PT2591125T - Estratégias 3-d de sequenciação de regiões genómicas de interesse - Google Patents

Estratégias 3-d de sequenciação de regiões genómicas de interesse

Info

Publication number
PT2591125T
PT2591125T PT117361907T PT11736190T PT2591125T PT 2591125 T PT2591125 T PT 2591125T PT 117361907 T PT117361907 T PT 117361907T PT 11736190 T PT11736190 T PT 11736190T PT 2591125 T PT2591125 T PT 2591125T
Authority
PT
Portugal
Prior art keywords
genomic region
sequencing strategies
interest
interest sequencing
strategies
Prior art date
Application number
PT117361907T
Other languages
English (en)
Inventor
Jan Van Min Max
Leonard De Laat Wouter
Original Assignee
Cergentis B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cergentis B V filed Critical Cergentis B V
Publication of PT2591125T publication Critical patent/PT2591125T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301—Endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/101—Crosslinking agents, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/107—Chemical cleaving agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/307—Circular oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • General Chemical & Material Sciences (AREA)
PT117361907T 2010-07-09 2011-07-08 Estratégias 3-d de sequenciação de regiões genómicas de interesse PT2591125T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36277810P 2010-07-09 2010-07-09

Publications (1)

Publication Number Publication Date
PT2591125T true PT2591125T (pt) 2018-05-09

Family

ID=44629077

Family Applications (2)

Application Number Title Priority Date Filing Date
PT181631235T PT3360975T (pt) 2010-07-09 2011-07-08 Estratégias de sequenciamento da região genómica de interesse 3-d
PT117361907T PT2591125T (pt) 2010-07-09 2011-07-08 Estratégias 3-d de sequenciação de regiões genómicas de interesse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT181631235T PT3360975T (pt) 2010-07-09 2011-07-08 Estratégias de sequenciamento da região genómica de interesse 3-d

Country Status (25)

Country Link
US (1) US12006538B2 (pt)
EP (3) EP3360975B1 (pt)
JP (1) JP5977234B2 (pt)
KR (1) KR101862756B1 (pt)
CN (1) CN103180459B (pt)
AU (1) AU2011274642B2 (pt)
BR (1) BR112013000552B8 (pt)
CA (1) CA2804450C (pt)
CY (1) CY1121702T1 (pt)
DK (2) DK3360975T3 (pt)
ES (2) ES2916339T3 (pt)
HR (1) HRP20180593T1 (pt)
HU (1) HUE037359T2 (pt)
IL (2) IL224127B (pt)
LT (1) LT2591125T (pt)
NO (1) NO2591125T3 (pt)
NZ (1) NZ606228A (pt)
PL (2) PL2591125T3 (pt)
PT (2) PT3360975T (pt)
RS (1) RS57295B1 (pt)
RU (1) RU2603082C2 (pt)
SG (1) SG186954A1 (pt)
SI (1) SI2591125T1 (pt)
WO (1) WO2012005595A2 (pt)
ZA (1) ZA201300375B (pt)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
PL2591125T3 (pl) 2010-07-09 2018-09-28 Cergentis B.V. Strategie sekwencjonowania będącego przedmiotem zainteresowania genomowego regionu 3-d
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP2753715A4 (en) 2011-09-09 2015-05-20 Univ Leland Stanford Junior METHODS FOR OBTAINING A SEQUENCE
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
EP2768983A4 (en) 2011-10-17 2015-06-03 Good Start Genetics Inc METHODS OF IDENTIFYING MUTATIONS ASSOCIATED WITH DISEASES
EP4108782B1 (en) 2011-12-22 2023-06-07 President and Fellows of Harvard College Compositions and methods for analyte detection
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
EP3885446A1 (en) * 2013-02-01 2021-09-29 The Regents of The University of California Methods for genome assembly and haplotype phasing
EP2959011A1 (en) * 2013-02-19 2015-12-30 Cergentis B.V. Sequencing strategies for genomic regions of interest
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US11618923B2 (en) 2013-03-15 2023-04-04 The Broad Institute, Inc. Methods of determining multiple interactions between nucleic acids in a cell
US10287621B2 (en) 2013-04-11 2019-05-14 Pelin Sahlén Targeted chromosome conformation capture
KR102512979B1 (ko) 2013-06-04 2023-03-22 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Rna-가이드된 전사 조절
CN106062207B (zh) * 2013-07-19 2020-07-03 路德维格癌症研究有限公司 全基因组且靶向的单体型重构
GB2517936B (en) * 2013-09-05 2016-10-19 Babraham Inst Chromosome conformation capture method including selection and enrichment steps
EP3049557B1 (en) * 2013-09-27 2021-05-05 University of Washington Methods and systems for large scale scaffolding of genome assemblies
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
GB201320351D0 (en) 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
EP2960818A1 (en) * 2014-06-24 2015-12-30 Institut Pasteur Method, device, and computer program for assembling pieces of chromosomes from one or several organisms
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
AU2015296029B2 (en) 2014-08-01 2022-01-27 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
CA2999708A1 (en) 2014-09-24 2016-03-31 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
EP3754027A1 (en) * 2014-12-01 2020-12-23 The Broad Institute, Inc. Methods for altering or modulating spatial proximity between nucleic acids inside of a cell
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
CN107533590B (zh) 2015-02-17 2021-10-26 多弗泰尔基因组学有限责任公司 核酸序列装配
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
CN107922959A (zh) 2015-07-02 2018-04-17 阿瑞玛基因组学公司 混合物样品的精确分子去卷积
EP3359686A1 (en) * 2015-10-05 2018-08-15 Koninklijke Nederlandse Akademie van Wetenschappen Targeted locus amplification using cloning strategies
CN108368542B (zh) 2015-10-19 2022-04-08 多弗泰尔基因组学有限责任公司 用于基因组组装、单元型定相以及独立于靶标的核酸检测的方法
US10900031B2 (en) 2015-10-19 2021-01-26 Zhejiang Annoroad Bio-Technology Co. Ltd. Method for constructing high-resolution single cell Hi-C library with a lot of information
GB201518843D0 (en) * 2015-10-23 2015-12-09 Isis Innovation Method of analysing DNA sequences
MX2018005611A (es) 2015-11-03 2018-11-09 Harvard College Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
CN108431232B (zh) 2015-12-04 2022-10-14 10X 基因组学有限公司 用于核酸分析的方法和组合物
US10975417B2 (en) 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
CN116200465A (zh) 2016-04-25 2023-06-02 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
GB201608000D0 (en) * 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection
CN105839196B (zh) * 2016-05-11 2018-04-17 北京百迈客生物科技有限公司 一种真核生物DNA的Hi‑C高通量测序建库方法
SG11201810088SA (en) 2016-05-13 2018-12-28 Dovetail Genomics Llc Recovering long-range linkage information from preserved samples
KR101915701B1 (ko) 2016-06-16 2018-11-07 한국한의학연구원 돌연변이 발생률의 측정 방법
CN109983125B (zh) 2016-08-31 2024-06-04 哈佛学院董事及会员团体 生成用于通过荧光原位测序检测的核酸序列文库的方法
CN109923216B (zh) 2016-08-31 2024-08-02 哈佛学院董事及会员团体 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
MY190153A (en) * 2016-12-01 2022-03-31 Oxford BioDynamics PLC Application of epigenetic chromosomal interactions in cancer diagnostics
WO2018191672A1 (en) 2017-04-14 2018-10-18 President And Fellows Of Harvard College Methods for generation of cell-derived microfilament network
CN107119120A (zh) * 2017-05-04 2017-09-01 河海大学常州校区 一种基于染色质3d构象技术的关键作用分子检测方法
US11873481B2 (en) 2017-11-21 2024-01-16 Arima Genomics, Inc. Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
WO2020236734A1 (en) * 2019-05-17 2020-11-26 The Broad Institute, Inc. Methods of determination of genome architecture and epigenetic profile
WO2021224233A1 (en) 2020-05-04 2021-11-11 Cergentis B.V. Method
WO2021224225A1 (en) 2020-05-04 2021-11-11 Cergentis B.V. Method
GB202006546D0 (en) 2020-05-04 2020-06-17 Cergentis B V Method
GB202006550D0 (en) 2020-05-04 2020-06-17 Cergentis B V Method
WO2022114957A1 (en) 2020-11-26 2022-06-02 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Personalized tumor markers
WO2022246275A1 (en) * 2021-05-21 2022-11-24 The Board Of Trustees Of The Leland Stanford Junior University Next-generation volumetric in situ sequencing
GB202111194D0 (en) 2021-08-03 2021-09-15 Cergentis B V Method

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077204A (en) * 1984-06-21 1991-12-31 Chiron Corporation Yeast endopeptidase for basic amino-acid site cleavage, preparation and use
US9328391B1 (en) 1984-08-22 2016-05-03 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cloning and expression of HIV-1 DNA
JPS6226300A (ja) 1984-10-10 1987-02-04 セントコ−・インコ−ポレ−テツド Ｈｔｌｖ−３ｄｎａのクロ−ニングおよび発現
US5221518A (en) * 1984-12-14 1993-06-22 Mills Randell L DNA sequencing apparatus
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
US6060644A (en) * 1994-03-24 2000-05-09 Iowa State University Research Foundation, Inc. Isolation and use of cuticular lipid genes
EP1736554B1 (en) * 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
WO1998020032A1 (en) * 1996-11-07 1998-05-14 The Board Of Trustees Of The Leland Stanford Junior University Sprouty protein and coding sequence
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
WO1998035012A2 (en) * 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
WO1999028446A2 (en) * 1997-12-02 1999-06-10 E.I. Du Pont De Nemours And Company Branched chain amino acid biosynthetic enzymes
US6455692B1 (en) * 1998-08-04 2002-09-24 Transgenomic, Inc. Method of concentrating polynucleotides using MIPC
US6291168B1 (en) * 1998-10-27 2001-09-18 Auburn University Nucleic acid sequences diagnostic for pathogenic E.coli O157:H7, methods of identification and kit therefore
US20050232900A1 (en) * 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
EP1218512A2 (en) * 1999-06-18 2002-07-03 Elitra Pharmaceuticals, Inc. Nucleotide sequences of moraxella catarrhalis genome
US7470507B2 (en) * 1999-09-01 2008-12-30 Whitehead Institute For Biomedical Research Genome-wide location and function of DNA binding proteins
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
CA2419479A1 (en) * 2000-08-14 2002-02-21 Transgenetics Incorporated Transcription factor target gene discovery
US6709861B2 (en) * 2000-11-17 2004-03-23 Lucigen Corp. Cloning vectors and vector components
US20030054347A1 (en) * 2001-04-27 2003-03-20 The Regents Of The University Of Michigan Latrophilin Polynucleotides
US20030013863A1 (en) * 2001-07-16 2003-01-16 Buchholz Wallace G. High resolution DNA size standards
US20030157705A1 (en) * 2001-08-10 2003-08-21 Fodor William L. Engineered recombinant molecule that regulates humoral and cellular effector functions of the immune system
AUPR823601A0 (en) * 2001-10-12 2001-11-08 University Of Queensland, The Automated genotyping
WO2003102147A2 (en) * 2002-05-29 2003-12-11 University Of Washington Mutants of gad65 and ian5 relating to diabetes
EP1923464A1 (en) * 2002-08-30 2008-05-21 Japan Science and Technology Agency Ligase of a hyperthermostable bacterium and chip using the same
EP1546376B9 (en) * 2002-09-30 2009-08-12 F.Hoffmann-La Roche Ag Oligonucleotides for genotyping thymidylate synthase gene
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CA2796381A1 (en) * 2003-03-06 2004-09-16 Children's Hospital, Inc. Genes of an otitis media isolate of nontypeable haemophilus influenzae
FR2852317B1 (fr) * 2003-03-13 2006-08-04 Biopuces a sondes et leurs methodes d'utilisation
EP1670505B1 (en) * 2003-09-18 2012-11-14 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Dna promoters and anthrax vaccines
US20060150283A1 (en) * 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20060107345A1 (en) * 2003-09-30 2006-05-18 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20050221341A1 (en) * 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
JP2007512811A (ja) * 2003-11-10 2007-05-24 インベスチゲン， インコーポレイテッド 検出のための核酸を調製する方法
AU2005284980A1 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US20060223073A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
WO2007145612A1 (en) * 2005-06-06 2007-12-21 454 Life Sciences Corporation Paired end sequencing
US8407013B2 (en) * 2005-06-07 2013-03-26 Peter K. Rogan AB initio generation of single copy genomic probes
US8445194B2 (en) * 2005-06-15 2013-05-21 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
EP2302070B1 (en) * 2005-06-23 2012-08-22 Keygene N.V. Strategies for high throughput identification and detection of polymorphisms
CA2613248A1 (en) * 2005-06-23 2006-12-28 Keygene N.V. Improved strategies for sequencing complex genomes using high throughput sequencing technologies
PL1899488T3 (pl) 2005-07-04 2016-03-31 Erasmus Univ Medical Center Test uchwytu konformacji chromosomu na czipie (4C)
US20090143240A1 (en) * 2005-08-25 2009-06-04 Harbison Christopher T Novel Methods for Genome-Wide Location Analysis
US20090221428A1 (en) * 2005-09-07 2009-09-03 Young Richard A Methods of Genome-Wide Location Analysis in Stem Cells
ES2422288T3 (es) * 2005-11-14 2013-09-10 Keygene Nv Método para el cribado ultrarrápido de poblaciones de transposón etiquetado e identificación masiva de la secuencia en paralelo de los sitios de inserción
US8481054B2 (en) * 2005-12-28 2013-07-09 The UAB Foundation Pneumococcal serotypes
GB0603251D0 (en) * 2006-02-17 2006-03-29 Isis Innovation DNA conformation
EP2043728A2 (en) 2006-07-11 2009-04-08 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
EP2049682A2 (en) * 2006-07-31 2009-04-22 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
DE112007002880T5 (de) * 2006-11-27 2009-10-29 Dsm Ip Assets B.V. Verfahren zur Herstellung von Hydroxytyrosol
EP2677308B1 (en) * 2006-12-14 2017-04-26 Life Technologies Corporation Method for fabricating large scale FET arrays
US8642295B2 (en) 2007-01-11 2014-02-04 Erasmus University Medical Center Circular chromosome conformation capture (4C)
ATE521948T1 (de) * 2007-01-26 2011-09-15 Illumina Inc System und verfahren zur nukleinsäuresequenzierung
US20100120036A1 (en) * 2007-03-07 2010-05-13 Kunio Shiota Method for amplifying dna fragment
US20080248958A1 (en) * 2007-04-05 2008-10-09 Hollenbach Andrew D System for pulling out regulatory elements in vitro
US7932030B2 (en) * 2007-04-05 2011-04-26 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College System for pulling out regulatory elements using yeast
CN101720359A (zh) * 2007-06-01 2010-06-02 454生命科学公司 从多重混合物中识别个别样本的系统和方法
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8263367B2 (en) * 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
WO2009143212A1 (en) * 2008-05-21 2009-11-26 Mito Tech Llc Computer system and computer-facilitated method for nucleic acid sequence alignment and analysis
CN104232617A (zh) * 2008-05-23 2014-12-24 生命科技公司 用于dna提取的方法和试剂盒
FR2945545B1 (fr) * 2009-05-14 2011-08-05 Univ Aix Marseille Ii Methode de detection d'adn procaryote extrait d'un echantillon de selles
EP2473625B1 (en) * 2009-09-01 2018-03-07 Koninklijke Philips N.V. Devices and methods for microarray selection
EP2354243A1 (en) 2010-02-03 2011-08-10 Lexogen GmbH Complexity reduction method
JP5901046B2 (ja) * 2010-02-19 2016-04-06 国立大学法人 千葉大学 ＯＡＴＰ１Ｂ３ｍＲＮＡの新規な選択的スプライシングバリアント
PL2591125T3 (pl) 2010-07-09 2018-09-28 Cergentis B.V. Strategie sekwencjonowania będącego przedmiotem zainteresowania genomowego regionu 3-d
US10858699B2 (en) * 2016-08-30 2020-12-08 Integrated Dna Technologies, Inc. Cleavable hairpin primers

Also Published As

Publication number Publication date
CN103180459A (zh) 2013-06-26
HUE037359T2 (hu) 2018-08-28
WO2012005595A2 (en) 2012-01-12
BR112013000552B8 (pt) 2023-01-17
RU2013105459A (ru) 2014-08-20
BR112013000552A2 (pt) 2016-05-24
ES2667346T3 (es) 2018-05-10
US20130183672A1 (en) 2013-07-18
EP2591125B1 (en) 2018-04-04
DK3360975T3 (da) 2022-04-11
BR112013000552B1 (pt) 2021-03-02
WO2012005595A8 (en) 2012-04-26
RS57295B1 (sr) 2018-08-31
JP5977234B2 (ja) 2016-08-24
NO2591125T3 (pt) 2018-09-01
SG186954A1 (en) 2013-02-28
EP4063518A1 (en) 2022-09-28
CN103180459B (zh) 2016-10-19
PL2591125T3 (pl) 2018-09-28
SI2591125T1 (en) 2018-08-31
KR20130049808A (ko) 2013-05-14
CY1121702T1 (el) 2020-07-31
HRP20180593T1 (hr) 2018-07-27
EP3360975B1 (en) 2022-03-30
IL224127B (en) 2018-01-31
ES2916339T3 (es) 2022-06-30
PL3360975T3 (pl) 2022-07-11
LT2591125T (lt) 2018-07-25
ZA201300375B (en) 2014-03-26
DK2591125T3 (en) 2018-05-14
PT3360975T (pt) 2022-04-11
KR101862756B1 (ko) 2018-05-30
AU2011274642A1 (en) 2013-02-21
AU2011274642B2 (en) 2015-05-21
JP2013530709A (ja) 2013-08-01
IL256509A (en) 2018-02-28
NZ606228A (en) 2014-12-24
EP2591125A2 (en) 2013-05-15
ES2667346T9 (es) 2018-06-11
WO2012005595A3 (en) 2012-03-08
CA2804450C (en) 2022-10-11
IL256509B (en) 2020-02-27
CA2804450A1 (en) 2012-01-12
US12006538B2 (en) 2024-06-11
EP3360975A1 (en) 2018-08-15
RU2603082C2 (ru) 2016-11-20

Similar Documents

Publication Publication Date Title
HRP20180593T1 (hr) Strategije 3-d sekvenciranja genomskog područja od interesa
HK1247254A1 (zh) 核酸測序的方法和組合物
GB2499340B (en) Methods for sequencing nucleic acids
GB2498163B (en) High-throughput immune sequencing
EP2576836A4 (en) COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING PURPOSES
EP2595664A4 (en) MODULATION OF NUCLEAR RETENTION RNA
SG190950A1 (en) Treatment of jak2-mediated conditions
HK1183911A1 (en) Method of dna sequencing by hybridisation dna
EP2539468A4 (en) DIAGNOSTIC PROCEDURE INCLUDING LOSS OF HETEROZYGOTY
EP2619333A4 (en) PARALLEL SEQUENCING WITH NATIVE EXTENSION
ZA201209620B (en) Polymorphs of osi-906
IL226536A (en) DNA position-oriented change
GB2502195B (en) Purification of nucleic acids
SI2621619T1 (sl) Postopek mešanja
HK1160777A1 (en) Novel use of neohesperidoside
GB201016452D0 (en) Rapid extrection of nucleic acids
PL390780A1 (pl) Sposób biologiczny zwalczania warrozy
TWM389753U (en) Improved structure of handle
HU1000688D0 (en) Use of trifluoro-phal
GB201004059D0 (en) Method of construction
PL119515U1 (pl) Zestaw elementów do pokrycia dachu