ATE521948T1 - System und verfahren zur nukleinsäuresequenzierung - Google Patents

System und verfahren zur nukleinsäuresequenzierung

Info

Publication number
ATE521948T1
ATE521948T1 AT08728393T AT08728393T ATE521948T1 AT E521948 T1 ATE521948 T1 AT E521948T1 AT 08728393 T AT08728393 T AT 08728393T AT 08728393 T AT08728393 T AT 08728393T AT E521948 T1 ATE521948 T1 AT E521948T1
Authority
AT
Austria
Prior art keywords
nucleotides
nucleic acid
added
quality
samples
Prior art date
Application number
AT08728393T
Other languages
English (en)
Inventor
Robert C Kain
David L Heiner
Chanfeng Zhao
Kevin Gunderson
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of ATE521948T1 publication Critical patent/ATE521948T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT08728393T 2007-01-26 2008-01-28 System und verfahren zur nukleinsäuresequenzierung ATE521948T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89764607P 2007-01-26 2007-01-26
US89764707P 2007-01-26 2007-01-26
PCT/US2008/052198 WO2008092150A1 (en) 2007-01-26 2008-01-28 Nucleic acid sequencing system and method

Publications (1)

Publication Number Publication Date
ATE521948T1 true ATE521948T1 (de) 2011-09-15

Family

ID=39327330

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08728393T ATE521948T1 (de) 2007-01-26 2008-01-28 System und verfahren zur nukleinsäuresequenzierung

Country Status (7)

Country Link
US (6) US8725425B2 (de)
EP (3) EP2126766A2 (de)
JP (1) JP2010516285A (de)
CN (1) CN101652780B (de)
AT (1) ATE521948T1 (de)
CA (1) CA2676570C (de)
WO (2) WO2008092155A2 (de)

Families Citing this family (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3492602A1 (de) 2005-06-15 2019-06-05 Complete Genomics, Inc. Einzelne molekülarrays für genetische und chemische analyse
CA2641271A1 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US8725425B2 (en) * 2007-01-26 2014-05-13 Illumina, Inc. Image data efficient genetic sequencing method and system
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
EP2291533B2 (de) 2008-07-02 2020-09-30 Illumina Cambridge Limited Verwendung von kügelchengruppen zur herstellung von arrays auf oberflächen
WO2010028366A2 (en) * 2008-09-05 2010-03-11 Life Technologies Corporation Methods and systems for nucleic acid sequencing validation, calibration and normalization
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
EP2425240A4 (de) 2009-04-30 2012-12-12 Good Start Genetics Inc Verfahren und zusammensetzung zur bewertung genetischer marker
TWI439548B (zh) * 2009-12-23 2014-06-01 Ind Tech Res Inst 序列校正方法與序列校正裝置
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
WO2011103467A2 (en) * 2010-02-19 2011-08-25 Life Technologies Corporation Methods and systems for nucleic acid sequencing validation, calibration and normalization
US10240194B2 (en) 2010-05-13 2019-03-26 Gen9, Inc. Methods for nucleotide sequencing and high fidelity polynucleotide synthesis
US20120035062A1 (en) 2010-06-11 2012-02-09 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
PT2591125T (pt) * 2010-07-09 2018-05-09 Cergentis B V Estratégias 3-d de sequenciação de regiões genómicas de interesse
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
US8976856B2 (en) * 2010-09-30 2015-03-10 Apple Inc. Optimized deblocking filters
GB2499340B (en) 2010-10-04 2015-10-28 Genapsys Inc Methods for sequencing nucleic acids
EP3141614B1 (de) 2010-10-27 2018-11-28 Life Technologies Corporation Prädiktives modell zur verwendung für sequenzierung nach synthese
US10273540B2 (en) 2010-10-27 2019-04-30 Life Technologies Corporation Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis
EP3709303A1 (de) * 2010-12-14 2020-09-16 Life Technologies Corporation Systeme und verfahren zur qualitätsüberwachung von laufzeitsequenzierungsläufen
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
WO2012092455A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
CN102146442B (zh) * 2010-12-31 2014-10-22 深圳华因康基因科技有限公司 一种对基因测序仪的测序过程进行控制的方法及系统
US9217132B2 (en) 2011-01-20 2015-12-22 Ibis Biosciences, Inc. Microfluidic transducer
WO2012138921A1 (en) 2011-04-08 2012-10-11 Life Technologies Corporation Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
EP2714932A4 (de) 2011-05-24 2015-06-10 Univ California In autismus dysregulierte gene als biomarker und ziele für therapeutische pfade
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
EP2768972B2 (de) * 2011-09-23 2020-07-22 Illumina, Inc. Verfahren und zusammensetzungen zur nucleinsäuresequenzierung
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
JP5863396B2 (ja) * 2011-11-04 2016-02-16 株式会社日立製作所 Ｄｎａ配列解読システム、ｄｎａ配列解読方法及びプログラム
JP6193252B2 (ja) 2011-12-01 2017-09-06 ジナプシス インコーポレイテッド 高効率電子配列決定及び検出のためのシステム並びに方法
CA3138752C (en) * 2012-04-03 2024-02-06 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US9444880B2 (en) 2012-04-11 2016-09-13 Illumina, Inc. Cloud computing environment for biological data
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9341589B2 (en) 2012-06-20 2016-05-17 Board Of Regents, The University Of Texas System Active-electrode integrated biosensor array and methods for use thereof
JP2015529131A (ja) * 2012-09-20 2015-10-05 コーニンクレッカ フィリップス エヌ ヴェ 皮膚治療方法及び装置
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
US9116139B2 (en) 2012-11-05 2015-08-25 Illumina, Inc. Sequence scheduling and sample distribution techniques
WO2014074611A1 (en) 2012-11-07 2014-05-15 Good Start Genetics, Inc. Methods and systems for identifying contamination in samples
EP4012716A1 (de) 2012-11-19 2022-06-15 Apton Biosystems, Inc. Digitale analyse molekularer analyten mittels einzelmolekülnachweis
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
US9128861B2 (en) 2013-01-17 2015-09-08 Personalis, Inc. Methods and systems for genetic analysis
CA2902099C (en) 2013-03-08 2020-06-02 F. Hoffmann-La Roche Ag Egfr mutation blood testing
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
EP2971159B1 (de) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Verfahren zur analyse von nukleinsäuren
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
CN105051214B (zh) 2013-03-15 2018-12-28 吉纳普赛斯股份有限公司 用于生物分析的系统和方法
GB201306444D0 (en) 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
EP2994538A1 (de) 2013-05-09 2016-03-16 Roche Diagnostics GmbH Verfahren zur bestimmung des anteils an fetaler dna in mütterlichem blut mit hla-markern
EP3005200A2 (de) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Verfahren und systeme zur speicherung von sequenzlesedaten
US9926597B2 (en) 2013-07-26 2018-03-27 Life Technologies Corporation Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
CN105637126B (zh) 2013-08-22 2022-09-23 雅普顿生物系统公司 使用电方法的分子分析物的数字分析
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015051275A1 (en) 2013-10-03 2015-04-09 Personalis, Inc. Methods for analyzing genotypes
JP6532456B2 (ja) 2013-10-04 2019-06-19 ライフ テクノロジーズ コーポレーション 終止化学を用いる配列決定における整相効果（ｐｈａｓｉｎｇ ｅｆｆｅｃｔｓ）をモデル化するための方法及びシステム
SG11201602903XA (en) 2013-10-18 2016-05-30 Seven Bridges Genomics Inc Methods and systems for genotyping genetic samples
WO2015058095A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for quantifying sequence alignment
EP3058096A1 (de) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Verfahren zur beurteilung eines genomischen bereichs einer person
SG11201603039PA (en) 2013-10-18 2016-05-30 Seven Bridges Genomics Inc Methods and systems for identifying disease-induced mutations
WO2015058120A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
US10415083B2 (en) 2013-10-28 2019-09-17 The Translational Genomics Research Institute Long insert-based whole genome sequencing
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
GB2522087B (en) * 2013-12-27 2016-02-17 Personalis Inc Methods and systems for genetic analysis
JP2017510871A (ja) 2014-01-10 2017-04-13 セブン ブリッジズ ジェノミクス インコーポレイテッド リードマッピングにおける公知の対立遺伝子の使用のためのシステム及び方法
US9817944B2 (en) 2014-02-11 2017-11-14 Seven Bridges Genomics Inc. Systems and methods for analyzing sequence data
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US20160017421A1 (en) 2014-07-16 2016-01-21 Roche Molecular Systems Non-invasive early detection of solid organ transplant rejection by quantitative analysis of hla gene amplicons
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
EP3224595A4 (de) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Prozesssteuerung für erhöhte robustheit von genetischen assays
CN104239732A (zh) * 2014-09-24 2014-12-24 湖南大学 一种运行于多核计算机平台的并行通用序列的比对方法
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
CN107408043A (zh) 2014-10-14 2017-11-28 七桥基因公司 用于序列流水线中的智能工具的系统和方法
EP3835429A1 (de) 2014-10-17 2021-06-16 Good Start Genetics, Inc. Genetisches screening und nachweis von aneuploidie im vorfeld einer implantation
CN113092563B (zh) 2014-10-22 2024-06-07 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
EP3212808B1 (de) 2014-10-30 2022-03-02 Personalis, Inc. Verfahren zur verwendung von mosaizismus in nukleinsäuren, die distal zu ihrem ursprung entnommen wurden
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
EP3227461A1 (de) 2014-12-05 2017-10-11 Amyris, Inc. Hochdurchsatz-sequenzierung von polynukleotiden
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
EP3235010A4 (de) 2014-12-18 2018-08-29 Agilome, Inc. Chemisch empfindlicher feldeffekttransistor
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
US10192026B2 (en) 2015-03-05 2019-01-29 Seven Bridges Genomics Inc. Systems and methods for genomic pattern analysis
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US10978174B2 (en) 2015-05-14 2021-04-13 Life Technologies Corporation Barcode sequences, and related systems and methods
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
CA2992578A1 (en) 2015-07-14 2017-01-19 Victor Velculescu Neoantigen analysis
US10465245B2 (en) 2015-07-29 2019-11-05 Progenity, Inc. Nucleic acids and methods for detecting chromosomal abnormalities
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
ES2796501T3 (es) 2015-10-10 2020-11-27 Guardant Health Inc Métodos y aplicaciones de la detección de fusión de genes en el análisis de ADN sin células
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
US11118154B2 (en) 2015-11-04 2021-09-14 Thrive Bioscience, Inc. Networked incubator operation
US11308121B2 (en) 2015-11-04 2022-04-19 Thrive Bioscience, Inc. Method and system for cell operations using a blockchain data network
US11230690B2 (en) 2015-11-04 2022-01-25 Thrive Bioscience, Inc. Method and system for cell operations using the internet of things
CA3005101A1 (en) * 2015-11-16 2017-05-26 Progenity, Inc. Nucleic acids and methods for detecting methylation status
EP3390668A4 (de) 2015-12-17 2020-04-01 Guardant Health, Inc. Verfahren zur bestimmung der tumorgenkopienzahl durch analyse von zellfreier dna
US20170199960A1 (en) 2016-01-07 2017-07-13 Seven Bridges Genomics Inc. Systems and methods for adaptive local alignment for graph genomes
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US11021742B2 (en) 2016-03-28 2021-06-01 Boreal Genomics, Inc. Linked-fragment sequencing
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
WO2017201081A1 (en) 2016-05-16 2017-11-23 Agilome, Inc. Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10600499B2 (en) 2016-07-13 2020-03-24 Seven Bridges Genomics Inc. Systems and methods for reconciling variants in sequence data relative to reference sequence data
CN116397014A (zh) 2016-07-20 2023-07-07 测序健康公司 用于核酸测序的系统和方法
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
CN110023509A (zh) 2016-11-15 2019-07-16 私人基因诊断公司 基因型分型测定中的非独特条形码
CA3048420A1 (en) 2016-12-09 2018-06-14 Boreal Genomics, Inc. Linked ligation
EP3342878B1 (de) * 2016-12-30 2020-07-15 GeneMind Biosciences Company Limited Verfahren zur steuerung der basensequenzbestimmungsreaktion, basensequenzbestimmungssystem und steuerungsvorrichtung
CN108265112B (zh) 2016-12-30 2023-04-25 深圳市真迈生物科技有限公司 对序列测定反应进行控制的方法、序列测定系统和控制装置
DK3566158T3 (da) * 2017-01-06 2022-07-18 Illumina Inc Faseinddelingskorrektion
CN109414673B (zh) 2017-02-01 2021-09-07 伊鲁米那股份有限公司 具有响应于多个激发频率的基准的系统和方法
GB201701688D0 (en) * 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701689D0 (en) * 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701691D0 (en) * 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
GB201701686D0 (en) * 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
CN114921537A (zh) 2017-03-17 2022-08-19 雅普顿生物系统公司 测序和高分辨率成像
WO2018197374A1 (en) * 2017-04-27 2018-11-01 Koninklijke Philips N.V. Compression and annotation of digital waveforms from serial read next generation sequencing to support remote computing base calling
US11599394B2 (en) 2017-07-14 2023-03-07 Illumina, Inc. Coordinated application processing
JP2021500858A (ja) 2017-09-21 2021-01-14 ジナプシス インコーポレイテッド 核酸シーケンシングのためのシステム及び方法
SG11201911784PA (en) * 2018-01-08 2020-01-30 Illumina Inc Systems and devices for high-throughput sequencing with semiconductor-based detection
US11561196B2 (en) * 2018-01-08 2023-01-24 Illumina, Inc. Systems and devices for high-throughput sequencing with semiconductor-based detection
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10338107B1 (en) 2018-08-02 2019-07-02 Altec Industries, Inc. System and method for detecting a contact between an aerial device and an electrical power source
EP3853382A4 (de) 2018-09-19 2022-06-22 Apton Biosystems, Inc. Dicht verpackte analytschichten und nachweisverfahren
WO2020132350A2 (en) * 2018-12-20 2020-06-25 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US11473136B2 (en) 2019-01-03 2022-10-18 Ncan Genomics, Inc. Linked target capture
EP3909053A4 (de) * 2019-01-07 2022-10-05 Personal Genome Diagnostics Inc. Quantifizierung von sequenzierinstrumenten und reagenzien zur verwendung in molekularen diagnostischen verfahren
EP3908823A4 (de) 2019-01-10 2022-10-12 Travera LLC Kalibrierung eines funktionellen biomarker-instruments
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
CN113924041A (zh) 2019-03-14 2022-01-11 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11347965B2 (en) 2019-03-21 2022-05-31 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
TW202104901A (zh) 2019-06-19 2021-02-01 美商伊路米納有限公司 儀器中的試劑交換
CN110415767B (zh) * 2019-06-20 2022-04-22 清华大学 液滴单细胞转录组测序数据降噪方法、装置和存储介质
US20220333194A1 (en) 2019-08-08 2022-10-20 Inserm (Institutnationaldelasanteetdelarecherchemedicale) Rna sequencing method for the analysis of b and t cell transcriptome in phenotypically defined b and t cell subsets
JP2022546117A (ja) 2019-08-28 2022-11-02 アッセンブリー バイオサイエンシズ，インコーポレイテッド 細菌種を含む組成物及びそれに関連する方法
CA3142971A1 (en) * 2019-12-30 2021-07-08 Illumina, Inc. Systems for monitoring fluidics in reagent cartridges and related methods
CN115698282A (zh) 2020-01-13 2023-02-03 福路伦特生物科学公司 单细胞测序
KR20220143854A (ko) 2020-02-20 2022-10-25 일루미나, 인코포레이티드 인공 지능 기반 다-대-다 염기 호출
CA3175931A1 (en) 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US20220042106A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of using cell-free nucleic acids to tailor cancer treatment
US20220042107A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of scoring risk and residual disease from passenger mutations
WO2022029484A1 (en) 2020-08-06 2022-02-10 Agendia NV Methods of assessing breast cancer using circulating hormone receptor transcripts
US20220042108A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of assessing breast cancer
GB202012434D0 (en) 2020-08-10 2020-09-23 Univ Manchester Multiomic analysis of nanoparticle-coronas
GB202012433D0 (en) 2020-08-10 2020-09-23 Univ Manchester Nanoparticle-enabled analysis of cell-free nucleic acid in complex biological fluids
JP2024501133A (ja) 2020-11-26 2024-01-11 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） 感染因子を識別するための方法
KR20230167028A (ko) * 2021-04-02 2023-12-07 일루미나, 인코포레이티드 시퀀싱을 위한 뉴클레오티드 샘플 슬라이드 내 거품을 검출하기 위한 기계-학습 모델
US20220336054A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures
WO2022219128A1 (en) 2021-04-15 2022-10-20 INSERM (Institut National de la Santé et de la Recherche Médicale) In vitro tests allowing to identify the potential for mdm2 inhibitors to induce the selection of mutations in patients suffering from a myeloproliferative neoplasm
WO2023107622A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
US11639499B1 (en) 2022-03-08 2023-05-02 Watchmaker Genomics, Inc. Reverse transcriptase variants
WO2023175042A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Parallel sample and index sequencing
CN116437217B (zh) * 2023-06-13 2023-08-18 深圳太古语科技有限公司 基因测序芯片的拍摄方法及基因测序仪

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US684460A (en) * 1898-09-10 1901-10-15 Corydon T Purdy Partition construction.
DE2540969A1 (de) 1975-09-13 1977-03-17 Bodenseewerk Perkin Elmer Co Automatische probenvorbereitungsvorrichtung
JP2539512B2 (ja) * 1989-07-17 1996-10-02 株式会社日立製作所 複数項目分析装置およびその分析装置を動作させる方法
CZ280777B6 (cs) 1990-02-02 1996-04-17 Ústav Organické Chemie A Biochemie Avčr Mnohonásobná automatizovaná syntéza peptidů na planárních nosičích
US5367401A (en) * 1990-11-23 1994-11-22 Perceptive Scientific Instruments, Inc. Microscope slide rotary stage
JPH0821015B2 (ja) * 1992-01-20 1996-03-04 インターナショナル・ビジネス・マシーンズ・コーポレイション コンピュータならびにそのシステム再構成化装置および方法
US5601141A (en) * 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5614608A (en) * 1995-01-20 1997-03-25 Selectide Corporation Apparatus and method for multiple synthesis of organic compounds on polymer support
US6045760A (en) * 1995-12-05 2000-04-04 Hitachi Koki Co., Ltd. Micro-plate adapter
WO1999008223A1 (de) * 1997-08-05 1999-02-18 Siemens Aktiengesellschaft Verfahren zur bestimmung eines abstandsmasses zwischen einem schriftzug und einem referenzschriftzug
CA2299325C (en) * 1997-08-07 2008-01-08 Imaging Research, Inc. A digital imaging system for assays in well plates, gels and blots
US6121054A (en) 1997-11-19 2000-09-19 Trega Biosciences, Inc. Method for separation of liquid and solid phases for solid phase organic syntheses
EP1930078A1 (de) 1998-05-01 2008-06-11 Gen-Probe Incorporated Verfahren zum Umrühren des Inhalts eines Containers
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
US6078390A (en) * 1998-05-04 2000-06-20 General Scanning, Inc. Scanning system and method of operation for automatically setting detection sensitivity
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6264891B1 (en) * 1998-12-22 2001-07-24 Eos Biotechnology, Inc. Apparatus and method for concurrent chemical synthesis
CA2361223A1 (en) 1999-01-29 2000-08-03 Illumina, Inc. Centrifuging apparatus and method for separation of liquid phases and organic synthesis
US6846460B1 (en) * 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6839454B1 (en) 1999-09-30 2005-01-04 Biodiscovery, Inc. System and method for automatically identifying sub-grids in a microarray
US6558623B1 (en) 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US7390459B2 (en) * 1999-12-13 2008-06-24 Illumina, Inc. Oligonucleotide synthesizer
DK1239952T3 (da) * 1999-12-13 2012-01-02 Illumina Inc Syntetiseringsindretning til oligonukleotider ved anvendelse af en centrifugalkraft
US6692972B1 (en) 2000-08-24 2004-02-17 University Of Chicago Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules
DE60103924T2 (de) * 2000-11-06 2005-07-14 Nanostream, Inc., Pasadena Mikrofluidische durchflussregelvorrichtung
CN2478110Y (zh) * 2001-04-25 2002-02-20 张宏 全自动基因测序仪
US20030124539A1 (en) 2001-12-21 2003-07-03 Affymetrix, Inc. A Corporation Organized Under The Laws Of The State Of Delaware High throughput resequencing and variation detection using high density microarrays
US20060083428A1 (en) * 2004-01-22 2006-04-20 Jayati Ghosh Classification of pixels in a microarray image based on pixel intensities and a preview mode facilitated by pixel-intensity-based pixel classification
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
GB2398383B (en) 2003-02-12 2005-03-09 Global Genomics Ab Method and means for nucleic acid sequencing
WO2006064199A1 (en) * 2004-12-13 2006-06-22 Solexa Limited Improved method of nucleotide detection
CA2596496A1 (en) * 2005-02-01 2006-08-10 Agencourt Bioscience Corp. Reagents, methods, and libraries for bead-based sequencing
US20060240443A1 (en) * 2005-04-20 2006-10-26 Combimatrix Corporation Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method
US7894648B2 (en) * 2005-06-17 2011-02-22 Mayo Foundation For Medical Education And Research Colonoscopy video processing for quality metrics determination
JP5055282B2 (ja) 2005-09-14 2012-10-24 イルミナ インコーポレイテッド 連続的なポリマー合成器
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
CN101460953B (zh) 2006-03-31 2012-05-30 索雷克萨公司 用于合成分析的序列的系统和装置
US8725425B2 (en) * 2007-01-26 2014-05-13 Illumina, Inc. Image data efficient genetic sequencing method and system
CN105349647B (zh) 2007-10-30 2020-08-28 完整基因有限公司 用于核酸高通量测序的方法

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