-14 | 2022-12-22 | President And Fellows Of Harvard College | Local sensing and control of ph for parallelized synthesis |
KR20240026932A (ko) | 2021-06-29 | 2024-02-29 | 일루미나, 인코포레이티드 | 게놈 좌표에 대한 신뢰도 분류를 생성하기 위한 기계 학습 모델 |
US20220415442A1 (en) | 2021-06-29 | 2022-12-29 | Illumina Software, Inc. | Signal-to-noise-ratio metric for determining nucleotide-base calls and base-call quality |
US20230021577A1 (en) | 2021-07-23 | 2023-01-26 | Illumina Software, Inc. | Machine-learning model for recalibrating nucleotide-base calls |
US20230047225A1 (en) | 2021-08-14 | 2023-02-16 | Illumina, Inc. | Polymerases, compositions, and methods of use |
WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
US20230070896A1 (en) | 2021-09-09 | 2023-03-09 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
CN117561573A (zh) | 2021-09-17 | 2024-02-13 | 因美纳有限公司 | 从碱基判读错误模式自动鉴定核苷酸测序中的故障来源 |
CN117546243A (zh) | 2021-09-21 | 2024-02-09 | 因美纳有限公司 | 使用推算的单倍型的图参考基因组和碱基检出方法 |
WO2023049073A1 (en) | 2021-09-22 | 2023-03-30 | Nautilus Biotechnology, Inc. | Methods and systems for determining polypeptide interactions |
WO2023064181A1 (en) | 2021-10-11 | 2023-04-20 | Nautilus Biotechnology, Inc. | Highly multiplexable analysis of proteins and proteomes |
EP4174189A1 (en) | 2021-10-28 | 2023-05-03 | Volker, Leen | Enzyme directed biomolecule labeling |
WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
CN117581303A (zh) | 2021-12-02 | 2024-02-20 | 因美纳有限公司 | 产生用于确定核苷酸碱基检出的簇特异性信号校正 |
WO2023122363A1 (en) | 2021-12-23 | 2023-06-29 | Illumina Software, Inc. | Dynamic graphical status summaries for nucelotide sequencing |
US20230215515A1 (en) | 2021-12-23 | 2023-07-06 | Illumina Software, Inc. | Facilitating secure execution of external workflows for genomic sequencing diagnostics |
US20230207050A1 (en) | 2021-12-28 | 2023-06-29 | Illumina Software, Inc. | Machine learning model for recalibrating nucleotide base calls corresponding to target variants |
WO2023129764A1 (en) | 2021-12-29 | 2023-07-06 | Illumina Software, Inc. | Automatically switching variant analysis model versions for genomic analysis applications |
WO2023126457A1 (en) | 2021-12-29 | 2023-07-06 | Illumina Cambridge Ltd. | Methods of nucleic acid sequencing using surface-bound primers |
BE1030246B1 (nl) | 2022-02-04 | 2023-09-04 | Leen Volker | Polymeer geassisteerde biomolecule analyse |
WO2023156628A1 (en) | 2022-02-18 | 2023-08-24 | Universiteit Antwerpen | Methods for predicting severity of dysbiosis caused by treatment with an antibiotic |
CA3224595A1 (en) | 2022-02-25 | 2023-08-31 | Steven Norberg | Machine-learning models for detecting and adjusting values for nucleotide methylation levels |
US20230410944A1 (en) | 2022-02-25 | 2023-12-21 | Illumina, Inc. | Calibration sequences for nucelotide sequencing |
WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
AU2023248405A1 (en) | 2022-04-07 | 2024-01-04 | Illumina, Inc. | Altered cytidine deaminases and methods of use |
AU2023250540A1 (en) | 2022-04-08 | 2024-01-18 | Illumina, Inc. | Aptamer dynamic range compression and detection techniques |
US20230360732A1 (en) | 2022-04-25 | 2023-11-09 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
US20230340571A1 (en) | 2022-04-26 | 2023-10-26 | Illumina, Inc. | Machine-learning models for selecting oligonucleotide probes for array technologies |
WO2023220627A1 (en) | 2022-05-10 | 2023-11-16 | Illumina Software, Inc. | Adaptive neural network for nucelotide sequencing |
WO2023225095A1 (en) | 2022-05-18 | 2023-11-23 | Illumina Cambridge Limited | Preparation of size-controlled nucleic acid fragments |
US20230392201A1 (en) | 2022-06-06 | 2023-12-07 | Element Biosciences, Inc. | Methods for assembling and reading nucleic acid sequences from mixed populations |
WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
WO2023250504A1 (en) | 2022-06-24 | 2023-12-28 | Illumina Software, Inc. | Improving split-read alignment by intelligently identifying and scoring candidate split groups |
WO2024006705A1 (en) | 2022-06-27 | 2024-01-04 | Illumina Software, Inc. | Improved human leukocyte antigen (hla) genotyping |
US20230420082A1 (en) | 2022-06-27 | 2023-12-28 | Illumina Software, Inc. | Generating and implementing a structural variation graph genome |
WO2024006779A1 (en) | 2022-06-27 | 2024-01-04 | Illumina, Inc. | Accelerators for a genotype imputation model |
US20240006019A1 (en) | 2022-06-30 | 2024-01-04 | Life Technologies Corporation | Methods for assessing genomic instability |
CN115184437B (zh) * | 2022-07-15 | 2024-02-02 | 山东云海国创云计算装备产业创新中心有限公司 | 一种基于risc-v的生物信号检测系统、方法及介质 |
WO2024015962A1 (en) | 2022-07-15 | 2024-01-18 | Pacific Biosciences Of California, Inc. | Blocked asymmetric hairpin adaptors |
WO2024026356A1 (en) | 2022-07-26 | 2024-02-01 | Illumina, Inc. | Rapid single-cell multiomics processing using an executable file |
WO2024039516A1 (en) | 2022-08-19 | 2024-02-22 | Illumina, Inc. | Third dna base pair site-specific dna detection |
WO2024059487A1 (en) | 2022-09-12 | 2024-03-21 | Life Technologies Corporation | Methods for detecting allele dosages in polyploid organisms |
WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
US20240112753A1 (en) | 2022-09-29 | 2024-04-04 | Illumina, Inc. | Target-variant-reference panel for imputing target variants |
WO2024073544A1 (en) | 2022-09-30 | 2024-04-04 | Life Technologies Corporation | System and method for genotyping structural variants |
WO2024069581A1 (en) | 2022-09-30 | 2024-04-04 | Illumina Singapore Pte. Ltd. | Helicase-cytidine deaminase complexes and methods of use |
WO2024073047A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Cytidine deaminases and methods of use in mapping modified cytosine nucleotides |
US20240141427A1 (en) | 2022-09-30 | 2024-05-02 | Illumina, Inc. | Polymerases, compositions, and methods of use |
WO2024073043A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Methods of using cpg binding proteins in mapping modified cytosine nucleotides |
US20240120027A1 (en) | 2022-09-30 | 2024-04-11 | Illumina, Inc. | Machine-learning model for refining structural variant calls |
WO2024077096A1 (en) | 2022-10-05 | 2024-04-11 | Illumina, Inc. | Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture |
US20240127906A1 (en) | 2022-10-11 | 2024-04-18 | Illumina, Inc. | Detecting and correcting methylation values from methylation sequencing assays |
WO2024118903A1 (en) | 2022-11-30 | 2024-06-06 | Illumina, Inc. | Chemoenzymatic correction of false positive uracil transformations |
WO2024118791A1 (en) | 2022-11-30 | 2024-06-06 | Illumina, Inc. | Accurately predicting variants from methylation sequencing data |
WO2024124073A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
WO2024129672A1 (en) | 2022-12-12 | 2024-06-20 | The Broad Institute, Inc. | Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy |
WO2024129969A1 (en) | 2022-12-14 | 2024-06-20 | Illumina, Inc. | Systems and methods for capture and enrichment of clustered beads on flow cell substrates |
WO2024130000A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
Family Cites Families (527)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US172963A (en) * | 1876-02-01 | Improvement in combined paper clips and weights | ||
US269927A (en) * | 1883-01-02 | Case fob | ||
US3531258A (en) | 1967-11-16 | 1970-09-29 | Us Health Education & Welfare | Apparatus for the automated synthesis of peptides |
DE2413703C3 (de) | 1974-03-21 | 1979-01-04 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Ventilanordnung für die Zuführung flüssiger oder gasförmiger Substanzen zu einem Verarbeitungsgefäß |
JPS5530312B2 (ja) * | 1975-01-16 | 1980-08-09 | ||
US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
JPS57136158A (en) | 1981-02-17 | 1982-08-23 | Sumitomo Electric Ind Ltd | Ph electrode |
GB2096824A (en) | 1981-04-09 | 1982-10-20 | Sibbald Alastair | Chemically sensitive field effect transistor |
EP0065202B1 (de) | 1981-05-15 | 1986-03-12 | Licentia Patent-Verwaltungs-GmbH | Verfahren zur Messung von Ionenkonzentrationen |
FR2510260A1 (fr) | 1981-07-24 | 1983-01-28 | Suisse Fond Rech Microtech | Dispositif semiconducteur sensible aux ions |
US4438354A (en) | 1981-08-14 | 1984-03-20 | American Microsystems, Incorporated | Monolithic programmable gain-integrator stage |
JPS5870155U (ja) | 1981-11-06 | 1983-05-12 | ヤマハ株式会社 | 電子機器用収納家具 |
US4411741A (en) | 1982-01-12 | 1983-10-25 | University Of Utah | Apparatus and method for measuring the concentration of components in fluids |
US4558845A (en) | 1982-09-22 | 1985-12-17 | Hunkapiller Michael W | Zero dead volume valve |
NL8302964A (nl) | 1983-08-24 | 1985-03-18 | Cordis Europ | Inrichting voor het bepalen van de aktiviteit van een ion (pion) in een vloeistof. |
NL8302963A (nl) * | 1983-08-24 | 1985-03-18 | Cordis Europ | Inrichting voor het selectief meten van ionen in een vloeistof. |
NL8303792A (nl) | 1983-11-03 | 1985-06-03 | Cordis Europ | Inrichting voorzien van een op een isfet gebaseerd meetcircuit; voor toepassing in het meetcircuit geschikte isfet en werkwijze ter vervaardiging van een in het meetcircuit toe te passen isfet. |
JPS60128345A (ja) | 1983-12-15 | 1985-07-09 | Olympus Optical Co Ltd | イオン濃度測定装置 |
US4660063A (en) | 1985-03-18 | 1987-04-21 | General Electric Company | Immersion type ISFET |
DE3513168A1 (de) | 1985-04-12 | 1986-10-16 | Thomas 8000 München Dandekar | Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren) |
US4743954A (en) | 1985-06-07 | 1988-05-10 | University Of Utah | Integrated circuit for a chemical-selective sensor with voltage output |
US4863849A (en) | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
EP0213825A3 (en) | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Multiple chemically modulated capacitance |
GB8522785D0 (en) | 1985-09-14 | 1985-10-16 | Emi Plc Thorn | Chemical-sensitive semiconductor device |
US5140393A (en) | 1985-10-08 | 1992-08-18 | Sharp Kabushiki Kaisha | Sensor device |
US4822566A (en) * | 1985-11-19 | 1989-04-18 | The Johns Hopkins University | Optimized capacitive sensor for chemical analysis and measurement |
DE3605178A1 (de) | 1986-02-19 | 1987-08-20 | Standard Elektrik Lorenz Ag | Bewegungssensor |
JPS62237349A (ja) | 1986-04-08 | 1987-10-17 | Nec Corp | 水素イオン濃度分布測定装置 |
US4864229A (en) | 1986-05-03 | 1989-09-05 | Integrated Ionics, Inc. | Method and apparatus for testing chemical and ionic sensors |
US4722830A (en) * | 1986-05-05 | 1988-02-02 | General Electric Company | Automated multiple stream analysis system |
US5082788A (en) | 1986-08-27 | 1992-01-21 | Porton Instruments, Inc. | Method of sequencing peptides and proteins using a valve block assembly |
US5113870A (en) | 1987-05-01 | 1992-05-19 | Rossenfeld Joel P | Method and apparatus for the analysis, display and classification of event related potentials by interpretation of P3 responses |
US4927736A (en) | 1987-07-21 | 1990-05-22 | Hoechst Celanese Corporation | Hydroxy polyimides and high temperature positive photoresists therefrom |
WO1989007263A1 (en) | 1988-02-08 | 1989-08-10 | I-Stat Corporation | Metal oxide electrodes |
US4971903A (en) | 1988-03-25 | 1990-11-20 | Edward Hyman | Pyrophosphate-based method and apparatus for sequencing nucleic acids |
US4874499A (en) | 1988-05-23 | 1989-10-17 | Massachusetts Institute Of Technology | Electrochemical microsensors and method of making such sensors |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US4893088A (en) | 1988-11-16 | 1990-01-09 | Harris Corporation | Transimpedance focal plane processor |
US4990974A (en) | 1989-03-02 | 1991-02-05 | Thunderbird Technologies, Inc. | Fermi threshold field effect transistor |
JPH02250331A (ja) | 1989-03-24 | 1990-10-08 | Hitachi Ltd | 半導体装置およびその製造方法 |
EP0394598B1 (en) * | 1989-04-28 | 1996-03-06 | International Business Machines Corporation | An improved gate array cell having FETS of different and optimized sizes |
JP2789109B2 (ja) | 1989-05-25 | 1998-08-20 | 三菱電機株式会社 | 半導体装置およびその製造方法 |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
JP3001104B2 (ja) | 1989-10-04 | 2000-01-24 | オリンパス光学工業株式会社 | センサー構造体及びその製造法 |
IT1238117B (it) | 1989-10-16 | 1993-07-07 | Marelli Autronica | Circuito a condensatori commutati, integrabile in tecnologia mos, con funzione di raddrizzatore a doppia semionda e di integratore |
US5110441A (en) * | 1989-12-14 | 1992-05-05 | Monsanto Company | Solid state ph sensor |
JP3120237B2 (ja) | 1990-01-10 | 2000-12-25 | セイコーインスツルメンツ株式会社 | イメージセンサ |
US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
US6054034A (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
JPH0458474A (ja) | 1990-06-26 | 1992-02-25 | Witco Of Jupiter Dentsu Kk | 小型コネクタ用雌型接触子とその製造方法 |
US5126759A (en) | 1990-06-26 | 1992-06-30 | Eastman Kodak Company | Non-impact printer with token bit control of data and current regulation signals |
US5202576A (en) | 1990-08-29 | 1993-04-13 | Texas Instruments Incorporated | Asymmetrical non-volatile memory cell, arrays and methods for fabricating same |
US5317407A (en) * | 1991-03-11 | 1994-05-31 | General Electric Company | Fixed-pattern noise correction circuitry for solid-state imager |
KR940010562B1 (ko) | 1991-09-06 | 1994-10-24 | 손병기 | Ta_2O_5수소이온 감지막을 갖는 감이온 전계효과 트랜지스터의 제조방법 |
JPH0580115A (ja) | 1991-09-19 | 1993-04-02 | Fujitsu Ltd | 不揮発性ランダムアクセスメモリ装置及び不揮発性ランダムアクセスメモリ装置における浮遊ゲート電圧レベルの検出方法 |
CA2121797A1 (en) | 1991-10-21 | 1993-04-29 | James W. Holm-Kennedy | Method and device for biochemical sensing |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
JPH0645875A (ja) | 1992-07-24 | 1994-02-18 | Nec Corp | スイッチトキャパシタ回路 |
US5313984A (en) | 1992-09-24 | 1994-05-24 | Santa Barbara Research Center | Multi-fluid, variable sequence, zero dead volume valve and system |
DE4232532A1 (de) | 1992-09-29 | 1994-04-28 | Ct Fuer Intelligente Sensorik | Anordnung und Verfahren zur Erhöhung der Zuverlässigkeit von ionensensitiven Feldeffekttransistoren |
US5284566A (en) * | 1993-01-04 | 1994-02-08 | Bacharach, Inc. | Electrochemical gas sensor with wraparound reference electrode |
US5436149A (en) * | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
WO1994026029A1 (en) | 1993-04-26 | 1994-11-10 | Unifet Incorporated | Method and apparatus for multiplexing devices having long thermal time constants |
EP0627763B1 (en) | 1993-05-31 | 2004-12-15 | STMicroelectronics S.r.l. | Process for improving the adhesion between dielectric layers at their interface in semiconductor devices manufacture |
US6800225B1 (en) | 1994-07-14 | 2004-10-05 | Novartis Ag | Process and device for the manufacture of mouldings and mouldings manufactured in accordance with that process |
JP3413664B2 (ja) | 1993-08-12 | 2003-06-03 | ソニー株式会社 | 電荷転送装置 |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
JPH07169861A (ja) | 1993-12-14 | 1995-07-04 | Nec Corp | 不揮発性半導体記憶装置 |
US5414284A (en) * | 1994-01-19 | 1995-05-09 | Baxter; Ronald D. | ESD Protection of ISFET sensors |
US6021172A (en) | 1994-01-28 | 2000-02-01 | California Institute Of Technology | Active pixel sensor having intra-pixel charge transfer with analog-to-digital converter |
AU1911795A (en) * | 1994-02-09 | 1995-08-29 | Abbott Laboratories | Diagnostic flow cell device |
JP3351088B2 (ja) | 1994-03-28 | 2002-11-25 | 松下電工株式会社 | 電源装置 |
US5439839A (en) | 1994-07-13 | 1995-08-08 | Winbond Electronics Corporation | Self-aligned source/drain MOS process |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
DE4430811C1 (de) | 1994-08-30 | 1995-09-07 | Fraunhofer Ges Forschung | Verfahren zum Herstellen eines integrierten ionensensitiven Feldeffekttransistors in CMOS-Silizium-Planartechnologie |
US6654505B2 (en) | 1994-10-13 | 2003-11-25 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
US5631704A (en) | 1994-10-14 | 1997-05-20 | Lucent Technologies, Inc. | Active pixel sensor and imaging system having differential mode |
US5490971A (en) | 1994-10-25 | 1996-02-13 | Sippican, Inc. | Chemical detector |
US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US6001299A (en) | 1995-02-21 | 1999-12-14 | Japan Vilene Company, Ltd. | Process and apparatus for manufacturing an electret article |
DE19512117A1 (de) * | 1995-04-04 | 1996-10-10 | Itt Ind Gmbh Deutsche | Meßeinrichtung |
KR19990008052A (ko) * | 1995-04-25 | 1999-01-25 | 마이클 피 노바 | 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도 |
US5961923A (en) * | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
FR2736205B1 (fr) | 1995-06-30 | 1997-09-19 | Motorola Semiconducteurs | Dispositif detecteur a semiconducteur et son procede de formation |
US5646558A (en) | 1995-09-27 | 1997-07-08 | Intel Corporation | Plurality of distinct multiplexers that operate as a single multiplexer |
US5702964A (en) | 1995-10-17 | 1997-12-30 | Lg Semicon, Co., Ltd. | Method for forming a semiconductor device having a floating gate |
US6825047B1 (en) | 1996-04-03 | 2004-11-30 | Applera Corporation | Device and method for multiple analyte detection |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
WO1998008092A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Rapid process for arraying and synthesizing bead-based combinatorial libraries |
JPH1078827A (ja) | 1996-09-02 | 1998-03-24 | Yokogawa Electric Corp | Icのスタート回路 |
GB9620209D0 (en) * | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
US5894284A (en) | 1996-12-02 | 1999-04-13 | Motorola, Inc. | Common-mode output sensing circuit |
US5958703A (en) | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
AU741076B2 (en) * | 1996-12-12 | 2001-11-22 | Prolume, Ltd. | Apparatus and method for detecting and identifying infectious agents |
DE19653439A1 (de) * | 1996-12-20 | 1998-07-02 | Svante Dr Paeaebo | Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung |
US6605428B2 (en) | 1996-12-20 | 2003-08-12 | Roche Diagnostics Gmbh | Method for the direct, exponential amplification and sequencing of DNA molecules and its application |
US20030215857A1 (en) | 1996-12-20 | 2003-11-20 | Roche Diagnostics Gmbh | Method for the direct, exponential amplification and sequencing of DNA molecules and its application |
US5912560A (en) | 1997-02-25 | 1999-06-15 | Waferscale Integration Inc. | Charge pump circuit for voltage boosting in integrated semiconductor circuits |
US5793230A (en) | 1997-02-26 | 1998-08-11 | Sandia Corporation | Sensor readout detector circuit |
US6197557B1 (en) | 1997-03-05 | 2001-03-06 | The Regents Of The University Of Michigan | Compositions and methods for analysis of nucleic acids |
US7622294B2 (en) * | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
US6391622B1 (en) * | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6872527B2 (en) | 1997-04-16 | 2005-03-29 | Xtrana, Inc. | Nucleic acid archiving |
EP1003908B1 (en) | 1997-04-16 | 2006-12-06 | Applera Corporation | Nucleic acid archiving |
US5944970A (en) | 1997-04-29 | 1999-08-31 | Honeywell Inc. | Solid state electrochemical sensors |
US5911873A (en) | 1997-05-02 | 1999-06-15 | Rosemount Analytical Inc. | Apparatus and method for operating an ISFET at multiple drain currents and gate-source voltages allowing for diagnostics and control of isopotential points |
US7220550B2 (en) * | 1997-05-14 | 2007-05-22 | Keensense, Inc. | Molecular wire injection sensors |
AU736321B2 (en) * | 1997-05-23 | 2001-07-26 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
US6969488B2 (en) * | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
JP4231560B2 (ja) * | 1997-05-29 | 2009-03-04 | 株式会社堀場製作所 | 化学量の分布の電気化学的測定方法および装置 |
US6002299A (en) | 1997-06-10 | 1999-12-14 | Cirrus Logic, Inc. | High-order multipath operational amplifier with dynamic offset reduction, controlled saturation current limiting, and current feedback for enhanced conditional stability |
FR2764702B1 (fr) | 1997-06-11 | 1999-09-03 | Lyon Ecole Centrale | Procede d'identification et/ou de dosage de substances biologiques, presentes dans un liquide conducteur, dispositif et capteur d'affinite utiles pour la mise en oeuvre de ce procede |
US5923421A (en) | 1997-07-24 | 1999-07-13 | Lockheed Martin Energy Research Corporation | Chemical detection using calorimetric spectroscopy |
JP4238377B2 (ja) * | 1997-08-15 | 2009-03-18 | ソニー株式会社 | 固体撮像素子およびその駆動方法 |
US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
AU737174B2 (en) | 1997-10-10 | 2001-08-09 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US6511803B1 (en) * | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
CA2306126A1 (en) | 1997-10-15 | 1999-04-22 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
KR100251528B1 (ko) | 1997-10-22 | 2000-04-15 | 김덕중 | 복수개의 센스 소오스 패드를 구비한 센스 전계효과 트랜지스터 |
US6369737B1 (en) | 1997-10-30 | 2002-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for converting a low dynamic range analog signal to a large dynamic range floating-point digital representation |
EP0928101A3 (en) | 1997-12-31 | 2001-05-02 | Texas Instruments Incorporated | CMOS area array sensors |
JP4183789B2 (ja) * | 1998-01-14 | 2008-11-19 | 株式会社堀場製作所 | 物理現象および/または化学現象の検出装置 |
CA2320798C (en) * | 1998-02-20 | 2008-01-15 | Nanogen, Inc. | Advanced active devices and methods for molecular biological analysis and diagnostics |
US7090975B2 (en) * | 1998-03-13 | 2006-08-15 | Promega Corporation | Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection |
CA2325886C (en) | 1998-04-09 | 2009-07-21 | California Institute Of Technology | Electronic techniques for analyte detection |
JP3813818B2 (ja) * | 1998-05-01 | 2006-08-23 | アリゾナ ボード オブ リージェンツ | オリゴヌクレオチドおよびdna分子のヌクレオチド配列の決定方法 |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6780591B2 (en) * | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
EP1090293B2 (en) * | 1998-06-24 | 2019-01-23 | Illumina, Inc. | Decoding of array sensors with microspheres |
US6195585B1 (en) | 1998-06-26 | 2001-02-27 | Advanced Bionics Corporation | Remote monitoring of implantable cochlear stimulator |
US6787111B2 (en) * | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
JP4137239B2 (ja) | 1998-08-03 | 2008-08-20 | 株式会社堀場製作所 | Isfetアレイ |
US6191444B1 (en) * | 1998-09-03 | 2001-02-20 | Micron Technology, Inc. | Mini flash process and circuit |
KR100324914B1 (ko) | 1998-09-25 | 2002-02-28 | 니시무로 타이죠 | 기판의 검사방법 |
JP2002529742A (ja) | 1998-11-06 | 2002-09-10 | オンガード システムズ,インク. | 電子回路 |
AU3691700A (en) | 1998-12-11 | 2000-07-03 | Symyx Technologies, Inc. | Sensor array-based system and method for rapid materials characterization |
US6232075B1 (en) | 1998-12-14 | 2001-05-15 | Li-Cor, Inc. | Heterogeneous assay for pyrophosphate detection |
DE19857953C2 (de) | 1998-12-16 | 2001-02-15 | Conducta Endress & Hauser | Vorrichtung zum Messen der Konzentration von Ionen in einer Meßflüssigkeit |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
US6361671B1 (en) | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
US20020150909A1 (en) * | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
WO2000051191A1 (en) | 1999-02-22 | 2000-08-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A hybrid electrical device with biological components |
AU3498900A (en) | 1999-02-23 | 2000-09-14 | Caliper Technologies Corporation | Sequencing by incorporation |
US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US20050191698A1 (en) | 1999-04-20 | 2005-09-01 | Illumina, Inc. | Nucleic acid sequencing using microsphere arrays |
US20030108867A1 (en) * | 1999-04-20 | 2003-06-12 | Chee Mark S | Nucleic acid sequencing using microsphere arrays |
CA2373537A1 (en) | 1999-05-12 | 2000-11-16 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
US7097973B1 (en) | 1999-06-14 | 2006-08-29 | Alpha Mos | Method for monitoring molecular species within a medium |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
WO2001006244A2 (en) | 1999-07-16 | 2001-01-25 | Board Of Regents, The University Of Texas System | General signaling protocols for chemical receptors in immobilized matrices |
US6459398B1 (en) | 1999-07-20 | 2002-10-01 | D.S.P.C. Technologies Ltd. | Pulse modulated digital to analog converter (DAC) |
WO2001007665A2 (en) | 1999-07-26 | 2001-02-01 | Clinical Micro Sensors, Inc. | Sequence determination of nucleic acids using electronic detection |
US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
US6423536B1 (en) * | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
US7211390B2 (en) * | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US7244559B2 (en) * | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US6671341B1 (en) | 1999-09-17 | 2003-12-30 | Agere Systems, Inc. | Glitch-free phase switching synthesizer |
US7124221B1 (en) | 1999-10-19 | 2006-10-17 | Rambus Inc. | Low latency multi-level communication interface |
US6878255B1 (en) | 1999-11-05 | 2005-04-12 | Arrowhead Center, Inc. | Microfluidic devices with thick-film electrochemical detection |
GB9926956D0 (en) | 1999-11-13 | 2000-01-12 | Koninkl Philips Electronics Nv | Amplifier |
US6518024B2 (en) * | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
US20030148301A1 (en) | 1999-12-10 | 2003-08-07 | Toshiya Aono | Method of detecting nucleotide polymorphism |
WO2001042498A1 (fr) | 1999-12-10 | 2001-06-14 | Toyo Boseki Kabushiki Kaisha | Procede de detection de polymorphisme nucleotidique |
JP2001175340A (ja) | 1999-12-14 | 2001-06-29 | Matsushita Electric Ind Co Ltd | 電位発生回路 |
US6372291B1 (en) | 1999-12-23 | 2002-04-16 | Applied Materials, Inc. | In situ deposition and integration of silicon nitride in a high density plasma reactor |
DE19963509A1 (de) | 1999-12-28 | 2001-07-05 | Merck Patent Gmbh | Verfahren zur Herstellung hochreiner Schwefelsäure |
WO2001061865A1 (en) | 2000-02-14 | 2001-08-23 | Koninklijke Philips Electronics N.V. | Current-to-voltage converter with controllable gain, and signal processing circuit comprising such converter |
EP1198596A1 (en) | 2000-02-15 | 2002-04-24 | Lynx Therapeutics, Inc. | Data analysis and display system for ligation-based dna sequencing |
WO2001061043A2 (en) * | 2000-02-16 | 2001-08-23 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
US6649416B1 (en) | 2000-02-18 | 2003-11-18 | Trustees Of Tufts College | Intelligent electro-optical sensor array and method for analyte detection |
FR2805826B1 (fr) | 2000-03-01 | 2002-09-20 | Nucleica | Nouvelles puces a adn |
DE60144142D1 (de) * | 2000-03-02 | 2011-04-14 | Microchips Inc | Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien |
JP3442338B2 (ja) | 2000-03-17 | 2003-09-02 | 株式会社日立製作所 | Dna分析装置、dna塩基配列決定装置、dna塩基配列決定方法、および反応モジュール |
WO2001075462A1 (de) * | 2000-03-30 | 2001-10-11 | Infineon Technologies Ag | Sensor-anordnung und verfahren zum erfassen eines zustands eines transistors einer sensor-anordnung |
US20040002470A1 (en) | 2000-04-13 | 2004-01-01 | Tim Keith | Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease |
US8232582B2 (en) | 2000-04-24 | 2012-07-31 | Life Technologies Corporation | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
WO2001081896A1 (en) | 2000-04-24 | 2001-11-01 | Eagle Research & Development, Llc | An ultra-fast nucleic acid sequencing device and a method for making and using the same |
US6413792B1 (en) * | 2000-04-24 | 2002-07-02 | Eagle Research Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US7001792B2 (en) * | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US7682837B2 (en) | 2000-05-05 | 2010-03-23 | Board Of Trustees Of Leland Stanford Junior University | Devices and methods to form a randomly ordered array of magnetic beads and uses thereof |
US20020042388A1 (en) * | 2001-05-01 | 2002-04-11 | Cooper Mark J. | Lyophilizable and enhanced compacted nucleic acids |
US20020168678A1 (en) | 2000-06-07 | 2002-11-14 | Li-Cor, Inc. | Flowcell system for nucleic acid sequencing |
US6482639B2 (en) | 2000-06-23 | 2002-11-19 | The United States Of America As Represented By The Secretary Of The Navy | Microelectronic device and method for label-free detection and quantification of biological and chemical molecules |
EP2100971A3 (en) | 2000-07-07 | 2009-11-25 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
US6611037B1 (en) | 2000-08-28 | 2003-08-26 | Micron Technology, Inc. | Multi-trench region for accumulation of photo-generated charge in a CMOS imager |
US6939451B2 (en) | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
JP2002195997A (ja) * | 2000-09-29 | 2002-07-10 | Toshiba Corp | 核酸検出用センサ |
CA2425476C (en) | 2000-10-10 | 2011-02-01 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US6537881B1 (en) | 2000-10-16 | 2003-03-25 | Advanced Micro Devices, Inc. | Process for fabricating a non-volatile memory device |
US6558626B1 (en) | 2000-10-17 | 2003-05-06 | Nomadics, Inc. | Vapor sensing instrument for ultra trace chemical detection |
AU2002241803A1 (en) | 2000-10-20 | 2002-06-18 | The Board Of Trustees Of The Leland Stanford Junior University | Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample |
US6770472B2 (en) | 2000-11-17 | 2004-08-03 | The Board Of Trustees Of The Leland Stanford Junior University | Direct DNA sequencing with a transcription protein and a nanometer scale electrometer |
JP4583710B2 (ja) * | 2000-12-11 | 2010-11-17 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | ナノセンサ |
GB2370410A (en) * | 2000-12-22 | 2002-06-26 | Seiko Epson Corp | Thin film transistor sensor |
DE10065013B4 (de) | 2000-12-23 | 2009-12-24 | Robert Bosch Gmbh | Verfahren zum Herstellen eines mikromechanischen Bauelements |
KR20020055785A (ko) | 2000-12-29 | 2002-07-10 | 구본준, 론 위라하디락사 | 횡전계 방식의 액정표시장치 |
WO2002079514A1 (en) | 2001-01-10 | 2002-10-10 | The Trustees Of Boston College | Dna-bridged carbon nanotube arrays |
JP2002221510A (ja) | 2001-01-26 | 2002-08-09 | Japan Science & Technology Corp | 蓄積型化学・物理現象検出装置 |
JP4809983B2 (ja) | 2001-02-14 | 2011-11-09 | 明彦 谷岡 | 生体高分子とリガンドとの相互作用を検出する装置及びその方法 |
EP1236804A1 (en) * | 2001-03-02 | 2002-09-04 | Boehringer Mannheim Gmbh | A method for determination of a nucleic acid using a control |
US8114591B2 (en) | 2001-03-09 | 2012-02-14 | Dna Electronics Ltd. | Sensing apparatus and method |
DE10111458B4 (de) | 2001-03-09 | 2008-09-11 | Siemens Ag | Analyseeinrichtung |
GB0105831D0 (en) * | 2001-03-09 | 2001-04-25 | Toumaz Technology Ltd | Method for dna sequencing utilising enzyme linked field effect transistors |
EP1368497A4 (en) | 2001-03-12 | 2007-08-15 | California Inst Of Techn | METHOD AND DEVICE FOR ANALYZING POLYNUCLEOTIDE SEQUENCES BY ASYNCHRONOUS BASE EXTENSION |
US7027932B2 (en) | 2001-03-21 | 2006-04-11 | Olympus Optical Co., Ltd. | Biochemical examination method |
JP2002272463A (ja) | 2001-03-22 | 2002-09-24 | Olympus Optical Co Ltd | 一塩基多型の型を判定する方法 |
US20040146849A1 (en) | 2002-01-24 | 2004-07-29 | Mingxian Huang | Biochips including ion transport detecting structures and methods of use |
US20050058990A1 (en) | 2001-03-24 | 2005-03-17 | Antonio Guia | Biochip devices for ion transport measurement, methods of manufacture, and methods of use |
AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6418968B1 (en) | 2001-04-20 | 2002-07-16 | Nanostream, Inc. | Porous microfluidic valves |
KR100455283B1 (ko) | 2001-04-23 | 2004-11-08 | 삼성전자주식회사 | 물질 유로의 측벽에 형성된 mosfet으로 이루어진물질 검출용 칩, 이를 포함하는 물질 검출 장치, 이의제조 방법 및 물질 검출 장치를 이용한 물질 검출 방법 |
JP3883512B2 (ja) | 2001-04-23 | 2007-02-21 | 三星電子株式会社 | 微細流路の側壁に形成されたmosfetよりなる物質検出用チップ、これを含む物質検出装置、及び物質検出装置を利用した物質検出方法 |
KR100442838B1 (ko) | 2001-12-11 | 2004-08-02 | 삼성전자주식회사 | 프로브의 고정화 검출방법 및 상기 프로브와 표적시료의결합정도 검출방법 |
US6571189B2 (en) | 2001-05-14 | 2003-05-27 | Hewlett-Packard Company | System and method for scanner calibration |
US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
US20050009022A1 (en) * | 2001-07-06 | 2005-01-13 | Weiner Michael P. | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
US7668697B2 (en) | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
DE10133363A1 (de) | 2001-07-10 | 2003-01-30 | Infineon Technologies Ag | Messzelle und Messfeld mit solchen Messzellen sowie Verwendung einer Messzelle und Verwendung eines Messfeldes |
US7485443B2 (en) | 2001-07-17 | 2009-02-03 | Northwestern University | Solid-phase reactions |
JP2003032908A (ja) | 2001-07-19 | 2003-01-31 | Nisshinbo Ind Inc | キャパシタ組電池、その制御方法、その制御装置及び自動車用蓄電システム |
ATE471369T1 (de) | 2001-07-30 | 2010-07-15 | Meso Scale Technologies Llc | Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung |
US6490220B1 (en) | 2001-08-13 | 2002-12-03 | Micron Technology, Inc. | Method for reliably shutting off oscillator pulses to a charge-pump |
JP4623887B2 (ja) | 2001-08-27 | 2011-02-02 | オー・エイチ・ティー株式会社 | 検査装置用センサ及び検査装置 |
US6929944B2 (en) | 2001-08-31 | 2005-08-16 | Beckman Coulter, Inc. | Analysis using a distributed sample |
GB0121602D0 (en) * | 2001-09-06 | 2001-10-24 | Randox Lab Ltd | Molecular array |
US20030054396A1 (en) * | 2001-09-07 | 2003-03-20 | Weiner Michael P. | Enzymatic light amplification |
DE10151020A1 (de) | 2001-10-16 | 2003-04-30 | Infineon Technologies Ag | Schaltkreis-Anordnung, Sensor-Array und Biosensor-Array |
DE10151021A1 (de) * | 2001-10-16 | 2003-04-30 | Infineon Technologies Ag | Sensor-Anordnung |
US6795117B2 (en) | 2001-11-06 | 2004-09-21 | Candela Microsystems, Inc. | CMOS image sensor with noise cancellation |
US20030124599A1 (en) * | 2001-11-14 | 2003-07-03 | Shiping Chen | Biochemical analysis system with combinatorial chemistry applications |
US7049645B2 (en) * | 2001-11-16 | 2006-05-23 | Bio-X Inc. | FET type sensor, ion density detecting method comprising this sensor, and base sequence detecting method |
CN1294260C (zh) | 2001-12-19 | 2007-01-10 | 株式会社日立高新技术 | 电位滴定dna微阵列、其制造方法及核酸解析方法 |
US20050106587A1 (en) * | 2001-12-21 | 2005-05-19 | Micronas Gmbh | Method for determining of nucleic acid analytes |
US6518146B1 (en) | 2002-01-09 | 2003-02-11 | Motorola, Inc. | Semiconductor device structure and method for forming |
FR2835058B1 (fr) | 2002-01-21 | 2004-03-12 | Centre Nat Rech Scient | Procede de detection d'au moins un parametre caracteristique de molecules sondes fixees sur au moins une zone active d'un capteur |
US7772383B2 (en) | 2002-01-25 | 2010-08-10 | The Trustees Of Princeton University | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions |
KR100403637B1 (ko) | 2002-01-26 | 2003-10-30 | 삼성전자주식회사 | 출력 일그러짐을 최소화하는 파워 앰프 클리핑 회로 |
US6614301B2 (en) * | 2002-01-31 | 2003-09-02 | Intel Corporation | Differential amplifier offset adjustment |
US7276749B2 (en) | 2002-02-05 | 2007-10-02 | E-Phocus, Inc. | Image sensor with microcrystalline germanium photodiode layer |
US6926865B2 (en) * | 2002-02-11 | 2005-08-09 | Matsushita Electric Industrial Co., Ltd. | Method and apparatus for detecting DNA hybridization |
JP2003258128A (ja) * | 2002-02-27 | 2003-09-12 | Nec Electronics Corp | 不揮発性半導体記憶装置およびその製造方法ならびにその動作方法 |
US7223371B2 (en) | 2002-03-14 | 2007-05-29 | Micronics, Inc. | Microfluidic channel network device |
US6953958B2 (en) * | 2002-03-19 | 2005-10-11 | Cornell Research Foundation, Inc. | Electronic gain cell based charge sensor |
JP2003279532A (ja) | 2002-03-22 | 2003-10-02 | Horiba Ltd | 化学濃度センサおよび化学濃度センサの製造方法 |
FR2838282B1 (fr) * | 2002-04-04 | 2004-06-11 | Celes | Perfectionnements apportes aux inducteurs de chauffage, notamment de bandes metalliques |
JP2003322633A (ja) | 2002-05-01 | 2003-11-14 | Seiko Epson Corp | センサセル、バイオセンサ及びこれらの製造方法 |
US20030215791A1 (en) | 2002-05-20 | 2003-11-20 | Applied Spectral Imaging Ltd. | Method of and system for multiplexed analysis by spectral imaging |
US6828685B2 (en) * | 2002-06-14 | 2004-12-07 | Hewlett-Packard Development Company, L.P. | Memory device having a semiconducting polymer film |
US6894930B2 (en) | 2002-06-19 | 2005-05-17 | Sandisk Corporation | Deep wordline trench to shield cross coupling between adjacent cells for scaled NAND |
WO2004003535A1 (en) | 2002-06-27 | 2004-01-08 | Nanosys Inc. | Planar nanowire based sensor elements, devices, systems and methods for using and making same |
US7092757B2 (en) | 2002-07-12 | 2006-08-15 | Cardiac Pacemakers, Inc. | Minute ventilation sensor with dynamically adjusted excitation current |
US6885827B2 (en) | 2002-07-30 | 2005-04-26 | Amplification Technologies, Inc. | High sensitivity, high resolution detection of signals |
WO2004017423A2 (de) | 2002-07-31 | 2004-02-26 | Infineon Technologies Ag | Sensor-anordnung |
US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
WO2004017068A1 (ja) | 2002-08-12 | 2004-02-26 | Hitachi High-Technologies Corporation | Dnaマイクロアレイを用いた核酸検出方法及び核酸検出装置 |
US7267751B2 (en) | 2002-08-20 | 2007-09-11 | Nanogen, Inc. | Programmable multiplexed active biologic array |
GB0219541D0 (en) | 2002-08-22 | 2002-10-02 | Secr Defence | Method and apparatus for stand-off chemical detection |
JP4092990B2 (ja) | 2002-09-06 | 2008-05-28 | 株式会社日立製作所 | 生体および化学試料検査装置 |
US8449824B2 (en) | 2002-09-09 | 2013-05-28 | Yizhong Sun | Sensor instrument system including method for detecting analytes in fluids |
US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
SE0202867D0 (sv) | 2002-09-27 | 2002-09-27 | Pyrosequencing Ab | New sequencing method |
CN1500887A (zh) * | 2002-10-01 | 2004-06-02 | 松下电器产业株式会社 | 引物伸长反应检测方法、碱基种类判别方法及其装置 |
US7303875B1 (en) | 2002-10-10 | 2007-12-04 | Nanosys, Inc. | Nano-chem-FET based biosensors |
DE10247889A1 (de) | 2002-10-14 | 2004-04-22 | Infineon Technologies Ag | Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung |
US20040079636A1 (en) | 2002-10-25 | 2004-04-29 | Chin Hsia | Biomedical ion sensitive semiconductor sensor and sensor array |
WO2004040291A1 (en) * | 2002-10-29 | 2004-05-13 | Cornell Research Foundation, Inc. | Chemical-sensitive floating gate field effect transistor |
US6700814B1 (en) * | 2002-10-30 | 2004-03-02 | Motorola, Inc. | Sense amplifier bias circuit for a memory having at least two distinct resistance states |
CN1717437B (zh) | 2002-11-01 | 2012-03-28 | 佐治亚技术研究公司 | 牺牲组合物、其应用以及分解方法 |
DE10251757B4 (de) | 2002-11-05 | 2006-03-09 | Micronas Holding Gmbh | Vorrichtung zur Bestimmung der Konzentration von in einer zu untersuchenden Probe enthaltenen Liganden |
US7022288B1 (en) | 2002-11-13 | 2006-04-04 | The United States Of America As Represented By The Secretary Of The Navy | Chemical detection sensor system |
US20040130377A1 (en) | 2002-11-26 | 2004-07-08 | Akira Takeda | Switched capacitor amplifier circuit and electronic device |
DE10255755B4 (de) * | 2002-11-28 | 2006-07-13 | Schneider, Christian, Dr. | Integrierte elektronische Schaltung mit Feldeffekt-Sensoren zum Nachweis von Biomolekülen |
JPWO2004051231A1 (ja) | 2002-11-29 | 2006-04-06 | 日本電気株式会社 | 分離装置および分離方法 |
US7163659B2 (en) | 2002-12-03 | 2007-01-16 | Hewlett-Packard Development Company, L.P. | Free-standing nanowire sensor and method for detecting an analyte in a fluid |
US20080047836A1 (en) | 2002-12-05 | 2008-02-28 | David Strand | Configurable Microfluidic Substrate Assembly |
US20040197803A1 (en) | 2002-12-06 | 2004-10-07 | Hidenobu Yaku | Method, primer and kit for determining base type |
US7575865B2 (en) * | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
EP2159285B1 (en) * | 2003-01-29 | 2012-09-26 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
US20050006234A1 (en) * | 2003-02-13 | 2005-01-13 | Arjang Hassibi | Semiconductor electrochemical bio-sensor array |
US7317484B2 (en) | 2003-02-26 | 2008-01-08 | Digital Imaging Systems Gmbh | CMOS APS readout scheme that combines reset drain current and the source follower output |
US20070262363A1 (en) | 2003-02-28 | 2007-11-15 | Board Of Regents, University Of Texas System | Low temperature fabrication of discrete silicon-containing substrates and devices |
WO2004081234A2 (en) | 2003-03-10 | 2004-09-23 | Casio Computer Co., Ltd. | Dna analyzing apparatus, dna sensor, and analyzing method |
JP4586329B2 (ja) | 2003-03-10 | 2010-11-24 | カシオ計算機株式会社 | Dna分析装置及び分析方法 |
TW586228B (en) | 2003-03-19 | 2004-05-01 | Univ Chung Yuan Christian | Method for fabricating a titanium nitride sensing membrane on an EGFET |
TWI235236B (en) | 2003-05-09 | 2005-07-01 | Univ Chung Yuan Christian | Ion-sensitive circuit |
JP2004343441A (ja) | 2003-05-15 | 2004-12-02 | Denso Corp | 受光回路および距離計測装置 |
JP3760411B2 (ja) | 2003-05-21 | 2006-03-29 | インターナショナル・ビジネス・マシーンズ・コーポレーション | アクティブマトリックスパネルの検査装置、検査方法、およびアクティブマトリックスoledパネルの製造方法 |
WO2004106891A2 (en) | 2003-05-22 | 2004-12-09 | University Of Hawaii | Ultrasensitive biochemical sensor |
US7795039B2 (en) | 2003-06-10 | 2010-09-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Electronic device for communication with living cells |
US7250115B2 (en) | 2003-06-12 | 2007-07-31 | Agilent Technologies, Inc | Nanopore with resonant tunneling electrodes |
US6795006B1 (en) | 2003-07-18 | 2004-09-21 | Zarlink Semiconductor Ab | Integrator reset mechanism |
WO2005015156A2 (en) * | 2003-08-04 | 2005-02-17 | Idaho Research Foundation, Inc. | Molecular detector |
JP2005077210A (ja) | 2003-08-29 | 2005-03-24 | National Institute For Materials Science | 生体分子検出素子及びそれを用いた核酸解析方法 |
TWI223062B (en) | 2003-09-03 | 2004-11-01 | Univ Chung Yuan Christian | Manufacture of an array pH sensor and device of its readout circuit |
US20050100939A1 (en) | 2003-09-18 | 2005-05-12 | Eugeni Namsaraev | System and methods for enhancing signal-to-noise ratios of microarray-based measurements |
GB0322010D0 (en) | 2003-09-19 | 2003-10-22 | Univ Cambridge Tech | Detection of molecular interactions using field effect transistors |
JP2005124126A (ja) | 2003-09-24 | 2005-05-12 | Seiko Epson Corp | インピーダンス回路網、これを用いたフィルタ回路、増幅回路、半導体集積回路、電子機器及び無線通信装置 |
US7008550B2 (en) | 2003-09-25 | 2006-03-07 | Hitachi Global Storage Technologies Netherlands B.V. | Method for forming a read transducer by ion milling and chemical mechanical polishing to eliminate nonuniformity near the MR sensor |
GB0323224D0 (en) | 2003-10-03 | 2003-11-05 | Rolls Royce Plc | A module for a fuel cell stack |
US20070087401A1 (en) * | 2003-10-17 | 2007-04-19 | Andy Neilson | Analysis of metabolic activity in cells using extracellular flux rate measurements |
US7317216B2 (en) * | 2003-10-31 | 2008-01-08 | University Of Hawaii | Ultrasensitive biochemical sensing platform |
US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
US20050095602A1 (en) * | 2003-11-04 | 2005-05-05 | West Jason A. | Microfluidic integrated microarrays for biological detection |
US7067886B2 (en) | 2003-11-04 | 2006-06-27 | International Business Machines Corporation | Method of assessing potential for charging damage in SOI designs and structures for eliminating potential for damage |
WO2005047474A2 (en) | 2003-11-10 | 2005-05-26 | Geneohm Sciences, Inc. | Nucleic acid detection method having increased sensitivity |
DE10352917A1 (de) * | 2003-11-11 | 2005-06-16 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Sensoranordnung mit mehreren potentiometrischen Sensoren |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
WO2005054431A2 (en) | 2003-12-01 | 2005-06-16 | 454 Corporation | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
US7279588B2 (en) | 2003-12-02 | 2007-10-09 | Seoul National University Foundation | Dinuclear metal complex and pyrophosphate assay using the same |
WO2005062049A2 (en) * | 2003-12-22 | 2005-07-07 | Interuniversitair Microelektronica Centrum (Imec) | The use of microelectronic structures for patterned deposition of molecules onto surfaces |
US6998666B2 (en) | 2004-01-09 | 2006-02-14 | International Business Machines Corporation | Nitrided STI liner oxide for reduced corner device impact on vertical device performance |
US7462512B2 (en) * | 2004-01-12 | 2008-12-09 | Polytechnic University | Floating gate field effect transistors for chemical and/or biological sensing |
US20050156584A1 (en) | 2004-01-21 | 2005-07-21 | Rosemount Analytical Inc. | Ion sensitive field effect transistor (ISFET) sensor with improved gate configuration |
JP4065855B2 (ja) | 2004-01-21 | 2008-03-26 | 株式会社日立製作所 | 生体および化学試料検査装置 |
US7927797B2 (en) | 2004-01-28 | 2011-04-19 | 454 Life Sciences Corporation | Nucleic acid amplification with continuous flow emulsion |
JP3903183B2 (ja) | 2004-02-03 | 2007-04-11 | 独立行政法人物質・材料研究機構 | 遺伝子検出電界効果デバイスおよびこれを用いた遺伝子多型解析方法 |
US7129883B2 (en) | 2004-02-23 | 2006-10-31 | Sony Corporation | Method and apparatus for AD conversion, semiconductor device for detecting distribution of physical quantity, and electronic apparatus |
JP2005242001A (ja) | 2004-02-26 | 2005-09-08 | Agilent Technol Inc | Tftアレイ試験方法 |
WO2005082098A2 (en) * | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
EP1730307A4 (en) | 2004-03-03 | 2008-11-05 | Univ Columbia | PHOTOSPACTABLE FLUORESCENZ NUCLEOTIDES FOR DNA SEQUENCING ON A MEASUREMENT BASED BY STATION-SPECIFIC COUPLING SCHEME CONSTRUCTED CHIP |
US20060057604A1 (en) | 2004-03-15 | 2006-03-16 | Thinkfar Nanotechnology Corporation | Method for electrically detecting oligo-nucleotides with nano-particles |
JP4127679B2 (ja) | 2004-03-18 | 2008-07-30 | 株式会社東芝 | 核酸検出カセット及び核酸検出装置 |
DE102004014537A1 (de) | 2004-03-23 | 2005-10-13 | Fujitsu Ltd., Kawasaki | Chipintegrierter Detektor zum Analysieren von Flüssigkeiten |
WO2005090961A1 (ja) | 2004-03-24 | 2005-09-29 | Japan Science And Technology Agency | 生体分子に関する形態及び情報をis−fetを利用して検出する測定法およびシステム |
US20050221473A1 (en) * | 2004-03-30 | 2005-10-06 | Intel Corporation | Sensor array integrated circuits |
WO2005095938A1 (en) | 2004-04-01 | 2005-10-13 | Nanyang Technological University | Addressable transistor chip for conducting assays |
US7117605B2 (en) | 2004-04-13 | 2006-10-10 | Gyrodata, Incorporated | System and method for using microgyros to measure the orientation of a survey tool within a borehole |
US7544979B2 (en) | 2004-04-16 | 2009-06-09 | Technion Research & Development Foundation Ltd. | Ion concentration transistor and dual-mode sensors |
US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
TWI261801B (en) | 2004-05-24 | 2006-09-11 | Rohm Co Ltd | Organic EL drive circuit and organic EL display device using the same organic EL drive circuit |
ITTO20040386A1 (it) | 2004-06-09 | 2004-09-09 | Infm Istituto Naz Per La Fisi | Dispositivo ad effetto di campo per la rilevazione di piccole quantita' di carica elettrica, come quelle generate in processi biomolecolari, immobilizzate nelle vicinanze della superficie. |
US7264934B2 (en) * | 2004-06-10 | 2007-09-04 | Ge Healthcare Bio-Sciences Corp. | Rapid parallel nucleic acid analysis |
US7361946B2 (en) | 2004-06-28 | 2008-04-22 | Nitronex Corporation | Semiconductor device-based sensors |
US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
GB2416210B (en) * | 2004-07-13 | 2008-02-20 | Christofer Toumazou | Ion sensitive field effect transistors |
JP3874772B2 (ja) | 2004-07-21 | 2007-01-31 | 株式会社日立製作所 | 生体関連物質測定装置及び測定方法 |
JP4455215B2 (ja) | 2004-08-06 | 2010-04-21 | キヤノン株式会社 | 撮像装置 |
TWI258173B (en) | 2004-10-08 | 2006-07-11 | Ind Tech Res Inst | Polysilicon thin-film ion sensitive FET device and fabrication method thereof |
US7276453B2 (en) | 2004-08-10 | 2007-10-02 | E.I. Du Pont De Nemours And Company | Methods for forming an undercut region and electronic devices incorporating the same |
US7190026B2 (en) | 2004-08-23 | 2007-03-13 | Enpirion, Inc. | Integrated circuit employable with a power converter |
JP4608697B2 (ja) | 2004-08-27 | 2011-01-12 | 独立行政法人物質・材料研究機構 | 電界効果デバイスを用いたdna塩基配列解析方法及び塩基配列解析装置 |
US20070212681A1 (en) | 2004-08-30 | 2007-09-13 | Benjamin Shapiro | Cell canaries for biochemical pathogen detection |
WO2006025481A1 (ja) | 2004-09-03 | 2006-03-09 | Japan Science And Technology Agency | センサユニット及び反応場セルユニット並びに分析装置 |
DE102004044299A1 (de) | 2004-09-10 | 2006-03-30 | Forschungszentrum Jülich GmbH | Vorrichtung und Verfahren zum Nachweis von geladenen Makromolekülen |
US7317215B2 (en) * | 2004-09-21 | 2008-01-08 | International Business Machines Corporation | SiGe heterojunction bipolar transistor (HBT) |
US20060073422A1 (en) | 2004-09-28 | 2006-04-06 | Imation Corp. | Portable conformable deep ultraviolet master mask |
US7609303B1 (en) | 2004-10-12 | 2009-10-27 | Melexis Tessenderlo Nv | Low noise active pixel image sensor using a modified reset value |
JP2006138846A (ja) | 2004-10-14 | 2006-06-01 | Toshiba Corp | 核酸検出センサ、核酸検出チップ及び核酸検出装置 |
US7534097B2 (en) * | 2004-10-15 | 2009-05-19 | Nanyang Technological University | Method and apparatus for controlling multi-fluid flow in a micro channel |
US7381936B2 (en) | 2004-10-29 | 2008-06-03 | Ess Technology, Inc. | Self-calibrating anti-blooming circuit for CMOS image sensor having a spillover protection performance in response to a spillover condition |
US8340914B2 (en) | 2004-11-08 | 2012-12-25 | Gatewood Joe M | Methods and systems for compressing and comparing genomic data |
US7785785B2 (en) * | 2004-11-12 | 2010-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Charge perturbation detection system for DNA and other molecules |
CA2588095A1 (en) | 2004-11-18 | 2006-08-17 | Morgan Research Corporation | Miniature fourier transform spectrophotometer |
US20060205061A1 (en) | 2004-11-24 | 2006-09-14 | California Institute Of Technology | Biosensors based upon actuated desorption |
WO2006056226A1 (de) | 2004-11-26 | 2006-06-01 | Micronas Gmbh | Elektrisches bauelement |
JP4678676B2 (ja) | 2004-12-10 | 2011-04-27 | 株式会社堀場製作所 | 物理現象または化学現象の測定方法または測定装置 |
US7417231B2 (en) | 2004-12-22 | 2008-08-26 | Cti Pet Systems, Inc. | Fourier re-binning of time-of-flight positron emission tomography data |
US7499513B1 (en) | 2004-12-23 | 2009-03-03 | Xilinx, Inc. | Method and apparatus for providing frequency synthesis and phase alignment in an integrated circuit |
KR100623177B1 (ko) | 2005-01-25 | 2006-09-13 | 삼성전자주식회사 | 높은 유전율을 갖는 유전체 구조물, 이의 제조 방법, 이를포함하는 불휘발성 반도체 메모리 장치 및 그 제조 방법 |
AU2006211150A1 (en) | 2005-01-31 | 2006-08-10 | Pacific Biosciences Of California, Inc. | Use of reversible extension terminator in nucleic acid sequencing |
US20060199493A1 (en) | 2005-02-04 | 2006-09-07 | Hartmann Richard Jr | Vent assembly |
US20060182664A1 (en) | 2005-02-14 | 2006-08-17 | Peck Bill J | Flow cell devices, systems and methods of using the same |
US9040237B2 (en) | 2005-03-04 | 2015-05-26 | Intel Corporation | Sensor arrays and nucleic acid sequencing applications |
JP4171820B2 (ja) | 2005-03-11 | 2008-10-29 | 国立大学法人豊橋技術科学大学 | 累積型化学・物理現象検出装置 |
JP2006284225A (ja) | 2005-03-31 | 2006-10-19 | Horiba Ltd | ポテンシャルの測定方法および測定装置 |
JP2008534987A (ja) | 2005-04-05 | 2008-08-28 | プロテイン・デイスカバリー・インコーポレーテツド | マトリックス支援レーザー脱離イオン化(maldi)質量分析法(ms)を含む化学分析のための検体の濃縮と分別のために改良された方法と装置 |
US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
TWI287041B (en) | 2005-04-27 | 2007-09-21 | Jung-Tang Huang | An ultra-rapid DNA sequencing method with nano-transistors array based devices |
GB0509275D0 (en) | 2005-05-06 | 2005-06-15 | Univ Cranfield | Synthetic receptor |
US20060269927A1 (en) | 2005-05-25 | 2006-11-30 | Lieber Charles M | Nanoscale sensors |
DE102005027245A1 (de) * | 2005-06-13 | 2006-12-21 | Siemens Ag | Schaltkreisanordnung |
CN1881457A (zh) | 2005-06-14 | 2006-12-20 | 松下电器产业株式会社 | 致动器控制方法和使用该方法的盘装置 |
EP3492602A1 (en) * | 2005-06-15 | 2019-06-05 | Complete Genomics, Inc. | Single molecule arrays for genetic and chemical analysis |
WO2007002204A2 (en) | 2005-06-21 | 2007-01-04 | The Trustees Of Columbia University In The City Of New York | Pyrosequencing methods and related compostions |
TW200701588A (en) | 2005-06-29 | 2007-01-01 | Leadtrend Tech Corp | Dual loop voltage regulation circuit of power supply chip |
US7890891B2 (en) | 2005-07-11 | 2011-02-15 | Peregrine Semiconductor Corporation | Method and apparatus improving gate oxide reliability by controlling accumulated charge |
JP2007035726A (ja) | 2005-07-22 | 2007-02-08 | Rohm Co Ltd | 半導体装置、モジュールおよび電子機器 |
US8129725B2 (en) | 2005-08-08 | 2012-03-06 | Microgan Gmbh | Semiconductor sensor |
US7365597B2 (en) | 2005-08-19 | 2008-04-29 | Micron Technology, Inc. | Switched capacitor amplifier with higher gain and improved closed-loop gain accuracy |
SG130066A1 (en) | 2005-08-26 | 2007-03-20 | Micron Technology Inc | Microelectronic device packages, stacked microelectronic device packages, and methods for manufacturing microelectronic devices |
JP4353958B2 (ja) * | 2005-09-15 | 2009-10-28 | 株式会社日立製作所 | Dna計測装置、及びdna計測方法 |
EP1940543B1 (en) | 2005-09-29 | 2012-03-07 | Siemens Medical Solutions USA, Inc. | Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography |
US7466258B1 (en) | 2005-10-07 | 2008-12-16 | Cornell Research Foundation, Inc. | Asynchronous analog-to-digital converter and method |
US7794584B2 (en) | 2005-10-12 | 2010-09-14 | The Research Foundation Of State University Of New York | pH-change sensor and method |
US7335526B2 (en) * | 2005-10-31 | 2008-02-26 | Hewlett-Packard Development Company, L.P. | Sensing system |
US20070096164A1 (en) | 2005-10-31 | 2007-05-03 | Peters Kevin F | Sensing system |
TWI295729B (en) | 2005-11-01 | 2008-04-11 | Univ Nat Yunlin Sci & Tech | Preparation of a ph sensor, the prepared ph sensor, systems comprising the same, and measurement using the systems |
US7239188B1 (en) | 2005-11-01 | 2007-07-03 | Integrated Device Technology, Inc. | Locked-loop integrated circuits having speed tracking circuits therein |
EP1948810A4 (en) | 2005-11-04 | 2010-06-30 | Biosyntech Canada Inc | COMPOSITION AND METHOD USING CHITOSAN FOR THE EFFICIENT ADMINISTRATION OF NUCLEIC ACIDS TO CELLS |
US7538827B2 (en) | 2005-11-17 | 2009-05-26 | Chunghwa Picture Tubes, Ltd. | Pixel structure |
US7576037B2 (en) * | 2005-11-18 | 2009-08-18 | Mei Technologies, Inc. | Process and apparatus for combinatorial synthesis |
US20080178692A1 (en) | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic methods |
US7566913B2 (en) | 2005-12-02 | 2009-07-28 | Nitronex Corporation | Gallium nitride material devices including conductive regions and methods associated with the same |
GB2436619B (en) | 2005-12-19 | 2010-10-06 | Toumaz Technology Ltd | Sensor circuits |
KR100718144B1 (ko) | 2006-01-09 | 2007-05-14 | 삼성전자주식회사 | 이온 물질 검출용 fet 기반 센서, 그를 포함하는 이온물질 검출 장치 및 그를 이용한 이온 물질 검출 방법 |
JP2007243003A (ja) | 2006-03-10 | 2007-09-20 | Oki Electric Ind Co Ltd | 半導体装置の製造方法 |
US8017938B2 (en) | 2006-03-17 | 2011-09-13 | The United States Of America As Represented By The Department Of Health And Human Services | Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors |
US20070233477A1 (en) | 2006-03-30 | 2007-10-04 | Infima Ltd. | Lossless Data Compression Using Adaptive Context Modeling |
US7923240B2 (en) | 2006-03-31 | 2011-04-12 | Intel Corporation | Photo-activated field effect transistor for bioanalyte detection |
WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
KR100723426B1 (ko) | 2006-04-26 | 2007-05-30 | 삼성전자주식회사 | 이온 물질 검출용 전계 효과 트랜지스터 및 그를 이용한이온 물질 검출 방법 |
WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
CN101454892B (zh) | 2006-05-26 | 2011-12-14 | 株式会社半导体能源研究所 | 半导体器件及其制造方法 |
JP4211805B2 (ja) | 2006-06-01 | 2009-01-21 | エプソンイメージングデバイス株式会社 | 電気光学装置および電子機器 |
JP4404074B2 (ja) | 2006-06-30 | 2010-01-27 | ソニー株式会社 | 固体撮像装置及びデータ伝送方法並びに撮像装置 |
WO2008007716A1 (en) | 2006-07-13 | 2008-01-17 | National University Corporation Nagoya University | Material detection device |
KR100799577B1 (ko) * | 2006-08-31 | 2008-01-30 | 한국전자통신연구원 | 가스 및 생화학물질 감지용 센서 제조 방법과 그 센서를포함하는 집적회로 및 그 제조 방법 |
US7960776B2 (en) | 2006-09-27 | 2011-06-14 | Cornell Research Foundation, Inc. | Transistor with floating gate and electret |
US20080085219A1 (en) | 2006-10-05 | 2008-04-10 | Beebe David J | Microfluidic platform and method |
US8231831B2 (en) | 2006-10-06 | 2012-07-31 | Sharp Laboratories Of America, Inc. | Micro-pixelated fluid-assay structure |
WO2008133719A2 (en) | 2006-11-06 | 2008-11-06 | Biowarn Llc | Methodology and apparatus for the detection of biological substances |
US20090111706A1 (en) | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by amplification |
DE102006052863B4 (de) | 2006-11-09 | 2018-03-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Schutzstruktur für Halbleitersensoren und deren Verwendung |
US20080136933A1 (en) | 2006-12-11 | 2008-06-12 | Digital Imaging Systems Gmbh | Apparatus for controlling operation of a multiple photosensor pixel image sensor |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
EP2092322B1 (en) | 2006-12-14 | 2016-02-17 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale fet arrays |
US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US7972828B2 (en) | 2006-12-19 | 2011-07-05 | Sigma-Aldrich Co. | Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent |
US7932034B2 (en) * | 2006-12-20 | 2011-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Heat and pH measurement for sequencing of DNA |
US7486145B2 (en) | 2007-01-10 | 2009-02-03 | International Business Machines Corporation | Circuits and methods for implementing sub-integer-N frequency dividers using phase rotators |
WO2008089282A2 (en) | 2007-01-16 | 2008-07-24 | Silver James H | Sensors for detecting subtances indicative of stroke, ischemia, infection or inflammation |
JP4325684B2 (ja) | 2007-02-20 | 2009-09-02 | 株式会社デンソー | センサ制御装置、及び印加電圧特性の調整方法 |
US8031809B2 (en) | 2007-02-28 | 2011-10-04 | Seiko Epson Corporation | Template pulse generating circuit, communication device, and communication method |
JP2008215974A (ja) | 2007-03-02 | 2008-09-18 | Citizen Holdings Co Ltd | 電界効果トランジスタ型イオンセンサ |
ES2440572T3 (es) | 2007-03-02 | 2014-01-29 | Dna Electronics Ltd | Aparato de detección para controlar la amplificación de ácido nucleico, usando un transistor de efecto de campo sensible a iones (ISFET) para detectar el pH |
EP1975246A1 (de) | 2007-03-29 | 2008-10-01 | Micronas Holding GmbH | Markierungsfreie Sequenzierung auf einer Festphase mittels Feldeffekttransistoren |
JP2010533840A (ja) * | 2007-07-13 | 2010-10-28 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | 改善された生物学的アッセイのための電場を用いる方法および器具 |
WO2009011164A1 (ja) | 2007-07-19 | 2009-01-22 | Renesas Technology Corp. | 半導体装置およびその製造方法 |
WO2009014155A1 (en) | 2007-07-25 | 2009-01-29 | Semiconductor Energy Laboratory Co., Ltd. | Photoelectric conversion device and electronic device having the same |
US7609093B2 (en) | 2007-08-03 | 2009-10-27 | Tower Semiconductor Ltd. | Comparator with low supply current spike and input offset cancellation |
US20090062132A1 (en) * | 2007-08-29 | 2009-03-05 | Borner Scott R | Alternative nucleic acid sequencing methods |
TWI345065B (en) | 2007-09-27 | 2011-07-11 | Chimei Innolux Corp | A flat panel display device, an electronic system and a testing method of the flat panel display device |
US20100285601A1 (en) | 2007-09-28 | 2010-11-11 | Agency For Science, Technology And Research | Method of electrically detecting a nucleic acid molecule |
US7936042B2 (en) | 2007-11-13 | 2011-05-03 | International Business Machines Corporation | Field effect transistor containing a wide band gap semiconductor material in a drain |
KR100940415B1 (ko) | 2007-12-03 | 2010-02-02 | 주식회사 동부하이텍 | 배면 드레인 구조 웨이퍼의 온저항 측정방법 |
US8124936B1 (en) | 2007-12-13 | 2012-02-28 | The United States Of America As Represented By The Secretary Of The Army | Stand-off chemical detector |
EP2222878A1 (en) * | 2007-12-13 | 2010-09-01 | Nxp B.V. | A biosensor device and a method of sequencing biological particles |
US8388893B2 (en) | 2007-12-20 | 2013-03-05 | National University Corporation Toyohashi University Of Technology | Combined detector |
US20090194416A1 (en) | 2008-01-31 | 2009-08-06 | Chung Yuan Christian University | Potentiometric biosensor for detection of creatinine and forming method thereof |
DE102008012899A1 (de) | 2008-03-06 | 2009-09-10 | Robert Bosch Gmbh | Verfahren zum Betreiben eines Gassensors |
US8067731B2 (en) | 2008-03-08 | 2011-11-29 | Scott Technologies, Inc. | Chemical detection method and system |
US7885490B2 (en) | 2008-03-10 | 2011-02-08 | Octrolix Bv | Optical chemical detector and method |
JP5259219B2 (ja) | 2008-03-19 | 2013-08-07 | 株式会社三社電機製作所 | 電源装置 |
US7667501B2 (en) | 2008-03-19 | 2010-02-23 | Texas Instruments Incorporated | Correlated double sampling technique |
US20090273386A1 (en) | 2008-05-01 | 2009-11-05 | Custom One Design, Inc | Apparatus for current-to-voltage integration for current-to-digital converter |
TWI377342B (en) | 2008-05-08 | 2012-11-21 | Univ Nat Yunlin Sci & Tech | Method for forming an extended gate field effect transistor (egfet) based sensor and the sensor formed thereby |
US7821806B2 (en) | 2008-06-18 | 2010-10-26 | Nscore Inc. | Nonvolatile semiconductor memory circuit utilizing a MIS transistor as a memory cell |
GB2461127B (en) | 2008-06-25 | 2010-07-14 | Ion Torrent Systems Inc | Methods and apparatus for measuring analytes using large scale FET arrays |
WO2010008480A2 (en) | 2008-06-25 | 2010-01-21 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes using large scale fet arrays |
EP2304420A4 (en) | 2008-06-26 | 2013-10-30 | Life Technologies Corp | METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS |
US7893718B2 (en) | 2008-08-13 | 2011-02-22 | Samsung Electronics Co., Ltd. | High-speed multiplexer and semiconductor device including the same |
JP5260193B2 (ja) | 2008-09-03 | 2013-08-14 | ルネサスエレクトロニクス株式会社 | 半導体集積回路及びそのスイッチングノイズ平準化方法 |
KR101026468B1 (ko) | 2008-09-10 | 2011-04-01 | 한국전자통신연구원 | 생분자 검출 장치 및 검출 방법 |
CN101676714A (zh) | 2008-09-16 | 2010-03-24 | 中研应用感测科技股份有限公司 | 整合式离子感测器 |
WO2010037085A1 (en) | 2008-09-29 | 2010-04-01 | The Board Of Trustees Of The University Of Illinois | Dna sequencing and amplification systems using nanoscale field effect sensor arrays |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
CN102301228A (zh) | 2008-10-22 | 2011-12-28 | 生命技术公司 | 用于生物和化学分析的集成式传感器阵列 |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
US8248356B2 (en) | 2008-10-24 | 2012-08-21 | Au Optronics Corp. | Driving circuit for detecting line short defects |
US8634817B2 (en) | 2008-10-28 | 2014-01-21 | Qualcomm Incorporated | Location information for control of mode/technology |
US7898277B2 (en) | 2008-12-24 | 2011-03-01 | Agere Systems Inc. | Hot-electronic injection testing of transistors on a wafer |
US8101479B2 (en) | 2009-03-27 | 2012-01-24 | National Semiconductor Corporation | Fabrication of asymmetric field-effect transistors using L-shaped spacers |
US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
US20120261274A1 (en) | 2009-05-29 | 2012-10-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
AT508322B1 (de) | 2009-06-05 | 2012-04-15 | Boehler Schmiedetechnik Gmbh & Co Kg | Verfahren zur warmformgebung eines werkstückes |
US20110037121A1 (en) | 2009-08-16 | 2011-02-17 | Tung-Hsing Lee | Input/output electrostatic discharge device with reduced junction breakdown voltage |
JP2011041205A (ja) | 2009-08-18 | 2011-02-24 | Panasonic Corp | 電圧発生回路、デジタルアナログ変換器、ランプ波発生回路、アナログデジタル変換器、イメージセンサシステム及び電圧発生方法 |
US8860442B2 (en) | 2009-09-11 | 2014-10-14 | Agency For Science, Technology And Research | Method of determining a sensitivity of a biosensor arrangement, and biosensor sensitivity determining system |
US9018684B2 (en) | 2009-11-23 | 2015-04-28 | California Institute Of Technology | Chemical sensing and/or measuring devices and methods |
US8545248B2 (en) | 2010-01-07 | 2013-10-01 | Life Technologies Corporation | System to control fluid flow based on a leak detected by a sensor |
TWI422818B (zh) | 2010-01-11 | 2014-01-11 | Nat Chip Implementation Ct Nat Applied Res Lab | 氫離子感測場效電晶體及其製造方法 |
US9088208B2 (en) | 2010-01-27 | 2015-07-21 | Intersil Americas LLC | System and method for high precision current sensing |
US20110262903A1 (en) | 2010-02-26 | 2011-10-27 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
US8878257B2 (en) | 2010-06-04 | 2014-11-04 | Freescale Semiconductor, Inc. | Methods and apparatus for an ISFET |
AU2011226767B1 (en) | 2010-06-30 | 2011-11-10 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
EP2588850B1 (en) | 2010-06-30 | 2016-12-28 | Life Technologies Corporation | Method for dry testing isfet arrays |
US9164070B2 (en) | 2010-06-30 | 2015-10-20 | Life Technologies Corporation | Column adc |
TWI527245B (zh) | 2010-07-03 | 2016-03-21 | 生命技術公司 | 具有微摻雜汲極之化學感測器 |
US8227877B2 (en) | 2010-07-14 | 2012-07-24 | Macronix International Co., Ltd. | Semiconductor bio-sensors and methods of manufacturing the same |
US8383896B2 (en) | 2010-07-28 | 2013-02-26 | Monsanto Technology Llc | Soybean variety A1023758 |
JP5959516B2 (ja) | 2010-08-18 | 2016-08-02 | ライフ テクノロジーズ コーポレーション | 電気化学的検出装置のためのマイクロウェルの化学コーティング法 |
CN103201696B (zh) | 2010-08-23 | 2015-09-23 | 生命科技股份有限公司 | 化学检测系统的温度控制 |
US8453494B2 (en) | 2010-09-13 | 2013-06-04 | National Semiconductor Corporation | Gas detector that utilizes an electric field to assist in the collection and removal of gas molecules |
WO2012036679A1 (en) | 2010-09-15 | 2012-03-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
CN105911126B (zh) | 2010-09-24 | 2018-12-18 | 生命科技公司 | 匹配的晶体管对电路 |
GB201017023D0 (en) | 2010-10-08 | 2010-11-24 | Dna Electronics Ltd | ISFET switch |
JP5735268B2 (ja) | 2010-12-20 | 2015-06-17 | サムソン エレクトロ−メカニックス カンパニーリミテッド. | 高周波半導体スイッチ |
WO2012092515A2 (en) | 2010-12-30 | 2012-07-05 | Life Technologies Corporation | Methods, systems, and computer readable media for nucleic acid sequencing |
JP5613605B2 (ja) | 2011-03-28 | 2014-10-29 | ルネサスエレクトロニクス株式会社 | クロック生成回路、それを用いたプロセッサシステム、及びクロック周波数制御方法 |
WO2012152308A1 (en) | 2011-05-06 | 2012-11-15 | X-Fab Semiconductor Foundries Ag | Ion sensitive field effect transistor |
US9518953B2 (en) | 2011-09-07 | 2016-12-13 | Technion Research And Development Foundation Ltd. | Ion sensitive detector |
WO2013049504A1 (en) | 2011-09-30 | 2013-04-04 | Stc.Unm | Dna sample preparation and sequencing |
US9459234B2 (en) | 2011-10-31 | 2016-10-04 | Taiwan Semiconductor Manufacturing Company, Ltd., (“TSMC”) | CMOS compatible BioFET |
US8547151B2 (en) | 2011-11-30 | 2013-10-01 | Taiwan Semiconductor Manufacturing Company, Ltd. | Phase-locked loops that share a loop filter |
AT12462U3 (de) | 2012-01-09 | 2013-05-15 | Plansee Se | Röntgendrehanode mit zumindest anteilig radial ausgerichteter schleifstruktur |
US8747748B2 (en) | 2012-01-19 | 2014-06-10 | Life Technologies Corporation | Chemical sensor with conductive cup-shaped sensor surface |
US8821798B2 (en) | 2012-01-19 | 2014-09-02 | Life Technologies Corporation | Titanium nitride as sensing layer for microwell structure |
US8847637B1 (en) | 2012-05-24 | 2014-09-30 | Massachusetts Institute Of Technology | Time-interleaved multi-modulus frequency divider |
US8786331B2 (en) | 2012-05-29 | 2014-07-22 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
EP2677307B1 (en) | 2012-06-21 | 2016-05-11 | Nxp B.V. | Integrated circuit with sensors and manufacturing method |
WO2014077783A1 (en) | 2012-11-15 | 2014-05-22 | Nanyang Technological University | Image capture device and image capture system |
US8728844B1 (en) | 2012-12-05 | 2014-05-20 | Taiwan Semiconductor Manufacturing Company, Ltd. | Backside CMOS compatible bioFET with no plasma induced damage |
US8962366B2 (en) | 2013-01-28 | 2015-02-24 | Life Technologies Corporation | Self-aligned well structures for low-noise chemical sensors |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US9389199B2 (en) | 2013-03-14 | 2016-07-12 | Taiwan Semiconductor Manufacturing Company, Ltd. | Backside sensing bioFET with enhanced performance |
JP2016510895A (ja) | 2013-03-15 | 2016-04-11 | ライフ テクノロジーズ コーポレーション | 一貫性のあるセンサ表面積を有する化学センサ |
US9228974B2 (en) | 2013-04-10 | 2016-01-05 | Taiwan Semiconductor Manufacturing Company, Ltd. | Biosensing well array by self-alignment and selective etching |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
US20140367748A1 (en) | 2013-06-14 | 2014-12-18 | International Business Machines Corporation | EXTENDED GATE SENSOR FOR pH SENSING |
US9023674B2 (en) | 2013-09-20 | 2015-05-05 | Taiwan Semiconductor Manufacturing Company, Ltd. | Biosensing well array with protective layer |
US20150097214A1 (en) | 2013-10-09 | 2015-04-09 | Taiwan Semiconductor Manufacturing Company Limited | Structures, apparatuses and methods for fabricating sensors in multi-layer structures |
US9488615B2 (en) | 2014-12-17 | 2016-11-08 | Taiwan Semiconductor Manufacturing Co., Ltd. | Biosensor with a sensing surface on an interlayer dielectric |
-
2007
- 2007-12-14 EP EP07867780.4A patent/EP2092322B1/en active Active
- 2007-12-14 EP EP13177039.8A patent/EP2677309B9/en active Active
- 2007-12-14 JP JP2009541416A patent/JP5622392B2/ja active Active
- 2007-12-14 AU AU2007334393A patent/AU2007334393A1/en not_active Abandoned
- 2007-12-14 EP EP22179321.9A patent/EP4134667A1/en active Pending
- 2007-12-14 CN CN200780051353.2A patent/CN101669026B/zh active Active
- 2007-12-14 EP EP13177590.0A patent/EP2674751B1/en active Active
- 2007-12-14 EP EP13164768.7A patent/EP2639579B1/en active Active
- 2007-12-14 EP EP13174555.6A patent/EP2677308B1/en active Active
- 2007-12-14 EP EP13161312.7A patent/EP2653861B1/en active Active
- 2007-12-14 CA CA002672315A patent/CA2672315A1/en not_active Abandoned
- 2007-12-14 GB GB0911039A patent/GB2457851B/en active Active
- 2007-12-14 WO PCT/US2007/025721 patent/WO2008076406A2/en active Application Filing
- 2007-12-14 EP EP17167536.6A patent/EP3285067B1/en active Active
- 2007-12-14 EP EP13163995.7A patent/EP2639578B1/en active Active
- 2007-12-14 ES ES17167536T patent/ES2923759T3/es active Active
- 2007-12-14 EP EP14152861.2A patent/EP2762872B1/en active Active
- 2007-12-14 US US12/002,291 patent/US7948015B2/en active Active
-
2010
- 2010-01-22 US US12/691,923 patent/US8426898B2/en active Active
- 2010-03-10 US US12/721,458 patent/US8306757B2/en active Active
- 2010-12-23 GB GBGB1022025.9A patent/GB201022025D0/en not_active Ceased
-
2011
- 2011-02-02 US US13/019,354 patent/US20120129703A1/en not_active Abandoned
- 2011-02-02 US US13/019,422 patent/US20120135870A1/en not_active Abandoned
- 2011-02-02 US US13/019,463 patent/US8264014B2/en active Active
- 2011-02-02 US US13/019,517 patent/US20120129732A1/en not_active Abandoned
- 2011-02-02 US US13/019,692 patent/US8426899B2/en active Active
- 2011-02-08 US US13/022,678 patent/US8530941B2/en active Active
- 2011-02-08 US US13/022,694 patent/US8269261B2/en active Active
- 2011-02-23 US US13/033,147 patent/US20110287945A1/en not_active Abandoned
- 2011-02-23 US US13/033,196 patent/US20120055811A1/en not_active Abandoned
- 2011-02-23 US US13/033,062 patent/US20120055813A1/en not_active Abandoned
- 2011-09-26 US US13/245,595 patent/US20120045844A1/en not_active Abandoned
- 2011-09-26 US US13/245,675 patent/US9269708B2/en active Active
-
2012
- 2012-07-20 US US13/554,895 patent/US20120286771A1/en not_active Abandoned
- 2012-07-20 US US13/554,585 patent/US8492800B2/en active Active
- 2012-07-20 US US13/554,900 patent/US8658017B2/en active Active
- 2012-07-20 US US13/554,842 patent/US8445945B2/en active Active
- 2012-07-20 US US13/554,813 patent/US8764969B2/en active Active
- 2012-07-20 US US13/554,816 patent/US8441044B2/en active Active
- 2012-07-23 US US13/555,998 patent/US8496802B2/en active Active
- 2012-07-23 US US13/555,992 patent/US8415716B2/en active Active
- 2012-07-23 US US13/556,005 patent/US8575664B2/en active Active
- 2012-07-23 US US13/556,001 patent/US8502278B2/en active Active
- 2012-07-23 US US13/556,021 patent/US8519448B2/en active Active
- 2012-07-24 US US13/556,634 patent/US8685230B2/en active Active
- 2012-11-08 JP JP2012246413A patent/JP5563044B2/ja active Active
- 2012-11-08 JP JP2012246417A patent/JP5643277B2/ja active Active
- 2012-11-08 JP JP2012246414A patent/JP5662407B2/ja active Active
- 2012-11-08 JP JP2012246415A patent/JP5622825B2/ja active Active
- 2012-11-08 JP JP2012246416A patent/JP5643276B2/ja active Active
-
2013
- 2013-06-19 US US13/922,149 patent/US8742472B2/en active Active
- 2013-06-20 US US13/923,282 patent/US8766328B2/en active Active
-
2014
- 2014-12-04 JP JP2014245830A patent/JP6125485B2/ja active Active
-
2016
- 2016-02-22 US US15/049,638 patent/US10203300B2/en active Active
-
2017
- 2017-02-07 US US15/427,047 patent/US9989489B2/en active Active
- 2017-02-22 JP JP2017030653A patent/JP2017127308A/ja active Pending
-
2018
- 2018-05-30 US US15/993,544 patent/US10502708B2/en active Active
-
2019
- 2019-11-08 US US16/677,666 patent/US10816506B2/en active Active
-
2020
- 2020-10-09 US US17/067,538 patent/US11435314B2/en active Active
-
2022
- 2022-08-16 US US17/820,202 patent/US20230058778A1/en not_active Abandoned
-
2023
- 2023-07-14 US US18/353,017 patent/US20240159702A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6125485B2 (ja) | 大規模fetアレイを用いた分析物測定のための方法および装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140107 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140407 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140410 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140424 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141104 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20141204 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5662407 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |