CY1121702T1 - Στρατηγικες ταυτοποιησεως αλληλουχιας γονιδιωματικης περιοχης ενδιαφεροντος v3-d - Google Patents
Στρατηγικες ταυτοποιησεως αλληλουχιας γονιδιωματικης περιοχης ενδιαφεροντος v3-dInfo
- Publication number
- CY1121702T1 CY1121702T1 CY20181100457T CY181100457T CY1121702T1 CY 1121702 T1 CY1121702 T1 CY 1121702T1 CY 20181100457 T CY20181100457 T CY 20181100457T CY 181100457 T CY181100457 T CY 181100457T CY 1121702 T1 CY1121702 T1 CY 1121702T1
- Authority
- CY
- Cyprus
- Prior art keywords
- genomic region
- sequence identification
- interest sequence
- identification strategies
- cross
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/301—Endonuclease
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/501—Ligase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/101—Crosslinking agents, e.g. psoralen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/107—Chemical cleaving agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/307—Circular oligonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- General Chemical & Material Sciences (AREA)
Abstract
Η εφεύρεση αναφέρεται σε μεθόδους προσδιορισμού της αλληλουχίας μίας γονιδιωματικής περιοχής ενδιαφέροντος που περιλαμβάνει μία νουκλεοτιδική αλληλουχία στόχο περιλαμβάνουσες τη θραυσματοποίηση ενός διασυνδεδεμένου DNA, την πρόσδεση του θραυσματοποιημένου διασυνδεδεμένου DNA, την αντιστροφή της διασυνδέσεως και τον προσδιορισμό τουλάχιστον μέρους των αλληλουχιών των προσδεδεμένων θραυσμάτων DNA που περιλαμβάνουν μία νουκλεοτιδική αλληλουχία στόχο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36277810P | 2010-07-09 | 2010-07-09 | |
PCT/NL2011/050504 WO2012005595A2 (en) | 2010-07-09 | 2011-07-08 | V3-d genomic region of interest sequencing strategies |
Publications (1)
Publication Number | Publication Date |
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CY1121702T1 true CY1121702T1 (el) | 2020-07-31 |
Family
ID=44629077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100457T CY1121702T1 (el) | 2010-07-09 | 2018-05-03 | Στρατηγικες ταυτοποιησεως αλληλουχιας γονιδιωματικης περιοχης ενδιαφεροντος v3-d |
Country Status (25)
Country | Link |
---|---|
US (1) | US12006538B2 (el) |
EP (3) | EP2591125B1 (el) |
JP (1) | JP5977234B2 (el) |
KR (1) | KR101862756B1 (el) |
CN (1) | CN103180459B (el) |
AU (1) | AU2011274642B2 (el) |
BR (1) | BR112013000552B8 (el) |
CA (1) | CA2804450C (el) |
CY (1) | CY1121702T1 (el) |
DK (2) | DK2591125T3 (el) |
ES (2) | ES2667346T3 (el) |
HR (1) | HRP20180593T1 (el) |
HU (1) | HUE037359T2 (el) |
IL (2) | IL224127B (el) |
LT (1) | LT2591125T (el) |
NO (1) | NO2591125T3 (el) |
NZ (1) | NZ606228A (el) |
PL (2) | PL3360975T3 (el) |
PT (2) | PT3360975T (el) |
RS (1) | RS57295B1 (el) |
RU (1) | RU2603082C2 (el) |
SG (1) | SG186954A1 (el) |
SI (1) | SI2591125T1 (el) |
WO (1) | WO2012005595A2 (el) |
ZA (1) | ZA201300375B (el) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010242073C1 (en) | 2009-04-30 | 2015-12-24 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
ES2667346T3 (es) | 2010-07-09 | 2018-05-10 | Cergentis B.V. | Estrategias de secuenciación de región genómica 3-D de interés |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
WO2013036929A1 (en) | 2011-09-09 | 2013-03-14 | The Board Of Trustees Of The Leland Stanford Junior | Methods for obtaining a sequence |
EP2766498B1 (en) | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequencing by structure assembly |
CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
US11021737B2 (en) | 2011-12-22 | 2021-06-01 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
CA2859761C (en) | 2011-12-22 | 2023-06-20 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
CN108624668B (zh) * | 2013-02-01 | 2022-12-02 | 加利福尼亚大学董事会 | 用于基因组组装及单体型定相的方法 |
US9411930B2 (en) * | 2013-02-01 | 2016-08-09 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
WO2014129894A1 (en) * | 2013-02-19 | 2014-08-28 | Cergentis B.V. | Sequencing strategies for genomic regions of interest |
EP2971184B1 (en) | 2013-03-12 | 2019-04-17 | President and Fellows of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
EP2971278B1 (en) * | 2013-03-15 | 2022-08-10 | The Broad Institute, Inc. | Methods for determining multiple interactions between nucleic acids in a cell |
ES2776202T3 (es) | 2013-04-11 | 2020-07-29 | Pelin Sahlen | Captura de conformación cromosómica dirigida |
EP3603679B1 (en) | 2013-06-04 | 2022-08-10 | President and Fellows of Harvard College | Rna-guided transcriptional regulation |
CN111705116A (zh) * | 2013-07-19 | 2020-09-25 | 路德维格癌症研究有限公司 | 全基因组且靶向的单体型重构 |
GB2517936B (en) * | 2013-09-05 | 2016-10-19 | Babraham Inst | Chromosome conformation capture method including selection and enrichment steps |
EP3049557B1 (en) | 2013-09-27 | 2021-05-05 | University of Washington | Methods and systems for large scale scaffolding of genome assemblies |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
GB201320351D0 (en) * | 2013-11-18 | 2014-01-01 | Erasmus Universiteit Medisch Ct | Method |
US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
EP2960818A1 (en) * | 2014-06-24 | 2015-12-30 | Institut Pasteur | Method, device, and computer program for assembling pieces of chromosomes from one or several organisms |
US10179932B2 (en) | 2014-07-11 | 2019-01-15 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
WO2016019360A1 (en) | 2014-08-01 | 2016-02-04 | Dovetail Genomics Llc | Tagging nucleic acids for sequence assembly |
US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
JP2017536087A (ja) | 2014-09-24 | 2017-12-07 | グッド スタート ジェネティクス, インコーポレイテッド | 遺伝子アッセイのロバストネスを増大させるためのプロセス制御 |
WO2016089920A1 (en) | 2014-12-01 | 2016-06-09 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
CA3010579A1 (en) | 2015-01-06 | 2016-07-14 | Good Start Genetics, Inc. | Screening for structural variants |
EP3259696A1 (en) | 2015-02-17 | 2017-12-27 | Dovetail Genomics LLC | Nucleic acid sequence assembly |
US11807896B2 (en) | 2015-03-26 | 2023-11-07 | Dovetail Genomics, Llc | Physical linkage preservation in DNA storage |
US10395759B2 (en) * | 2015-05-18 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for copy number variant detection |
US12018314B2 (en) | 2015-07-02 | 2024-06-25 | Arima Genomics, Inc. | Accurate molecular deconvolution of mixture samples |
WO2017061861A1 (en) * | 2015-10-05 | 2017-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Targeted locus amplification using cloning strategies |
KR20180096586A (ko) | 2015-10-19 | 2018-08-29 | 더브테일 제노믹스 엘엘씨 | 게놈 어셈블리, 하플로타입 페이징 및 표적 독립적 핵산 검출을 위한 방법 |
US10900031B2 (en) | 2015-10-19 | 2021-01-26 | Zhejiang Annoroad Bio-Technology Co. Ltd. | Method for constructing high-resolution single cell Hi-C library with a lot of information |
GB201518843D0 (en) | 2015-10-23 | 2015-12-09 | Isis Innovation | Method of analysing DNA sequences |
WO2017079406A1 (en) | 2015-11-03 | 2017-05-11 | President And Fellows Of Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
CN115369161A (zh) * | 2015-12-04 | 2022-11-22 | 10X 基因组学有限公司 | 用于核酸分析的方法和组合物 |
CA3014911A1 (en) * | 2016-02-23 | 2017-08-31 | Dovetail Genomics, Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
CN116200465A (zh) | 2016-04-25 | 2023-06-02 | 哈佛学院董事及会员团体 | 用于原位分子检测的杂交链反应方法 |
GB201608000D0 (en) * | 2016-05-06 | 2016-06-22 | Oxford Biodynamics Ltd | Chromosome detection |
CN105839196B (zh) * | 2016-05-11 | 2018-04-17 | 北京百迈客生物科技有限公司 | 一种真核生物DNA的Hi‑C高通量测序建库方法 |
IL262946B2 (en) | 2016-05-13 | 2023-03-01 | Dovetail Genomics Llc | Retrieving long-range grip information from preserved samples |
KR101915701B1 (ko) | 2016-06-16 | 2018-11-07 | 한국한의학연구원 | 돌연변이 발생률의 측정 방법 |
EP4428536A2 (en) | 2016-08-31 | 2024-09-11 | President and Fellows of Harvard College | Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing |
JP7239465B2 (ja) | 2016-08-31 | 2023-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 蛍光in situ配列決定による検出のための核酸配列ライブラリの作製法 |
PL3548633T3 (pl) * | 2016-12-01 | 2024-04-02 | Oxford BioDynamics PLC | Zastosowanie epigenetycznych interakcji chromosomów w diagnostyce nowotworów |
EP3448396A4 (en) | 2017-04-14 | 2020-01-22 | President and Fellows of Harvard College | METHOD FOR PRODUCING A MICROFILAMENT NETWORK FROM CELLS |
CN107119120A (zh) * | 2017-05-04 | 2017-09-01 | 河海大学常州校区 | 一种基于染色质3d构象技术的关键作用分子检测方法 |
CN111655848A (zh) * | 2017-11-21 | 2020-09-11 | 阿瑞玛基因组学公司 | 在核酸模板中保留空间邻位邻接性和分子邻接性 |
SG11202101934SA (en) | 2018-07-30 | 2021-03-30 | Readcoor Llc | Methods and systems for sample processing or analysis |
WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
US20220251640A1 (en) * | 2019-05-17 | 2022-08-11 | The Broad Institute, Inc. | Methods of determination of genome architecture and epigenetic profile |
WO2021224225A1 (en) | 2020-05-04 | 2021-11-11 | Cergentis B.V. | Method |
GB202006550D0 (en) | 2020-05-04 | 2020-06-17 | Cergentis B V | Method |
WO2021224233A1 (en) | 2020-05-04 | 2021-11-11 | Cergentis B.V. | Method |
GB202006546D0 (en) | 2020-05-04 | 2020-06-17 | Cergentis B V | Method |
WO2022114957A1 (en) | 2020-11-26 | 2022-06-02 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Personalized tumor markers |
JP2024521142A (ja) * | 2021-05-21 | 2024-05-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 次世代体積インサイチュ配列決定 |
GB202111194D0 (en) | 2021-08-03 | 2021-09-15 | Cergentis B V | Method |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077204A (en) * | 1984-06-21 | 1991-12-31 | Chiron Corporation | Yeast endopeptidase for basic amino-acid site cleavage, preparation and use |
US9328391B1 (en) | 1984-08-22 | 2016-05-03 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Cloning and expression of HIV-1 DNA |
JPS6226300A (ja) | 1984-10-10 | 1987-02-04 | セントコ−・インコ−ポレ−テツド | Htlv−3dnaのクロ−ニングおよび発現 |
US5221518A (en) * | 1984-12-14 | 1993-06-22 | Mills Randell L | DNA sequencing apparatus |
US5258507A (en) * | 1990-11-08 | 1993-11-02 | Amoco Corporation | Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes |
US6060644A (en) * | 1994-03-24 | 2000-05-09 | Iowa State University Research Foundation, Inc. | Isolation and use of cuticular lipid genes |
CA2255774C (en) * | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
JP2002500623A (ja) * | 1996-11-07 | 2002-01-08 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニヴァーシティー | スプルーティタンパク質およびコーディング配列 |
US6261804B1 (en) * | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
EP1009802B1 (en) * | 1997-02-12 | 2004-08-11 | Eugene Y. Chan | Methods for analyzimg polymers |
AU1463299A (en) * | 1997-12-02 | 1999-06-16 | E.I. Du Pont De Nemours And Company | Branched chain amino acid biosynthetic enzymes |
US6455692B1 (en) * | 1998-08-04 | 2002-09-24 | Transgenomic, Inc. | Method of concentrating polynucleotides using MIPC |
US6291168B1 (en) * | 1998-10-27 | 2001-09-18 | Auburn University | Nucleic acid sequences diagnostic for pathogenic E.coli O157:H7, methods of identification and kit therefore |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
CA2378687A1 (en) * | 1999-06-18 | 2000-12-28 | Elitra Pharmaceuticals, Inc. | Nucleotide sequences of moraxella catarrhalis genome |
US7470507B2 (en) * | 1999-09-01 | 2008-12-30 | Whitehead Institute For Biomedical Research | Genome-wide location and function of DNA binding proteins |
US20040014195A1 (en) * | 1999-12-29 | 2004-01-22 | Diversa Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
US20060292560A1 (en) * | 2000-08-14 | 2006-12-28 | Robert Burgess | Transcription factor target gene discovery |
US6709861B2 (en) * | 2000-11-17 | 2004-03-23 | Lucigen Corp. | Cloning vectors and vector components |
US20030054347A1 (en) * | 2001-04-27 | 2003-03-20 | The Regents Of The University Of Michigan | Latrophilin Polynucleotides |
US20030013863A1 (en) * | 2001-07-16 | 2003-01-16 | Buchholz Wallace G. | High resolution DNA size standards |
US20030157705A1 (en) * | 2001-08-10 | 2003-08-21 | Fodor William L. | Engineered recombinant molecule that regulates humoral and cellular effector functions of the immune system |
AUPR823601A0 (en) * | 2001-10-12 | 2001-11-08 | University Of Queensland, The | Automated genotyping |
US20040142387A1 (en) * | 2002-05-29 | 2004-07-22 | University Of Washington | Mutants of GAD65 and Ian5 relating to diabetes |
EP1548105A4 (en) * | 2002-08-30 | 2006-03-01 | Japan Science & Tech Agency | TARGETED GENE DISRUPTION METHOD, HYPERTHERMOSTABLE BACTERIUM GENOME AND GENOMIC CHIP USING SUCH A METHOD |
DE60229890D1 (de) * | 2002-09-30 | 2008-12-24 | Hoffmann La Roche | Oligonukleotide zur genotypisierung des thymidylat-synthase gens |
US7575865B2 (en) * | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
EP1601688A2 (en) * | 2003-03-06 | 2005-12-07 | Children's Hospital, Inc. | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
FR2852317B1 (fr) * | 2003-03-13 | 2006-08-04 | Biopuces a sondes et leurs methodes d'utilisation | |
EP1670505B1 (en) * | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna promoters and anthrax vaccines |
US20060150283A1 (en) * | 2004-02-13 | 2006-07-06 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
US20060107345A1 (en) * | 2003-09-30 | 2006-05-18 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
WO2005039389A2 (en) * | 2003-10-22 | 2005-05-06 | 454 Corporation | Sequence-based karyotyping |
WO2005047521A2 (en) * | 2003-11-10 | 2005-05-26 | Investigen, Inc. | Methods of preparing nucleic acid for detection |
WO2006031745A2 (en) * | 2004-09-10 | 2006-03-23 | Sequenom, Inc. | Methods for long-range sequence analysis of nucleic acids |
US20070048748A1 (en) * | 2004-09-24 | 2007-03-01 | Li-Cor, Inc. | Mutant polymerases for sequencing and genotyping |
US20060223073A1 (en) * | 2005-03-31 | 2006-10-05 | Boyes Barry E | Methods of using a DNase I-like enzyme |
WO2007145612A1 (en) * | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
US8407013B2 (en) * | 2005-06-07 | 2013-03-26 | Peter K. Rogan | AB initio generation of single copy genomic probes |
US7709197B2 (en) * | 2005-06-15 | 2010-05-04 | Callida Genomics, Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
ES2387878T3 (es) * | 2005-06-23 | 2012-10-03 | Keygene N.V. | Estrategias para la identificación de alto rendimiento y la detección de polimorfismos |
DE602006013831D1 (de) * | 2005-06-23 | 2010-06-02 | Keygene Nv | Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz |
AU2006264564B2 (en) | 2005-07-04 | 2012-04-19 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
US20090143240A1 (en) * | 2005-08-25 | 2009-06-04 | Harbison Christopher T | Novel Methods for Genome-Wide Location Analysis |
US20090221428A1 (en) * | 2005-09-07 | 2009-09-03 | Young Richard A | Methods of Genome-Wide Location Analysis in Stem Cells |
WO2007055568A1 (en) | 2005-11-14 | 2007-05-18 | Keygene N.V. | Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites |
JP5285431B2 (ja) * | 2005-12-28 | 2013-09-11 | ザ ユーエイビー リサーチ ファウンデイション | 肺炎球菌血清型 |
GB0603251D0 (en) * | 2006-02-17 | 2006-03-29 | Isis Innovation | DNA conformation |
WO2008008845A2 (en) | 2006-07-11 | 2008-01-17 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
US9328378B2 (en) * | 2006-07-31 | 2016-05-03 | Illumina Cambridge Limited | Method of library preparation avoiding the formation of adaptor dimers |
WO2008064839A2 (en) * | 2006-11-27 | 2008-06-05 | Dsm Ip Assets B.V. | Method for preparing hydroxytyrosol |
EP2639578B1 (en) * | 2006-12-14 | 2016-09-14 | Life Technologies Corporation | Apparatus for measuring analytes using large scale fet arrays |
DK2121977T3 (en) | 2007-01-11 | 2017-09-18 | Erasmus Univ Medical Center | Capture (4C) OF CHROMOSOMES WITH CIRCULAR CONFORMATION |
JP2010516285A (ja) * | 2007-01-26 | 2010-05-20 | イルミナ インコーポレイテッド | 核酸配列決定システムおよび方法 |
WO2008111453A1 (ja) * | 2007-03-07 | 2008-09-18 | The University Of Tokyo | Dna断片の増幅方法 |
US20080248958A1 (en) * | 2007-04-05 | 2008-10-09 | Hollenbach Andrew D | System for pulling out regulatory elements in vitro |
US7932030B2 (en) * | 2007-04-05 | 2011-04-26 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | System for pulling out regulatory elements using yeast |
JP2010528608A (ja) * | 2007-06-01 | 2010-08-26 | 454 ライフ サイエンシーズ コーポレイション | 複合的な混合物から個々の試料を特定するためのシステムおよび方法 |
EP2053132A1 (en) * | 2007-10-23 | 2009-04-29 | Roche Diagnostics GmbH | Enrichment and sequence analysis of geomic regions |
US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
US8263367B2 (en) * | 2008-01-25 | 2012-09-11 | Agency For Science, Technology And Research | Nucleic acid interaction analysis |
WO2009143212A1 (en) * | 2008-05-21 | 2009-11-26 | Mito Tech Llc | Computer system and computer-facilitated method for nucleic acid sequence alignment and analysis |
EP2304028B1 (en) * | 2008-05-23 | 2017-10-25 | Life Technologies Corporation | Methods and kits for extraction of dna |
FR2945545B1 (fr) * | 2009-05-14 | 2011-08-05 | Univ Aix Marseille Ii | Methode de detection d'adn procaryote extrait d'un echantillon de selles |
KR20120089476A (ko) * | 2009-09-01 | 2012-08-10 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 마이크로어레이 선택을 위한 장치 및 방법 |
EP2354243A1 (en) | 2010-02-03 | 2011-08-10 | Lexogen GmbH | Complexity reduction method |
JP5901046B2 (ja) * | 2010-02-19 | 2016-04-06 | 国立大学法人 千葉大学 | OATP1B3mRNAの新規な選択的スプライシングバリアント |
ES2667346T3 (es) | 2010-07-09 | 2018-05-10 | Cergentis B.V. | Estrategias de secuenciación de región genómica 3-D de interés |
US10858699B2 (en) * | 2016-08-30 | 2020-12-08 | Integrated Dna Technologies, Inc. | Cleavable hairpin primers |
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